494
Views
5
CrossRef citations to date
0
Altmetric
Original Research

Comparative Study of Fentanyl vs Dexmedetomidine as Adjuvants to Intrathecal Bupivacaine in Cesarean Section: A Randomized, Double-Blind Clinical Trial

ORCID Icon, & ORCID Icon
Pages 2475-2482 | Published online: 07 Oct 2020

References

  • Khosravi F, Alishahi M, Khanchemehr Y, Jarineshin H. A comparison between the effects of preloading with Ringer’s solution and voluven on hemodynamic changes in patients undergoing elective cesarean section under spinal anesthesia. Med Arch. 2019;73(1):44. doi:10.5455/medarh.2019.73.44-48
  • Sun Y, Xu Y, Wang G-N. Comparative evaluation of intrathecal bupivacaine alone, bupivacaine-fentanyl, and bupivacaine-dexmedetomidine in caesarean section. Drug Res. 2015;65(09):468–472.
  • Jain N, Mathur PR, Soni P, Patodi V, Sethi SK, Mathur V. A comparative clinical study of intrathecal bupivacaine 2.5 mg with dexmedetomidine 5 μg versus intrathecal bupivacaine 2.5 mg with fentanyl 25 μg on the duration of labor analgesia using combined spinal epidural technique. J Obstet Anaesth Crit Care. 2019;9(1):24-29. doi:10.4103/joacc.JOACC_21_18
  • Rahimzadeh P, Faiz SHR, Imani F, Derakhshan P, Amniati S. Comparative addition of Dexmedetomidine and fentanyl to intrathecal bupivacaine in orthopedic procedure in lower limbs. BMC Anesthesiol. 2018;18(1):62. doi:10.1186/s12871-018-0531-7
  • Dahl JB, Jeppesen IS, Jorgensen H, Wetterslev J, Moiniche S. Intraoperative and postoperative analgesic efficacy and adverse effects of intrathecal opioids in patients undergoing cesarean section with spinal anesthesia: a qualitative and quantitative systematic review of randomized controlled trials. Anesthesiol J Am Soc Anesthesiol. 1999;91(6):1919–1927.
  • Jarineshin H, Fekrat F, Kermanshah AK. Treatment of postoperative pain in pediatric operations: comparing the efficiency of bupivacaine, bupivacaine-dexmedetomidine and bupivacaine-fentanyl for caudal block. Anesthesiol Pain Med. 2016;6(5). doi:10.5812/aapm.39495
  • Belzarena SD. Clinical effects of intrathecally administered fentanyl in patients undergoing cesarean section. Anesth Analg. 1992;74(5):653–657. doi:10.1213/00000539-199205000-00006
  • Contractor HU, Gajjar VA, Shah VA. Evaluating effect of intravenous Dexmedetomidine on hyperbaric bupivacaine spinal anesthesia. Anaesth Pain Intensive Care. 2016;20(4):398–403.
  • Bajwa SJS, Bajwa SK, Kaur J, et al. Dexmedetomidine and clonidine in epidural anaesthesia: a comparative evaluation. Indian J Anaesth. 2011;55(2):116. doi:10.4103/0019-5049.79883
  • Niu X-Y, Ding X-B, Guo T, Chen M-H, Fu S-K, Li Q. Effects of intravenous and intrathecal dexmedetomidine in spinal anesthesia: a meta-analysis. CNS Neurosci Ther. 2013;19(11):897–904. doi:10.1111/cns.12172
  • Gómez-Vázquez ME, Hernández-Salazar E, Hernández-Jiménez A, Pérez-Sánchez A, Zepeda-López VA, Salazar-Páramo M. Clinical analgesic efficacy and side effects of dexmedetomidine in the early postoperative period after arthroscopic knee surgery. J Clin Anesth. 2007;19(8):576–582. doi:10.1016/j.jclinane.2007.06.013
