Vitamin D deficiency and childhood obesity: interactions, implications, and recommendations

References

• Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766–781.
   PubMed Web of Science ®Google Scholar
• Wang Y, Lim H. The global childhood obesity epidemic and the association between socio-economic status and childhood obesity. Int Rev Psychiatry. 2012;24:176–188.
   PubMed Web of Science ®Google Scholar
• Committee on Accelerating Progress in Obesity Prevention, Food and Nutrition Board, Institute of Medicine. Accelerating Progress in Obesity Prevention: Solving the Weight of the Nation. Washington, DC: National Academies Press; 2012.
   Google Scholar
• Abrams P, Levitt Katz LE. Metabolic effects of obesity causing disease in childhood. Curr Opin Endocrinol Diabetes Obes. 2011;18:23–27.
   PubMed Web of Science ®Google Scholar
• Campbell F, Conti G, Heckman JJ, et al. Early childhood investments substantially boost adult health. Science. 2014;343:1478–1485.
   PubMed Web of Science ®Google Scholar
• Olshansky SJ, Passaro DJ, Hershow RC, et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med. 2005;352:1138–1145.
   PubMed Web of Science ®Google Scholar
• Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080S–1086S.
   PubMed Web of Science ®Google Scholar
• Foss YJ. Vitamin D deficiency is the cause of common obesity. Med Hypotheses. 2009;72:314–321.
   PubMed Web of Science ®Google Scholar
• DeLuca HF. History of the discovery of vitamin D and its active metabolites. Bonekey Rep. 2014;3:479.
   PubMedGoogle Scholar
• Holick MF. Vitamin D. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, editors. Modern Nutrition in Health and Disease. 10th ed. Baltimore, MD: Lippincott Williams and Wilkins; 2006:376–395.
   Google Scholar
• Macdonald HM. Contributions of sunlight and diet to vitamin D status. Calcif Tissue Int. 2013;92:163–176.
   PubMed Web of Science ®Google Scholar
• Li J, Byrne ME, Chang E, et al. 1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes. J Steroid Biochem Mol Biol. 2008;112:122–126.
   Web of Science ®Google Scholar
• Zehnder D, Bland R, Williams MC, et al. Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab. 2001;86:888–894.
   PubMed Web of Science ®Google Scholar
• Jones G. Extrarenal vitamin D activation and interactions between vitamin D(2), vitamin D(3), and vitamin D analogs. Annu Rev Nutr. 2013;33:23–44.
   PubMed Web of Science ®Google Scholar
• Schwartz JB, Lai J, Lizaola B, et al. A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. J Clin Endocrinol Metab. 2014;99:1631–1637.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhu J, DeLuca HF. Where is the vitamin D receptor? Arch Biochem Biophys. 2012;523:123–133.
   PubMed Web of Science ®Google Scholar
• Haussler MR, Whitfield GK, Kaneko I, et al. Molecular mechanisms of vitamin D action. Calcif Tissue Int. 2013;92:77–98.
   PubMed Web of Science ®Google Scholar
• Kremer R, Campbell PP, Reinhardt T, Gilsanz V. Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women. J Clin Endocrinol Metab. 2009;94:67–73.
   PubMed Web of Science ®Google Scholar
• Ding C, Gao D, Wilding J, Trayhurn P, Bing C. Vitamin D signalling in adipose tissue. Br J Nutr. 2012;108:1915–1923.
   PubMed Web of Science ®Google Scholar
• Mitri J, Dawson-Hughes B, Hu FB, Pittas AG. Effects of vitamin D and calcium supplementation on pancreatic beta cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the calcium and vitamin D for diabetes mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr. 2011;94:486–494.
   PubMed Web of Science ®Google Scholar
• O’Riordan JL, Bijvoet OL. Rickets before the discovery of vitamin D. Bonekey Rep. 2014;3:478.
   PubMedGoogle Scholar
• Prentice A. Vitamin D deficiency: a global perspective. Nutr Rev. 2008;66:S153–S164.
