Mortality Rate in Upper Gastrointestinal Bleeding Associated with Anti-Thrombotic Therapy Before and During Covid-19 Pandemic

References

• Collet JP, Thiele H, Barbato E, et al.; ESC Scientific Document Group. 2020 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2021;42(14):1289–1367. doi:10.1093/eurheartj/ehaa575
   PubMed Web of Science ®Google Scholar
• Ginghină C. Mic tratat de Cardiologie. Ed Acad Rom. 2017;451:869–871; 1024–1026.
   Google Scholar
• Çelik O, Çil C, Başaran Ö, et al. Inappropriate use of aspirin in real-life cardiology practice: results from the appropriateness of aspirin use in medical outpatients: a multicenter, observational study (ASSOS) study. Balkan Med J. 2021;38(3):183–189. doi:10.5152/balkanmedj.2021.21143
   PubMed Web of Science ®Google Scholar
• Arbelo E, Suleman A, Bollmann A, et al. Quality indicators for the care and outcomes of adults with atrial fibrillation. Europace. 2021;23(4):495. doi:10.1093/europace/euaa253
   PubMed Web of Science ®Google Scholar
• Ferro EG, Kazi DS, Zimetbaum PJ. Informing the choice of direct oral anticoagulant therapy in patients with atrial fibrillation. JAMA. 2021;326(23):2372–2374. doi:10.1001/jama.2021.21305
   PubMed Web of Science ®Google Scholar
• Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(12):1139–1151. doi:10.1056/NEJMoa0905561
   PubMed Web of Science ®Google Scholar
• Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981–992. doi:10.1056/NEJMoa1107039
   PubMed Web of Science ®Google Scholar
• Patel MR, Mahaffey KW, Garg J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365(10):883–891. doi:10.1056/NEJMoa1009638
   PubMed Web of Science ®Google Scholar
• Lin L, Lim WS, Zhou HJ, et al. Clinical and safety outcomes of oral antithrombotics for stroke prevention in atrial fibrillation: a systematic review and network meta-analysis. J Am Med Dir Assoc. 2015;16(12):1103e1–19. doi:10.1016/j.jamda.2015.09.008
   Web of Science ®Google Scholar
• Ridker PM, Goldhaber SZ, Danielson E, et al. Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism. N Engl J Med. 2003;348(15):1425–1434. doi:10.1056/NEJMoa035029
   PubMed Web of Science ®Google Scholar
• Bergmark BA, Bhatt DL, Steg PG, et al. Long-term ticagrelor in patients with prior coronary stenting in the PEGASUS-TIMI 54 trial. J Am Heart Assoc. 2021;10(17):e020446. doi:10.1161/JAHA.120.020446
   PubMed Web of Science ®Google Scholar
• Bavishi C, Abbott JD. Anticoagulation in ST-elevation myocardial infarction. Interv Cardiol Clin. 2021;10(3):307–316. doi:10.1016/j.iccl.2021.03.003
   PubMedGoogle Scholar
• Mauri L, Kereaikes DJ, Yeh RW, et al; DAPT Study Investigators. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med. 2014;371(23):2155–2166. doi:10.1056/NEJMoa1409312
   PubMed Web of Science ®Google Scholar
• Abraham NS, Hlatky MA, Antman EM, et al. ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Am J Gastroenterol. 2010;105:2533–2549. doi:10.1038/ajg.2010.445
   PubMed Web of Science ®Google Scholar
• Bhatt DL, Scheiman J, Abraham NS, et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American college of cardiology foundation task force on clinical expert consensus documents. J Am Coll Cardiol. 2008;52(18):1502–1517. doi:10.1016/j.jacc.2008.08.002
   PubMed Web of Science ®Google Scholar
• Cheung KS, Leung WK. Gastrointestinal bleeding in patients on novel oral anticoagulants: risk, prevention and management. World J Gastroenterol. 2017;23(11):1954–1963. PMID: 28373761. doi:10.3748/wjg.v23.i11.1954
   PubMed Web of Science ®Google Scholar
• Jin MC, Sussman ES, Feng AY, et al. Hemorrhage risk of direct oral anticoagulants in real-world venous thromboembolism patients. Thromb Res. 2021;204:126–133. PMID: 34198049. doi:10.1016/j.thromres.2021.06.015
   PubMed Web of Science ®Google Scholar
• Levi M. Management of bleeding in patients treated with direct oral anticoagulants. Crit Care. 2016;20:249. PMID: 27543264. doi:10.1186/s13054-016-1413-3
