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Original Research

Not all partial dopamine D2 receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate striatal dopaminergic synapse

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Pages 589-603 | Published online: 06 Sep 2010

References

  • HowesODKapurSThe dopamine hypothesis of schizophrenia: version III – the final common pathwaySchizophr Bull200935354956219325164
  • HowesODMontgomeryAJAsselinMCElevated striatal dopamine function linked to prodromal signs of schizophreniaArch Gen Psychiatry2009661132019124684
  • KomossaKRummel-KlugeCSchmidFAripiprazole versus other atypical antipsychotics for schizophreniaCochrane Database Syst Rev200974CD00656919821375
  • CaseyDESandsEEHeisterbergJYangHMEfficacy and safety of bifeprunox in patients with an acute exacerbation of schizophrenia, results from a randomized, double-blind, placebo-controlled, multicenter, dose-finding studyPsychopharmacology (Berl)2008200331733118597078
  • CraggSJHilleCJGreenfieldSADopamine release and uptake dynamics within nonhuman primate striatum in vitroJ Neurosci200020218209821711050144
  • WuQReithMEWalkerQDKuhnCMCarrollFIGarrisPAConcurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission, an in vivo voltammetric studyJ Neurosci200222146272628112122086
  • TadoriYForbesRAMcQuadeRDKikuchiTReceptor reserve-dependent properties of antipsychotics at human dopamine D2 receptorsEur J Pharmacol200960713354019326565
  • PaniLPiraLMarcheseGAntipsychotic efficacy, relationship to optimal D2-receptor occupancyEur Psychiatry200722526727517419008
  • DahanLHusumHMnie-FilaliOArntJHertelPHaddjeriNEffects of bifeprunox and aripiprazole on rat serotonin and dopamine neuronal activity and anxiolytic behaviourJ Psychopharmacol200923217718918515444
  • BrownPOlivieroAMazzonePInsolaATonaliPDi LazzaroVDopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson’s diseaseJ Neurosci20012131033103811157088
  • ZhangLDoyonWMClarkJJPhillipsPEDaniJAControls of tonic and phasic dopamine transmission in the dorsal and ventral striatumMol Pharmacol200976239640419460877
  • MontaguePMcClureSBaldwinPDynamic gain control of dopamine delivery in freely moving animalsJ Neurosci20042471754175914973252
  • KoeltzowTEXuMCooperDCAlterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant miceJ Neurosci1998186223122389482807
  • PovlockSLSchenkJOA multisubstrate kinetic mechanism of dopamine transport in the nucleus accumbens and its inhibition by cocaineJ Neurochem1997693109311059282932
  • WaymentHSchenkJSorgBCharacterization of extracellular dopamine clearance in the medial prefrontal cortex, role of monoamine uptake and monoamine oxidase inhibitionJ Neurosci2001211354211150317
  • SeemanPTargeting the dopamine D2 receptor in schizophreniaExpert Opin Ther Targets200610451553116848689
  • KapurSVanderSpekSCBrownleeBANobregaJNAntipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancyJ Pharmacol Exp Ther2003305262563112606608
  • SautelFGriffonNLévesqueDPilonCSchwartzJCSokoloffPA functional test identifies dopamine agonists selective for D3 versus D2 receptorsNeuroreport1995623293327756621
  • PugsleyTADavisMDAkunneHCNeurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907J Pharmacol Exp Ther19952753135513668531103
  • HalldinCFardeLHögbergTCarbon-11-FLB 457, a radioligand for extrastriatal D2 dopamine receptorsJ Nucl Med1995367127512817790956
  • BrückeTTsaiYFMcLellanCIn vitro binding properties and autoradiographic imaging of 3-iodobenzamide ([125I]-IBZM), a potential imaging ligand for D-2 dopamine receptors in SPECTLife Sci19884221209721043260318
  • DelforgeJBottlaenderMPappataSLoc’hCSyrotaAAbsolute quantification by positron emission tomography of the endogenous ligandJ Cereb Blood Flow Metab200121561363011333372
  • CatafauAMSuarezMBullichSWithin-subject comparison of striatal D2 receptor occupancy measurements using [123I] IBZM SPECT and [11C]Raclopride PETNeuroimage200946244745819233294
  • WoodMDScottCClarkeKAripiprazole and its human metabolite are partial agonists at the human dopamine D2 receptor, but the rodent metabolite displays antagonist propertiesEur J Pharmacol200654613889416914136
