Keeping the human: neuroethics and the conciliation of dissonant values in the 21st century

References

• Van Essen DC, Ugurbil K. The future of the human connectome. Neuroimage. 2012;62(2):1299–1310.
   Web of Science ®Google Scholar
• BrainFacts.org [Homepage on Internet]. Available from: http://www.brainfacts.org/press/new-web-site-brainfactsorg-launches. Accessed December 5, 2015.
   Google Scholar
• Society for Neuroscience (webpage on the Internet). About Neuroscience. Available from: http://www.sfn.org/about/about-neuroscience. Accessed December 20, 2014.
   Google Scholar
• Eichenbaum H. Hippocampus: cognitive processes and neural representations that underlie declarative memory. Neuron. 2004;44(1):109–120.
   PubMed Web of Science ®Google Scholar
• Buckner RL, Krienen FM. The evolution of distributed association networks in the human brain. Trends Cogn Sci. 2013;17(12):648–665.
   Web of Science ®Google Scholar
• Bird CM, Burgess N. The hippocampus and memory: insights from spatial processing. Nat Rev Neurosci. 2008;9(3):182–194.
   PubMed Web of Science ®Google Scholar
• Broadbent NJ, Scquire LR, Clark RE. Spatial memory, recognition memory, and the hippocampus. Proc Natl Acad Sci U S A. 2004;101(40):14515–14520.
   PubMed Web of Science ®Google Scholar
• Howard MW, Eichenbaum H. The hippocampus, time, and memory across scales. J Exp Psychol Gen. 2013;142(4):1211–1230.
   Web of Science ®Google Scholar
• Lømo T. The discovery of long-term potentiation. Philos Trans R Soc Lond B Biol Sci. 2003;358(1432):617–620.
   Web of Science ®Google Scholar
• Roskies A. Neuroethics for the new millenium. Neuron. 2002;35(1):21.
   PubMed Web of Science ®Google Scholar
• Evers K. Towards a philosophy for neuroethics. An informed materialist view of the brain might help to develop theoretical frameworks for applied neuroethics. EMBO Rep. 2007;8 Spec No:S48–S51.
   Web of Science ®Google Scholar
• Churchland P. Neurophilosophy: Toward a Unified Science of the Mind-Brain. Cambridge, MA: MIT Press; 1986.
   Google Scholar
• Evers K. Neuroéthique. Quand la matière s’éveille [When the matter arises]. Paris: Éditions Odile Jacob; 2009.
   Google Scholar
• Changeux JP. The Physiology of Truth. Cambridge, MA: Harvard University Press; 2009.
   Google Scholar
• Gillett GR. Subjectivity and Being Somebody: Human Identity and Neuroethics. Exeter: Imprint Academic; 2009.
   Google Scholar
• Gillett GR. The subjective brain, identity, and neuroethics. Am J Bioeth. 2009;9(9):5–13.
   PubMed Web of Science ®Google Scholar
• Northoff G. What are the subjective processes in our brain? Empirical and ethical implications of a relational concept of the brain. Am J Bioeth. 2009;9(9):27–28.
   PubMed Web of Science ®Google Scholar
• Northoff G. Minding the Brain: A Guide to Philosophy and Neuroscience. Houndmills, Basingstoke, Hampshire: Palgrave Macmillan; 2014.
   Google Scholar
• Northoff G. What is neuroethics? Empirical and theoretical neuroethics. Curr Opin Psychiatry. 2009;22(6):565–569.
   Web of Science ®Google Scholar
• Choudhury S, Slaby J, editors. Critical Neuroscience: A Handbook of the Social and Cultural Contexts of Neuroscience. Chichester: Wiley & Sons Ltd; 2012.
   Google Scholar
• Farisco M. In need of meta-scientific experts? AJOB Neuroscience. 2014;7(2):243–245.
   Google Scholar
• Valentini L. Human rights, freedom, and political authority. Political Theory. 2012;40(5):573–601.
   Web of Science ®Google Scholar
• Ochsner KN, Ray RR, Hughes B, et al. Bottom-up and top-down processes in emotion generation: common and distinct neural mechanisms. Psychol Sci. 2009;20(11):1322–1331.
   PubMed Web of Science ®Google Scholar
• Goldin PR, McRae K, Ramel W, Gross JJ. The neural bases of emotion regulation: reappraisal and suppression of negative emotion. Biol Psychiatry. 2008;63(6):577–586.
   PubMed Web of Science ®Google Scholar
• Schroeder S, Verrel J. Cognitive processing and motor execution in the lexical decision task: a developmental study. Psychon Bull Rev. 2014;21(2):496–504.
