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Original Research

In vitro and in vivo Evaluation of the Efficacy and Safety of Powder Hydroxypropylmethylcellulose as Nasal Mucosal Barrier

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Pages 107-113 | Published online: 30 Mar 2020

References

  • Phadtare D, Phadtare G, Nilesh B, Asawat M. Hypromellose – a choice of polymer in extended release tablet formulation. World J Pharmacy Pharmaceut Sci. 2014;3(9):551–566.
  • Product general information Available from: https://www.nasaleze.com/. Accessed 15 Mar 2019.
  • Popov TA, Aberg N, Emberlin J, et al. Methyl-cellulose powder for prevention and management of nasal symptoms. Expert Rev Respir Med. 2017;11(11):885–892. doi:10.1080/17476348.2017.1375408
  • Hristova DM, Kralimarkova TZ, Valerieva A, Popov TA. Objective indicators substantiating the benefits of micronized methylcellulose use by sensitized subjects during the grass pollens season. Allergy. 2017;72(Suppl. 103):729–730.
  • Valerieva A, Popov TA, Staevska M, et al. Effect of micronized cellulose powder on the efficacy of topical oxymetazoline in allergic rhinitis. Allergy Asthma Proc. 2015;36(6):e134–139. doi:10.2500/aap.2015.36.3879
  • Chen X, Guan WJ, Sun SX, et al. Effects of intranasal cellulose powder on asthma control in children with mild-to-moderate perennial allergic rhinitis: a randomized, placebo-controlled trial. Am J Rhinol Allergy. 2019;33(2):184–193. doi:10.1177/1945892419826509
  • Valerieva A, Church MK, Staevska M, et al. Micronized cellulose powder as a means to enhance intranasal symptoms-driven treatment: patients’ attitudes in a real life setting. Allergy. 2016;71(Supplement 102):13.
  • Popov TA, Valerieva A, Church M, et al. Real-life study on the effect of micronized cellulose powder as add-on to intranasal as-needed treatment of subjects with pollen allergic rhinitis. J Allergy Clin Immunol. 2016;137(2 Supplement):AB402. doi:10.1016/j.jaci.2015.12.1246
  • Popov TA, Hristova D, Josling P, Kralimarkova TZ, DuBuske L. Symptom-guided approach for allergic rhinitis treatment augmented with powder methylcellulose sealant. Ann Allergy Asthma Immunol. 2018;121(5– Suppl.):S61–62. doi:10.1016/j.anai.2018.09.203
  • Diethart B, Emberlin JC, Lewis RA. Hydroxypropylmethylcellulose gel application delays Der p 1 diffusion in vitro. Natural Sci. 2010;2(2):79–84. doi:10.4236/ns.2010.22012
  • Popov TA, Josling P, Church MK. In-vitro setup to test hydroxy-propyl-methyl-cellulose as allergen barrier over a span of 360 minutes. J Allergy Clin Immunol. 2019;143(2 Suppl.):AB193. doi:10.1016/j.jaci.2018.12.592
  • Seifalian A, Birchall M, Bielory L. Investigation of the laryngopharyngeal mucosal distribution of hydroxypropylmethyl cellulose (HPMC) powder after transnasal aerosol application in vivo. Ann Allergy Asthma Immunol. 2012;109(5– Suppl.):A134.
  • Telko MJ, Hickey AJ. Dry powder inhaler formulation. Respir Care. 2005;50(9):1209–1227.
  • Hong Z, Guo Z, Zhang R, et al. Airborne fine particulate matter induces oxidative stress and inflammation in human nasal epithelial cells. Tohoku J Exp Med. 2016;239(2):117–125. doi:10.1620/tjem.239.117
  • Heyder J. Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery. Proc Am Thorac Soc. 2004;1(4):315–320. doi:10.1513/pats.200409-046TA
