556
Views
45
CrossRef citations to date
0
Altmetric
Rapid Communication

Fitting the pieces together: current research on the genetic basis of attention-deficit/hyperactivity disorder (ADHD)

&
Pages 551-560 | Published online: 24 Aug 2010

References

  • FaraoneSVPerlisRHDoyleAEMolecular genetics of attention-deficit/hyperactivity disorderBiol Psychiatry200557111313132315950004
  • GoodmanRStevensonJA twin study of hyperactivity – II. The aetiological role of genes, family relationships and perinatal adversityJ Child Psychol Psychiatry19893056917092793957
  • CantwellDPGenetics of hyperactivityJ Child Psychol Psychiatry19751632612641171894
  • SprichSBiedermanJCrawfordMHMundyEFaraoneSVAdoptive and biological families of children and adolescents with ADHDJ Am Acad Child Adolesc Psychiatry200039111432143711068899
  • LevyFHayDAMcStephenMWoodCWaldmanIAttention-deficit hyperactivity disorder: a category or a continuum? Genetic analysis of a large-scale twin studyJ Am Acad Child Adolesc Psychiatry19973667377449183127
  • ThaparAHolmesJPoultonKHarringtonRGenetic basis of attention deficit and hyperactivityBr J Psychiatry19992174105111
  • MillJPetronisAPre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibilityJ Child Psychol Psychiatry200849101020103018492038
  • ThaparALangleyKOwenMJO’DonovanMCAdvances in genetic findings on attention deficit hyperactivity disorderPsychol Med2007371681169217506925
  • ThaparALangleyKO’DonovanMOwenMRefining the attention deficit hyperactivity disorder phenotype for molecular genetic studiesMol Psychiatry200611871472016702977
  • McGoughJJSadockBSadockVRouizPAdult Manifestations of Attention-Deficit/Hyperactivity DisorderKaplan and Sadock’s Comprehensive Textbook of Psychiatry2PhiladelphiaWloters Kluwer2009
  • StawickiJANiggJTvon EyeAFamily psychiatric history evidence on the nosological relations of DSM-IV ADHD combined and inattentive subtypes: new data and meta-analysisJ Child Psychol Psychiatry200647993594516930388
  • McLoughlinGRonaldAKuntsiJAshersonPPlominRGenetic support for the dual nature of attention deficit hyperactivity disorder: substantial genetic overlap between the inattentive and hyperactive-impulsive componentsJ Abnorm Child Psychol2007356999100817690977
  • KleinRGMannuzzaSLong-term outcome of hyperactive children: a reviewJ Am Acad Child Adolesc Psychiatry19913033833872055874
  • TaylorESonuga-BarkeERutterMBishopDVPineDDisorders of attention and activityRutter’s Child and Adolescent Psychiatry5th edMaldenWiley-Blackwell2008
  • LarssonHLichtensteinPLarssonJOGenetic contributions to the development of ADHD subtypes from childhood to adolescenceJ Am Acad Child Adolesc Psychiatry200645897398116865040
  • FrankeBVasquezAAJohanssonSMulticenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHDNeuropsychopharmacology201035365666419890261
  • Costa e SilvaJAAutism, a brain developmental disorder: some new pathopysiologic and genetics findingsMetabolism20081057Suppl 2S40S4318803965
  • CuffeSPMooreCGMcKeownREPrevalence and correlates of ADHD symptoms in the national health interview surveyJ Atten Disord20059239240116371662
  • ReiersenAMConstantinoJNGrimmerMMartinNGToddRDEvidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twinsTwin Res Hum Genet200811657958519016613
  • RonaldASimonoffEKuntsiJAshersonPPlominREvidence for overlapping genetic influences on autistic and ADHD behaviors in a community twin sampleJ Child Psychol Psychiatry200849553554218221348
  • MoffittTEAdolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomyPsychol Rev199310046747018255953
  • ThaparAHarringtonRMcGuffinPExamining the comorbidity of ADHD-related behaviors and conduct problems using a twin study designBr J Psychiatry200117922422911532799
  • TaylorEChadwickOHeptinstallEDanckaertsMHyperactivity and conduct problems as risk factors for adolescent developmentJ Am Acad Child Adolesc Psychiatry1996359121312268824065