   Web of Science ®Google Scholar
• Orr LE, Russ BE, Cohen YE. Disruption of decision making capacities in the rhesus macaque by prefrontal cortex TMS. Abstract presented at: Thirty Eighth Annual Meeting S Neuroscience. 2008;875.24(RR86); Washington, DC.
   Google Scholar
• Vuilleumier P, Sander D. Trust and valence processing in the amygdala. Soc Cogn Affect Neurosci. 2008;3(4):299–302.
   Web of Science ®Google Scholar
• Funahashi S. Neuronal mechanisms of executive control by the prefrontal cortex. Neurosci Res. 2001;39(2):147–165.
   PubMed Web of Science ®Google Scholar
• Wager TD, Davidson ML, Hughes BL, Lindquist MA, Ochsner KN. Prefrontal-subcortical pathways mediating successful emotion regulation. Neuron. 2008;59(6):1037–1050.
   PubMed Web of Science ®Google Scholar
• Anderson MC, Ochsner KN, Kuhl B, et al. Neural systems underlying the suppression of unwanted memories. Science. 2004;303(5655):232–235.
   PubMed Web of Science ®Google Scholar
• Phelps EA. Emotion and cognition: insights from studies of the human amygdala. Annu Rev Psychol. 2006;57:27–53.
   PubMed Web of Science ®Google Scholar
• Glannon W. Neuropsychological aspects of enhancing the will. The Monist. 2012;95(3):378–398.
   Web of Science ®Google Scholar
• Mulder MJ, Wagenmakers EJ, Ratcliff R, Boekel W, Forstmann BU. Bias in the brain: a diffusion model analysis of prior probability and potential payoff. J Neurosci. 2012;32(7):2335–2343.
   PubMed Web of Science ®Google Scholar
• Fellows LK. The cognitive neuroscience of human decision making: a review and conceptual framework. Behav Cogn Neurosci Rev. 2004;3(3):159–172.
   PubMedGoogle Scholar
• Gold JI, Shadlen MN. The neural basis of decision making. Ann Rev Neurosci. 2007;30:535–574.
   PubMed Web of Science ®Google Scholar
• Sanguineti JJ.. Can free decisions be both intentional and neural operations. In: Sanguineti JJ, Acerbi A, Lombo JA, editors. Moral Behavior and Free Will: A Neurobiological and Philosophical Approach. Rome: IF Press; 2011:179–202.
   Google Scholar
• Kim J. The myth of nonreductive materialism. Proceedings and Addresses of the American Philosophical Association. 1989;63(3):31–47.
   Google Scholar
• Libet B.. The neural time factor in conscious and unconscious events. In: Ciba Foundation Symposium #174 Experimental and Theoretical Studies of Consciousness. Chichester: Wiley Press; 1993:123–146.
   Google Scholar
• Pierre JM. The neuroscience of free will: implications for psychiatry. Psychol Med. 2014;44(12):2465–2474.
   Web of Science ®Google Scholar
• Murphy N. Avoiding neurobiological reductionism: the role of downward causation in complex systems. In: Sanguineti JJ, Acerbi A, Lombo JA, editors. Moral Behavior and Free Will: A Neurobiological and Philosophical Approach. Rome: IF Press; 2011:201–222.
   Google Scholar
• Glannon W. Neuromodulation, agency and autonomy. Brain Topogr. 2014;27(1):46–54.
   PubMed Web of Science ®Google Scholar
• Mallet L, Polosan M, Jaafari N, et al; STOC Study Group. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N Engl J Med. 2008;359(20):2121–2134.
   PubMed Web of Science ®Google Scholar
• Schlaepfer TE, Cohen MX, Frick C, et al. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology. 2008;33(2):368–377.
   PubMed Web of Science ®Google Scholar
• Focquaert F. Mandatory neurotechnological treatment: ethical issues. Theor Med Bioeth. 2014;35(1):59–72.
   PubMed Web of Science ®Google Scholar
• Canavero S. Criminal minds: neuromodulation of the psychopathic brain. Front Hum Neurosci. 2014;8:124.
   Web of Science ®Google Scholar
• Gordijn B, Buyx AM. Neural engineering: the ethical challenges ahead. In: Giordano JJ, Gordijn B, editors. Scientific and Philosophical Perspectives in Neuroethics. Cambridge: Cambridge University Press; 2010:283–301.
   Google Scholar
• Rohlf M. Immanuel Kant [webpage on the Internet]. The Stanford Encyclopedia of Philosophy. Stanford, CA: Stanford University; 2010. Available from: http://plato.stanford.edu/entries/kant/. Accessed May 20, 2010.
