Advanced search
Publication Cover
Neuropsychiatric Disease and Treatment Volume 12, 2016 - Issue
Submit an article Journal homepage
85
Views
24
CrossRef citations to date
0
Altmetric
Original Research

Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis

Knut A Hestad1 Department of Research, Innlandet Hospital Trust, Brumunddal, Norway;2 Department of Psychology, Faculty of Social Sciences and Technology Management, Norwegian University of Science and Technology (NTNU), Trondheim, Norway;3 Department of Public Health, Hedmark University College, Elverum, NorwayCorrespondence[email protected]
,
Knut Engedal4 Norwegian Centre for Aging and Health, Vestfold Health Trust, Tønsberg, Norway
,
Jon Elling Whist1 Department of Research, Innlandet Hospital Trust, Brumunddal, Norway
,
Pål Aukrust5 Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway;6 Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway;7 Institute of Clinical Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway;8 K.G. Jebsen IRC, University of Oslo, Oslo, Norway;9 K.G. Jebsen TREC, University of Tromsø, Tromsø, Norway
,
Per G Farup1 Department of Research, Innlandet Hospital Trust, Brumunddal, Norway;10 Unit for Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
,
Tom Eirik Mollnes9 K.G. Jebsen TREC, University of Tromsø, Tromsø, Norway;11 Centre of Molecular Inflammation Research, Norwegian University of Science and Technology (NTNU), Trondheim, Norway;12 Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway;13 Research Laboratory, Nordland Hospital, Bodø, Norway
&
Thor Ueland5 Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway;7 Institute of Clinical Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway;9 K.G. Jebsen TREC, University of Tromsø, Tromsø, Norway
 show all
Pages 817-822 | Published online: 13 Apr 2016

References

  • WHO [webpage on the Internet]Depression: Fact Sheet N°369 Available from: http://www.who.int/mediacentre/factsheets/fs369/en/Accessed January 29, 2016
  • PoonDCHoYSChiuKWongHLChangRCSickness: from the focus on cytokines, prostaglandins, and complement factors to the perspectives of neuronsNeurosci Biobehav Rev201557304526363665
  • YoungJJBrunoDPomaraNA review of the relationship between proinflammatory cytokines and major depressive disorderJ Affect Disord2014169152025128861
  • JansenRPenninxBWMadarVGene expression in major depressive disorderMol Psychiatry Epub2015526
  • CapuronLGumnickJFMusselmanDLNeurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensionsNeuropsychopharmacology200226564365211927189
  • CapuronLRavaudANeveuPJMillerAHMaesMDantzerRAssociation between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapyMol Psychiatry20027546847312082564
  • DantzerRWollmanEEVitkovicLYirmiyaRCytokines, stress, and depression. Conclusions and perspectivesAdv Exp Med Biol199946131732910442180
  • WatsonSGallagherPRitchieJCFerrierINYoungAHHypothalamic-pituitary-adrenal axis function in patients with bipolar disorderBr J Psychiatry200418449650215172943
  • KohlerOBenrosMENordentoftMEffect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trialsJAMA Psychiatry201471121381139125322082
  • RomanoGFTomassiSRussellAMondelliVParianteCMFibromyalgia and chronic fatigue: the underlying biology and related theoretical issuesAdv Psychosom Med201534617725832514
  • MaesMTwiskFNKuberaMRingelKEvidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-alpha, PMN-elastase, lysozyme and neopterinJ Affect Disord2012136393393921975140
  • MontgomerySAAsbergMA new depression scale designed to be sensitive to changeBr J Psychiatry1979134382389444788
  • BeckATSteerRABallRRanieriWComparison of Beck Depression Inventories-IA and -II in psychiatric outpatientsJ Pers Assess19966735885978991972
  • SteerRABallRRanieriWFBeckATFurther evidence for the construct validity of the Beck depression Inventory-II with psychiatric outpatientsPsychol Rep19978024434469129364
  • SteerRABallRRanieriWFBeckATDimensions of the Beck Depression Inventory-II in clinically depressed outpatientsJ Clin Psychol199955111712810100838
  • FolsteinMFFolsteinSEMcHughPR“Mini-mental state”. A practical method for grading the cognitive state of patients for the clinicianJ Psychiatr Res19751231891981202204
  • HestadKAukrustPTønsethSReitanSKDepression has a Strong Relationship to Alterations in the Immune, Endocrine and Neural SystemCurrent psychiatry reviews200954287297
  • MaesMAn intriguing and hitherto unexplained co-occurrence: depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathwaysProg Neuropsychopharmacol Biol Psychiatry201135378479420609377
  • SanduREBugaAMUzoniAPetcuEBPopa-WagnerANeuroinflammation and comorbidities are frequently ignored factors in CNS pathologyNeural Regen Res20151091349135526604877
  • Popa-WagnerABugaAMTicaAAAlbuCVPerfusion deficits, inflammation and aging precipitate depressive behaviourBiogerontology201415543944825033986
  • FreretTGaudreauPSchumann-BardPBillardJMPopa-WagnerAMechanisms underlying the neuroprotective effect of brain reserve against late life depressionJ Neural Transm (Vienna)2015122suppl 1S55S6124390152
  • LevineJBarakYChengappaKNRapoportARebeyMBarakVCerebrospinal cytokine levels in patients with acute depressionNeuropsychobiology199940417117610559698
  • LindqvistDJanelidzeSHagellPInterleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severityBiol Psychiatry200966328729219268915
  • RaisonCLBorisovASMajerMActivation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depressionBiol Psychiatry200965429630318801471
  • TakeshitaYRansohoffRMInflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro modelsImmunol Rev2012248122823922725965

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.