Wnt3a Inhibitor Attenuates Remifentanil-Induced Hyperalgesia via Downregulating Spinal NMDA Receptor in Rats

References

• Angst MS, Clark JD. Opioid-induced hyperalgesia - A qualitative systematic review. Anesthesiology. 2006;104(3):570–587. doi:10.1097/00000542-200603000-00025
   PubMed Web of Science ®Google Scholar
• Shin SW, Cho AR, Lee HJ, et al. Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery. Br J Anaesth. 2010;105(5):661–667. doi:10.1093/bja/aeq257
   Web of Science ®Google Scholar
• Chu LF, Dairmont J, Zamora AK, Young CA, Angst MS. The endogenous opioid system is not involved in modulation of opioid-induced hyperalgesia. J Pain. 2011;12(1):108–115. doi:10.1016/j.jpain.2010.05.006
   Web of Science ®Google Scholar
• Zhao M, Joo DT. Enhancement of spinal N-methyl-D-aspartate receptor function by remifentanil action at delta-opioid receptors as a mechanism for acute opioid-induced hyperalgesia or tolerance. Anesthesiology. 2008;109(2):308–317. doi:10.1097/ALN.0b013e31817f4c5d
   Web of Science ®Google Scholar
• Guignard B, Bossard AE, Coste C, et al. Acute opioid tolerance - intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology. 2000;93(2):409–417. doi:10.1097/00000542-200008000-00019
   PubMed Web of Science ®Google Scholar
• Kuner R. Central mechanisms of pathological pain. Nat Med. 2010;16(11):1258–1266. doi:10.1038/nm.2231
   PubMed Web of Science ®Google Scholar
• Xu ZL, Chen Y, Yu J, et al. TCF4 mediates the maintenance of neuropathic pain through Wnt/beta-Catenin signaling following peripheral nerve injury in rats. J Mol Neurosci. 2015;56(2):397–408. doi:10.1007/s12031-015-0565-y
   Web of Science ®Google Scholar
• Sun J, Lin H, Feng X, Dong J, Ansong E, Xu X. A comparison of intrathecal magnesium and ketamine in attenuating remifentanil-induced hyperalgesia in rats. BMC Anesthesiol. 2016;16:74–80. doi:10.1186/s12871-016-0235-9
   Web of Science ®Google Scholar
• Sun J, Lin H, He G, Lin W, Yang J. Magnesium sulphate attenuate remifentanil-induced postoperative hyperalgesia via regulating tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord. BMC Anesthesiol. 2017;17:30–38. doi:10.1186/s12871-017-0325-3
   Web of Science ®Google Scholar
• Zhang YK, Huang ZJ, Liu S, Liu YP, Song AA, Song XJ. WNT signaling underlies the pathogenesis of neuropathic pain in rodents. J Clin Invest. 2013;123(5):2268–2286. doi:10.1172/JCI65364
   PubMed Web of Science ®Google Scholar
• Itokazu T, Hayano Y, Takahashi R, Yamashita T. Involvement of Wnt/beta-catenin signaling in the development of neuropathic pain. Neurosci Res. 2014;79:34–40. doi:10.1016/j.neures.2013.12.002
   PubMed Web of Science ®Google Scholar
• Liu S, Liu YP, Huang ZJ, et al. Wnt/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats. Pain. 2015;156(12):2572–2584. doi:10.1097/j.pain.0000000000000366
   PubMed Web of Science ®Google Scholar
• Li YS, Xi Y, Li XJ, et al. Up-regulation of the biosynthesis and release of substance P through wnt/beta-catenin signaling pathway in rat dorsal root ganglion cells. PLoS One. 2015;10(6):e0129701. doi:10.1371/journal.pone.0129701
   Web of Science ®Google Scholar
• Balut CM, Gao YJ, Murray SA, Thibodeau PH, Devor DC. ESCRT-dependent targeting of plasma membrane localized KCa3.1 to the lysosomes. Am J Physiol Cell Ph. 2010;299(5):C1015–C1027. doi:10.1152/ajpcell.00120.2010
   Web of Science ®Google Scholar
• Wan XZ, Li B, Li YC, et al. Activation of NMDA receptors upregulates a disintegrin and metalloproteinase 10 via a Wnt/MAPK signaling pathway. J Neurosci. 2012;32(11):3910–3916. doi:10.1523/JNEUROSCI.3916-11.2012
   Web of Science ®Google Scholar
• Won L, Kraig RP. Insulin-Like Growth Factor-1 inhibits spreading depression-induced trigeminal calcitonin gene related peptide, oxidative stress & neuronal activation in rat. Brain Res. 2020;1732:146673. doi:10.1016/j.brainres.2020.146673
   Web of Science ®Google Scholar
• Yamaguchi K, Kumakura S, Murakami T, Someya A, Inada E, Nagaoka I. Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG glioblastoma/astrocytoma cells. Int J Mol Med. 2017;39(3):687–692. doi:10.3892/ijmm.2017.2875
