102
Views
41
CrossRef citations to date
0
Altmetric
Review

Evidence for the endothelin system as an emerging therapeutic target for the treatment of chronic pain

, , &
Pages 531-545 | Published online: 30 Aug 2014

References

  • YanagisawaMKuriharaHKimuraSGotoKMasakiTA novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channelsJ Hypertens Suppl198864S188S1912853725
  • RubanyiGMPolokoffMAEndothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiologyPharmacol Rev19944633254157831383
  • GiannessiDDel RySVitaleRLThe role of endothelins and their receptors in heart failurePharmacol Res200143211112611243712
  • LalichMMcNeelDGWildingGLiuGEndothelin receptor antagonists in cancer therapyCancer Invest200725878579418058475
  • DahlöfBGustafssonDHednerTJernSHanssonLRegional haemodynamic effects of endothelin-1 in rat and man: unexpected adverse reactionJ Hypertens1990898118172172370
  • NelsonJBHedicanSPGeorgeDJIdentification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostateNat Med1995199449497585222
  • LermanAEdwardsBSHallettJWHeubleinDMSandbergSMBurnettJCJrCirculating and tissue endothelin immunoreactivity in advanced atherosclerosisN Engl J Med19913251499710011886637
  • SuzukiTKumazakiTMitsuiYEndothelin-1 is produced and secreted by neonatal rat cardiac myocytes in vitroBiochem Biophys Res Commun199319138238308466520
  • HaradaMItohHNakagawaOSignificance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy: evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytesCirculation19979610373737449396478
  • HansGDeseureKAdriaensenHEndothelin-1-induced pain and hyperalgesia: a review of pathophysiology, clinical manifestations and future therapeutic optionsNeuropeptides200842211913218194815
  • HasueFKuwakiTKisanukiYYIncreased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout miceNeuroscience2005130234935815664691
  • LiuYYamadaHOchiJImmunocytochemical studies on endothelin in mast cells and macrophages in the rat gastrointestinal tractHistochem Cell Biol199810943013079562379
  • EhrenreichHAndersonRWFoxCHEndothelins, peptides with potent vasoactive properties, are produced by human macrophagesJ Exp Med19901726174117481701822
  • CarducciMAJimenoATargeting bone metastasis in prostate cancer with endothelin receptor antagonistsClinical Cancer Research: An Official Journal of the American Association for Cancer Research101520061220 Pt 26296s6300s17062717
  • AhnGYButtKIJindoTYaguchiHTsuboiROgawaHThe expression of endothelin-1 and its binding sites in mouse skin increased after ultraviolet B irradiation or local injection of tumor necrosis factor alphaJ Dermatol199825278849563273
  • KopetzESNelsonJBCarducciMAEndothelin-1 as a target for therapeutic intervention in prostate cancerInvest New Drugs200220217318212099577
  • MoreauPd’UscioLVShawSTakaseHBartonMLüscherTFAngiotensin II increases tissue endothelin and induces vascular hypertrophy: reversal by ET(A)-receptor antagonistCirculation1997965159315979315552
  • WagnerOFChristGWojtaJPolar secretion of endothelin-1 by cultured endothelial cellsJ Biol Chem19922672316066160681644793
  • RubinSALevinERClinical review 53: The endocrinology of vasoactive peptides: synthesis to functionJ Clin Endocrinol Metab19947816108288715
  • BremnesTPaascheJDMehlumASandbergCBremnesBAttramadalHRegulation and intracellular trafficking pathways of the endothelin receptorsJ Biol Chem200027523175961760410747877
