Mechanisms of Neuropathic Pain and Pain-Relieving Effects of Exercise Therapy in a Rat Neuropathic Pain Model

References

• Raja SN, Carr DB, Cohen M, et al. The revised international association for the study of pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161(9):1976–1982. doi:10.1097/j.pain.0000000000001939
   PubMed Web of Science ®Google Scholar
• Scholz J, Finnerup NB, Attal N, et al. The IASP classification of chronic pain for ICD-11: chronic neuropathic pain. Pain. 2019;160(1):53–59. doi:10.1097/j.pain.0000000000001365
   PubMed Web of Science ®Google Scholar
• Rice ASC, Smith BH, Blyth FM. Pain and the global burden of disease. Pain. 2016;157(4):791–796. doi:10.1097/j.pain.0000000000000454
   PubMed Web of Science ®Google Scholar
• van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain. 2014;155(9):654–662. doi:10.1016/j.pain.2013.11.013
   PubMed Web of Science ®Google Scholar
• Dworkin RH, O’Connor AB, Backonja M, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain. 2007;132(3):237–251. doi:10.1016/j.pain.2007.08.033
   PubMed Web of Science ®Google Scholar
• Cavalli E, Mammana S, Nicoletti F, Bramanti P, Mazzon E. The neuropathic pain: an overview of the current treatment and future therapeutic approaches. Int J Immunopathol Pharmacol. 2019;33:2058738419838383. doi:10.1177/2058738419838383
   Web of Science ®Google Scholar
• Bannister K, Sachau J, Baron R, Dickenson AH. Neuropathic pain: mechanism-based therapeutics. Annu Rev Pharmacol Toxicol. 2020;60:257–274. doi:10.1146/annurev-pharmtox-010818-021524
   PubMed Web of Science ®Google Scholar
• Inoue K, Tsuda M. Microglia and neuropathic pain. Glia. 2009;57(14):1469–1479. doi:10.1002/glia.20871
   PubMed Web of Science ®Google Scholar
• Zhu KJ, Yang JS. Anti-allodynia effect of safranal on neuropathic pain induced by spinal nerve transection in rat. Int J Clin Exp Med. 2014;7(12):4990–4996.
   PubMed Web of Science ®Google Scholar
• Tsuda M. Microglia in the spinal cord and neuropathic pain. J Diabetes Investig. 2016;7(1):17–26. doi:10.1111/jdi.12379
   PubMed Web of Science ®Google Scholar
• Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci. 2009;32:1–32. doi:10.1146/annurev.neuro.051508.135531
   PubMed Web of Science ®Google Scholar
• Piotrowska A, Kwiatkowski K, Rojewska E, et al. Direct and indirect pharmacological modulation of CCL2/CCR2 pathway results in attenuation of neuropathic pain – in vivo and in vitro evidence. J Neuroimmunol. 2016;297:9–19. doi:10.1016/j.jneuroim.2016.04.017
   PubMed Web of Science ®Google Scholar
• Xian H, Jiang Y, Zhang H, Ma SB, Zhao R, Cong R. CCL2-CCR2 axis potentiates NMDA receptor signaling to aggravate neuropathic pain induced by brachial plexus avulsion. Neuroscience. 2020;425:29–38. doi:10.1016/j.neuroscience.2019.11.012
   PubMed Web of Science ®Google Scholar
• Lu Y, Jiang BC, Cao DL, et al. TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling. Pain. 2014;155(12):2618–2629. doi:10.1016/j.pain.2014.09.027
   PubMed Web of Science ®Google Scholar
• Egorova E, Starinets A, Tyrtyshnaia A, et al. Hippocampal neurogenesis in conditions of chronic stress induced by sciatic nerve injury in the rat. Cells Tissues Organs. 2019;207(1):58–68. doi:10.1159/000501236
   PubMed Web of Science ®Google Scholar
• Lavado A, Lagutin OV, Chow LM, Baker SJ, Oliver G. Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLOS Biol. 2010;8(8):e1000460. doi:10.1371/journal.pbio.1000460
   PubMed Web of Science ®Google Scholar
• Somelar K, Jürgenson M, Jaako K, et al. Development of depression-like behavior and altered hippocampal neurogenesis in a mouse model of chronic neuropathic pain. Brain Res. 2021;1758:147329. doi:10.1016/j.brainres.2021.147329
   PubMed Web of Science ®Google Scholar
• Abbott LC, Nigussie F. Adult neurogenesis in the mammalian dentate gyrus. Anat Histol Embryol. 2020;49(1):3–16. doi:10.1111/ahe.12496
   PubMed Web of Science ®Google Scholar
