Acute Cytokine Response During Breast Cancer Surgery: Potential Role of Dexamethasone and Lidocaine and Relationship with Postoperative Pain and Complications – Analysis of Three Pooled Pilot Randomized Controlled Trials

References

• Desborough JP. The stress response to trauma and surgery. Br J Anaesth. 2000;85(1):109–117. doi:10.1093/bja/85.1.109
   PubMed Web of Science ®Google Scholar
• Miyaoka K, Iwase M, Suzuki R, et al. Clinical evaluation of circulating interleukin-6 and interleukin-10 levels after surgery-induced inflammation. J Surg Res. 2005;125(2):144–150. doi:10.1016/j.jss.2004.12.001
   Web of Science ®Google Scholar
• Mokart D, Merlin M, Sannini A, et al. Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): early markers of postoperative sepsis after major surgery. Br J Anaesth. 2005;94(6):767–773. doi:10.1093/bja/aei143
   PubMed Web of Science ®Google Scholar
• Oka Y, Murata A, Nishijima J, et al. Circulating interleukin 6 as a useful marker for predicting postoperative complications. Cytokine. 1992;4(4):298–304. doi:10.1016/1043-4666(92)90070-8
   Web of Science ®Google Scholar
• Tian Y, Schofield PE, Gough K, Mann GB. Profile and predictors of long-term morbidity in breast cancer survivors. Ann Surg Oncol. 2013;20(11):3453–3460. doi:10.1245/s10434-013-3004-8
   PubMed Web of Science ®Google Scholar
• Verbelen H, Tjalma W, Meirte J, Gebruers N. Long-term morbidity after a negative sentinel node in breast cancer patients. Eur J Cancer Care. 2019;28:e13077.
   Web of Science ®Google Scholar
• Schug SA, Bruce J. Risk stratification for the development of chronic postsurgical pain. Pain Rep. 2017;2(6):e627. doi:10.1097/PR9.0000000000000627
   PubMedGoogle Scholar
• Lavand’homme P. Transition from acute to chronic pain after surgery. Pain. 2017;158(Suppl 1):S50–S54. doi:10.1097/j.pain.0000000000000809
   Web of Science ®Google Scholar
• Austin PJ, Moalem-Taylor G. The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines. J Neuroimmunol. 2010;229(1–2):26–50. doi:10.1016/j.jneuroim.2010.08.013
   PubMed Web of Science ®Google Scholar
• van Boekel RLM, Warle MC, Nielen RGC, et al. Relationship between postoperative pain and overall 30-day complications in a broad surgical population: an observational study. Ann Surg. 2019;269(5):856–865.
   PubMed Web of Science ®Google Scholar
• Amaya F, Hosokawa T, Okamoto A, et al. Can acute pain treatment reduce postsurgical comorbidity after breast cancer surgery? A literature review. Biomed Res Int. 2015;2015:641508. doi:10.1155/2015/641508
   PubMed Web of Science ®Google Scholar
• El Azab SR, Rosseel PM, de Lange JJ, et al. Dexamethasone decreases the pro- to anti-inflammatory cytokine ratio during cardiac surgery. Br J Anaesth. 2002;88(4):496–501. doi:10.1093/bja/88.4.496
   PubMed Web of Science ®Google Scholar
• van der Wal SE, van den Heuvel SA, Radema SA, et al. The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain. Eur J Pain. 2016;20(5):655–674. doi:10.1002/ejp.794
   PubMed Web of Science ®Google Scholar
• Kranke P, Jokinen J, Pace NL, et al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery. Cochrane Database Syst Rev. 2015;7:CD009642.
   Google Scholar
• Waldron NH, Jones CA, Gan TJ, Allen TK, Habib AS. Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review and meta-analysis. Br J Anaesth. 2013;110(2):191–200. doi:10.1093/bja/aes431
   PubMed Web of Science ®Google Scholar
• Hjermstad MJ, Fayers PM, Haugen DF, et al. Studies comparing numerical rating scales, verbal rating scales, and visual analogue scales for assessment of pain intensity in adults: a systematic literature review. J Pain Symptom Manage. 2011;41(6):1073–1093. doi:10.1016/j.jpainsymman.2010.08.016
   PubMed Web of Science ®Google Scholar
• Aldo P, Marusov G, Svancara D, David J, Mor G. Simple Plex™: a novel multi-analyte, automated microfluidic immunoassay platform for the detection of human and mouse cytokines and chemokines. Am J Reprod Immunol. 2016;75(6):678–693. doi:10.1111/aji.12512
   Web of Science ®Google Scholar
• Ter Horst R, Jaeger M, Smeekens SP, et al. Host and environmental factors influencing individual human cytokine responses. Cell. 2016;167(4):1111–1124 e1113. doi:10.1016/j.cell.2016.10.018
   PubMed Web of Science ®Google Scholar
• Clavien PA, Barkun J, de Oliveira ML, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250(2):187–196. doi:10.1097/SLA.0b013e3181b13ca2
