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Original Research

Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy

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Pages 49-57 | Published online: 09 Feb 2015

References

  • WongMHendrixMJCvon der MarkKLittleCSternRCollagen in the egg shell membranes of the henDev Biol1984104128366203793
  • BakerJRBalchDAA study of the organic material of hen’s-egg shellBiochem J19628235236113864145
  • LongFDAdamsRGDeVoreDPinventorsPreparation of hyaluronic acid from eggshell membrane. United States patent US 69465519202005
  • BensonKFRuffKJJensenGSEffects of natural eggshell membrane (NEM) on cytokine production in cultures of peripheral blood mononuclear cells: increased suppression of tumor necrosis factor-α levels after in vitro digestionJ Med Food201215436036822168811
  • RuffKJDeVoreDPReduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived productMod Res Inflamm2014311925
  • RuffKJDeVoreDPLeuMDRobinsonMAEggshell membrane: a possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studiesClin Interv Aging2009423524019554094
  • RuffKJWinklerAJacksonRWDeVoreDPRitzBWEggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical studyClin Rheumatol20092890791419340512
  • DaneschUSeyboldMRittinghausenRTreibelWBitterlichNNEM® brand eggshell membrane effective in the treatment of pain associated with knee and hip osteoarthritis: results from a six-center, open-label German clinical studyJ Arthritis201433136
  • BauerKLDierenfeldESHartupBKEvaluation of a nutraceutical joint supplement in cranesProc North Am Crane Workshop2014122732
  • DierenfeldESBaumDHampeLJensenJAtwellCWedekindKEvaluation of a nutraceutical joint supplement in camelsAmer Hol Vet Med Assoc J2014395966
  • JiaHSaitoKAwWTranscriptional profiling in rats and an ex vivo analysis implicate novel beneficial function of egg shell membrane in liver fibrosisJ Funct Foods2013516111619
  • SenRBaltimoreDMultiple nuclear factors interact with the immunoglobulin enhancer sequencesCell1986467057163091258
  • GilmoreTDIntroduction to NF-κB: players, pathways, perspectivesOncogene2006256680668417072321
  • AkiraSUematsuSTakeuchiOPathogen recognition and innate immunityCell200612478380116497588
  • HaydenMWestAGhoshSNF-kB and the immune responseOncogene2006256758678017072327
  • BegAFincoTNantermetPBaldwinATumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IKBa: a mechanism for NF-κB activationMol Cell Biol1993136330133108497253
  • FlodstriimMWelshNEizirikDCytokines activate the nuclear factor kB (NF-κB) and induce nitric oxide production in human pancreatic isletsFEBS Letters1996385468641463
  • SchreckRAlbermannKBaeuerlePNuclear factor kB: an oxidative stress-responsive transcription factor of eukaryotic cells (a review)Free Rad Res Comms1992174221237
  • ScandaliosJOxidative stress: molecular perception and transduction of signals triggering antioxidant gene defensesBraz J Med Biol Res200538995101416007271
  • CooperSBowdenGUltraviolet B regulation of transcription factor families: roles of nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1) in UVB-induced skin carcinogenesisCurr Cancer Drug Targets2007732533417979627
  • ReelfsOTyrrellRPourzandCUltraviolet A radiation-induced immediate iron release is a key modulator of the activation of NF-κB in human skin fibroblastsJ Invest Dermatol20041221440144715175035
  • KonoHRusynIYinMNADPH oxidase–derived free radicals are key oxidants in alcohol-induced liver diseaseJ Clin Invest200010686787211018074
  • SheHXiongSLinMZandiEGiuliviCTsukamotoHIron activates NF-κB in Kupffer cellsAm J Physiol Gastrointest Liver Physiol2002283G719G72612181188
  • YamamotoYGaynorRRole of the NF-κB pathway in the pathogenesis of human disease statesCurr Mol Med2001128729611899077
  • PrajapatiBSinghalMYashwantSharmaGGuptaVRole of NFκB in various immunological and inflammatory disordersInt J Toxicol Pharmacol Res2010213539
  • CourtoisGGilmoreTMutations in the NF-κB signaling pathway: implications for human diseaseOncogene2006256831684317072331
  • TakPFiresteinGNF-κB: a key role in inflammatory diseasesJ Clin Invest2001107171111134171
  • BrandKPageSRoglerGactivated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesionJ Clin Invest1996977171517228601637
  • HajraLEvansAChenMHydukSCollinsTCybulskyMThe NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formationProc Natl Acad Sci U S A200097169052905710922059