  • BurkhardtMBartonMShawSGReceptor- and non-receptor-mediated clearance of big-endothelin and endothelin-1: differential effects of acute and chronic ETA receptor blockadeJ Hypertens200018327327910726713
  • GohlaASchultzGOffermannsSRole for G(12)/G(13) in agonist-induced vascular smooth muscle cell contractionCirc Res200087322122710926873
  • MasakiTEndothelin in vascular biologyAnn N Y Acad Sci199471411011088017758
  • NicolGDETET – phone the pain clinicTrends Neurosci2004274177180 discussion 18015108686
  • AraiHHoriSAramoriIOhkuboHNakanishiSCloning and expression of a cDNA encoding an endothelin receptorNature199034863037307322175396
  • SakuraiTYanagisawaMTakuwaYCloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptorNature199034863037327352175397
  • RashidAJO’DowdBFGeorgeSRMinireview: Diversity and complexity of signaling through peptidergic G protein-coupled receptorsEndocrinology200414562645265215044354
  • ZhouZDavarGStrichartzGEndothelin-1 (ET-1) selectively enhances the activation gating of slowly inactivating tetrodotoxin-resistant sodium currents in rat sensory neurons: a mechanism for the pain-inducing actions of ET-1J Neurosci200222156325633012151509
  • MasakiTMiwaSSawamuraTNinomiyaHOkamotoYSubcellular mechanisms of endothelin action in vascular systemEur J Pharmacol19993751–313313810443571
  • GhoneimMAYamamotoTHiroseSNagasawaTHagiwaraHEndothelium localization of ETB receptor revealed by immunohistochemistryJ Cardiovasc Pharmacol199322Suppl 8S111S1127509918
  • ShettySSOkadaTWebbRLDelGrandeDLappeRWFunctionally distinct endothelin B receptors in vascular endothelium and smooth muscleBiochem Biophys Res Commun199319124594648461004
  • Sakurai-YamashitaYYamashitaKYoshidaARat peritoneal macrophages express endothelin ET(B) but not endothelin ET(A) receptorsEur J Pharmacol199733821992039456003
  • PomonisJDRogersSDPetersCMGhilardiJRMantyhPWExpression and localization of endothelin receptors: implications for the involvement of peripheral glia in nociceptionJ Neurosci2001213999100611157085
  • ChichorroJGFiuzaCRBressanEClaudinoRFLeiteDFRaeGAEndothelins as pronociceptive mediators of the rat trigeminal system: role of ETA and ETB receptorsBrain Res20101345738320450894
  • Berti-MatteraLNGariepyCEBurkeRMHallAKReduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetesExp Neurol2006201239940616806184
  • PlantTDZöllnerCKepuraFEndothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase CMol Pain2007313518001466
  • GiaidAGibsonSJIbrahimBNEndothelin-1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root gangliaProc Natl Acad Sci U S A19898619763476382678110
  • FengBStrichartzGEndothelin-1 raises excitability and reduces potassium currents in sensory neuronsBrain Res Bull200979634535019409452
  • HouckCSKhodorovaARealeAMStrichartzGRDavarGSensory fibers resistant to the actions of tetrodotoxin mediate nocifensive responses to local administration of endothelin-1 in ratsPain2004110371972615288413
  • CardenasLMCardenasCGScroggsRS5HT increases excitability of nociceptor-like rat dorsal root ganglion neurons via cAMP-coupled TTX-resistant Na(+) channelsJ Neurophysiol200186124124811431505
  • LeeMEde la MonteSMNgSCBlochKDQuertermousTExpression of the potent vasoconstrictor endothelin in the human central nervous systemJ Clin Invest19908611411472195059
  • GiaidAGibsonSJHerreroMTTopographical localisation of endothelin mRNA and peptide immunoreactivity in neurones of the human brainHistochemistry19919533033142050550