   PubMed Web of Science ®Google Scholar
• Raiten DJ, Picciano MF. Vitamin D and health in the 21st century: bone and beyond. Executive summary. Am J Clin Nutr. 2004;80: 1673S–1677S.
   PubMed Web of Science ®Google Scholar
• Holick MF. Vitamin D: extraskeletal health. Endocrinol Metab Clin North Am. 2010;39:381–400.
   Web of Science ®Google Scholar
• Brannon PM, Yetley EA, Bailey RL, Picciano MF. Overview of the conference “vitamin D and health in the 21st century: an update”. Am J Clin Nutr. 2008;88:483S–490S.
   PubMed Web of Science ®Google Scholar
• Ross AC. The 2011 report on dietary reference intakes for calcium and vitamin D. Public Health Nutr. 2011;14:938–939.
   PubMed Web of Science ®Google Scholar
• Holick MF, Binkley NC, Bischoff-Ferrari HA, et al; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–1930.
   PubMed Web of Science ®Google Scholar
• Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008;122:398–417.
   PubMed Web of Science ®Google Scholar
• Harel Z, Cromer B, DiVasta AD, Gordon CM. Recommended vitamin D intake and management of low vitamin D status in adolescents: a position statement of the society for adolescent health and medicine. J Adolesc Health. 2013;52:801–803.
   Web of Science ®Google Scholar
• Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc. 2013;88:720–755.
   PubMed Web of Science ®Google Scholar
• Wahl DA, Cooper C, Ebeling PR, et al. A global representation of vitamin D status in healthy populations. Arch Osteoporos. 2012;7: 155–172.
   PubMedGoogle Scholar
• Shin YH, Shin HJ, Lee YJ. Vitamin D status and childhood health. Korean J Pediatr. 2013;56:417–423.
   PubMedGoogle Scholar
• Turer CB, Lin H, Flores G. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics. 2013;131:e152–e161.
   PubMed Web of Science ®Google Scholar
• Bellone S, Esposito S, Giglione E, et al. Vitamin D levels in a paediatric population of normal weight and obese subjects. J Endocrinol Invest. 2014;37(9):805–809.
   Web of Science ®Google Scholar
• Gonzalez-Molero I, Rojo-Martinez G, Morcillo S, et al. Hypovitaminosis D and incidence of obesity: a prospective study. Eur J Clin Nutr. 2013;67:680–682.
   PubMed Web of Science ®Google Scholar
• Lourenco BH, Qi L, Willett WC, Cardoso MA. FTO genotype, vitamin D status, and weight gain during childhood. Diabetes. 2014;63: 808–814.
   PubMed Web of Science ®Google Scholar
• Vimaleswaran KS, Berry DJ, Lu C, et al; Genetic Investigation of Anthropometric Traits-GIANT Consortium. Causal relationship between obesity and vitamin D status: bi-directional mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10: e1001383.
   PubMed Web of Science ®Google Scholar
• Morrison JA, Friedman LA, Gray-McGuire C. Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton Lipid Research Clinics Follow-up Study. Pediatrics. 2007;120: 340–345.
   PubMed Web of Science ®Google Scholar
• Morrison JA, Friedman LA, Wang P, Glueck CJ. Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later. J Pediatr. 2008;152:201–206.
   PubMed Web of Science ®Google Scholar
• Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007;92:2017–2029.
   PubMed Web of Science ®Google Scholar
• Peterson CA, Tosh AK, Belenchia AM. Vitamin D insufficiency and insulin resistance in obese adolescents. Ther Adv Clin Endocrinol Metab. 2014;5(6):166–189.
   Google Scholar
• Belenchia AM, Tosh AK, Hillman LS, Peterson CA. Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr. 2013;97:774–781.
   PubMed Web of Science ®Google Scholar
• George PS, Pearson ER, Witham MD. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med. 2012;29:e142–e150.