  • Gupta R, Verma R, Bogra J, Kohli M, Raman R, Kushwaha JK. A comparative study of intrathecal Dexmedetomidine and fentanyl as adjuvants to bupivacaine. J Anaesthesiol Clin Pharmacol. 2011;27(3):339. doi:10.4103/0970-9185.83678
  • Jain D, Khan RM, Kumar D, Kumar N. Perioperative effect of epidural Dexmedetomidine with intrathecal bupivacaine on haemodynamic parameters and quality of analgesia. South Afr J Anaesth Analg. 2012;18(2):105–109. doi:10.1080/22201173.2012.10872835
  • Bhure A, Jagtap N. A comparison of intrathecal Dexmedetomidine and fentanyl as an adjuvant to isobaric levobupivacaine for lower limb orthopaedic surgery. Indian J Clin Anaesth. 2019;6(1):89–96. doi:10.18231/2394-4994.2019.0017
  • Qi X, Chen D, Li G, et al. Comparison of intrathecal Dexmedetomidine with morphine as adjuvants in cesarean sections. Biol Pharm Bull. 2016;b16–00145.
  • Jarineshin H, Baghaei AA, Fekrat F, et al. Comparison of two different doses of Dexmedetomidine in attenuating cardiovascular responses during laryngoscopy and endotracheal intubation: a double blind, randomized, clinical trial study. J Med Life. 2015;8(Spec Iss 4):45.
  • Nayagam HA, Singh NR, Singh HS. A prospective randomised double blind study of intrathecal fentanyl and Dexmedetomidine added to low dose bupivacaine for spinal anesthesia for lower abdominal surgeries. Indian J Anaesth. 2014;58(4):430. doi:10.4103/0019-5049.138979
  • Gupta R, Bogra J, Verma R, Kohli M, Kushwaha JK, Kumar S. Dexmedetomidine as an intrathecal adjuvant for postoperative analgesia. Indian J Anaesth. 2011;55(4):347. doi:10.4103/0019-5049.84841
  • Khosravi F, Sadeghi N, Jarineshin H. The effect of Dexmedetomidine on spinal anesthesia quality and hemodynamic changes in patients undergoing inguinal hernia repair surgery: intravenous versus intrathecal. Eur J Clin Pharmacol. 2020;76(7):923–928. doi:doi:10.1007/s00228-020-02870-8
  • Arain SR, Ruehlow RM, Uhrich TD, Ebert TJ. The efficacy of Dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesth Analg. 2004;98(1):153–158. doi:10.1213/01.ANE.0000093225.39866.75
  • Shukla D, Verma A, Agarwal A, Pandey HD, Tyagi C. Comparative study of intrathecal Dexmedetomidine with intrathecal magnesium sulfate used as adjuvants to bupivacaine. J Anaesthesiol Clin Pharmacol. 2011;27(4):495. doi:10.4103/0970-9185.86594
  • Suthar O, Sethi P, Sharma UD. Comparison of Dexmedetomidine and clonidine as an adjuvant to intrathecal bupivacaine in lower limb surgery: a randomised, double-blind, placebo controlled trial. Anaesth Pain Intensive Care. 2019;147–152.
  • Shahi V, Verma AK, Agarwal A, Singh CS. A comparative study of magnesium sulfate vs Dexmedetomidine as an adjunct to epidural bupivacaine. J Anaesthesiol Clin Pharmacol. 2014;30(4):538. doi:10.4103/0970-9185.142852
  • Mahendru V, Tewari A, Katyal S, Grewal A, Singh MR, Katyal R. A comparison of intrathecal Dexmedetomidine, clonidine, and fentanyl as adjuvants to hyperbaric bupivacaine for lower limb surgery: a double blind controlled study. J Anaesthesiol Clin Pharmacol. 2013;29(4):496. doi:10.4103/0970-9185.119151
  • Khalifa IF. A comparative study of adding intrathecal Dexmedetomidine versus sufentanil to heavy bupivacaine for postoperative analgesia in patients undergoing inguinal hernia repair. Benha Med J. 2009;26:3–11.