Advanced search
Publication Cover
Journal of Pain Research Volume 13, 2020 - Issue
Submit an article Journal homepage
84
Views
8
CrossRef citations to date
0
Altmetric
Original Research

Usefulness of a Double-Blind Placebo-Controlled Response Test to Demonstrate Rapid Onset Analgesia with Phenytoin 10% Cream in Polyneuropathy

David J Kopsky1 Institute for Neuropathic Pain, Amsterdam, the NetherlandsCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4820-489X
ORCID Icon,
Alexander F J E Vrancken2 Department of Neurology, Brain Centre University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsORCID Iconhttps://orcid.org/0000-0003-4649-6534
ORCID Icon,
Jan M Keppel Hesselink3 Institute for Neuropathic Pain, Bosch En Duin, the NetherlandsORCID Iconhttps://orcid.org/0000-0002-0186-8050
ORCID Icon,
Ruben P A van Eijk2 Department of Neurology, Brain Centre University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands;4 Biostatistics & Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the NetherlandsORCID Iconhttps://orcid.org/0000-0002-7132-5967
ORCID Icon &
Nicolette C Notermans2 Department of Neurology, Brain Centre University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsORCID Iconhttps://orcid.org/0000-0002-9363-4103
ORCID Icon
Pages 877-882 | Published online: 01 May 2020

References

  • Poliakov I, Toth C. The impact of pain in patients with polyneuropathy. Eur J Pain. 2011;15(10):1015–1022. doi:10.1016/j.ejpain.2011.04.013
  • Liedberg GM, Vrethem M. Polyneuropathy, with and without neurogenic pain, and its impact on daily life activities – a descriptive study. Disabil Rehabil. 2009;31(17):1402–1408. doi:10.1080/09638280802621382
  • Erdmann PG, van Genderen FR, Teunissen LL, et al. Pain in patients with chronic idiopathic axonal polyneuropathy. Eur Neurol. 2010;64(1):58–64. doi:10.1159/000315037
  • Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162–173. doi:10.1016/S1474-4422(14)70251-0
  • Finnerup NB, Haroutounian S, Baron R, et al. Neuropathic pain clinical trials: factors associated with decreases in estimated drug efficacy. Pain. 2018;159(11):2339–2346. doi:10.1097/j.pain.0000000000001340
  • Keppel Hesselink JM, Kopsky DJ, Bhaskar AK. Skin matters! The role of keratinocytes in nociception: a rational argument for the development of topical analgesics. J Pain Res. 2016;10:1–8. doi:10.2147/JPR.S122765
  • Peppin JF, Albrecht PJ, Argoff C, et al. Skin matters: a review of topical treatments for chronic pain. Part one: skin physiology and delivery systems. Pain Ther. 2015;4(1):17–32. doi:10.1007/s40122-015-0031-0
  • Casale R, Symeonidou Z, Bartolo M. Topical treatments for localized neuropathic pain. Curr Pain Headache Rep. 2017;21(3):017–0615. doi:10.1007/s11916-017-0615-y
  • Mick G, Baron R, Finnerup NB, et al. What is localized neuropathic pain? A first proposal to characterize and define a widely used term. Pain Management. 2012;2(1):71–77. doi:10.2217/pmt.11.77
  • Kopsky DJ, Keppel Hesselink JM. Single-blind placebo-controlled response test with phenytoin 10% cream in neuropathic pain patients. Pharmaceuticals. 2018;11(4):4. doi:10.3390/ph11040122
  • Kopsky DJ, Keppel Hesselink JM. Phenytoin cream for the treatment for neuropathic pain: case series. Pharmaceuticals. 2018;11(2):2. doi:10.3390/ph11020053
  • Enck P, Bingel U, Schedlowski M, Rief W. The placebo response in medicine: minimize, maximize or personalize? Nat Rev Drug Discov. 2013;12(3):191–204. doi:10.1038/nrd3923
  • Wampold BE. The therapeutic value of the relationship for placebo effects and other healing practices. Int Rev Neurobiol. 2018;139:191–210.
  • Finniss DG, Kaptchuk TJ, Miller F, Benedetti F. Biological, clinical, and ethical advances of placebo effects. Lancet. 2010;375(9715):686–695. doi:10.1016/S0140-6736(09)61706-2
  • Your research: Is it subject to the WMO or not? Central Committee on Research Invovling Human Subjects. Available from https://english.ccmo.nl/investigators/legal-framework-for-medical-scientific-research/your-research-is-it-subject-to-the-wmo-or-not. Accessed March 19, 2020.
  • REGULATION (EU) No 536/2014 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 April 2014 on clinical trials on medicinal products for human use, and repealing Directive 2001/20/EC.
  • Bostick NA, Sade R, Levine MA, Stewart DM Jr. Placebo use in clinical practice: report of the american medical association council on ethical and judicial affairs. J Clin Ethics. 2008;19(1):58–61.
  • Keppel Hesselink JM, Kopsky DJ, Bhaskar AK. Ethical justification of single-blind and double-blind placebo-controlled response tests in neuropathic pain and N-of-1 treatment paradigm in clinical settings. J Pain Res. 2019;12:345–352. doi:10.2147/JPR.S180792
  • Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. 2015;67(1):48.
  • Bos JD, Meinardi Marcus MHM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol. 2000;9(3):165–169. doi:10.1034/j.1600-0625.2000.009003165.x
  • Hrobjartsson A. Clinical placebo interventions are unethical, unnecessary, and unprofessional. J Clin Ethics. 2008;19(1):66–69.
  • Derry S, Conaghan P, Da Silva JA, Wiffen PJ, Moore RA. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev. 2016;22:4.
  • OCEBM Levels of Evidence Working Group. The Oxford 2011 levels of evidence. Available from http://www.cebm.net/index.aspx?o=5653. Accessed 2 September 2019.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.