  • Diethart B. The Use of Inert Hydoxypropylmethylcellulose Powder as a Remedy for Allergic Rhinitis. [Chpt 10 “ The effect of HPMC application on human nasal cells”]. University of Coventry in collaboration with University of Worcester; 2009.
  • Cruz AA, Popov T, Pawankar R, et al. Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA(2)LEN. Allergy. 2007;62(Suppl 84):1–41. doi:10.1111/j.1398-9995.2007.01551.x
  • Feng S, Gao D, Liao F, Zhou F, Wang X. The health effects of ambient PM2.5 and potential mechanisms. Ecotoxicol Environ Saf. 2016;128:67–74. doi:10.1016/j.ecoenv.2016.01.030
  • Josling P, Church MK, Popov TA. In vitro study of the adsorption of 2.5 mm particles(PM2.5) by hydroxy-propyl-methyl-cellulose powder (HPMC). J Allergy Clin Immunol. 2019;143(2 Suppl.):AB24. doi:10.1016/j.jaci.2018.12.074
  • Zhou M, Zuo KJ, Xu ZF, et al. Effect of cellulose powder on human nasal epithelial cell activity and ciliary beat frequency. Int Arch Allergy Immunol. 2019;178(3):229–237. doi:10.1159/000493582
  • Popov TA, Emberlin J, Church MK, Aberg N, Josling P. Powder cellulose in allergic rhinitis management: relevance of in vitro findings to real-life safety. Int Arch Allergy Immunol. 2019;26:1–2.
  • Burdock GA. Safety assessment of hydroxypropyl methylcellulose as a food ingredient. Food Chem Toxicol. 2007;45(12):2341–2351. doi:10.1016/j.fct.2007.07.011
  • Ye J, Zhang H, Wu H, et al. Cytoprotective effect of hyaluronic acid and hydroxypropyl methylcellulose against DNA damage induced by thimerosal in Chang conjunctival cells. Graefe’s Arch Clin Exp Ophthalmol. 2012;250(10):1459–1466. doi:10.1007/s00417-012-2087-4
  • Andersson M, Greiff L, Ojeda P, Wollmer P. Barrier-enforcing measures as treatment principle in allergic rhinitis: a systematic review. Curr Med Res Opin. 2014;30(6):1131–1137. doi:10.1185/03007995.2014.882299
  • Olze H, Wustrow TP, Grigorov A. Provokationstest mit Immerfit Pollenschutzcreme bei Patienten mit allergischer Rhinitis., 2002. Originalia Erfarungsheilkunde (Heidelb). 2002;51:S416–421. doi:10.1055/s-2002-32436
  • Schwetz S, Olze H, Melchisedech S, Grigorov A, Latza R. Efficacy of pollen blocker cream in the treatment of allergic rhinitis. Arch Otolaryngol Head Neck Surg. 2004;130(8):979–984. doi:10.1001/archotol.130.8.979
  • Geisthoff UW, Blum A, Rupp-Classen M, Plinkert PK. Lipid-based nose ointment for allergic rhinitis. Otolaryngol Head Neck Surg. 2005;133(5):754–761. doi:10.1016/j.otohns.2005.06.026
  • Ojeda P, Pique N, Alonso A, et al. A topical microemulsion for the prevention of allergic rhinitis symptoms: results of a randomized, controlled, double-blind, parallel group, multicentre, multinational clinical trial (Nares study). Allergy Asthma Clin Immunol. 2013;9(1):32. doi:10.1186/1710-1492-9-32
  • Bohm M, Avgitidou G, El Hassan E, Mosges R. Liposomes: a new non-pharmacological therapy concept for seasonal-allergic-rhinoconjunctivitis. Eur Arch Oto-Rhino-Laryngol. 2012;269(2):495–502. doi:10.1007/s00405-011-1696-6
  • Cingi C, Unlu HH, Songu M, et al. Seawater gel in allergic rhinitis: entrapment effect and mucociliary clearance compared with saline. Ther Adv Respir Dis. 2010;4(1):13–18. doi:10.1177/1753465809358190