   PubMed Web of Science ®Google Scholar
• Kramer CK, Swaminathan B, Hanley AJ, et al. Prospective associations of vitamin D status with beta-cell function, insulin sensitivity and glycemia: the impact of parathyroid hormone status. Diabetes. 2014; 63(11):3868–3879.
   PubMed Web of Science ®Google Scholar
• Alemzadeh R, Kichler J, Babar G, Calhoun M. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism. 2008;57:183–191.
   PubMed Web of Science ®Google Scholar
• Dolinsky DH, Armstrong S, Mangarelli C, Kemper AR. The association between vitamin D and cardiometabolic risk factors in children: a systematic review. Clin Pediatr (Phila). 2013;52:210–223.
   PubMed Web of Science ®Google Scholar
• Marzuillo P, Del Giudice EM, Santoro N. Pediatric non-alcoholic fatty liver disease: new insights and future directions. World J Hepatol. 2014;6:217–225.
   Google Scholar
• Pirgon O, Cekmez F, Bilgin H, Eren E, Dundar B. Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease. Obes Res Clin Pract. 2013;7: e275–e283.
   Google Scholar
• Yildiz I, Erol OB, Toprak S, et al. Role of vitamin D in children with hepatosteatosis. J Pediatr Gastroenterol Nutr. 2014;59:106–111.
   Web of Science ®Google Scholar
• Black LJ, Jacoby P, She Ping-Delfos WC, et al. Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity. J Gastroenterol Hepatol. 2014;29:1215–1222.
   Web of Science ®Google Scholar
• Katz K, Brar PC, Parekh N, Liu YH, Weitzman M. Suspected nonalcoholic fatty liver disease is not associated with vitamin d status in adolescents after adjustment for obesity. J Obes. 2010;2010:496829.
   Google Scholar
• National Institutes of Health. Osteoporosis prevention, diagnosis, and therapy. NIH Consens Statement. 2000;17:1–45.
   Google Scholar
• Whiting SJ. Obesity is not protective for bones in childhood and adolescence. Nutr Rev. 2002;60:27–30.
   Web of Science ®Google Scholar
• Leonard MB, Shults J, Wilson BA, Tershakovec AM, Zemel BS. Obesity during childhood and adolescence augments bone mass and bone dimensions. Am J Clin Nutr. 2004;80:514–523.
   PubMed Web of Science ®Google Scholar
• Junior IF, Cardoso JR, Christofaro DG, Codogno JS, de Moraes AC, Fernandes RA. The relationship between visceral fat thickness and bone mineral density in sedentary obese children and adolescents. BMC Pediatr. 2013;13:37.
   PubMed Web of Science ®Google Scholar
• Pirgon O, Bilgin H, Tolu I, Odabas D. Correlation of insulin sensitivity with bone mineral status in obese adolescents with nonalcoholic fatty liver disease. Clin Endocrinol (Oxf). 2011;75:189–195.
   Web of Science ®Google Scholar
• Nobrega da Silva V, Goldberg TB, Mosca LN, Bisi Rizzo AC, Teixeira AS, Corrente JE. Metabolic syndrome reduces bone mineral density in overweight adolescents. Bone. 2014;66:1–7.
   PubMed Web of Science ®Google Scholar
• Pacifico L, Bezzi M, Lombardo CV, et al. Adipokines and C-reactive protein in relation to bone mineralization in pediatric nonalcoholic fatty liver disease. World J Gastroenterol. 2013;19:4007–4014.
   Web of Science ®Google Scholar
• Klein KO, Larmore KA, de LE, Brown JM, Considine RV, Hassink SG. Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children. J Clin Endocrinol Metab. 1998;83:3469–3475.
   PubMed Web of Science ®Google Scholar
• Dimitri P, Wales JK, Bishop N. Adipokines, bone-derived factors and bone turnover in obese children; evidence for altered fat-bone signalling resulting in reduced bone mass. Bone. 2011;48:189–196.