  • YoshizawaTKimuraSKanazawaIUchiyamaYYanagisawaMMasakiTEndothelin localizes in the dorsal horn and acts on the spinal neurones: possible involvement of dihydropyridine-sensitive calcium channels and substance P releaseNeurosci Lett19891022–31791842478929
  • KurokawaKYamadaHOchiJTopographical distribution of neurons containing endothelin type A receptor in the rat brainJ Comp Neurol199738923483609416926
  • YamadaHKurokawaKHistochemical studies on endothelin and the endothelin-A receptor in the hypothalamusJ Cardiovasc Pharmacol199831Suppl 1S215S2189595441
  • FerreiraSHRomitelliMde NucciGEndothelin-1 participation in overt and inflammatory painJ Cardiovasc Pharmacol198913Suppl 5S220S2222473319
  • RaffaRBJacobyHIEndothelin-1, -2 and -3 directly and big-endothelin-1 indirectly elicit an abdominal constriction response in miceLife Sci19914817PL85PL901826753
  • RaffaRBSchupskyJJMartinezRPJacobyHIEndothelin-1-induced nociceptionLife Sci19914911PL61PL651875787
  • HansGDeseureKRobertDDe HertSNeurosensory changes in a human model of endothelin-1 induced pain: a behavioral studyNeurosci Lett2007418211712117403578
  • GokinAPFareedMUPanHLHansGStrichartzGRDavarGLocal injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in ratsJ Neurosci200121145358536611438612
  • NamerBHilligesMOrstavikKEndothelin-1 activates and sensitizes human C-nociceptorsPain20081371414917884295
  • PiovezanAPD’Orléans-JustePTonussiCRRaeGAEndothelins potentiate formalin-induced nociception and paw edema in miceCan J Physiol Pharmacol19977565966009276135
  • D’AmicoMDi FilippoCRossiFSelective and non-selective ET antagonists reveal an ET(A)/ET(B) receptor mediated ET-1-induced antinociceptive effect in PAG area of miceLife Sci19976125PL 397PL 401
  • SchmelzMSchmidtRWeidnerCHilligesMTorebjorkHEHandwerkerHOChemical response pattern of different classes of C-nociceptors to pruritogens and algogensJ Neurophysiol20038952441244812611975
  • DavarGHansGFareedMUSinnottCStrichartzGBehavioral signs of acute pain produced by application of endothelin-1 to rat sciatic nerveNeuroreport1998910227922839694215
  • KhodorovaAStrichartzGRContralateral paw sensitization following injection of endothelin-1: effects of local anesthetics differentiate peripheral and central processesNeuroscience2010165255356019874873
  • RaffaRBSchupskyJJJacobyHIEndothelin-induced nociception in mice: mediation by ETA and ETB receptorsJ Pharmacol Exp Ther199627626476518632332
  • PiovezanAPD’Orléans-JustePSouzaGERaeGAEndothelin-1-induced ET(A) receptor-mediated nociception, hyperalgesia and oedema in the mouse hind-paw: modulation by simultaneous ET(B) receptor activationBr J Pharmacol2000129596196810696096
  • KhodorovaAFareedMUGokinAStrichartzGRDavarGLocal injection of a selective endothelin-B receptor agonist inhibits endothelin-1-induced pain-like behavior and excitation of nociceptors in a naloxone-sensitive mannerJ Neurosci200222177788779612196602
  • MenéndezLLastraAHidalgoABaamondeANociceptive reaction and thermal hyperalgesia induced by local ET-1 in mice: a behavioral and Fos studyNaunyn Schmiedebergs Arch Pharmacol20033671283412616338
  • McKelvyADMarkTRSweitzerSMAge- and sex-specific nociceptive response to endothelin-1J Pain20078865766617553749
  • ShresthaSGraciasNGMujendaFKhodorovaAVaskoMRStrichartzGRLocal antinociception induced by endothelin-1 in the hairy skin of the rat’s backJ Pain200910770271419559389
  • GomesLOHaraDBRaeGAEndothelin-1 induces itch and pain in the mouse cheek modelLife Sci Mar20129113–14628633
