Effect of Lactic Acid Bacteria-Fermented Soy Milk Extract (LEX) on Urinary 3-Indoxyl Sulfate in Japanese Healthy Adult Women: An Open-Label Pilot Study

References

• Durack J, Lynch SV. The gut microbiome: relationships with disease and opportunities for therapy. J Exp Med. 2019;216(1):20–40. doi:10.1084/jem.20180448
   PubMed Web of Science ®Google Scholar
• Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464(7285):59–65. doi:10.1038/nature08821
   PubMed Web of Science ®Google Scholar
• Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489(7415):220–230. doi:10.1038/nature11550
   PubMed Web of Science ®Google Scholar
• Ferguson JF, Allayee H, Gerszten RE, et al. Nutrigenomics, the microbiome, and gene-environment interactions: new directions in cardiovascular disease research, prevention, and treatment: a scientific statement from the American heart association. Circ Cardiovasc Genet. 2016;9(3):291–313. doi:10.1161/HCG.0000000000000030
   Google Scholar
• Wang Z, Klipfell E, Bennett BJ, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472(7341):57–63. doi:10.1038/nature09922
   PubMed Web of Science ®Google Scholar
• Hsiao EY, McBride SW, Hsien S, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013;155(7):1451–1463. doi:10.1016/j.cell.2013.11.024
   PubMed Web of Science ®Google Scholar
• Tang WH, Wang Z, Levison BS, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368(17):1575–1584. doi:10.1056/NEJMoa1109400
   PubMed Web of Science ®Google Scholar
• Zhang LS, Davies SS. Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions. Genome Med. 2016;8(1):46. doi:10.1186/s13073-016-0296-x
   PubMedGoogle Scholar
• Kirkland JL, Vargas E, Lye M. Indican excretion in the elderly. Postgrad Med J. 1983;59(697):717–719. doi:10.1136/pgmj.59.697.717
   Web of Science ®Google Scholar
• Bures J, Cyrany J, Kohoutova D, et al. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol. 2010;16(24):2978–2990. doi:10.3748/wjg.v16.i24.2978
   PubMed Web of Science ®Google Scholar
• de Andrade LS, Ramos CI, Cuppari L. The cross-talk between the kidney and the gut: implications for chronic kidney disease. Nutrire. 2017;42(1):27. doi:10.1186/s41110-017-0054-x:
   Google Scholar
• Greenberger NJ, Saegh S, Ruppert RD. Urine indicant excretion in malabsorptive disorders. Gastroenterology. 1968;55(2):204–211. doi:10.1016/S0016-5085(19)34071-5
   Web of Science ®Google Scholar
• Tabaqchali S, Okubadejo OA, Neale G, Booth CC. Influence of abnormal bacterial flora on small intestinal function. Proc R Soc Med. 1966;59(12):1244–1246.
   Google Scholar
• Azhari AA. Beneficial role of lactic acid bacteria in food preservation and human health: a review. Res J Microbiol. 2010;5(12):1213–1221. doi:10.3923/jm.2010.1213.1221
   Google Scholar
• Gilliland SE. Health and nutritional benefits from lactic acid bacteria. FEMS Microbiol Rev. 1990;7(1–2):175–188. doi:10.1111/j.1574-6968.1990.tb04887.x
   PubMed Web of Science ®Google Scholar
• Cavallini DC, Suzuki JY, Abdalla DS, et al. Influence of a probiotic soy product on fecal microbiota and its association with cardiovascular risk factors in an animal model. Lipids Health Dis. 2011;10(1):126. doi:10.1186/1476-511X-10-126
   Google Scholar
• Cheik NC, Rossi EA, Guerra RLF, et al. Effects of ferment soy product on the adipocyte area reduction and dyslipidemia control in hypercholesterolemic adult male rats. Lipids Health Dis. 2008;7(1):50. doi:10.1186/1476-511X-7-50
   Google Scholar
• Kitawaki R, Nishimura Y, Takagi N, Iwasaki M, Tsuzuki K, Fukuda M. Effects of lactobacillus fermented soymilk and soy yogurt on hepatic lipid accumulation in rats fed a cholesterol-free diet. Biosci Biotechnol Biochem. 2009;73(7):1484–1488. doi:10.1271/bbb.80753
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Harada T, Takagi N, Tsuzuki K, Sugawara M, Fukuda M. Effect of lactic acid-fermented soymilk on lipid metabolism-related gene expression in rat liver. Biosci Biotechnol Biochem. 2012;76(1):19–24. doi:10.1271/bbb.100354
   PubMed Web of Science ®Google Scholar