   Web of Science ®Google Scholar
• Boucher-Berry C, Speiser PW, Carey DE, et al. Vitamin D, osteocalcin, and risk for adiposity as comorbidities in middle school children. J Bone Miner Res. 2012;27:283–293.
   PubMed Web of Science ®Google Scholar
• Heaney RP. The Vitamin D requirement in health and disease. J Steroid Biochem Mol Biol. 2005;97:13–19.
   PubMed Web of Science ®Google Scholar
• Maguire JL, Birken C, Thorpe KE, Sochett EB, Parkin PC. Parathyroid hormone as a functional indicator of vitamin D sufficiency in children. JAMA Pediatr. 2014;168:383–385.
   Web of Science ®Google Scholar
• Drincic AT, Armas LA, Van Diest EE, Heaney RP. Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity (Silver Spring). 2012;20:1444–1448.
   PubMed Web of Science ®Google Scholar
• Wolden-Kirk H, Overbergh L, Gysemans C, et al. Unraveling the effects of 1,25OH2D3 on global gene expression in pancreatic islets. J Steroid Biochem Mol Biol. 2013;136:68–79.
   PubMed Web of Science ®Google Scholar
• Mei Z, Grummer-Strawn LM, Pietrobelli A, Goulding A, Goran MI, Dietz WH. Validity of body mass index compared with other body-composition screening indexes for the assessment of body fatness in children and adolescents. Am J Clin Nutr. 2002;75:978–985.
   PubMed Web of Science ®Google Scholar
• Mutt SJ, Hypponen E, Saarnio J, Jarvelin MR, Herzig KH. Vitamin D and adipose tissue-more than storage. Front Physiol. 2014;5:228.
   PubMed Web of Science ®Google Scholar
• Lehr S, Hartwig S, Sell H. Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. Proteomics Clin Appl. 2012;6:91–101.
   PubMed Web of Science ®Google Scholar
• Lehr S, Hartwig S, Lamers D, et al. Identification and validation of novel adipokines released from primary human adipocytes. Mol Cell Proteomics. 2012;11:M111.
   PubMed Web of Science ®Google Scholar
• Zoico E, Franceschetti G, Chirumbolo S, et al. Phenotypic shift of adipocytes by cholecalciferol and 1alpha,25 dihydroxycholecalciferol in relation to inflammatory status and calcium content. Endocrinology. 2014;155:4178–4188.
   Web of Science ®Google Scholar
• Peterson CA, Heffernan ME. Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women. J Inflamm (Lond). 2008;5:10.
   PubMed Web of Science ®Google Scholar
• Laird E, McNulty H, Ward M, et al. Vitamin D deficiency is associated with inflammation in older Irish adults. J Clin Endocrinol Metab. 2014;99:1807–1815.
   PubMed Web of Science ®Google Scholar
• Vilarrasa N, Vendrell J, Maravall J, et al. Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population? Endocrine. 2010;38: 235–242.
   Google Scholar
• Ding C, Wilding JP, Bing C. 1,25-dihydroxyvitamin D3 protects against macrophage-induced activation of NFkappaB and MAPK signalling and chemokine release in human adipocytes. PLoS One. 2013;8:e61707.
   PubMed Web of Science ®Google Scholar
• Creo AL, Rosen JS, Ariza AJ, Hidaka KM, Binns HJ. Vitamin D levels, insulin resistance, and cardiovascular risks in very young obese children. J Pediatr Endocrinol Metab. 2013;26:97–104.
   Web of Science ®Google Scholar
• Smotkin-Tangorra M, Purushothaman R, Gupta A, Nejati G, Anhalt H, Ten S. Prevalence of vitamin D insufficiency in obese children and adolescents. J Pediatr Endocrinol Metab. 2007;20:817–823.
   PubMed Web of Science ®Google Scholar
• Bailey RL, Dodd KW, Goldman JA, et al. Estimation of total usual calcium and vitamin D intakes in the United States. J Nutr. 2010;140: 817–822.