   PubMed Web of Science ®Google Scholar
• Kirchmayer U, Narduzzi S, Mayer F, et al. Safety and effectiveness of direct oral anticoagulants versus vitamin K antagonists: results from 3 Italian regions. Recenti Prog Med. 2019;110(4):195–202. doi:10.1701/3154.31345
   PubMedGoogle Scholar
• Holster IL, Valkhoff VE, Kuipers EJ, et al. New oral anticoagulants increase risk for gastrointestinal bleeding: a systematic review and meta-analysis. Gastroenterology. 2013;145(1):105–112. e15. doi:10.1053/j.gastro.2013.02.041
   PubMed Web of Science ®Google Scholar
• Ruff CT, Giugliano RP, Braunwald E, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014;383(9921):955–962. PMID: 24315724. doi:10.1016/S0140-6736(13)62343-0
   PubMed Web of Science ®Google Scholar
• Undas A, Drabik L, Potpara T. Bleeding in anticoagulated patients with atrial fibrillation: practical considerations. Pol Arch Intern Med. 2020;130(1):47–58. PMID: 31933483. doi:10.20452/pamw.15136
   PubMedGoogle Scholar
• Caldeira D, Barra M, Ferreira A, et al. Systematic review with meta-analysis: the risk of major gastrointestinal bleeding with non-vitamin K antagonist oral anticoagulants. Aliment Pharmacol Ther. 2015;42(11–12):1239–1249. PMID: 26434935. doi:10.1111/apt.13412
   PubMed Web of Science ®Google Scholar
• Burr N, Lummis K, Sood R, Kane JS, Corp A, Subramanian V. Risk of gastrointestinal bleeding with direct oral anticoagulants: a systematic review and network meta-analysis. Lancet Gastroenterol Hepatol. 2017;2(2):85–93. PMID: 28403994. doi:10.1016/S2468-1253(16)30162-5
   PubMed Web of Science ®Google Scholar
• Radaelli F, Fuccio L, Paggi S, Bono CD, Dumonceau JM, Dentali F. What gastroenterologists should know about direct oral anticoagulants. Dig Liver Dis. 2020;52(10):1115–1125. PMID: 32532603. doi:10.1016/j.dld.2020.04.032
   PubMedGoogle Scholar
• Kwong JS, Lam YY, Yan BP, Yu CM. Bleeding of new oral anticoagulants for stroke prevention in atrial fibrillation: a meta-analysis of randomized controlled trials. Cardiovasc Drugs Ther. 2013;27(1):23–35. doi:10.1007/s10557-012-6426-9
   PubMed Web of Science ®Google Scholar
• Chen J, Lv M, Wu S, et al. Editor’s choice - severe bleeding risks of direct oral anticoagulants in the prevention and treatment of venous thromboembolism: a network meta-analysis of randomised controlled trials. Eur J Vasc Endovasc Surg. 2022;63(3):465–474. PMID: 34973879. doi:10.1016/j.ejvs.2021.10.054
   PubMed Web of Science ®Google Scholar
• Hirschl M, Kundi M. Safety and efficacy of direct acting oral anticoagulants and vitamin K antagonists in nonvalvular atrial fibrillation - a network meta-analysis of real-world data. Vasa. 2019;48(2):134–147. PMID: 30376416. doi:10.1024/0301-1526/a000746
   PubMed Web of Science ®Google Scholar
• He Y, Wong IC, Li X, et al. The association between non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observational studies. Br J Clin Pharmacol. 2016;82:285–300. doi:10.1111/bcp.12911
   PubMed Web of Science ®Google Scholar
• Gouriou C, Bouguen G, Lahmek P, et al. Outcomes of upper gastrointestinal bleeding are similar between direct oral anticoagulants and vitamin K antagonists. Aliment Pharmacol Ther. 2021;53(6):688–695. PMID: 33400827. doi:10.1111/apt.16236
   PubMed Web of Science ®Google Scholar
• Wu C, Alotaibi GS, Alsaleh K, Sean McMurtry M. Case fatality of bleeding and recurrent venous thromboembolism during, initial therapy with direct oral anticoagulants: a systematic review. Thromb Res. 2014;134(3):627–632. PMID: 25047174. doi:10.1016/j.thromres.2014.07.001
   PubMed Web of Science ®Google Scholar
• Turcato G, Bonora A, Zorzi E, et al. Thirty-day mortality in atrial fibrillation patients with gastrointestinal bleeding in the emergency department: differences between direct oral anticoagulant and warfarin users. Intern Emerg Med. 2020;15(2):311–318. PMID: 31754969. doi:10.1007/s11739-019-02229-7
   PubMed Web of Science ®Google Scholar