  • BiedermanJMickEFaraoneSVInfluence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinicAm J Psychiatry20021591364211772687
  • RheeSHWaldmanIDHayDALevyFSex differences in genetic and environmental influences on DSM-III-R attention-deficit/hyperactivity disorderJ Abnorm Psychol19991081244110066990
  • RutterMGene-environment interdependenceDev Sci2007101121817181693
  • LinnetKMDalsgaardSObelCMaternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidenceAm J Psychiatry200316061028104012777257
  • ThaparARutterMDo prenatal risk factors cause psychiatric disorder? Be wary of causal claimsBr J Psychiatry2009195210010119648537
  • ThaparAHaroldGRiceFLangleyKO’DonovanMThe contribution of gene-environment interaction to psychopathologyDev Psychopathol2007194989100417931430
  • ThaparAStergiakouliEGenetic influences on the development of childhood psychiatric disordersPsychiatry200877277281
  • ZhouKDempfleAArcos-BurgosMMeta-analysis of genome- wide linkage scans of attention deficit hyperactivity disorderAm J Med Genet B Neuropsychiatr Genet2008147B81392139818988193
  • DiMaioSGrizenkoNJooberRDopamine genes and attention-deficit hyperactivity disorder: a reviewJ Psychiatry Neurosci2003281273812587848
  • GainetdinovRRDopamine transporter mutant mice in experimental neuropharmacologyNaunyn Schmiedebergs Arch Pharmacol200837746301313
  • SpencerTJBiedermanJMadrasBKIn vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporterBiol Psychiatry200557111293130015950001
  • SharpSIMcQuillinAGurlingHMGenetics of attention-deficit hyperactivity disorder (ADHD)Neuropharmacology20095778590600
  • GizerIRFicksCWaldmanIDCandidate gene studies of ADHD: a meta-analytic reviewHum Genet20091261519019506906
  • FaraoneSVDoyleAEMickEBiedermanJMeta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorderAm J Psychiatry200115871052105711431226
  • LiDShamPCOwenMJHeLMeta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD)Hum Mol Genet200615142276228416774975
  • El-FaddaghMLauchtMMarasAVohringerLSchmidtMHAssociation of dopamine D4 receptor (DRD4) gene with attention-deficit/hyperactivity disorder (ADHD) in a high-risk community sample: a longitudinal study from birth to 11 years of ageJ Neural Transm2004111788388915206004
  • LangleyKFowlerTAGradyDLMolecular genetic contribution to the developmental course of attention-deficit hyperactivity disorderEur Child Adolesc Psychiatry2009181263218563476
  • ShawPGornickMLerchJPolymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorderArch Gen Psychiatry200764892193117679637
  • LiJWangYZhouRAssociation between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese Han subjectsAm J Med Genet B Neuropsychiatr Genet20071441141916941663
  • LoweNKirleyAHawiZJoint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypesAm J Hum Genet200474234835614732906
  • MaherBSMarazitaMLFerrellREVanyukovMMDopamine system genes and attention deficit hyperactivity disorder: a meta-analysisPsychiatr Genet200212420721512454525
  • Purper-OuakilDWohlMMourenMCVerpillatPAdesJGorwoodPMeta-analysis of family-based association studies between the dopamine transporter gene and attention deficit hyperactivity disorderPsychiatr Genet2005151535915722958
  • YangBChanRCJingJLiTShamPChenRYA meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3′-UTR of dopamine transporter gene and attention deficit hyperactivity disorderAm J Med Genet B Neuropsychiatr Genet2007144B454155017440978
  • BrookesKXuXChenWThe analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genesMol Psychiatry2006111093495316894395
  • KahnRSKhouryJNicholsWCLanphearBPRole of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviorsJ Pediatr2003143110411012915833
  • NeumanRJLobosEReichWHendersonCASunLWToddRDPrenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtypeBiol Psychiatry200761121320132817157268