   PubMed Web of Science ®Google Scholar
• Al-Othman A, Al-Musharaf S, Al-Daghri NM, et al. Effect of physical activity and sun exposure on vitamin D status of Saudi children and adolescents. BMC Pediatr. 2012;12:92.
   Web of Science ®Google Scholar
• Lagunova Z, Porojnicu AC, Lindberg FA, Aksnes L, Moan J. Vitamin D status in Norwegian children and adolescents with excess body weight. Pediatr Diabetes. 2011;12:120–126.
   PubMed Web of Science ®Google Scholar
• Burt Solorzano CM, McCartney CR. Obesity and the pubertal transition in girls and boys. Reproduction. 2010;140:399–410.
   PubMed Web of Science ®Google Scholar
• Travers SH, Jeffers BW, Bloch CA, Hill JO, Eckel RH. Gender and tanner stage differences in body composition and insulin sensitivity in early pubertal children. J Clin Endocrinol Metab. 1995;80:172–178.
   PubMed Web of Science ®Google Scholar
• Hannon TS, Janosky J, Arslanian SA. Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Pediatr Res. 2006;60:759–763.
   PubMed Web of Science ®Google Scholar
• Buyukinan M, Ozen S, Kokkun S, Saz EU. The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents. J Pediatr Endocrinol Metab. 2012;25:83–87.
   Web of Science ®Google Scholar
• Khadgawat R, Thomas T, Gahlot M, et al. The effect of puberty on interaction between vitamin D status and insulin resistance in obese Asian-Indian children. Int J Endocrinol. 2012;2012:173581.
   Web of Science ®Google Scholar
• Kelly A, Brooks LJ, Dougherty S, Carlow DC, Zemel BS. A cross-sectional study of vitamin D and insulin resistance in children. Arch Dis Child. 2011;96:447–452.
   PubMed Web of Science ®Google Scholar
• Ortega RM, Aparicio A, Rodríguez-Rodríguez E, et al. Preliminary data about the influence of vitamin D status on the loss of body fat in young overweight/obese women following two types of hypocaloric diet. Br J Nutr. 2008;100:269–272.
   Web of Science ®Google Scholar
• Pathak K, Soares MJ, Calton EK, Zhao Y, Hallett J. Vitamin D supplementation and body weight status: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2014;15:528–537.
   PubMed Web of Science ®Google Scholar
• St-Onge MP, Goree LL, Gower B. High-milk supplementation with healthy diet counseling does not affect weight loss but ameliorates insulin action compared with low-milk supplementation in overweight children. J Nutr. 2009;139:933–938.
   Web of Science ®Google Scholar
• El-Hajj Fuleihan G, Nabulsi M, Tamim H, et al. Effect of vitamin D replacement on musculoskeletal parameters in school children: a randomized controlled trial. J Clin Endocrinol Metab. 2006;91: 405–412.
   PubMed Web of Science ®Google Scholar
• Reinehr T, de Sousa G, Alexy U, Kersting M, Andler W. Vitamin D status and parathyroid hormone in obese children before and after weight loss. Eur J Endocrinol. 2007;157:225–232.
   PubMed Web of Science ®Google Scholar
• Rock CL, Emond JA, Flatt SW, et al. Weight loss is associated with increased serum 25-hydroxyvitamin D in overweight or obese women. Obesity (Silver Spring). 2012;20:2296–2301.
   Web of Science ®Google Scholar
• Tzotzas T, Papadopoulou FG, Tziomalos K, et al. Rising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance. J Clin Endocrinol Metab. 2010;95:4251–4257.
   PubMed Web of Science ®Google Scholar
• Braegger C, Campoy C, Colomb V, et al; ESPGHAN Committee on Nutrition. Vitamin D in the healthy European paediatric population. J Pediatr Gastroenterol Nutr. 2013;56:692–701.
   PubMed Web of Science ®Google Scholar
• Wagner CL, Greer FR. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008;122:1142–1152.