• Brodie MM, Newman JC, Smith T, Rockey DC. Severity of gastrointestinal bleeding in patients treated with direct-acting oral anticoagulants. Am J Med. 2018;131(5):573.e9–573.e15. doi:10.1016/j.amjmed.2017.11.007
   PubMed Web of Science ®Google Scholar
• Khan F, Tritschler T, Kimpton M, et al.; MAJESTIC Collaborators. Long-term risk for major bleeding during extended oral anticoagulant therapy for first unprovoked venous thromboembolism: a systematic review and meta-analysis. Ann Intern Med. 2021;174(10):1420–1429. PMID: 34516270. doi:10.7326/M21-1094
   PubMed Web of Science ®Google Scholar
• Bouget J, Oger E. Emergency admissions for major haemorrhage associated with direct oral anticoagulants. Thromb Res. 2015;136(6):1190–1194. PMID: 26545315. doi:10.1016/j.thromres.2015.10.036
   PubMed Web of Science ®Google Scholar
• Butt JH, Li A, Xian Y, et al. Direct oral anticoagulant- versus vitamin K antagonist-related gastrointestinal bleeding: insights from a nationwide cohort. Am Heart J. 2019;216:117–124. PMID: 31425898. doi:10.1016/j.ahj.2019.07.012
   PubMed Web of Science ®Google Scholar
• Martin TA, Wan DW, Hajifathalian K, et al. Gastrointestinal bleeding in patients with coronavirus disease 2019: a matched case-control study. Am J Gastroenterol. 2020;115(10):1609–1616. doi:10.14309/ajg.0000000000000805
   PubMed Web of Science ®Google Scholar
• Iqbal U, Anwar H, Siddiqui HU, et al. Acute gastrointestinal bleeding in COVID-19 patients: a systematic review and meta-analysis. Clin Endosc. 2021;54(4):534–541. doi:10.5946/ce.2021.071
   PubMed Web of Science ®Google Scholar
• Mauro A, De Grazia F, Lenti MV, et al. Upper gastrointestinal bleeding in COVID-19 inpatients: incidence and management in a multicenter experience from Northern Italy. Clin Res Hepatol Gastroenterol. 2021;45(3):101521. doi:10.1016/j.clinre.2020.07.025
   PubMed Web of Science ®Google Scholar
• Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020;18(5):1094–1099. doi:10.1111/jth.14817
   PubMed Web of Science ®Google Scholar
• Ebrahimi Bakhtavar H, Morteza Bagi HR, Rahmani F, Shahsavari Nia K, Ettehadi A. Clinical scoring systems in predicting the outcome of acute upper gastrointestinal bleeding; a narrative review. Emerg. 2017;5(1):e36.
   PubMed Web of Science ®Google Scholar
• Desai JC, Chatterjee P, Friedman K, et al. Incidence and clinical presentation of gastrointestinal bleeding in atrial fibrillation patients taking direct oral anticoagulants. Am Gastroenterol Suppl. 2016;3(1):13–21. doi:10.1038/ajgsup.2016.3
   Google Scholar
• Abraham NS, Singh S, Alexander GC, et al. Comparative risk of gastrointestinal bleeding with dabigatran, rivaroxaban, and warfarin: population based cohort study. BMJ. 2015;350:h1857. doi:10.1136/bmj.h1857
   PubMed Web of Science ®Google Scholar
• Chai-Adisaksopha C, Hillis C, Isayama T, Lim W, Iorio A, Crowther M. Mortality outcomes in patients receiving direct oral anticoagulants: a systematic review and meta-analysis of randomized controlled trials. J Thromb Haemost. 2015;13(11):2012–2020. PMID: 26356595. doi:10.1111/jth.13139
   PubMed Web of Science ®Google Scholar
• Pourafkari L, Ghaffari S, Khaki N, et al. Predictors of hospital mortality and serious complications in patients admitted with excessive warfarin anticoagulation. Thromb Res. 2016;137:79–84. doi:10.1016/j.thromres.2015.11.014
   PubMed Web of Science ®Google Scholar
• Masclee GM, Valkhoff VE, Coloma PM, et al. Risk of upper gastrointestinal bleeding from different drug combinations. Gastroenterology. 2014;147:784–792. doi:10.1053/j.gastro.2014.06.007
   PubMed Web of Science ®Google Scholar
• Hosni M, Rahal M, Tamim H, et al. Increased rebleeding and mortality in patients with gastrointestinal bleeding treated with anticoagulant drugs compared to antiplatelet drugs. Eur J Gastroenterol Hepatol. 2021;33(1S Suppl 1):e490–e498. PMID: 33867445. doi:10.1097/MEG.0000000000002148
   PubMed Web of Science ®Google Scholar