• Shin R, Suzuki M, Mizutani T, Susa N. Improvement of experimentally induced hepatic and renal disorders in rats using lactic acid bacteria-fermented soybean extract (BiofermenticsTM). Evid Based Complement Alternat Med. 2009;6(3):357–363. doi:10.1093/ecam/nem126
   Web of Science ®Google Scholar
• Xiao CW. Health effects of soy protein and isoflavones in humans. J Nutr. 2008;138(6):1244S–1249S. doi:10.1093/jn/138.6.1244S
   PubMed Web of Science ®Google Scholar
• Fukui M, Fujino T, Tsutsui K, et al. The tumor-preventing effect of a mixture of several lactic acid bacteria on 1,2-dimethylhydrazine-induced colon carcinogenesis in mice. Oncol Rep. 2001;8(5):1073–1078. doi:10.3892/or.8.5.1073
   Web of Science ®Google Scholar
• Takahashi S, Kawamura T, Kanda Y, et al. Activation of CD1d-independent NK1.1+ T cells in the large intestine by lactobacilli. Immunol Lett. 2006;102(1):74–78. doi:10.1016/j.imlet.2005.07.003
   Web of Science ®Google Scholar
• Odashiro K, Fukata M, Saito K, et al. The effects of lactic acid bacteria-fermented soymilk extract on patients with colonic polyps: a randomized, double-blind, placebo-controlled pilot trial. J Integr Stud Diet Habis. 2014;25(1):20–25. doi:10.2740/jisdh.25.20
   Google Scholar
• Shima Y, Sasuga Y. Effects of lactic acid bacteria-fermented soymilk extract on intestinal microflora: an open pilot study on human volunteer. J Jpn Mibyo Sys Assoc. 2014;20(1):71–75.
   Google Scholar
• Yoshimine M, Kamoi H, Yonekura K, Sasuga Y, Kamoi K. Effects of extract obtained from lactic-acid-producing bacteria throughout periodontitis. Nihon Shishubyo Gakkai Kaishi. 2018;60(3):139–146. doi:10.2329/perio.60.139
   Google Scholar
• Aguilar-Toalá JE, Garcia-Varela R, Garcia HS, et al. Postbiotics: an evolving term within the functional foods field. Trends Food Sci Tech. 2018;75:105–114. doi:10.1016/j.tifs.2018.03.009
   Web of Science ®Google Scholar
• Wegh CAM, Geerlings SY, Knol J, Roeselers G, Belzer C. Postbiotics and their potential applications in early life nutrition and beyond. Int J Mol Sci. 2019;20(19):4673. doi:10.3390/ijms20194673
   PubMed Web of Science ®Google Scholar
• Kira I. Validity and reliability of a Japanese version of the patient assessment of constipation quality of life questionnaire. Kango Kenkyu. 2013;36(2):119–127. doi:10.15065/jjsnr.20130421012
   Google Scholar
• McMillan SC, Williams FA. Validity and reliability of the constipation assessment scale. Cancer Nurs. 1989;12(3):183–188. doi:10.1097/00002820-198906000-00012
   PubMed Web of Science ®Google Scholar
• Shaw W. Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia. Nutr Neurosci. 2010;13(3):135–143. doi:10.1179/147683010X12611460763968
   PubMed Web of Science ®Google Scholar
• Gao J, Xu K, Liu H, et al. Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism. Front Cell Infect Microbiol. 2018;8:13. doi:10.3389/fcimb.2018.00013
   PubMed Web of Science ®Google Scholar
• Venkatesh M, Mukherjee S, Wang H, et al. Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and toll-like receptor 4. Immunity. 2014;41(2):296–310. doi:10.1016/j.immuni.2014.06.014
   PubMed Web of Science ®Google Scholar
• Zelante T, Iannitti RG, Cunha C, et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity. 2013;39(2):372–385. doi:10.1016/j.immuni.2013.08.003
   PubMed Web of Science ®Google Scholar
• Li G, Young KD. Indole production by the tryptophanase TnaA in Escherichia coli is determined by the amount of exogenous tryptophan. Microbiology. 2013;159(2):402–410. doi:10.1099/mic.0.064139-0
   Google Scholar
• Leong SC, Sirich TL. Indoxyl sulfate—review of toxicity and therapeutic strategies. Toxins (Basel). 2016;8(12):358. doi:10.3390/toxins8120358
   Web of Science ®Google Scholar
• Liu WC, Tomino Y, Lu KC. Impacts of indoxyl sulfate and p-cresol sulfate on chronic kidney disease and mitigating effects of AST-120. Toxins (Basel). 2018;10(9):367. doi:10.3390/toxins10090367
   PubMed Web of Science ®Google Scholar
• Kawashima A, Mimuro T, Matsuue K, Nitta K. Effects of probiotics on blood indoxyl sulfate in patients on maintenance dialysis. Japan Soc Nephrol. 2006;48(3):280. doi:10.14842/jpnjnephrol1959.48.234
   Google Scholar