Rosuvastatin: A Potential Therapeutic Agent for Inhibition of Mechanical Pressure-Induced Intervertebral Disc Degeneration

References

• Zhang C, Lu Z, Lyu C, et al. Andrographolide inhibits static mechanical pressure-induced intervertebral disc degeneration via the MAPK/Nrf2/HO-1 pathway. Drug Des Devel Ther. 2023;17:535–550. doi:10.2147/DDDT.S392535
   PubMed Web of Science ®Google Scholar
• Xu H, Qi G, Li K, et al. Impact of NF-kappaB pathway on the intervertebral disc inflammation and degeneration induced by over-mechanical stretching stress. J Inflamm -Lond. 2021;18(1):6. doi:10.1186/s12950-021-00273-9
   PubMed Web of Science ®Google Scholar
• Adams SP, Sekhon SS, Wright JM. Lipid-lowering efficacy of rosuvastatin. Cochrane Database Syst Rev. 2014;2014:CD10254. doi:10.1002/14651858.CD010254.pub2
   Google Scholar
• Ren G, Zhou Q, Lu M, et al. Rosuvastatin corrects oxidative stress and inflammation induced by LPS to attenuate cardiac injury by inhibiting the NLRP3/TLR4 pathway. Can J Physiol Pharmacol. 2021;99(9):964–973. doi:10.1139/cjpp-2020-0321
   PubMed Web of Science ®Google Scholar
• Baraka SA, Tolba MF, Elsherbini DA, et al. Rosuvastatin and low-dose carvedilol combination protects against isoprenaline-induced myocardial infarction in rats: role of PI3K/Akt/Nrf2/HO-1 signalling. Clin Exp Pharmacol Physiol. 2021;48(10):1358–1370. doi:10.1111/1440-1681.13535
   PubMed Web of Science ®Google Scholar
• Zhang Q, Wang L, Wang S, et al. Signaling pathways and targeted therapy for myocardial infarction. Signal Transduct Target Ther. 2022;7(1):78. doi:10.1038/s41392-022-00925-z
   PubMed Web of Science ®Google Scholar
• Wang Y, Gao L, Chen J, et al. Pharmacological modulation of Nrf2/HO-1 signaling pathway as a therapeutic target of Parkinson’s disease. Front Pharmacol. 2021;12:757161. doi:10.3389/fphar.2021.757161
   PubMed Web of Science ®Google Scholar
• Yang J, Mo J, Dai J, et al. Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer. Cell Death Dis. 2021;12(11):1079. doi:10.1038/s41419-021-04367-3
   PubMed Web of Science ®Google Scholar
• Sun YY, Zhu HJ, Zhao RY, et al. Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2/HO-1 pathway in MCAO mice. Redox Biol. 2023;66:102852. doi:10.1016/j.redox.2023.102852
   PubMed Web of Science ®Google Scholar
• Shahcheraghi SH, Salemi F, Small S, et al. Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: therapeutic and biotechnological prospects. Phytother Res. 2023;37(4):1590–1605. doi:10.1002/ptr.7754
   PubMed Web of Science ®Google Scholar
• Sun Y, Zhang W, Li X. Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration. Stem Cell Res Ther. 2021;12(1):286. doi:10.1186/s13287-021-02362-1
   PubMed Web of Science ®Google Scholar
• Wang Z, Chen X, Chen N, et al. Mechanical factors regulate Annulus Fibrosus (AF) injury repair and remodeling: a review. ACS Biomater Sci Eng. 2024;10(1):219–233. doi:10.1021/acsbiomaterials.3c01091
   PubMed Web of Science ®Google Scholar
• Zhang W, Wang H, Yuan Z, et al. Moderate mechanical stimulation rescues degenerative annulus fibrosus by suppressing caveolin-1 mediated pro-inflammatory signaling pathway. Int J Biol Sci. 2021;17(5):1395–1412. doi:10.7150/ijbs.57774
   PubMed Web of Science ®Google Scholar
• Wang D, Chen Y, Cao S, et al. Cyclic mechanical stretch ameliorates the degeneration of nucleus pulposus cells through promoting the ITGA2/PI3K/AKT signaling pathway. OxidMed Cell Longevity. 2021;2021:6699326. doi:10.1155/2021/6699326
   PubMed Web of Science ®Google Scholar
• Ning L, Gao L, Zhang F, Li X, Wang T. Mechanical stretch induces annulus fibrosus cell senescence through activation of the RhoA/ROCK pathway. BioMed Res Int. 2021;2021:5321121. doi:10.1155/2021/5321121
   PubMed Web of Science ®Google Scholar