   PubMed Web of Science ®Google Scholar
• Arnaoutoglou E, Kouvelos G, Papa N, et al. Prospective evaluation of post-implantation inflammatory response after EVAR for AAA: influence on patients’ 30 day outcome. Eur J Vasc Endovasc Surg. 2015;49(2):175–183. doi:10.1016/j.ejvs.2014.12.006
   Web of Science ®Google Scholar
• Cruz FF, Rocco PR, Pelosi P. Anti-inflammatory properties of anesthetic agents. Crit Care. 2017;21(1):67. doi:10.1186/s13054-017-1645-x
   PubMed Web of Science ®Google Scholar
• Hsing CH, Wang JJ. Clinical implication of perioperative inflammatory cytokine alteration. Acta Anaesthesiol Taiwan. 2015;53(1):23–28. doi:10.1016/j.aat.2015.03.002
   Google Scholar
• Ortiz MP, Godoy MC, Schlosser RS, et al. Effect of endovenous lidocaine on analgesia and serum cytokines: double-blinded and randomized trial. J Clin Anesth. 2016;35:70–77. doi:10.1016/j.jclinane.2016.07.021
   Web of Science ®Google Scholar
• Yardeni IZ, Beilin B, Mayburd E, Levinson Y, Bessler H. The effect of perioperative intravenous lidocaine on postoperative pain and immune function. Anest Analg. 2009;109(5):1464–1469. doi:10.1213/ANE.0b013e3181bab1bd
   Web of Science ®Google Scholar
• Sato N, Koeda K, Ikeda K, et al. Randomized study of the benefits of preoperative corticosteroid administration on the postoperative morbidity and cytokine response in patients undergoing surgery for esophageal cancer. Ann Surg. 2002;236(2):184–190. doi:10.1097/00000658-200208000-00006
   Web of Science ®Google Scholar
• Holte K, Kehlet H. Perioperative single-dose glucocorticoid administration: pathophysiologic effects and clinical implications. J Am Coll Surg. 2002;195(5):694–712. doi:10.1016/S1072-7515(02)01491-6
   PubMed Web of Science ®Google Scholar
• Zargar-Shoshtari K, Sammour T, Kahokehr A, Connolly AB, Hill AG. Randomized clinical trial of the effect of glucocorticoids on peritoneal inflammation and postoperative recovery after colectomy. Br J Surg. 2009;96(11):1253–1261. doi:10.1002/bjs.6744
   Web of Science ®Google Scholar
• Kirdak T, Yilmazlar A, Cavun S, Ercan I, Yilmazlar T. Does single, low-dose preoperative dexamethasone improve outcomes after colorectal surgery based on an enhanced recovery protocol? Double-blind, randomized clinical trial. Am Surg. 2008;74(2):160–167.
   Web of Science ®Google Scholar
• Lisowska B, Maldyk P, Kontny E, Michalak C, Jung L, Cwiek R. Postoperative evaluation of plasma interleukin-6 concentration in patients after total hip arthroplasty. Ortop Traumatol Rehabil. 2006;8(5):547–554.
   Google Scholar
• Edwards RR, Kronfli T, Haythornthwaite JA, Smith MT, McGuire L, Page GG. Association of catastrophizing with interleukin-6 responses to acute pain. Pain. 2008;140(1):135–144. doi:10.1016/j.pain.2008.07.024
   PubMed Web of Science ®Google Scholar
• Zhou YQ, Liu Z, Liu ZH, et al. Interleukin-6: an emerging regulator of pathological pain. J Neuroinflammation. 2016;13(1):141. doi:10.1186/s12974-016-0607-6
   PubMed Web of Science ®Google Scholar
• Ren K, Torres R. Role of interleukin-1beta during pain and inflammation. Brain Res Rev. 2009;60(1):57–64. doi:10.1016/j.brainresrev.2008.12.020
   PubMed Web of Science ®Google Scholar
• Gomez-Hernandez J, Orozco-Alatorre AL, Dominguez-Contreras M, et al. Preoperative dexamethasone reduces postoperative pain, nausea and vomiting following mastectomy for breast cancer. BMC Cancer. 2010;10:692. doi:10.1186/1471-2407-10-692
   PubMed Web of Science ®Google Scholar
• Wattwil M, Thorn SE, Lovqvist A, Wattwil L, Gupta A, Liljegren G. Dexamethasone is as effective as ondansetron for the prevention of postoperative nausea and vomiting following breast surgery. Acta Anaesthesiol Scand. 2003;47(7):823–827. doi:10.1034/j.1399-6576.2003.00172.x
   Web of Science ®Google Scholar
• Grigoras A, Lee P, Sattar F, Shorten G. Perioperative intravenous lidocaine decreases the incidence of persistent pain after breast surgery. Clin J Pain. 2012;28(7):567–572. doi:10.1097/AJP.0b013e31823b9cc8
   Web of Science ®Google Scholar
• Kim MH, Lee KY, Park S, Kim SI, Park HS, Yoo YC. Effects of systemic lidocaine versus magnesium administration on postoperative functional recovery and chronic pain in patients undergoing breast cancer surgery: a prospective, randomized, double-blind, comparative clinical trial. PLoS One. 2017;12(3):e0173026. doi:10.1371/journal.pone.0173026
   Web of Science ®Google Scholar