Intrathecal Morphine versus Morphine-Dexmedetomidine Combination for Postoperative Pain Control After Total Knee Replacement: A Randomized Controlled Trial

References

• Priebe H-J. The aged cardiovascular risk patient. Br J Anaesth. 2000;85(5):763–778. doi:10.1093/bja/85.5.763
   PubMed Web of Science ®Google Scholar
• Yaksh T. CNS mechanisms of pain and analgesia. Cancer Surv. 1988;7(1):5–28.
   PubMedGoogle Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG; Group* P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–269. doi:10.7326/0003-4819-151-4-200908180-00135
   PubMed Web of Science ®Google Scholar
• Giovannelli M, Bedforth N, Aitkenhead A. Survey of intrathecal opioid usage in the UK. Eur J Anaesthesiol. 2008;25(2):118–122. doi:10.1017/S0265021507001305
   PubMed Web of Science ®Google Scholar
• Payne R. Neuropathic pain syndromes, with special reference to causalgia and reflex sympathetic dystrophy. Clin J Pain. 1986;2(1):59–73. doi:10.1097/00002508-198602010-00010
   Google Scholar
• Mantz J, Josserand J, Hamada S. Dexmedetomidine: new insights. Eur J Anaesthesiol. 2011;28(1):3–6. doi:10.1097/EJA.0b013e32833e266d
   PubMed Web of Science ®Google Scholar
• Harada Y, Nishioka K, Kitahata L, Kishikawa K, Collins J. Visceral antinociceptive effects of spinal clonidine combined with morphine,[D-Pen sup 2, D-Pen sup 5] enkephalin, or U50, 488H. J Am Soc Anesthesiol. 1995;83(2):344–352.
   PubMed Web of Science ®Google Scholar
• Horvath G, Joo G, Dobos I, Klimscha W, Toth G, Benedek G. The synergistic antinociceptive interactions of endomorphin-1 with dexmedetomidine and/or S (+)-ketamine in rats. Anesth Analg. 2001;93(4):1018–1024. doi:10.1097/00000539-200110000-00044
   PubMed Web of Science ®Google Scholar
• Meert TF, De Kock M. Potentiation of the analgesic properties of fentanyl-like opioids with alpha 2-adrenoceptor agonists in rats. Anesthesiology. 1994;81(3):677–688. doi:10.1097/00000542-199409000-00022
   PubMed Web of Science ®Google Scholar
• Murphy P, Stack D, Kinirons B, Laffey J. Optimizing the dose of intrathecal morphine in older patients undergoing Hip arthroplasty. Anesth Analg. 2003;97(6):1709–1715. doi:10.1213/01.ANE.0000089965.75585.0D
   PubMed Web of Science ®Google Scholar
• Al-Ghanem SM, Massad IM, Al-Mustafa MM, et al. Effect of adding dexmedetomidine versus fentanyl to intrathecal bupivacaine on spinal block characteristics in gynecological procedures: a double blind controlled study. Am J Appl Sci. 2009;6(5):882. doi:10.3844/ajassp.2009.882.887
   Google Scholar
• Ramsay M, Savege T, Simpson B, Goodwin R. Controlled sedation with alphaxalone-alphadolone. BMJ. 1974;2(5920):656–659. doi:10.1136/bmj.2.5920.656
   PubMed Web of Science ®Google Scholar
• Khandelwal M, Rao H, Kumar P, Bafna U, Beniwal S. Comparative study of morphine or dexmedetomidine as intrathecal adjuvants to 0.5% hyperbaric bupivacaine in infraumbilical surgeries. Indian J Pain. 2019;33(3):156. doi:10.4103/ijpn.ijpn_31_19
   Google Scholar
• Shaikh SI, Dattatri R. Dexmedetomidine as an adjuvant to hyperbaric spinal bupivacaine for infra-umbilical procedures: a dose related study. Anaesth Pain Intensive Care. 2019;2019:180–185.
   Google Scholar
• Kehlet H. Enhanced postoperative recovery: good from afar, but far from good? Anaesthesia. 2020;75:e54–e61. doi:10.1111/anae.14860
   PubMed Web of Science ®Google Scholar
• Maze M, Scarfini C, Cavaliere F. New agents for sedation in the intensive care unit. Crit Care Clin. 2001;17(4):881–898. doi:10.1016/S0749-0704(05)70185-8
   PubMed Web of Science ®Google Scholar
• Blaudszun G, Lysakowski C, Elia N, Tramer MR. Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials. J Am Soc Anesthesiol. 2012;116(6):1312–1322.
