Effects of Exercise-Induced Hypoalgesia at Different Aerobic Exercise Intensities in Healthy Young Adults

References

• Pedersen BK, Saltin B. Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015;25:1–72. doi:10.1111/sms.12581
   PubMed Web of Science ®Google Scholar
• Foster NE, Anema JR, Cherkin D, et al. Prevention and treatment of low back pain: evidence, challenges, and promising directions. Lancet. 2018;391:2368–2383. doi:10.1016/S0140-6736(18)30489-6
   PubMed Web of Science ®Google Scholar
• Roos EM, Juhl CB. Osteoarthritis 2012 year in review: rehabilitation and outcomes. Osteoarthritis Cartilage. 2012;20:1477–1483. doi:10.1016/j.joca.2012.08.028
   PubMed Web of Science ®Google Scholar
• Koltyn KF. Analgesia following exercise: a review. Sports Med. 2000;29:85–98. doi:10.2165/00007256-200029020-00002
   PubMed Web of Science ®Google Scholar
• Koltyn KF. Exercise-induced hypoalgesia and intensity of exercise. Sports Med. 2002;32:477–487. doi:10.2165/00007256-200232080-00001
   PubMed Web of Science ®Google Scholar
• Naugle KM, Fillingim RB, Riley JL. A meta-analytic review of the hypoalgesic effects of exercise. J Pain. 2012;13:1139–1150. doi:10.1016/j.jpain.2012.09.006
   PubMed Web of Science ®Google Scholar
• Vaegter HB, Handberg G, Graven-Nielsen T. Similarities between exercise-induced hypoalgesia and conditioned pain modulation in humans. Pain. 2014;155:158–167. doi:10.1016/j.pain.2013.09.023
   PubMed Web of Science ®Google Scholar
• Wewege MA, Jones MD. Exercise-induced hypoalgesia in healthy individuals and people with chronic musculoskeletal pain: a systematic review and meta-analysis. J Pain. 2021;22:21–31. doi:10.1016/j.jpain.2020.04.003
   PubMed Web of Science ®Google Scholar
• Hoffman MD, Shepanski MA, Ruble SB, et al. Intensity and duration threshold for aerobic exercise-induced analgesia to pressure pain. Arch Phys Med Rehabil. 2004;85:1183–1187. doi:10.1016/j.apmr.2003.09.010
   PubMed Web of Science ®Google Scholar
• Ickmans K, Malfliet A, De Kooning M, et al. Lack of gender and age differences in pain measurements following exercise in people with chronic whiplash-associated disorders. Pain Physician. 2017;20:E829–E840. doi:10.36076/ppj.20.5.E829
   PubMed Web of Science ®Google Scholar
• Meeus M, Hermans L, Ickmans K, et al. Endogenous pain modulation in response to exercise in patients with rheumatoid arthritis, patients with chronic fatigue syndrome and comorbid fibromyalgia, and healthy controls: a double-blind randomized controlled trial. Pain Pract. 2015;15:98–106. doi:10.1111/papr.12181
   PubMed Web of Science ®Google Scholar
• Meeus M, Roussel NA, Truijen S, et al. Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study. J Rehabil Med. 2010;42:884–890. doi:10.2340/16501977-0595
   PubMed Web of Science ®Google Scholar
• Van Oosterwijck J, Nijs J, Meeus M, et al. Lack of endogenous pain inhibition during exercise in people with chronic whiplash associated disorders: an experimental study. J Pain. 2012;13:242–254. doi:10.1016/j.jpain.2011.11.006
   PubMed Web of Science ®Google Scholar
• Meeus M, Nijs J, Van Wilgen CP, et al. Moving on to movement in patients with chronic joint pain. Pain Clin Update. 2016;24:1–8.