   Web of Science ®Google Scholar
• Kaur A, Singh L, Singh N, Bhatti MS, Bhatti R. Ameliorative effect of imperatorin in chemically induced fibromyalgia: role of NMDA/NFkB mediated downstream signaling. Biochem Pharmacol. 2019;166:56–69. doi:10.1016/j.bcp.2019.05.012
   PubMed Web of Science ®Google Scholar
• Deng MC, Chen SR, Pan HL. Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain. Cell Mol Life Sci. 2019;76(10):1889–1899. doi:10.1007/s00018-019-03047-y
   PubMed Web of Science ®Google Scholar
• Hahnenkamp K, Nollet J, Van Aken HK, et al. Remifentanil directly activates human N-methyl-D-aspartate receptors expressed in xenopus laevis oocytes. Anesthesiology. 2004;100(6):1531–1537. doi:10.1097/00000542-200406000-00028
   Web of Science ®Google Scholar
• Guntz E, Dumont H, Roussel C, et al. Effects of remifentanil on N-methyl-D-aspartate receptor - an electrophysiologic study in rat spinal cord. Anesthesiology. 2005;102(6):1235–1241. doi:10.1097/00000542-200506000-00025
   Web of Science ®Google Scholar
• Tang J, Ji Q, Jin L, Tian M, Zhang LD, Liu XY. Secreted frizzled-related protein 1 regulates the progression of neuropathic pain in mice following spinal nerve ligation. J Cell Physiol. 2018;233(8):5815–5822. doi:10.1002/jcp.26358
   Web of Science ®Google Scholar
• Zhao Y, Yang Z. Effect of Wnt signaling pathway on pathogenesis and intervention of neuropathic pain. Exp Ther Med. 2018;16(4):3082–3088. doi:10.3892/etm.2018.6512
   PubMed Web of Science ®Google Scholar
• Resham K, Sharma SS. Pharmacologic inhibition of porcupine, disheveled, and β-Catenin in Wnt signaling pathway ameliorates diabetic peripheral neuropathy in rats. J Pain. 2019;20(11):1338–1352. doi:10.1016/j.jpain.2019.04.010
   Web of Science ®Google Scholar
• McLeod F, Salinas PC. Wnt proteins as modulators of synaptic plasticity. Curr Opin Neurobiol. 2018;53:90–95. doi:10.1016/j.conb.2018.06.003
   PubMed Web of Science ®Google Scholar
• Cerpa W, Latorre-Esteves E, Barria A. RoR2 functions as a noncanonical wnt receptor that regulates NMDAR-mediated synaptic transmission. P Natl Acad Sci USA. 2015;112:4797–4802. doi:10.1073/pnas.1417053112
   Web of Science ®Google Scholar
• Cerpa W, Gambrill A, Inestrosa NC, et al. Regulation of NMDA-receptor synaptic transmission by Wnt signaling. J Neurosci. 2011;31:9466–9471. doi:10.1523/JNEUROSCI.6311-10.2011
   Web of Science ®Google Scholar
• Bamji SX, Shimazu K, Kimes N, et al. Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron. 2003;40(4):719–731. doi:10.1016/S0896-6273(03)00718-9
   Web of Science ®Google Scholar
• Maguschak KA, Ressler KJ. A role for WNT/beta-catenin signaling in the neural mechanisms of behavior. J Neuroimmune Pharm. 2012;7(4):763–773. doi:10.1007/s11481-012-9350-7
   PubMed Web of Science ®Google Scholar
• Cerpa W, Ramos-Fernandez E, Inestrosa NC. Modulation of the NMDA receptor through secreted soluble factors. Mol Neurobiol. 2016;53(1):299–309. doi:10.1007/s12035-014-9009-x
   Web of Science ®Google Scholar
• Stephane P, Changiz T, Clarrisa B, et al. LTP Inhibits LTD in the hippocampus via regulation of GSK3β. Neuron. 2007;53:703–717. doi:10.1016/j.neuron.2007.01.029
   Web of Science ®Google Scholar
• Eduardo M, CecIlia CX, Brenda GN, et al. Antinociceptive and anti-inflammatory effects of ketamine and the relationship to its antidepressant action and GSK3 inhibition. Basic Clin Pharmacol. 2016;119(6):562–573. doi:10.1111/bcpt.12637
   Web of Science ®Google Scholar
• Li Y, Wang H, Xie K, et al. Inhibition of glycogen synthase kinase-3β prevents remifentanil- induced hyperalgesia via regulating the expression and function of spinal N-Methyl-D-Aspartate receptors in vivo and vitro. PLoS One. 2013;10:e77790. doi:10.1371/journal.pone.0077790
   Web of Science ®Google Scholar
• Resham K, Sharma SS. Pharmacological interventions targeting Wnt/beta-catenin signaling pathway attenuate paclitaxel-induced peripheral neuropathy. Eur J Pharmacol. 2019;864:172714. doi:10.1016/j.ejphar.2019.172714
   PubMed Web of Science ®Google Scholar