Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series

References

• LoeserJDFive crises in pain managementPain Clin Updates20122014
   Google Scholar
• DworkinRHO’ConnorABAudetteJRecommendations for the pharmacological management of neuropathic pain: an overview and literature updateMayo Clin Proc201085S3S1420194146
   PubMed Web of Science ®Google Scholar
• Keppel HesselinkJMNew targets in pain, non-neuronal cells, and the role of palmitoylethanolamideOpen Pain J201251223
   Google Scholar
• LoVermeJRussoRLa RanaGRapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alphaJ Pharmacol Exp Ther200631051106116997973
   PubMed Web of Science ®Google Scholar
• Lo VermeJFuJAstaritaGThe nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamideMol Pharmacol200567151915465922
   PubMed Web of Science ®Google Scholar
• DarmaniNAIzzoAADegenhardtBInvolvement of the cannabimimetic compound, N-palmitoylethanolamine, in inflammatory and neuropathic conditions. A review of the available preclinical data and first human studiesNeuropharmacology2005481154116315910891
   PubMed Web of Science ®Google Scholar
• GenoveseTEspositoEMazzonEEffects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injuryJ Pharmacol Exp Ther2008326122318367664
   PubMed Web of Science ®Google Scholar
• NaderiNMajidiMMousaviZKhoramian TusiSMansouriZThe interaction between intrathecal administration of low doses of palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in ratsNeurochem Res20123777878522201038
   PubMed Web of Science ®Google Scholar
• YoshiharaSMorimotoHOhoriMYamadaYAbeTArisakaOCannabinoid receptor agonists inhibit Ca(2+) influx to synaptosomes from rat brainPharmacology20067615716216446560
   PubMed Web of Science ®Google Scholar
• HoWSBar rettDARandallMD‘Entourage’ effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptorsBr J Pharmacol2008683784618695637
   PubMed Web of Science ®Google Scholar
• AppendinoGLigrestiAMinassiAConformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probesJ Med Chem2009523001300919361197
   PubMed Web of Science ®Google Scholar
• LoríaFPetrosinoSMestreLStudy of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamideEur J Neurosci20082863364118657182
   PubMed Web of Science ®Google Scholar
• EspositoEPaternitiIMazzonEEffects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injuryBrain Behav Immun2011251099111221354467
   PubMed Web of Science ®Google Scholar
• CerratoSBrazisPdella ValleMFMioloAPuigdemontAEffects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNF-alpha release from canine skin mast cellsVet Immunol Immunopathol201013391519625089
   PubMed Web of Science ®Google Scholar
• De FilippisDLuongoLCiprianoMPalmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in ratsMol Pain201010:73
   Web of Science ®Google Scholar
• Keppel HesselinkJMGlia as a new target for neuropathic pain, clinical proof of concept for palmitoylethanolamide, a glia modulatorAnesth Pain Intensive Care201115143145
   Google Scholar
• BouhassiraDAttalNAlchaarHComparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)Pain2005114293615733628
   PubMed Web of Science ®Google Scholar
• ZieglerDNowakHKemplerPVarghaPLowPATreatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysisDiabet Med20042111412114984445
   PubMed Web of Science ®Google Scholar
• ZieglerDAmetovABarinovAOral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trialDiabetes Care2006292365237017065669
   PubMed Web of Science ®Google Scholar
• RuessmannHJSwitching from pathogenetic treatment with alpha-lipoic acid to gabapentin and other analgesics in painful diabetic neuropathy: a real-world study in outpatientsJ Diabetes Complications20092317417718403218
   PubMed Web of Science ®Google Scholar
• VorobeychikYGordinVMaoJCombination therapy for neuropathic pain: a review of current evidenceCNS Drugs2011251023103422133325
   PubMed Web of Science ®Google Scholar
• ThalerAGuptaACohenSPCannabinoids for pain managementAdv Psychosom Med20113012513821508629
   PubMed Web of Science ®Google Scholar
• JaggiASSinghNTherapeutic targets for the management of peripheral nerve injury-induced neuropathic painCNS Neurol Disord Drug Targets20111058960921631400
   PubMed Web of Science ®Google Scholar
• KopskyDJKeppel HesselinkJMHigh doses of topical amitriptyline in neuropathic pain: two cases and literature reviewPain Pract20111214815321676162
   PubMed Web of Science ®Google Scholar
• FinnerupNBSindrupSHJensenTSThe evidence for pharmacological treatment of neuropathic painPain201015057358120705215
   PubMed Web of Science ®Google Scholar
• TruiniABiasiottaADi StefanoGPalmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathyCNS Neurol Disord Drug Targets20111091692022229320
   PubMed Web of Science ®Google Scholar
• KopskyDJKeppel HesselinkJMMultimodal stepped care approach involving topical analgesics for severe intractable neuropathic pain in CRPS type 1: a case reportCase Report Med2011201131975022028723
   PubMedGoogle Scholar
• LiebregtsRKopskyDJKeppel HesselinkJMTopical amitriptyline in post-traumatic neuropathic painJ Pain Symptom Manage201141e6e821481735
   PubMed Web of Science ®Google Scholar
• Keppel HesselinkJMKopskyDJIntractable neuropathic pain due to ulnar nerve entrapment treated with cannabis and ketamine 10%J Clin Anesth201224787922227162
   PubMed Web of Science ®Google Scholar
• GuidaGde MartinoMde FabianiALa palmitoiletanolamida (Normast) en el dolor neuropatico cronico por lumbociatalgia de tipo compresivo: estudio clinico multicentricoPalmitoylethanolamide treatment of sciatic pain: results form a multicenter studyDolor2010253542
   Google Scholar
• CanteriLReduction of analgesics in patients suffering from lumbosciatic pain, treated with palmitoylethanolamideDolor201025227234
   Google Scholar
• AssiniALaricchiaDPizzoRThe carpal tunnel syndrome in diabetes: clinical and electrophysiological improvement after treatment with palmitoylethanolamideEur J Neurol20101729519863647
   PubMed Web of Science ®Google Scholar
• BiasiottaALa CesaSLeoneCDi StefanoGTruiniACruccuGEfficacy of palmitoylethanolamide in patients with painful neuropathy. A clinical and neurophysiological open study. Preliminary resultsEur J Pain Suppl2010477
   Google Scholar
• BortolottiFRussoMBartolucciMLAlessandri BonettiGGattoMRMariniIPalmitoylethanolamide vs NSAID in the treatment of TMJD painJ Orofac Pain2012
   Google Scholar
• PhanNQSiepmannDGralowIStänderSAdjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgiaJ Dtsch Dermatol Ges20108889119744255
   PubMed Web of Science ®Google Scholar
• DesioPCombination of pregabalin and palmitoylethanolamide (PEA) for neuropathic pain treatmentPathos201017914
   Google Scholar