• Ao X, Li Y, Jiang T, et al. Angiopoietin-2 promotes mechanical stress-induced extracellular matrix degradation in annulus fibrosus via the HIF-1α/NF-κB signaling pathway. Orthop Surg. 2023;15(9):2410–2422. doi:10.1111/os.13797
   PubMed Web of Science ®Google Scholar
• Jiang Y, Fu L, Song Y. Responses of apoptosis and matrix metabolism of annulus fibrosus cells to different magnitudes of mechanical tension in vitro. Biosci Rep. 2019;39(2). doi:10.1042/BSR20182375
   Google Scholar
• Kang L, Liu S, Li J, et al. The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance. Cell Prolif. 2020;53(3):e12779. doi:10.1111/cpr.12779
   PubMed Web of Science ®Google Scholar
• Ding F, Shao ZW, Yang SH, et al. Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells. Apoptosis. 2012;17(6):579–590. doi:10.1007/s10495-012-0708-3
   PubMed Web of Science ®Google Scholar
• Fang H, Li X, Shen H, et al. Osteogenic protein-1 attenuates apoptosis and enhances matrix synthesis of nucleus pulposus cells under high-magnitude compression though inhibiting the p38 MAPK pathway. Biosci Rep. 2018;38(2). doi:10.1042/BSR20180018
   Google Scholar
• Husain I, Akhtar M, Madaan T, et al. Rosuvastatin alleviates high-salt and cholesterol diet-induced cognitive impairment in rats via Nrf2-ARE pathway. Redox Rep. 2018;23(1):168–179. doi:10.1080/13510002.2018.1492774
   PubMed Web of Science ®Google Scholar
• Chen W, Deng Z, Zhu J, et al. Rosuvastatin suppresses TNF-alpha-induced matrix catabolism, pyroptosis and senescence via the HMGB1/NF-kappaB signaling pathway in nucleus pulposus cells. Acta Biochim Biophys Sin. 2023;55:795–808. doi:10.3724/abbs.2023026
   Google Scholar
• Yilmaz I, Karaarslan N. Examining the effects of HMG-CoA reductase inhibitors on anabolic and catabolic signaling pathway proteins associated with degenerative disc disease. Eur Rev Med Pharmacol Sci. 2022;26(8):2990–3000. doi:10.26355/eurrev_202204_28630
   PubMed Web of Science ®Google Scholar
• Yahia S, Khalil IA, El-Sherbiny IM. Fortified gelatin-based hydrogel scaffold with simvastatin-mixed nanomicelles and platelet rich plasma as a promising bioimplant for tissue regeneration. Int J Biol Macromol. 2023;225:730–744. doi:10.1016/j.ijbiomac.2022.11.136
   PubMed Web of Science ®Google Scholar
• Karamouzian S, Eskandary H, Saeed A, et al. Effect of atorvastatin on angiogenesis in degenerated intervertebral disc in rat. SPINE. 2011;36(22):1824–1828. doi:10.1097/BRS.0b013e3181d4e15a
   PubMed Web of Science ®Google Scholar
• Hu MH, Yang KC, Chen YJ, et al. Lovastatin prevents discography-associated degeneration and maintains the functional morphology of intervertebral discs. Spine J. 2014;14(10):2459–2466. doi:10.1016/j.spinee.2014.03.050
   PubMed Web of Science ®Google Scholar
• Cross GB, Sari IP, Kityo C, et al. Rosuvastatin adjunctive therapy for rifampicin-susceptible pulmonary tuberculosis: a phase 2b, randomised, open-label, multicentre trial. Lancet Infect Dis. 2023;23(7):847–855. doi:10.1016/S1473-3099(23)00067-1
   PubMed Web of Science ®Google Scholar
• Pienkos SM, Moore AR, Guan J, et al. Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials. Crit Care. 2023;27(1):126. doi:10.1186/s13054-023-04387-9
   PubMed Web of Science ®Google Scholar
• Tao S, Shen Z, Chen J, et al. Red light-mediated photoredox catalysis triggers nitric oxide release for treatment of cutibacterium acne induced intervertebral disc degeneration. ACS Nano. 2022;16(12):20376–20388. doi:10.1021/acsnano.2c06328
   PubMedGoogle Scholar
• Lin Y, Jiao Y, Yuan Y, et al. Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway. Emerg Microbes Infect. 2018;7(1):1. doi:10.1038/s41426-017-0002-0
   PubMed Web of Science ®Google Scholar
• Stirling A, Worthington T, Rafiq M, et al. Association between sciatica and Propionibacterium acnes. Lancet. 2001;357(9273):2024–2025. doi:10.1016/S0140-6736(00)05109-6
   PubMed Web of Science ®Google Scholar