  • AkamaKAlbaneseCPestellRVan EldikLAmyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanismProc Natl Acad Sci U S A19989510579558009576964
  • AkamaKVan EldikLβ-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1β- and tumor necrosis factor-α (TNFα)-dependent, and involves a TNFα receptor-associated factor- and NFκB-inducing kinase-dependent signaling mechanismJ Biol Chem2000275117918792410713108
  • MiterskiBBohringerSKleinWInhibitors in the NFkappaB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinationsGenes Immun2002321121912058256
  • YanJGreerJNF-kappa B, a potential therapeutic target for the treatment of multiple sclerosisCNS Neurolog Disord Drug Targets200876536557
  • PatelSSantaniDRole of NF-κB in the pathogenesis of diabetes and its associated complicationsPharmacol Rep20096159560319815941
  • AndreasenAKellyMBergRMøllerKPedersenBType 2 diabetes is associated with altered NF-κB DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPSPLoS One201169e2399921931634
  • BasseresDBaldwinANuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progressionOncogene2006256817383017072330
  • KordesUKrappmannDHeissmeyerVLudwigWScheidereitCTranscription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cellsLeukemia20001439940210720133
  • BauerleKTSchweppeREHaugenBRInhibition of nuclear factor-kappa B differentially affects thyroid cancer cell growth, apoptosis, and invasionMol Cancer2010911720492683
  • StrohbehnREEtzelLRFigginsJinventorsSolubilized protein composition obtained from avian eggshell membrane. United States patent US 8173174582012
  • BowieAGO’NeillLAJVitamin C inhibits NF-κB activation by TNF via the activation of p38 mitogen-activated protein kinaseJ Immunol2000165127180718811120850
  • Systat Software, Inc Available at: http://www.systat.comAccessed January 6, 2015
  • ReichertTDeBruyereMDeneysVLymphocyte subset reference ranges in adult caucasiansClin Immunol Immunopathol1991601902081712687
  • Jentsch-UllrichKKoenigsmannMMohrenMFrankeALymphocyte subsets’ reference ranges in an age- and gender-balanced population of 100 healthy adults: a monocentric German studyClin Immunol2005116219219715993366
  • HomandbergGADavisGManigliaCShrikhandeACartilage chondrolysis by fibronectin fragments causes cleavage of aggrecan at the same site as found in osteoarthritic cartilageOsteoarthritis Cartilage1997564504539536293
  • YoshidaMTsujiMKurosakaDAutoimmunity to citrullinated type II collagen in rheumatoid arthritisMod Rheumatol200616527628117039307
  • GyörgyBTóthfalusiLNagyGNatural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritisArthritis Res Ther200810R11018789149
  • NoblePWMcKeeCMCowmanMShinHSHyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophagesJ Exp Med19961835237323788642348
  • SaklatvalaJInflammatory signaling in cartilage: MAPK and NF-κB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritisCurr Drug Targets2007830531317305508
  • Van Der HeijdenIMWilbrinkBTchetverikovIPresence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritidesArthritis Rheum200043359359810728753
  • ScanzelloCRPlaasACrowMKInnate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?Curr Opin Rheumatol200820556557218698179
  • KlinmanDDoes activation of the innate immune system contribute to the development of rheumatoid arthritis?Arthritis Rheum200348359059312632408
  • PughNDTamtaHBalachandranPThe majority of in vitro macrophage activation exhibited by extracts of some immune enhancing botanicals is due to bacterial lipoproteins and lipopolysaccharidesInt Immunopharmacol2008871023103218486914
  • MorrisonDCJacobsDMInhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin BInfect Immun1976131298301175019
  • FriedmanAWeinerHLInduction of anergy or active suppression following oral tolerance is determined by antigen dosageProc Natl Acad Sci U S A19949114668866928022835
  • FariaAMCWeinerHLOral toleranceImmunol Rev2005206123225916048553
  • GarsidePMowatAMKhorutsAOral tolerance in diseaseGut19994411371429862840
  • FariaAMCWeinerHLOral tolerance: therapeutic implications for autoimmune diseasesClin Dev Immunol2006132–414315717162357
  • StancikovaMStancikRGubzovaZRovenskyJCollagen in the treatment of rheumatic diseases: oral toleranceBratisl Med J199910010567571
  • BroereFWietenLKoerkampEIKOral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodesJ Immunol2008181289990618606641