  • KhodorovaANavarroBJouavilleLSEndothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injuryNat Med2003981055106112847519
  • da CunhaJMRaeGAFerreiraSHCunhaFQEndothelins induce ETB receptor-mediated mechanical hypernociception in rat hindpaw: roles of cAMP and protein kinase CEur J Pharmacol20045011–3879415464066
  • MottaEMCalixtoJBRaeGAMechanical hyperalgesia induced by endothelin-1 in rats is mediated via phospholipase C, protein kinase C, and MAP kinasesExp Biol Med (Maywood)200623161141114516741065
  • BaamondeALastraAVillazónMBordalloJHidalgoAMenéndezLInvolvement of endogenous endothelins in thermal and mechanical inflammatory hyperalgesia in miceNaunyn Schmiedebergs Arch Pharmacol2004369224525114661069
  • VerriWAJrSchivoIRCunhaTMLiewFYFerreiraSHCunhaFQInterleukin-18 induces mechanical hypernociception in rats via endothelin acting on ETB receptors in a morphine-sensitive mannerJ Pharmacol Exp Ther2004310271071715075358
  • KhodorovaARichterJVaskoMRStrichartzGEarly and late contributions of glutamate and CGRP to mechanical sensitization by endothelin-1J Pain200910774074919559390
  • KawamataTJiWYamamotoJNiiyamaYFuruseSNamikiAContribution of transient receptor potential vanilloid subfamily 1 to endothelin-1-induced thermal hyperalgesiaNeuroscience200815431067107618495351
  • MottaEMChichorroJGD’Orléans-JustePRaeGARoles of endothelin ETA and ETB receptors in nociception and chemical, thermal and mechanical hyperalgesia induced by endothelin-1 in the rat hindpawPeptides200930591892519428770
  • StösserSAgarwalNTappe-TheodorAYanagisawaMKunerRDissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletionPain2010148220621419879049
  • PlantTDZöllnerCMousaSAOkscheAEndothelin-1 potentiates capsaicin-induced TRPV1 currents via the endothelin A receptorExp Biol Med (Maywood)200623161161116416741069
  • YamamotoHKawamataTNinomiyaTOmoteKNamikiAEndothelin-1 enhances capsaicin-evoked intracellular Ca2+ response via activation of endothelin a receptor in a protein kinase Cepsilon-dependent manner in dorsal root ganglion neuronsNeuroscience2006137394996016298080
  • PiovezanAPD’Orléans-JustePTonussiCRRaeGAEffects of endothelin-1 on capsaicin-induced nociception in miceEur J Pharmacol1998351115229698200
  • SmithTBeasleySSmithSMarkISweitzerSMEndothelin-1-induced priming to capsaicin in young animalsNeurosci Lett2014567151824674771
  • MujendaFHDuarteAMReillyEKStrichartzGRCutaneous endothelin-A receptors elevate post-incisional painPain20071331–316117317467172
  • KameiJHitosugiHKawashimaNMisawaMKasuyaYAntinociceptive effects of intrathecally administered endothelin-1 in miceNeurosci Lett1993153169728510826
  • YamamotoTShimoyamaNAsanoHMizuguchiTAnalysis of the role of endothelin-A and endothelin-B receptors on nociceptive information transmission in the spinal cord with FR139317, an endothelin-A receptor antagonist, and sarafotoxin S6c, an endothelin-B receptor agonistJ Pharmacol Exp Ther199427111561637965709
  • HungVKChenSMTaiLWChenAYChungSKCheungCWOver-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injectionLife Sci20129113–1461862222820168
  • D’AmicoMBerrinoLMaioneSFilippelliAde NovellisVRossiFEndothelin-1 in periaqueductal gray area of mice induces analgesia via glutamatergic receptorsPain1996652–32052098826508
  • HasueFKuwakiTYamadaHFukudaYShimoyamaMInhibitory actions of endothelin-1 on pain processingJ Cardiovasc Pharmacol200444Suppl 1S318S32015838310
  • ErgulAShoemakerKPuettDTackettRLGender differences in the expression of endothelin receptors in human saphenous veins in vitroJ Pharmacol Exp Ther199828525115179580591