• Moisset X, Bouhassira D, Avez Couturier J, et al. Pharmacological and non-pharmacological treatments for neuropathic pain: systematic review and French recommendations. Rev Neurol. 2020;176(5):325–352. doi:10.1016/j.neurol.2020.01.361
   PubMed Web of Science ®Google Scholar
• Stagg NJ, Mata HP, Ibrahim MM, et al. Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids. Anesthesiology. 2011;114(4):940–948. doi:10.1097/ALN.0b013e318210f880
   PubMed Web of Science ®Google Scholar
• Ghodrati-Jaldbakhan S, Ahmadalipour A, Rashidy-Pour A, Vafaei AA, Miladi-Gorji H, Alizadeh M. Low- and high-intensity treadmill exercise attenuates chronic morphine-induced anxiogenesis and memory impairment but not reductions in hippocampal BDNF in female rats. Brain Res. 2017;1663:20–28. doi:10.1016/j.brainres.2017.02.024
   PubMed Web of Science ®Google Scholar
• Bement MK, Sluka KA. Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner. Arch Phys Med Rehabil. 2005;86(9):1736–1740. doi:10.1016/j.apmr.2005.03.029
   PubMed Web of Science ®Google Scholar
• Véras-Silva AS, Mattos KC, Gava NS, Brum PC, Negrão CE, Krieger EM. Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats. Am J Physiol. 1997;273(6):H2627–H2631. doi:10.1152/ajpheart.1997.273.6.H2627
   PubMed Web of Science ®Google Scholar
• Sumizono M, Sakakima H, Otsuka S, et al. The effect of exercise frequency on neuropathic pain and pain-related cellular reactions in the spinal cord and midbrain in a rat sciatic nerve injury model. J Pain Res. 2018;11:281–291. doi:10.2147/JPR.S156326
   PubMed Web of Science ®Google Scholar
• Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33(1):87–107. doi:10.1016/0304-3959(88)90209-6
   PubMed Web of Science ®Google Scholar
• Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53(1):55–63. doi:10.1016/0165-0270(94)90144-9
   PubMed Web of Science ®Google Scholar
• Zhang ZJ, Jiang BC, Gao YJ. Chemokines in neuron-glial cell interaction and pathogenesis of neuropathic pain. Cell Mol Life Sci. 2017;74(18):3275–3291. doi:10.1007/s00018-017-2513-1
   PubMed Web of Science ®Google Scholar
• Kubíčková L, Klusáková I, Dubový P. Bilateral activation of glial cells and cellular distribution of the chemokine CCL2 and its receptor CCR2 in the trigeminal subnucleus caudalis of trigeminal neuropathic pain model. Histochem Cell Biol. 2020;153(4):239–255. doi:10.1007/s00418-020-01850-4
   PubMed Web of Science ®Google Scholar
• Xu J, Dong H, Qian Q, et al. Astrocyte-derived CCL2 participates in surgery-induced cognitive dysfunction and neuroinflammation via evoking microglia activation. Behav Brain Res. 2017;332:145–153. doi:10.1016/j.bbr.2017.05.066
   PubMed Web of Science ®Google Scholar
• Zhang J, Shi XQ, Echeverry S, Mogil JS, De Koninck Y, Rivest S. Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci. 2007;27(45):12396–12406. doi:10.1523/JNEUROSCI.3016-07.2007
   PubMed Web of Science ®Google Scholar
• Wu H, Arron JR. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. BioEssays. 2003;25(11):1096–1105. doi:10.1002/bies.10352
   PubMed Web of Science ®Google Scholar
• Grilli M. Chronic pain and adult hippocampal neurogenesis: translational implications from preclinical studies. J Pain Res. 2017;10:2281–2286. doi:10.2147/JPR.S146399
   PubMed Web of Science ®Google Scholar
• Xia SH, Hu SW, Ge DG, et al. Chronic pain impairs memory formation via disruption of neurogenesis mediated by mesohippocampal brain-derived neurotrophic factor signaling. Biol Psychiatry. 2020;88(8):597–610. doi:10.1016/j.biopsych.2020.02.013
   PubMed Web of Science ®Google Scholar
• Manzhulo I, Manzhulo O, Tyrtyshnaia A, et al. Modulation of hippocampal astroglial activity by synaptamide in rats with neuropathic pain. Brain Sci. 2021;11(12):1561. doi:10.3390/brainsci11121561
   PubMed Web of Science ®Google Scholar
• Lesnak JB, Sluka KA. Mechanism of exercise-induced analgesia: what we can learn from physically active animals. PAIN Rep. 2020;5(5):e850. doi:10.1097/PR9.0000000000000850
   PubMedGoogle Scholar