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Original Research

The Effect of Different Doses of Intravenous Dexmedetomidine on the Properties of Subarachnoid Blockade: A Systematic Review and Meta-Analysis

ORCID Icon, , , &
Pages 207-215 | Published online: 15 Dec 2020

References

  • Weinger MB, Segal IS, Maze M. Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat. Anesthesiology. 1989;71(2):242–249. doi:10.1097/00000542-198908000-000132569282
  • Zhang C, Li C, Pirrone M, Sun L, Mi W. Comparison of dexmedetomidine and clonidine as adjuvants to local anesthetics for intrathecal anesthesia: a meta-analysis of randomized controlled trials. J Clin Pharmacol. 2016;56(7):827–834. doi:10.1002/jcph.66626510095
  • Hussain N, Grzywacz VP, Ferreri CA, et al. Investigating the efficacy of dexmedetomidine as an adjuvant to local anesthesia in brachial plexus block: a systematic review and meta-analysis of 18 randomized controlled trials. Reg Anesth Pain Med. 2017;42(2):184–196. doi:10.1097/AAP.000000000000056428178091
  • Abdallah FW, Abrishami A, Brull R. The facilitatory effects of intravenous dexmedetomidine on the duration of spinal anesthesia: a systematic review and meta-analysis. Anesth Analg. 2013;117(1):271–278. doi:10.1213/ANE.0b013e318290c56623632057
  • Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1. doi:10.1186/2046-4053-4-125554246
  • Halpern SH, Douglas MJ. Jadad scale for reporting randomized controlled trials. Evid Based Obstet Anesth. 2005;237–238. doi:10.1002/9780470988343
  • Zhang H, Li M, Zhang SY, Fu M, Zhang SY. Intravenous dexmedetomidine promotes spinal bupivacaine anesthesia and postoperative analgesia in lower limb surgery: a double-blind, randomized clinical consort study. Med (United States). 2016;95(8). doi:10.1097/MD.0000000000002880
  • Subramanian A, Agrawal D, Sharma S, Mukhopadhayay A, Chhabra G, Rangarajan K. Hypofibrinogenemia in isolated traumatic brain injury in Indian patients. Neurol India. 2010;58(5):756. doi:10.4103/0028-3886.7217521045504
  • Kim MH, Jung SY, Shin JD, et al. The comparison of the effects of intravenous ketamine or dexmedetomidine infusion on spinal block with bupivacaine. Korean J Anesthesiol. 2014;67(2):85–89. doi:10.4097/kjae.2014.67.2.8525237443
  • Al-Mustafa MM, Badran I, Abu-Ali HM, Al-BarazangI BA, Massad IM, Al-ghanem SM. Intravenous dexmedetomidine prolongs bupivacaine spinal analgesia. Middle East J Anesthesiol. 2009;20(2):225–231.19583070
  • Reddy VS, Shaik NA, Donthu B, Sannala VKR, Jangam V. Intravenous dexmedetomidine versus clonidine for prolongation of bupivacaine spinal anesthesia and analgesia: a randomized double-blind study. J Anaesthesiol Clin Pharmacol. 2013;29(3):342–347. doi:10.4103/0970-9185.11710124106359
  • Kaya FN, Yavascaoglu B, Turker G, et al. Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia. Can J Anesth. 2010;57(1):39–45. doi:10.1007/s12630-009-9231-620039221
  • Elcicek K, Tekin M, Kati I. The effects of intravenous dexmedetomidine on spinal hyperbaric ropivacaine anesthesia. J Anesth. 2010;24(4):544–548. doi:10.1007/s00540-010-0939-920467879
  • Jung SH, Lee SK, Lim KJ, et al. The effects of single-dose intravenous dexmedetomidine on hyperbaric bupivacaine spinal anesthesia. J Anesth. 2013;27(3):380–384. doi:10.1007/s00540-012-1541-023307164
  • Tekin M, Kati I, Tomak Y, Kisli E. Effect of dexmedetomidine IV on the duration of spinal anesthesia with prilocaine: a double-blind, prospective study in adult surgical patients. Curr Ther Res. 2007;68(5):313–324.24692763
  • Harsoor SS, Rani DD, Yalamuru B, Sudheesh K, Nethra SS. Effect of supplementation of low dose intravenous dexmedetomidine on characteristics of spinal anaesthesia with hyperbaric bupivacaine. Indian J Anaesth. 2013;57(3):265–269. doi:10.4103/0019-5049.11561623983285
  • Hong JY, Kim WO, Yoon Y, Choi Y, Kim SH, Kil HK. Effects of intravenous dexmedetomidine on low-dose bupivacaine spinal anaesthesia in elderly patients. Acta Anaesthesiol Scand. 2012;56(3):382–387. doi:10.1111/j.1399-6576.2011.02614.x22220945
