112
Views
0
CrossRef citations to date
0
Altmetric
REVIEW

Evaluation of Global Post-Outbreak COVID-19 Treatment Interventions: A Systematic Review and Bibliometric Analysis of Randomized Controlled Trials

ORCID Icon, ORCID Icon, ORCID Icon &
Pages 4193-4209 | Received 08 Nov 2023, Accepted 18 Dec 2023, Published online: 22 Dec 2023

References

  • Benita F. Human mobility behavior in COVID-19: a systematic literature review and bibliometric analysis. Sustain Cities Soc. 2021;70:102916. doi:10.1016/J.SCS.2021.102916
  • Utami AM, Rendrayani F, Khoiry QA, et al. Economic evaluation of COVID-19 vaccination: a systematic review. J Glob Health. 2023;13:6001. doi:10.7189/JOGH.13.06001
  • Cheng ZJ, Shan J. 2019 Novel coronavirus: where we are and what we know. Infection. 2020;48(2):155–163. doi:10.1007/S15010-020-01401-Y/TABLES/3
  • Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708–1720. doi:10.1056/NEJMOA2002032/SUPPL_FILE/NEJMOA2002032_DISCLOSURES.PDF
  • World Health Organization. WHO Coronavirus (COVID-19) dashboard with vaccination data; 2023. Available from: https://covid19.who.int/. Accessed September 10, 2023.
  • Ang L, Song E, Lee MS. Randomized controlled trials of traditional, complementary, and integrative medicine-based interventions for coronavirus disease 2019 (COVID-19): a bibliometric analysis and review of study designs. Integr Med Res. 2021;10:100777. doi:10.1016/J.IMR.2021.100777
  • Qomara WF, Primanissa DN, Amalia SH, Purwadi FV, Zakiyah N. Effectiveness of remdesivir, lopinavir/ritonavir, and favipiravir for COVID-19 treatment: a systematic review. Int J Gen Med. 2021;14:8557–8571. doi:10.2147/IJGM.S332458
  • Lou Y, Liu L, Yao H, et al. clinical outcomes and plasma concentrations of baloxavir marboxil and favipiravir in COVID-19 patients: an exploratory randomized, controlled trial. Eur J Pharm Sci. 2021:157. doi:10.1016/J.EJPS.2020.105631
  • Hariton E, Locascio JJ. Randomised controlled trials—the gold standard for effectiveness research. BJOG. 2018;125(13):1716. doi:10.1111/1471-0528.15199
  • Fragkou PC, Belhadi D, Peiffer-Smadja N, et al. Review of trials currently testing treatment and prevention of COVID-19. Clin Microbiol Infect. 2020;26(8):988–998. doi:10.1016/J.CMI.2020.05.019
  • Murakami N, Hayden R, Hills T, et al. Therapeutic advances in COVID-19. Nat Rev Nephrol. 2022;19(1):38–52. doi:10.1038/s41581-022-00642-4
  • Nalbandian A, Sehgal K, Gupta A, et al. Post-acute COVID-19 syndrome. Nat Med. 2021;27(4):601–615. doi:10.1038/s41591-021-01283-z
  • Karampitsakos T, Papaioannou O, Tsiri P, et al. Tocilizumab versus baricitinib in hospitalized patients with severe COVID-19: an open label, randomized controlled trial. Clin Microbiol Infect. 2023;29(3):372–378. doi:10.1016/J.CMI.2022.10.015
  • Karampitsakos T, Sotiropoulou V, Katsaras M, et al. Post-COVID-19 interstitial lung disease: insights from a machine learning radiographic model. Front Med Lausanne. 2023:9. doi:10.3389/fmed.2022.1083264
  • World Health Organization. COVID-19 studies from the world health organization database; 2023. Available from: https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov. Accessed September 10, 2023.
  • ClinicalTrials.gov. COVID-19 studies from ClinicalTrials.gov Database; 2023. Available from: https://clinicaltrials.gov/. Accessed September 10, 2023.