   Google Scholar
• Howley ET. Type of activity: resistance, aerobic and leisure versus occupational physical activity. Med Sci Sports Exerc. 2001;33:S364–S369;discussion S419–420. doi:10.1097/00005768-200106001-00005
   Web of Science ®Google Scholar
• Lawford BJ, Walters J, Ferrar K. Does walking improve disability status, function, or quality of life in adults with chronic low back pain? A systematic review. Clin Rehabil. 2016;30:523–536. doi:10.1177/0269215515590487
   PubMed Web of Science ®Google Scholar
• Vaegter HB, Handberg G, Graven-Nielsen T. Isometric exercises reduce temporal summation of pressure pain in humans. Eur J Pain. 2015;19:973–983. doi:10.1002/ejp.623
   PubMed Web of Science ®Google Scholar
• Micalos PS, Arendt-Nielsen L. Differential pain response at local and remote muscle sites following aerobic cycling exercise at mild and moderate intensity. Springerplus. 2016;5:91. doi:10.1186/s40064-016-1721-8
   PubMedGoogle Scholar
• Nguy V, Barry BK, Moloney N, et al. Exercise-induced hypoalgesia is present in people with Parkinson’s disease: two observational cross-sectional studies. Eur J Pain. 2019;23:1329–1339. doi:10.1002/ejp.1400
   PubMed Web of Science ®Google Scholar
• Rice D, Nijs J, Kosek E, et al. Exercise-induced hypoalgesia in pain-free and chronic pain populations: state of the art and future directions. J Pain. 2019;20:1249–1266. doi:10.1016/j.jpain.2019.03.005
   PubMed Web of Science ®Google Scholar
• Vaegter HB, Jones MD. Exercise-induced hypoalgesia after acute and regular exercise: experimental and clinical manifestations and possible mechanisms in individuals with and without pain. Pain Rep. 2020;5:e823. doi:10.1097/PR9.0000000000000823
   PubMedGoogle Scholar
• Arendt-Nielsen L, Yarnitsky D. Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera. J Pain. 2009;10:556–572. doi:10.1016/j.jpain.2009.02.002
   PubMed Web of Science ®Google Scholar
• Jones MD, Nuzzo JL, Taylor JL, et al. Aerobic exercise reduces pressure more than heat pain sensitivity in healthy adults. Pain Med. 2019;20:1534–1546. doi:10.1093/pm/pny289
   PubMed Web of Science ®Google Scholar
• Uddin Z, MacDermid JC. Quantitative sensory testing in chronic musculoskeletal pain. Pain Med. 2016;17:1694–1703. doi:10.1093/pm/pnv105
   PubMed Web of Science ®Google Scholar
• Andrew D, Craig AD. Responses of spinothalamic lamina I neurons to maintained noxious mechanical stimulation in the cat. J Neurophysiol. 2002;87:1889–1901. doi:10.1152/jn.00577.2001
   PubMed Web of Science ®Google Scholar
• Staud R, Robinson ME, Price DD. Temporal summation of second pain and its maintenance are useful for characterizing widespread central sensitization of fibromyalgia patients. J Pain. 2007;8:893–901. doi:10.1016/j.jpain.2007.06.006
   PubMed Web of Science ®Google Scholar
• Naugle KM, Naugle KE, Fillingim RB, et al. Intensity thresholds for aerobic exercise-induced hypoalgesia. Med Sci Sports Exerc. 2014;46:817–825. doi:10.1249/MSS.0000000000000143
   PubMed Web of Science ®Google Scholar
• Pacheco-Barrios K, Gianlorenço AC, Machado R, et al. Exercise-induced pain threshold modulation in healthy subjects: a systematic review and meta-analysis. Princ Pract Clin Res. 2020;6:11–28. doi:10.21801/ppcrj.2020.63.2
   PubMedGoogle Scholar
• Rampazo ÉP, de Andrade ALM, da Silva VR, et al. Photobiomodulation therapy and transcutaneous electrical nerve stimulation on chronic neck pain patients: study protocol clinical trial (SPIRIT Compliant). Medicine. 2020;99:e19191. doi:10.1097/MD.0000000000019191
   PubMed Web of Science ®Google Scholar