   Google Scholar
• René Descartes. Discourse on Method. Adam C, Tannery P, editors. Indianapolis: Hackett; 1993.
   Google Scholar
• Bourdeau M. Auguste Comte [webpage on the Internet]. The Stanford Encyclopedia of Philosophy. Stanford, CA: Stanford University; 2008 [updated September 30, 2013]. Available from: http://plato.stanford.edu/entries/comte/. Accessed October 16, 2014.
   Google Scholar
• Flynn T. Jean-Paul Sartre [webpage on the Internet]. The Stanford Encyclopedia of Philosophy. Stanford, CA: Stanford University; 2004 [updated December 5, 2011]. Available from: http://plato.stanford.edu/entries/sartre/. Accessed October 16, 2014.
   Google Scholar
• Wojtyla K. The Acting Person. Dordrecht, Holland: D Reidel Publishing; 1979.
   Google Scholar
• Rhonheimer M. Norm-ethics, moral responsibility, and the virtues. In: Murphy WF, editor. The Perspective of the Acting Person. Washington, DC: Catholic University Press; 2008:18–36.
   Google Scholar
• Hampson P. By knowledge and by love: the integrative role of habitus in Christian psychology. Edification. 2012;6(1):5–18.
   Google Scholar
• Daw ND, Shohamy D. The cognitive neuroscience of motivation and learning. Social Cognition. 2008;26(5):593–620.
   Web of Science ®Google Scholar
• Rankin CH, Abrams T, Barry RJ, et al. Habituation revisited: an updated and revised description of the behavioral characteristics of habituation. Neurobiol Learn Mem. 2009;92(2):135–138.
   PubMed Web of Science ®Google Scholar
• Merzenich M. Soft-Wired, How the New Science of Brain Plasticity Can Change Your Life. San Francisco, CA: Parnassus Publishing; 2013.
   Google Scholar
• Northoff G. Neuroscience of decision making and informed consent: an investigation in neuroethics. J Med Ethics. 2006;32(2):70–73.
   PubMed Web of Science ®Google Scholar
• Haber SN, Knutson B. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology. 2010;35(1):4–26.
   PubMed Web of Science ®Google Scholar
• Kramer PD. Listening to Prozac. A psychiatrist explores antidepressant drugs and the remaking of the self. Viking, New York 1993.
   Google Scholar
• Amodio VA. Neuroscienze: farmaci “potenzianti” per modificare il normale funzionamento del corpo e della psiche [Neuroscience: enhancing drugs to modify the normal functioning of body and mind]. Il Nuovo Medico d’Italia. 2014. Available from: http://www.numedionline.it/apps/essay.php?id=14624. Accessed January 16, 2014.
   Google Scholar
• Repantis, D. Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: A systematic review. Pharmacological Research. 2010;61(6).
   Web of Science ®Google Scholar
• Farah MJ, Illes J, Cook-Deegan R, et al. Neurocognitive enhancement: what can we do and what should we do? Nat Rev Neurosci. 2004;5(5):421–425.
   PubMed Web of Science ®Google Scholar
• Parens E.. How far will the treatment/enhancement distinction get us as we grapple with new ways to shape ourselves. In: Marcus SJ, editor. Neuroethics: Mapping the Field. New York, NY: The Dana Press; 2002: 152–158.
   Google Scholar
• Benanti P. Neuroenhancement in young people: cultural need or medical technology? AJOB Neuroscience. 2000;1(1):27–29.
   Google Scholar
• Gini A, Rossi J, Giordano J. Considering enhancement and treatment: on the need to regard contingency and develop dialectic evaluation. AJOB Neuroscience. 2010;1(1):25–27.
   Google Scholar
• Sironi VA. Origin and evolution of deep brain stimulation. Front Integr Neurosci. 2011;5:42.
   PubMedGoogle Scholar
• Zotev V, Krueger F, Phillips R, et al. Self-regulation of amygdala activation using real-time FMRI neurofeedback. PLoS One. 2011;6(9):e24522.
   PubMed Web of Science ®Google Scholar
• Zotev V, Phillips R, Yuan H, Misaki M, Bodurka J. Self-regulation of human brain activity using simultaneous real-time fMRI and EEG neurofeedback. Neuroimage. 2014;85(Pt 3):985–995.
   Google Scholar
• Clark VP, Parasuraman R. Neuroenhancement: enhancing brain and mind in health and in disease. Neuroimage. 2014;85 Pt 3:889–894.
   Google Scholar
• Sironi VA, Porta M. Il controllo della mente. Scienza ed etica della neuromodulazione cerebrale [The Mind Control. Science and Ethics of Brain Neuromodulation]. Roma-Bari: Laterza; 2011. Italian.