  • Carley S, Horner D, Body R, MacKway-Jones K. Evidence-based medicine and COVID-19: what to believe and when to change. Emer Med J. 2020;37(9):572–575. doi:10.1136/EMERMED-2020-210098
  • Siemieniuk RAC, Bartoszko JJ, Ge L, et al. Drug treatments for covid-19: living systematic review and network meta-analysis. BMJ. 2020:370. doi:10.1136/BMJ.M2980
  • Hernandez AV, Roman YM, Pasupuleti V, Barboza JJ, White CM. Hydroxychloroquine or chloroquine for treatment or prophylaxis of COVID-19: a living systematic review. Ann Intern Med. 2020;173(4):287–297. doi:10.7326/M20-2496/SUPPL_FILE/M20-2496_SUPPLEMENT.PDF
  • Kudhail K, Thompson J, Mathews V, Morrison B, Hemming K. Randomized controlled trials in patients with COVID-19: a systematic review and critical appraisal. Inter J Infect Dis. 2022;122:72–80. doi:10.1016/j.ijid.2022.05.034
  • Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi:10.1136/BMJ.N71
  • Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. doi:10.1136/bmj.l4898
  • Risk of bias tools. Current version of RoB 2; 2019. Available from: https://sites.google.com/site/riskofbiastool/welcome/rob-2-0-tool/current-version-of-rob-2?authuser=0. Accessed September 13, 2023.
  • Ding Y, Chowdhury GG, Foo S. Bibliometric cartography of information retrieval research by using co-word analysis. Inf Process Manag. 2001;37(6):817–842. doi:10.1016/S0306-4573(00)00051-0
  • van Eck NJ, Waltman L. Software survey: vOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84(2):523–538. doi:10.1007/s11192-009-0146-3
  • VOSviewer. Visualizing scientific landscapes; 2023. Available from: https://www.vosviewer.com/. Accessed September 13, 2023.
  • Tableau. Tableau Desktop 8.1.10; 2023. Available from: https://www.tableau.com/support/releases/desktop/8.1.10. Accessed September 13, 2023.
  • Dalavi AM, Gomes A, Javed Husain A. Bibliometric analysis of nature inspired optimization techniques. Comput Ind Eng. 2022;169:108161. doi:10.1016/J.CIE.2022.108161
  • McGuinness LA, Higgins JP. T. Risk-of-bias VISualization (robvis): an R package and Shiny web app for visualizing risk-of-bias assessments. Res Synth Methods. 2021;12(1):55–61. doi:10.1002/jrsm.1411
  • Rabie ASI, Salah H, Said ASA, et al. Clinical consequences for individuals treated with tocilizumab for serious COVID-19 Infection. Healthcare. 2023;11(4). doi:10.3390/healthcare11040607
  • Baldeón ME, Maldonado A, Ochoa-Andrade M, et al. Effect of convalescent plasma as complementary treatment in patients with moderate COVID-19 infection. Transfus Med. 2022;32(2):153–161. doi:10.1111/tme.12851
  • Muralidharan J, Kashyap S, P S, et al. The effect of L-arginine supplementation on amelioration of oxygen support in severe COVID-19 pneumonia. Clin Nutr ESPEN. 2022;52:431–435. doi:10.1016/j.clnesp.2022.09.024
  • Liu ST, Zhan C, Ma YJ, et al. Effect of qigong exercise and acupressure rehabilitation program on pulmonary function and respiratory symptoms in patients hospitalized with severe COVID-19: a randomized controlled trial. Integr Med Res. 2021:10. doi:10.1016/j.imr.2021.100796
  • Srivastava A, Rengaraju M, Srivastava S, et al. Efficacy of two siddha polyherbal decoctions, Nilavembu Kudineer and Kaba Sura Kudineer, along with standard allopathy treatment in the management of mild to moderate symptomatic COVID-19 patients—a double-blind, placebo-controlled, clinical trial. Trials. 2021;22(1). doi:10.1186/s13063-021-05478-0
  • Panatto D, Orsi A, Bruzzone B, et al. Efficacy of the sentinox spray in reducing viral load in mild COVID-19 and its virucidal activity against other respiratory viruses: results of a randomized controlled trial and an in vitro study. Viruses. 2022;14(5):1033. doi:10.3390/v14051033
  • Zhang L, Wu L, Xu X, et al. Effectiveness of lianhua qingwen capsule in treatment of asymptomatic COVID-19 patients: a randomized, controlled multicenter trial. J Complement Integr Med. 2022;28(11):887–894. doi:10.1089/jicm.2021.0352