   PubMed Web of Science ®Google Scholar
• Sullivan A, Kalso E, McQuay H, Dickenson A. The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetized rat. Eur J Pharmacol. 1992;215(1):127–133. doi:10.1016/0014-2999(92)90617-D
   PubMed Web of Science ®Google Scholar
• Kabalak A, Ekmekçioğlu E, Ceylan A, Kahveci K. The synergistic antinociceptive interactions of morphine and dexmedetomidine in rats with nerve-ligation injury. Hippokratia. 2013;17(4):326.
   PubMed Web of Science ®Google Scholar
• Coggeshall RE, Carlton SM. Receptor localization in the mammalian dorsal horn and primary afferent neurons. Brain Res Rev. 1997;24(1):28–66. doi:10.1016/s0165-0173(97)00010-6
   PubMedGoogle Scholar
• Ueda M, Oyama T, Kuraishi Y, Akaike A, Satoh M. Alpha2-adrenoceptor-mediated inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices. Neurosci Lett. 1995;188(2):137–139. doi:10.1016/0304-3940(95)11397-F
   PubMed Web of Science ®Google Scholar
• Smith I, Walley G, Bridgman S. Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery. Eur J Anaesthesiol. 2008;25(10):790–799. doi:10.1017/S026502150800464X
   PubMed Web of Science ®Google Scholar
• Liang X, Zhou M, Feng JJ, et al. Efficacy of dexmedetomidine on postoperative nausea and vomiting: a meta-analysis of randomized controlled trials. Int J Clin Exp Med. 2015;8(6):8450–8471.
   PubMed Web of Science ®Google Scholar
• Jacobson L, Chabal C, Brody MC. A dose-response study of intrathecal morphine: efficacy, duration, optimal dose, and side effects. Anesth Analg. 1988;67(11):1082–1088. doi:10.1213/00000539-198867110-00011
   PubMed Web of Science ®Google Scholar
• Crowgey TR, Dominguez JE, Peterson-Layne C, Allen TK, Muir HA, Habib AS. A retrospective assessment of the incidence of respiratory depression after neuraxial morphine administration for postcesarean delivery analgesia. Anesth Analg. 2013;117(6):1368–1370. doi:10.1213/ANE.0b013e3182a9b042
   PubMed Web of Science ®Google Scholar
• Albrecht E, Bayon V, Hirotsu C, Al Ja’Bari A, Heinzer R. Intrathecal morphine and sleep apnoea severity in patients undergoing Hip arthroplasty: a randomised, controlled, triple-blinded trial. Br J Anaesth. 2020;125(5):811–817. doi:10.1016/j.bja.2020.07.052
   PubMed Web of Science ®Google Scholar
• Cousins MJ, Cousins M, Mather L. Intrathecal and epidural administration of opioids. Anesthesiology. 1984;61:276–310. doi:10.1097/00000542-198409000-00008
   PubMed Web of Science ®Google Scholar
• Gonvers E, El‐Boghdadly K, Grape S, Albrecht E. Efficacy and safety of intrathecal morphine for analgesia after lower joint arthroplasty: a systematic review and meta‐analysis with meta‐regression and trial sequential analysis. Anaesthesia. 2021;76(12):1648–1658. doi:10.1111/anae.15569
   PubMed Web of Science ®Google Scholar
• Abdel-Ghaffar HS, Mohamed SA, Fares KM. Combined intrathecal morphine and dexmedetomidine for postoperative analgesia in patients undergoing major abdominal cancer surgery. Pain Med. 2016;17(11):2109–2118. doi:10.1093/pm/pnw031
   PubMed Web of Science ®Google Scholar
• Liu H-J, Gao X-Z, Liu X-M, Xia M, Li W-Y, Jin Y. Effect of intrathecal dexmedetomidine on spinal morphine analgesia in patients with refractory cancer pain. J Palliat Med. 2014;17(7):837–840. doi:10.1089/jpm.2013.0544
   PubMed Web of Science ®Google Scholar