  • YoshibayashiMNishiokaKNakaoKPlasma endothelin levels in healthy children: high values in early infancyJ Cardiovasc Pharmacol199117Suppl 7S404S4051725392
  • GiannessiDDel RySAndreassiMGHigh density of endothelin binding sites in the hearts of infants and childrenLife Sci199964869770510069532
  • JosephEKLevineJDSexual dimorphism in endothelin-1 induced mechanical hyperalgesia in the ratExp Neurol2012233150551222155617
  • McKelvyADSweitzerSMEndothelin-1 exposure on postnatal day 7 alters expression of the endothelin B receptor and behavioral sensitivity to endothelin-1 on postnatal day 11Neurosci Lett20094511899319111903
  • CuiPTaniKKitamuraHA novel bioactive 31-amino acid endothelin-1 is a potent chemotactic peptide for human neutrophils and monocytesJ Leukoc Biol200170230631211493624
  • MiyasakaNHirataYAndoKIncreased production of endothelin-1 in patients with inflammatory arthritidesArthritis Rheum19923543974001567488
  • KhodorovaAZouSRenKDubnerRDavarGStrichartzGDual Roles for Endothelin-B Receptors in Modulating Adjuvant-Induced Inflammatory Hyperalgesia in RatsOpen Pain J200921304020559459
  • De-MeloJDTonussiCRD’Orléans-JustePRaeGAArticular nociception induced by endothelin-1, carrageenan and LPS in naive and previously inflamed knee-joints in the rat: inhibition by endothelin receptor antagonistsPain19987732612699808351
  • De-MeloJDTonussiCRD’Orléans-JustePRaeGAEffects of endothelin-1 on inflammatory incapacitation of the rat knee jointJ Cardiovasc Pharmacol199831Suppl 1S518S5209595530
  • ImhofAKGlückLGajdaMBräuerRSchaibleHGSchulzSPotent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic miceArthritis Res Ther2011133R9721689431
  • PiovezanAPD’Orléans-JustePFrighettoMSouzaGEHenriquesMGRaeGAEndothelins contribute towards nociception induced by antigen in ovalbumin-sensitised miceBr J Pharmacol2004141475576314744803
  • PirtskhalaishviliGNelsonJBEndothelium-derived factors as paracrine mediators of prostate cancer progressionProstate2000441778710861760
  • QuangPNSchmidtBLPeripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in micePain2010149225426220206445
  • DavarGEndothelin-1 and metastatic cancer painPain Med200121242715102314
  • YuyamaHKoakutsuAFujiyasuNInhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in miceJ Cardiovasc Pharmacol200444Suppl 1S479S48215838353
  • HamamotoDTKhasabovSGCainDMSimoneDATumor-evoked sensitization of C nociceptors: a role for endothelinJ Neurophysiol200810042300231118684911
  • PickeringVJay GuptaRQuangPJordanRCSchmidtBLEffect of peripheral endothelin-1 concentration on carcinoma-induced pain in miceEur J Pain200812329330017664075
  • WacnikPWEikmeierLJRugglesTRFunctional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer painJ Neurosci200121239355936611717369
  • PetersCMLindsayTHPomonisJDEndothelin and the tumorigenic component of bone cancer painNeuroscience200412641043105215207337
  • SchmidtBLPickeringVLiuSPeripheral endothelin A receptor antagonism attenuates carcinoma-induced painEur J Pain200711440641416807013
  • FujitaMAndohTSaikiIKuraishiYInvolvement of endothelin and ET(A) endothelin receptor in mechanical allodynia in mice given orthotopic melanoma inoculationJ Pharmacol Sci2008106225726318270470
  • BaamondeALastraAFresnoMFImplantation of tumoral XC cells induces chronic, endothelin-dependent, thermal hyperalgesia in miceCell Mol Neurobiol200424226928115176440