  • Koshak AE, Koshak EA, Mobeireek AF, et al. Nigella sativa for the treatment of COVID-19: an open-label randomized controlled clinical trial. Complement Ther Med. 2021:61. doi:10.1016/j.ctim.2021.102769
  • Salvarani C, Dolci G, Massari M, et al. Effect of tocilizumab vs standard care on clinical worsening in patients hospitalized with COVID-19 pneumonia: a randomized clinical trial. JAMA Intern Med. 2021;181(1):24–31. doi:10.1001/jamainternmed.2020.6615
  • Kumari P, Dembra S, Dembra P, et al. The role of vitamin c as adjuvant therapy in COVID-19. Cureus. 2020. doi:10.7759/cureus.11779
  • Chowdhury AT, Shahbaz M, Karim MR, Islam J, Dan G, He S. A comparative study on ivermectin-doxycycline and hydroxychloroquine-azithromycin therapy on COVID-19 patients. Eurasian J Med Oncol. 2021;5(1):63–70. doi:10.14744/ejmo.2021.16263
  • Welzel T, Atkinson A, Schöbi N, et al. Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial. Lancet Child Adolesc Health. 2023;7(4):238–248. doi:10.1016/S2352-4642(23)00020-2
  • Rodrigues C, Freitas-Santos RS, Levi JE, et al. Hydroxychloroquine plus azithromycin early treatment of mild COVID-19 in an outpatient setting: a randomized, double-blinded, placebo-controlled clinical trial evaluating viral clearance. Int J Antimicrob Agents. 2021;58(5):106428. doi:10.1016/j.ijantimicag.2021.106428
  • Ranjbar K, Moghadami M, Mirahmadizadeh A, et al. Methylprednisolone or dexamethasone, which one is superior corticosteroid in the treatment of hospitalized COVID-19 patients: a triple-blinded randomized controlled trial. BMC Infect Dis. 2021;21(1). doi:10.1186/s12879-021-06045-3
  • Heydari M, Rahimi J, Foroozanfar Z, et al. The efficacy of ivermectin and metronidazole vs. standard treatment protocols on outcomes of COVID-19 in hospitalized patients: a triple-blinded randomized controlled trial. Arch Clin Infect Dis. 2022;17(5). doi:10.5812/archcid-122525
  • Schwartz IS, Boulware DR, Lee TC. Hydroxychloroquine for COVID19: the curtains close on a comedy of errors. Lancet Regional Health. 2022;11. doi:10.1016/j.lana.2022.100268
  • Chen CP, Lin YC, Chen TC, et al. A multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with mild to moderate coronavirus disease 2019 (COVID-19). PLoS One. 2020;15(12 December). doi:10.1371/journal.pone.0242763
  • Nojomi M, Yassin Z, Keyvani H, et al. Effect of Arbidol (Umifenovir) on COVID-19: a randomized controlled trial. BMC Infect Dis. 2020;20(1). doi:10.1186/s12879-020-05698-w
  • Kamran SM, Moeed HA, Mirza Z, et al. Clearing the fog: is hydroxychloroquine effective in reducing coronavirus disease-2019 progression? A randomized controlled trial. Cureus. 2021;30. doi:10.7759/cureus.14186
  • Annweiler C, Beaudenon M, Gautier J, et al. High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): a multicenter, open-label, randomized controlled superiority trial. PLoS Med. 2022;19(5):e1003999. doi:10.1371/journal.pmed.1003999
  • Golan Y, Campos JAS, Woolson R, et al. Favipiravir in patients with early mild-to-moderate coronavirus disease 2019 (COVID-19): a randomized controlled trial. Clin Infect Dis. 2023;76(3):E10–E17. doi:10.1093/cid/ciac712
  • Ali K, Azher T, Baqi M, et al. Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial. CMAJ. 2022;194(7):E242–E251. doi:10.1503/CMAJ.211698
  • Avezum Á, Oliveira GBF, Oliveira H, et al. Hydroxychloroquine versus placebo in the treatment of non-hospitalised patients with COVID-19 (COPE – coalition V): a double-blind, multicentre, randomised, controlled trial. Lancet Regional Health. 2022;11:100243. doi:10.1016/j.lana.2022.100243
  • Xie Y, Zhang P, Zhao H, Suyun L, Li J. Analysis of clinical research characteristics of clinical study on coronavirus disease 2019: based on inter- national clinical trial registration platform. J Traditional Chin Med. 2020. doi:10.13288/J.11-2166
  • London AJ, Kimmelman J. Against pandemic research exceptionalism. Science. 2020;368(6490):476–477. doi:10.1126/SCIENCE.ABC1731/ASSET/590F0371-2E1E-417F-BC49-828C4D4D4DF7/ASSETS/GRAPHIC/368_476_F1.JPEG