   Google Scholar
• Utz KS, Dimova V, Oppenländer K, Kerkhoff G. Electrified minds: transcranial direct current stimulation (tDCS) and galvanic vestibular stimulation (GVS) as methods of non-invasive brain stimulation in neuropsychology – a review of current data and future implications. Neuropsychologia. 2010;48(10):2789–2810.
   PubMed Web of Science ®Google Scholar
• Cogiamanian F, Marceglia S, Ardolino G, Barbieri S, Priori A. Improved isometric force endurance after transcranial direct current stimulation over the human motor cortical areas. Eur J Neurosci. 2007;26(1):242–249.
   PubMed Web of Science ®Google Scholar
• Normann C, Berger M. Neuroenhancement: status quo and perspectives. Eur Arch Psychiatry Clin Neurosci. 2008;258(Suppl 5):110–114.
   PubMed Web of Science ®Google Scholar
• Normann C, Boldt J, Maio G, Berger M. [Options, limits and ethics of pharmacological neuroenhancement]. Nervenarzt. 2010;81(1):66–74. German.
   Web of Science ®Google Scholar
• Fecteau S, Knoch D, Fregni F, Sultani N, Boggio P, Pascual-Leone A. Diminishing risk-taking behavior by modulating activity in the prefrontal cortex: a direct current stimulation study. J Neurosci. 2007;27(46):12500–12505.
   PubMed Web of Science ®Google Scholar
• Fecteau S, Pascual-Leone A, Zald DH, et al. Activation of prefrontal cortex by transcranial direct current stimulation reduces appetite for risk during ambiguous decision making. J Neurosci. 2007;27(23):6212–6218.
   PubMed Web of Science ®Google Scholar
• Fumagalli M, Giannicola G, Rosa M, et al. Conflict-dependent dynamic of subthalamic nucleus oscillations during moral decisions. Soc Neurosci. 2011;6(3):243–256.
   PubMed Web of Science ®Google Scholar
• Karim AA, Schneider M, Lotze M, et al. The truth about lying: inhibition of the anterior prefrontal cortex improves deceptive behavior. Cereb Cortex. 2010;20(1):205–213.
   Web of Science ®Google Scholar
• Knoch D, Gianotti LR, Pascual-Leone A, et al. Disruption of right prefrontal cortex by low-frequency repetitive transcranial magnetic stimulation induces risk-taking behavior. J Neurosci. 2006;26(24):6469–6472.
   PubMed Web of Science ®Google Scholar
• Mameli F, Mrakic-Sposta S, Vergari M, et al. Dorsolateral prefrontal cortex specifically processes general – but not personal – knowledge deception: Multiple brain networks for lying. Behav Brain Res. 2010;211(2):164–168.
   Web of Science ®Google Scholar
• Priori A, Mameli F, Cogiamanian F, et al. Lie-specific involvement of dorsolateral prefrontal cortex in deception. Cereb Cortex. 2008;18(2):451–455.
   PubMed Web of Science ®Google Scholar
• Young L, Bechara A, Tranel D, Damasio H, Hauser M, Damasio A. Damage to ventromedial prefrontal cortex impairs judgment of harmful intent. Neuron. 2010;65(6):845–851.
   PubMed Web of Science ®Google Scholar
• Ferrucci R, Fumagalli M, Mameli FA, Priori A. Etica della neurostimolazione [Ethics of neurostimulation], in Sironi A.Vittorio, Porta M, Il controllo della mente. Scienza ed etica della neuromodulazione cerebrale. Roma-Bari: Laterza; 2011:223–240.
   Google Scholar
• Okun MS, Bowers D, Springer U, et al. What’s in a “smile?” Intra-operative observations of contralateral smiles induced by deep brain stimulation. Neurocase. 2004;10(4):271–279.
   PubMed Web of Science ®Google Scholar
• Okun MS, Mann G, Foote KD, et al. Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programming. J Neurol Neurosurg Psychiatry. 2007;78(3):310–314.
   PubMed Web of Science ®Google Scholar
• Synofzik M, Schlaepfer TE. Stimulating personality: ethical criteria for deep brain stimulation in psychiatric patients and for enhancement purposes. Biotechnol J. 2008;3(12):1511–1520.
   PubMedGoogle Scholar
• Sironi VA, Gini A. Neuroethical implications of neuromodulation using deep brain stimulation. Poster presented at: International Neuroethics Society Annual Meeting; November 8, 2013; San Diego, CA.
   Google Scholar
• Sironi VA, Gini A. Poster presented at the Neuronanotechnology and neuroethics. International Neuroethics Society Annual Meeting; November 8, 2013; San Diego, CA, USA.
   Google Scholar