• Vaegter HB, Dørge DB, Schmidt KS, et al. Test-retest reliability of exercise-induced hypoalgesia after aerobic exercise. Pain Med. 2018;19:2212–2222. doi:10.1093/pm/pny009
   PubMed Web of Science ®Google Scholar
• Arendt-Nielsen L, Nie H, Laursen MB, et al. Sensitization in patients with painful knee. osteoarthritis. Pain. 2010;149:573–581. doi:10.1016/j.pain.2010.04.003
   PubMed Web of Science ®Google Scholar
• Hattori T, Shimo K, Niwa Y, et al. Association of chronic pain with radiologic severity and central sensitization in Hip osteoarthritis patients. J Pain Res. 2021;14:1153–1160. doi:10.2147/JPR.S296273
   PubMed Web of Science ®Google Scholar
• Nie H, Graven-Nielsen T, Arendt-Nielsen L. Spatial and temporal summation of pain evoked by mechanical pressure stimulation. Eur J Pain. 2009;13:592–599. doi:10.1016/j.ejpain.2008.07.013
   PubMed Web of Science ®Google Scholar
• Henriksen M, Klokker L, Graven-Nielsen T, et al. Association of exercise therapy and reduction of pain sensitivity in patients with knee osteoarthritis: a randomized controlled trial. Arthritis Care Res. 2014;66:1836–1843. doi:10.1002/acr.22375
   PubMed Web of Science ®Google Scholar
• Izumi M, Petersen KK, Laursen MB, et al. Facilitated temporal summation of pain correlates with clinical pain intensity after Hip arthroplasty. Pain. 2017;158:323–332. doi:10.1097/j.pain.0000000000000764
   PubMed Web of Science ®Google Scholar
• Karvonen MJ, Kentala E, Mustala O. The effects of training on heart rate; a longitudinal study. Ann Med Exp Biol Fenn. 1957;35:307–315.
   PubMedGoogle Scholar
• Naugle KM, Naugle KE, Riley JL. Reduced modulation of pain in older adults after isometric and aerobic exercise. J Pain. 2016;17:719–728. doi:10.1016/j.jpain.2016.02.013
   PubMed Web of Science ®Google Scholar
• Kodesh E, Weissman-Fogel I. Exercise-induced hypoalgesia - interval versus continuous. mode. Appl Physiol Nutr Metab. 2014;39:829–834. doi:10.1139/apnm-2013-0481
   PubMed Web of Science ®Google Scholar
• Cohen J. Statistical Power Analysis for the Behavioral Science. 2nd ed. Hillsdale: Lawrence Earlbaum Associates; 1988.
   Google Scholar
• Taguchi S, Kami K, Tajima F, et al. Increase of M2 macrophages in injured sciatic nerve by treadmill running may contribute to the relief of neuropathic pain. Pain Res. 2015;30:135–147. Japanese. doi:10.11154/pain.30.135
   Google Scholar
• Kami K, Tajima F, Senba E. Exercise-induced hypoalgesia: potential mechanisms in animal models of neuropathic pain. Anat Sci Int. 2017;92:79–90. doi:10.1007/s12565-016-0360-z
   PubMed Web of Science ®Google Scholar
• Da Silva Santos R, Galdino G. Endogenous systems involved in exercise-induced analgesia. J Physiol Pharmacol. 2018;69:3–13. doi:10.26402/jpp.2018.1.01
   PubMed Web of Science ®Google Scholar
• Basso JC, Suzuki WA. The effects of acute exercise on mood, cognition, neurophysiology, and neurochemical pathways: a review. Brain Plast. 2017;2:127–152. doi:10.3233/BPL-160040
   PubMedGoogle Scholar
• Raichlen DA, Foster AD, Seillier A, et al. Exercise-induced endocannabinoid signaling is modulated by intensity. Eur J Appl Physiol. 2013;113:869–875. doi:10.1007/s00421-012-2495-5
   PubMed Web of Science ®Google Scholar
• Berger BG, Motl RW. Exercise and mood: a selective review and synthesis of research employing the profile of mood states. J Appl Sport Psychol. 2000;12:69–92. doi:10.1080/10413200008404214
   Web of Science ®Google Scholar
• Reed J, Ones DS. The effect of acute aerobic exercise on positive activated affect: a meta-analysis. Psychol Sport Exerc. 2006;7:477–514. doi:10.1016/j.psychsport.2005.11.003
   Web of Science ®Google Scholar