  • Horby P, Mafham M, Linsell L, et al. Effect of hydroxychloroquine in hospitalized patients with covid-19. N Engl J Med. 2020;383(21):2030–2040. doi:10.1056/NEJMOA2022926/SUPPL_FILE/NEJMOA2022926_DATA-SHARING.PDF
  • Saag MS. Misguided use of hydroxychloroquine for COVID-19: the infusion of politics into science. JAMA. 2020;324(21):2161–2162. doi:10.1001/JAMA.2020.22389
  • Chan AW, Tetzlaff JM, Gøtzsche PC, et al. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ. 2013:346. doi:10.1136/BMJ.E7586
  • Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340(7748):698–702. doi:10.1136/BMJ.C332
  • Li J, Hu JY, Zhai JB, et al. CONSORT extension for reporting N-of-1 trials for traditional Chinese medicine (CENT for TCM): recommendations, explanation and elaboration. Complement Ther Med. 2019;46:180–188. doi:10.1016/J.CTIM.2019.08.014
  • Olivo SA, Macedo LG, Gadotti IC, Fuentes J, Stanton T, Magee DJ. Scales to assess the quality of randomized controlled trials: a systematic review. Phys Ther. 2008;88(2):156–175. doi:10.2522/PTJ.20070147
  • Freiman JA, Chalmers TC, Smith HA, Kuebler RR. The importance of beta, the type II error, and sample size in the design and interpretation of the randomized controlled trial: survey of two sets of “negative” trials. Medical Uses Statistics. 2019;357–389. doi:10.1201/9780429187445-19
  • Moher D, Wells GA, Dulberg CS. Statistical power, sample size, and their reporting in randomized controlled trials. JAMA. 1994;272(2):122–124. doi:10.1001/JAMA.1994.03520020048013
  • Zhu RF, Gao YL, Robert SH, et al. Systematic review of the registered clinical trials for coronavirus disease 2019 (COVID-19). J Transl Med. 2020;18(1):274. doi:10.1186/s12967-020-02442-5
  • Mubaroq SR, Abdullah AG, Setiawan A. The evolution of smart working and sustainability in socio-technical perspective: a scientometrics technology analysis. J Eng Sci Technol. 2020;15:1868–1882.
  • CNN. Covid-19 vaccine trial on humans starts as UK warns restrictions could stay in place until next year | CNN; 2020. Available from: https://edition.cnn.com/2020/04/23/health/coronavirus-vaccine-trial-uk-gbr-intl/index.html. Accessed September 20, 2023.
  • Tran BX, Ha GH, Nguyen LH, et al. Studies of novel coronavirus disease 19 (COVID-19) pandemic: a global analysis of literature. Int J Environ Res Public Health. 2020;17(11):4095. doi:10.3390/ijerph17114095
  • Zhao MZ, Zhao C, Tu S, Wei XX, Shang HC. Evaluating the methodology of studies conducted during the global COVID-19 pandemic: a systematic review of randomized controlled trials. J Integr Med. 2021;19(4):317–326. doi:10.1016/J.JOIM.2021.03.003
  • Zuidgeest MGP, Goetz I, Groenwold RH, Irving E, van Thiel GJ, Grobbee DE. Series: pragmatic trials and real world evidence: paper 1. Introduction. J Clin Epidemiol. 2017;88:7–13. doi:10.1016/J.JCLINEPI.2016.12.023
  • Head BW. Reconsidering evidence-based policy: key issues and challenges. Policy Soc. 2010;29(2):77–94. doi:10.1016/J.POLSOC.2010.03.001
  • Alexander PE, Debono VB, Mammen MJ, et al. COVID-19 coronavirus research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine. J Clin Epidemiol. 2020;123:120–126. doi:10.1016/J.JCLINEPI.2020.04.016
  • Hiebert R, Nordin M. Methodological aspects of outcomes research. Eur Spine J. 2006;15(Suppl 1):S4. doi:10.1007/S00586-005-1057-5
  • Garrison LP, Neumann PJ, Erickson P, Marshall D, Mullins CD. using real-world data for coverage and payment decisions: the ISPOR real-world data task force report. Value Health. 2007;10(5):326–335. doi:10.1111/J.1524-4733.2007.00186.X
  • Porat T, Nyrup R, Calvo RA, Paudyal P, Ford E. Public health and risk communication during COVID-19-enhancing psychological needs to promote sustainable behaviour change In review Conflict of interest statement; 2020. Available from: www.frontiersin.org. Accessed September 30, 2023.