   PubMed Web of Science ®Google Scholar
• Pramyothin P, Holick MF. Vitamin D supplementation: guidelines and evidence for subclinical deficiency. Curr Opin Gastroenterol. 2012;28:139–150.
   PubMed Web of Science ®Google Scholar
• Radhakishun NN, van Vliet M, Poland DC, et al. Efficacy and tolerability of a high loading dose (25,000 IU weekly) vitamin D3 supplementation in obese children with vitamin D insufficiency/deficiency. Horm Res Paediatr. 2014;82:103–106.
   PubMed Web of Science ®Google Scholar
• Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000;72: 690–693.
   PubMed Web of Science ®Google Scholar
• Dhaliwal R, Mikhail M, Feuerman M, Aloia JF. The vitamin D dose response in obesity. Endocr Pract. 2014;20:1258–1264.
   PubMed Web of Science ®Google Scholar
• Holick MF, Biancuzzo RM, Chen TC, et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab. 2008;93:677–681.
   PubMed Web of Science ®Google Scholar
• Rajakumar K, Fernstrom JD, Holick MF, Janosky JE, Greenspan SL. Vitamin D status and response to Vitamin D(3) in obese vs non-obese African American children. Obesity (Silver Spring). 2008;16: 90–95.
   PubMed Web of Science ®Google Scholar
• Holick MF, Jenkins M. The UV Advantage. New York: ibooks; 2003.
   Google Scholar
• Webb AR, Engelsen O. Calculated ultraviolet exposure levels for a healthy vitamin D status. Photochem Photobiol. 2006;82: 1697–1703.
   PubMed Web of Science ®Google Scholar
• Wacker M, Holick MF. Sunlight and Vitamin D: a global perspective for health. Dermatoendocrinol. 2013;5:51–108.
   PubMedGoogle Scholar
• Holick MF, Matsuoka LY, Wortsman J. Regular use of sunscreen on vitamin D levels. Arch Dermatol. 1995;131:1337–1339.
   PubMed Web of Science ®Google Scholar
• Matsuoka LY, Wortsman J, Haddad JG, Kolm P, Hollis BW. Racial pigmentation and the cutaneous synthesis of vitamin D. Arch Dermatol. 1991;127:536–538.
   PubMed Web of Science ®Google Scholar
• Hall LM, Kimlin MG, Aronov PA, et al. Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations. J Nutr. 2010;140:542–550.
   PubMed Web of Science ®Google Scholar
• Schmid A, Walther B. Natural vitamin D content in animal products. Adv Nutr. 2013;4:453–462.
   PubMed Web of Science ®Google Scholar
• Holden JM, Lemar LE, Exler J. Vitamin D in foods: development of the US Department of Agriculture database. Am J Clin Nutr. 2008;87:1092S–1096S.
   Web of Science ®Google Scholar
• Calvo MS, Whiting SJ, Barton CN. Vitamin D intake: a global perspective of current status. J Nutr. 2005;135:310–316.
   PubMed Web of Science ®Google Scholar
• Whiting SJ, Green TJ, Calvo MS. Vitamin D intakes in North America and Asia-Pacific countries are not sufficient to prevent vitamin D insufficiency. J Steroid Biochem Mol Biol. 2007;103:626–630.
   PubMed Web of Science ®Google Scholar
• Dror DK, Allen LH. Dairy product intake in children and adolescents in developed countries: trends, nutritional contribution, and a review of association with health outcomes. Nutr Rev. 2014;72:68–81.
   PubMed Web of Science ®Google Scholar
• Biancuzzo RM, Clarke N, Reitz RE, Travison TG, Holick MF. Serum concentrations of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in response to vitamin D2 and vitamin D3 supplementation. J Clin Endocrinol Metab. 2013;98:973–979.
   PubMed Web of Science ®Google Scholar
• Tripkovic L, Lambert H, Hart K, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012;95: 1357–1364.