  • Dinesh CN, Sai Tej NA, Yatish B, Pujari VS, Mohan Kumar RM, Mohan CVR. Effects of intravenous dexmedetomidine on hyperbaric bupivacaine spinal anesthesia: a randomized study. Saudi J Anaesth. 2014;8(2):202–208. doi:10.4103/1658-354X.13071924843333
  • Kumari R, Kumar A, Kumar S, Singh R. Intravenous dexmedetomidine as an adjunct to subarachnoid block: a simple effective method of better perioperative efficacy. J Anaesthesiol Clin Pharmacol. 2017;33(2):203–208. doi:10.4103/joacp.JOACP_367_1528781446
  • Rekhi BK, Kaur T, Arora D, Dugg P. Comparison of intravenous dexmedetomidine with midazolam in prolonging spinal anaesthesia with ropivacaine. J Clin Diagn Res. 2017;11(2):UC01–UC04. doi:10.7860/JCDR/2017/23874.9344
  • Lee MH, Ko JH, Kim EM, Cheung MH, Choi YR, Choi EM. The effects of intravenous dexmedetomidine on spinal anesthesia: comparision of different dose of dexmedetomidine. Korean J Anesthesiol. 2014;67(4):252–257. doi:10.4097/kjae.2014.67.4.25225368783
  • Kavya UR, Laxmi S, Ramkumar V. Effect of intravenous dexmedetomidine administered as bolus or as bolus-plus-infusion on subarachnoid anesthesia with hyperbaric bupivacaine. J Anaesthesiol Clin Pharmacol. 2018;34(1):46–50. doi:10.4103/joacp.JOACP_132_1629643622
  • Park SH, Shin YD, Yu HJ, Bae JH, Yim KH. Comparison of two dosing schedules of intravenous dexmedetomidine in elderly patients during spinal anesthesia. Korean J Anesthesiol. 2014;66(5):371–376. doi:10.4097/kjae.2014.66.5.37124910729
  • Liberati A, Altman D, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Journal of clinical epidemiology. 2009;62(10).
  • Vorobeichik L, Brull R, Abdallah FW. Evidence basis for using perineural dexmedetomidine to enhance the quality of brachial plexus nerve blocks: a systematic review and meta-analysis of randomized controlled trials. Br J Anaesth. 2017;118(2):167–181. doi:10.1093/bja/aew41128100520
  • Andersen JH, Jaeger P, Grevstad U, et al. Systemic dexmedetomidine is not as efficient as perineural dexmedetomidine in prolonging an ulnar nerve block. Reg Anesth Pain Med. 2019;44(3):333–340. doi:10.1136/rapm-2018-100089
  • Gupta M, Gupta P, Singh DK. Effect of 3 different doses of intrathecal dexmedetomidine (2.5µg, 5µg, and 10 µg) on subarachnoid block characteristics: a prospective randomized double blind dose-response trial. Pain Physician. 2016;19(3):E411–E420.27008297
  • Yektaş A, Belli E. The effects of 2 μg and 4 μg doses of dexmedetomidine in combination with intrathecal hyperbaric bupivacaine on spinal anesthesia and its postoperative analgesic characteristics. Pain Res Manag. 2014;19.
  • Abdallah FW, Dwyer T, Chan VWS, et al. IV and perineural dexmedetomidine similarly prolong the duration of analgesia after interscalene brachial plexus block: a randomized, three-arm, triple-masked, placebo-controlled trial. Anesthesiology. 2016;124(3):683–695. doi:10.1097/ALN.000000000000098326649424
  • Kaur M, Singh P. Current role of dexmedetomidine in clinical anesthesia and intensive care. Anesth Essays Res. 2011;5(2):128. doi:10.4103/0259-1162.9475025885374
  • Halder S, Das A, Mandal D, et al. Effect of different doses of dexmedetomidine as adjuvant in bupivacaine -induced subarachnoid block for traumatized lower limb orthopaedic surgery: a prospective, double-blinded and randomized controlled study. J Clin Diagn Res. 2014;8(11):GC01.
  • Agrawal A, Agrawal S, Payal YS. Comparison of block characteristics of spinal anesthesia following intravenous dexmedetomidine and clonidine. J Anaesthesiol Clin Pharmacol. 2016;32(3):339–343. doi:10.4103/0970-9185.18883027625482
  • Chan IA, Maslany JG, Gorman KJ, O’Brien JM, McKay WP. Dexmedetomidine during total knee arthroplasty performed under spinal anesthesia decreases opioid use: a randomized-controlled trial. Can J Anesth. 2016;63(5):569–576. doi:10.1007/s12630-016-0597-y26830642