  • TadaHMuramatsuINakaiTKigoshiSMiyaboSEffects of chronic diabetes on the responsiveness to endothelin-1 and other agents of rat atria and thoracic aortaGen Pharmacol1994256122112287875548
  • JarvisMFWessaleJLZhuCZABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic painEur J Pharmacol20003881293510657544
  • KameiJHitosugiHKawashimaNMisawaMKasuyaYEffects of diabetes on the antinociceptive effects of intrathecally administered endothelin-1Res Commun Chem Pathol Pharmacol19937922092178451542
  • ChichorroJGZampronioARRaeGAEndothelin ET(B) receptor antagonist reduces mechanical allodynia in rats with trigeminal neuropathic painExp Biol Med (Maywood)200623161136114016741064
  • ChichorroJGZampronioARSouzaGERaeGAOrofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugsPain20061231–2647416563629
  • MillecampsMLaferrièreARagavendranJVStoneLSCoderreTJRole of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I)Pain2010151117418320675053
  • KlassMHordAWilcoxMDensonDCseteMA role for endothelin in neuropathic pain after chronic constriction injury of the sciatic nerveAnesth Analg200510161757176216301255
  • WernerMFTrevisaniMCampiBAndréEGeppettiPRaeGAContribution of peripheral endothelin ETA and ETB receptors in neuropathic pain induced by spinal nerve ligation in ratsEur J Pain201014991191720350830
  • RaffaRBSchupskyJJLeeDKJacobyHICharacterization of endothelin-induced nociception in mice: evidence for a mechanistically distinct analgesic modelJ Pharmacol Exp Ther19962781178764328
  • GriswoldDEDouglasSAMartinLDEndothelin B receptor modulates inflammatory pain and cutaneous inflammationMol Pharmacol199956480781210496965
  • ZagorodnyukVPKylohMNicholasSLoss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung’s diseaseJ Physiol2011589Pt 71691170621320883
  • KanazawaSTsunodaTOnumaEMajimaTKagiyamaMKikuchiKVEGF, basic-FGF, and TGF-beta in Crohn’s disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammationAm J Gastroenterol200196382282811280558
  • MurchSHBraeggerCPSessaWCMacDonaldTTHigh endothelin-1 immunoreactivity in Crohn’s disease and ulcerative colitisLancet199233987903813851346658
  • LetiziaCBoirivantMDe TomaGPlasma levels of endothelin-1 in patients with Crohn’s disease and ulcerative colitisItal J Gastroenterol Hepatol19983032662699759593
  • ShiuYTMcIntireLVUddenMMSickle erythrocytes increase prostacyclin and endothelin-1 production by cultured human endothelial cells under flow conditionsEur J Haematol200268316316912068797
  • PhelanMPerrineSPBrauerMFallerDVSickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in cultureJ Clin Invest1995962114511517635951
  • HammermanSIKourembanasSConcaTJTucciMBrauerMFarberHWEndothelin-1 production during the acute chest syndrome in sickle cell diseaseAm J Respir Crit Care Med199715612802859230761
  • TharauxPLHagègeIPlacierSUrinary endothelin-1 as a marker of renal damage in sickle cell diseaseNephrol Dial Transplant200520112408241316144850
  • Graido-GonzalezEDohertyJCBergreenEWOrganGTelferMMcMillenMAPlasma endothelin-1, cytokine, and prostaglandin E2 levels in sickle cell disease and acute vaso-occlusive sickle crisisBlood1998927255125559746797
  • ErgulSBrunsonCYHutchinsonJVasoactive factors in sickle cell disease: in vitro evidence for endothelin-1-mediated vasoconstrictionAm J Hematol200476324525115224360
  • RybickiACBenjaminLJIncreased levels of endothelin-1 in plasma of sickle cell anemia patientsBlood1998927259425969746804