  • BrookesKJMillJGuindaliniCA common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancyArch Gen Psychiatry2006631748116389200
  • LangleyKTuricDRiceFTesting for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behaviorAm J Med Genet B Neuropsychiatr Genet2008147B1495317579368
  • LauchtMSkowronekMHBeckerKInteracting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sampleArch Gen Psychiatry200764558559017485610
  • CheukDKWongVMeta-analysis of association between a catechol- O-methyltransferase gene polymorphism and attention deficit hyperactivity disorderBehav Genet200636565165916676224
  • ThaparALangleyKFowlerTCatechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorderArch Gen Psychiatry200562111275127816275815
  • CaspiALangleyKMilneBA replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorderArch Gen Psychiatry200865220321018250258
  • MonuteauxMCBiedermanJDoyleAEMickEFaraoneSVGenetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptomsJ Am Acad Child Adolesc Psychiatry200948775776419465875
  • O’DonovanMCCraddockNNortonNIdentification of loci associated with schizophrenia by genome-wide association and follow-upNat Genet20084091053105518677311
  • ShifmanSJohannessonMBronsteinMGenome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in womenPLoS Genet200842e2818282107
  • SullivanPFLinDTzengJYGenomewide association for schizophrenia in the CATIE study: results of stage 1Mol Psychiatry200813657058418347602
  • Wellcome Trust Case Control ConsortiumGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature2007447714566167817554300
  • WeissLAAutism genetics: emerging data from genome-wide copy- number and single nucleotide polymorphism scansExpert Rev Mol Diagn20099879580319895225
  • FrankeBNealeBMFaraoneSVGenome-wide association studies in ADHDHum Genet20091261135019384554
  • NealeBMLasky-SuJAnneyRGenome-wide association scan of attention deficit hyperactivity disorderAm J Med Genet B Neuropsychiatr Genet2008147B81337134418980221
  • ZuoLKranzlerHRLuoXCovaultJGelernterJCNR1 variation modulates risk for drug and alcohol dependenceBiol Psychiatry200762661662617509535
  • Lasky-SuJNealeBMFrankeBGenome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associationsAm J Med Genet B Neuropsychiatr Genet2008147B81345135418821565
  • UhlGRDrgonTJohnsonCMolecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify „connectivity constellation“ and drug target genes with pleiotropic effectsAnn N Y Acad Sci2008114131838118991966
  • LeschKPTimmesfeldNRennerTJMolecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studiesJ Neural Transm2008115111573158518839057
  • AnneyRJLasky-SuJO’DushlaineCConduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics studyAm J Med Genet B Neuropsychiatr Genet2008147B81369137818951430
  • Sonuga-BarkeEJLasky-SuJNealeBMDoes parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scanAm J Med Genet B Neuropsychiatr Genet2008147B81359136818846501
  • SchererSWLeeCBirneyEChallenges and standards in integrating surveys of structural variationNat Genet2007397 SupplS7S1517597783
  • SebatJLakshmiBMalhotraDStrong association of de novo copy number mutations with autismScience2007316582344544917363630
  • EliaJGaiXXieHMRare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genesMol Psychiatry20101563764619546859
  • LeschKPSelchSRennerTJGenome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigreeMol Psychiatry2010323 [Epub ahead of print]
  • KarlTHerzogHBehavioral profiling of NPY in aggression and neuropsychiatric diseasesPeptides200728232633317196302
  • WilliamsHJOwenMJO’DonovanMCSchizophrenia genetics: new insights from new approachesBr Med Bull200991617419443537
  • MardisERThe impact of next-generation sequencing technology on geneticsTrends Genet200824313314118262675
  • SivaN1000 Genomes projectNat Biotechnol200826325618327223