   PubMed Web of Science ®Google Scholar
• Bilinski K, Talbot P. Vitamin d supplementation in australia: implications for the development of supplementation guidelines. J Nutr Metab. 2014;2014:374208.
   Google Scholar
• LeBlanc ES, Perrin N, Johnson JD Jr, Ballatore A, Hillier T. Over-the-counter and compounded vitamin D: is potency what we expect? JAMA Intern Med. 2013;173:585–586.
   Web of Science ®Google Scholar
• Demetriou ET, Travison TG, Holick MF. Treatment with 50,000 IU vitamin D(2) every other week and effect on serum 25-hydroxyvitamin D(2), 25-hydroxyvitamin D(3), and total 25-hydroxyvitamin D in a clinical setting. Endocr Pract. 2012;18:399–402.
   Web of Science ®Google Scholar
• Zabihiyeganeh M, Jahed A, Nojomi M. Treatment of hypovitaminosis D with pharmacologic doses of cholecalciferol, oral vs intramuscular; an open labeled RCT. Clin Endocrinol (Oxf). 2013;78:210–216.
   Web of Science ®Google Scholar
• Masson CJ, Plat J, Mensink RP, et al. Fatty acid- and cholesterol transporter protein expression along the human intestinal tract. PLoS One. 2010;5:e10380.
   Web of Science ®Google Scholar
• Reboul E, Goncalves A, Comera C, et al. Vitamin D intestinal absorption is not a simple passive diffusion: evidences for involvement of cholesterol transporters. Mol Nutr Food Res. 2011;55:691–702.
   PubMed Web of Science ®Google Scholar
• Rautureau M, Rambaud JC. Aqueous solubilisation of vitamin D3 in normal man. Gut. 1981;22:393–397.
   PubMed Web of Science ®Google Scholar
• Reboul E. Intestinal absorption of vitamin D: from the meal to the enterocyte. Food Funct. 2015.
   Web of Science ®Google Scholar
• Armas LA, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004;89: 5387–5391.
   PubMed Web of Science ®Google Scholar
• Biancuzzo RM, Young A, Bibuld D, et al. Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults. Am J Clin Nutr. 2010;91: 1621–1626.
   PubMed Web of Science ®Google Scholar
• Romagnoli E, Mascia ML, Cipriani C, et al. Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly. J Clin Endocrinol Metab. 2008;93:3015–3020.
   PubMed Web of Science ®Google Scholar
• Wagner D, Sidhom G, Whiting SJ, Rousseau D, Vieth R. The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults. J Nutr. 2008;138:1365–1371.
   PubMed Web of Science ®Google Scholar
• Borel P, Caillaud D, Cano NJ. Vitamin D bioavailability: state of the art. Crit Rev Food Sci Nutr. 2013.
   Web of Science ®Google Scholar
• Goncalves A, Gleize B, Bott R, et al. Phytosterols can impair vitamin D intestinal absorption in vitro and in mice. Mol Nutr Food Res. 2011; 55(Suppl 2):S303–S311.
   Google Scholar
• Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266–281.
   PubMed Web of Science ®Google Scholar
• Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77:204–210.
   PubMed Web of Science ®Google Scholar
• Rosenstreich SJ, Rich C, Volwiler W. Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat. J Clin Invest. 1971;50:679–687.
   PubMed Web of Science ®Google Scholar
• Wu F, Staykova T, Horne A, et al. Efficacy of an oral, 10-day course of high-dose calciferol in correcting vitamin D deficiency. N Z Med J. 2003;116:U536.
   PubMedGoogle Scholar
• Heaney RP, Armas LA, Shary JR, Bell NH, Binkley N, Hollis BW. 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr. 2008;87: 1738–1742.
   PubMed Web of Science ®Google Scholar
• Vogiatzi MG, Jacobson-Dickman E, DeBoer MD. Vitamin D supplementation and risk of toxicity in pediatrics: a review of current literature. J Clin Endocrinol Metab. 2014;99:1132–1141.
   PubMed Web of Science ®Google Scholar