  • BrunMBourdoulousSCouraudPOElionJKrishnamoorthyRLapoumeroulieCHydroxyurea downregulates endothelin-1 gene expression and upregulates ICAM-1 gene expression in cultured human endothelial cellsPharmacogenomics J20033421522612931135
  • OdièvreMHBrunMKrishnamoorthyRLapouméroulieCElionJSodium phenyl butyrate downregulates endothelin-1 expression in cultured human endothelial cells: relevance to sickle-cell diseaseAm J Hematol200782535736217373676
  • LapouméroulieCBenkerrouMOdièvreMHDucrocqRBrunMElionJDecreased plasma endothelin-1 levels in children with sickle cell disease treated with hydroxyureaHaematologica200590340140315749673
  • De FranceschiLPlattOSMalpeliGProtective effects of phosphodiesterase-4 (PDE-4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell miceFASEB J20082261849186018245171
  • SabaaNde FranceschiLBonninPEndothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell diseaseJ Clin Invest200811851924193318382768
  • SchlenzAMMcClellanCBMarkTRSensitization to acute procedural pain in pediatric sickle cell disease: modulation by painful vaso-occlusive episodes, age, and endothelin-1J Pain201213765666522633685
  • RiveraAJarolimPBrugnaraCModulation of Gardos channel activity by cytokines in sickle erythrocytesBlood200299135760311756192
  • BenzaRLPulmonary hypertension associated with sickle cell disease: pathophysiology and rationale for treatmentLung2008186424725418470553
  • RiveraAReduced sickle erythrocyte dehydration in vivo by endothelin-1 receptor antagonistsAm J Physiol Cell Physiol20072933C960C96617494628
  • ChaarVTarerVEtienne-JulanMDiaraJPElionJRomanaMET-1 and ecNOS gene polymorphisms andsusceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemiaHaematologica20069191277127816956834
  • GladwinMTCrawfordJHPatelRPThe biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulationFree Radic Biol Med200436670771714990351
  • MorrisCRGladwinMTKatoGJNitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disordersCurr Mol Med20088762063218991648
  • WoodKCHsuLLGladwinMTSickle cell disease vasculopathy: a state of nitric oxide resistanceFree Radic Biol Med20084481506152818261470
  • BhallaSMatwyshynGGulatiAMorphine tolerance does not develop in mice treated with endothelin-A receptor antagonistsBrain Res200510641–212613516289404
  • MatwyshynGABhallaSGulatiAEndothelin ETA receptor blockade potentiates morphine analgesia but does not affect gastrointestinal transit in miceEur J Pharmacol20065431–3485316814278
  • Selenko-GebauerNDuschekNMinimairGStinglGKarlhoferFSuccessful treatment of patients with severe secondary Raynaud’s phenomenon with the endothelin receptor antagonist bosentanRheumatology (Oxford)200645Suppl 3iii45iii4816987835
  • NaprawaJTBonsuBKGoodmanDGRanalliMASerum biomarkers for identifying acute chest syndrome among patients who have sickle cell disease and present to the emergency departmentPediatrics20051163e420e42516099851
  • MuntsAGZijlstraFJNibberingPHAnalysis of cerebrospinal fluid inflammatory mediators in chronic complex regional pain syndrome related dystoniaClin J Pain2008241303418180633
  • DhaunNWebbDJEndothelin-receptor antagonism: the future is brightLancet200837196302061206218572063
  • GriswoldDEDouglasSAMartinLDTargeted disruption of the endothelin-B-receptor gene attenuates inflammatory nociception and cutaneous inflammation in miceJ Cardiovasc Pharmacol2000365Suppl 1S78S8111078342
  • CainDMWacnikPWEikmeierLBeitzAWilcoxGLSimoneDAFunctional interactions between tumor and peripheral nerve in a model of cancer pain in the mousePain Med200121152315102313