  • KimJRSeoHBChoJYPopulation pharmacokinetic modeling of aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patientsBr J Clin Pharmacol200866680281019032724
  • CosiCCarilla-DurandEAssiéMBPartial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors, G protein activation and prolactin releaseEur J Pharmacol20065351313514416527269
  • BurrisKDMolskiTFXuCAripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptorsJ Pharmacol Exp Ther2002302138138912065741
  • EtievantABétryCArntJHaddjeriNBifeprunox and aripiprazole suppress in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activationNeurosci Lett20094601828619450663
  • ShapiroDARenockSArringtonEAripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacologyNeuropsychopharmacology20032881400141112784105
  • UsielloABaikJHRougé-PontFDistinct functions of the two isoforms of dopamine D2 receptorsNature2000408680919920311089973
  • SalzmanCRosenbergJFeldmanJJSchizophrenia symptoms remain stable during decreases from 2 antipsychotics to aripiprazoleJ Clin Psychiatry200768697017592928
  • KaneJMCarsonWHSahaAREfficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorderJ Clin Psychiatry200263976377112363115
  • ChristensenAFPoulsenJNielsenCTBorkBChristensenAChristensenMPatients with schizophrenia treated with aripiprazole, a multicentre naturalistic studyActa Psychiatr Scand2006113214815316423167
  • TandonRMarcusRNStockEGA prospective, multicenter, randomized, parallel-group, open-label study of aripiprazole in the management of patients with schizophrenia or schizoaffective disorder in general psychiatric practice: Broad Effectiveness Trial with Aripiprazole (BETA)Schizophr Res2006841778916483745
  • PotkinSGSahaARKujawaMJAripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorderArch Gen Psychiatry200360768169012860772
  • CaseyDECarsonWHSahaARSwitching patients to aripiprazole from other antipsychotic agents, a multicenter randomized studyPsychopharmacology (Berl)2003166439139912610718
  • YokoiFGründerGBiziereKDopamine D2 and D3 receptor occupancy in normal humans treated with the antipsychotic drug aripiprazole (OPC 14597): a study using positron emission tomography and [11C]racloprideNeuropsychopharmacology200227224825912093598
  • KegelesLSSlifsteinMFrankleWGDose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallyprideNeuropsychopharmacology2008333111312518418366
  • ZimbroffDLKaneJMTammingaCAControlled, dose-response study of sertindole and haloperidol in the treatment of schizophrenia. Sertindole Study GroupAm J Psychiatry199715467827919167505
  • GomezJCCrawfordAMSuperior efficacy of olanzapine over haloperidol: analysis of patients with schizophrenia from a multicenter international trialJ Clin Psychiatry200162Suppl 261111232753
  • SikichLHamerRMBashfordRASheitmanBBLiebermanJAA pilot study of risperidone, olanzapine, and haloperidol in psychotic youth: a double-blind, randomized, 8-week trialNeuropsychopharmacology200429113314514583740
  • ZipurskyRBChristensenBKDaskalakisZTreatment response to olanzapine and haloperidol and its association with dopamine D receptor occupancy in first-episode psychosisCan J Psychiatry200550846246916127964
  • KapurSRemingtonGJonesCHigh levels of dopamine D2 receptor occupancy with low-dose haloperidol treatment: a PET studyAm J Psychiatry199615379489508659621
  • KapurSZipurskyRBRemingtonGClinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophreniaAm J Psychiatry199915622862939989565
  • BernardoMParelladaELomenaFDouble-blind olanzapine vs haloperidol D2 dopamine receptor blockade in schizophrenic patients: a baseline-endpointPsychiatry Res20011072879711530275
  • LaruelleMD’SouzaCDBaldwinRMImaging D2 receptor occupancy by endogenous dopamine in humansNeuropsychopharmacology19971731621749272483
  • FisherREMorrisEDAlpertNFischmanAJIn vivo imaging of neuromodulatory synaptic transmission using PET, a review of relevant neurophysiologyHum Brain Mapp199532434
  • AbbottDHBarnettDKColmanRJYamamotoMESchultz-DarkenNJAspects of common marmoset basic biology and life history important for biomedical researchComp Med200353433935014524409
  • PerezXAParameswaranNHuangLZO’LearyKTQuikMPresynaptic dopaminergic compensation after moderate nigrostriatal damage in non-human primatesJ Neurochem200810551861187218248617
  • FriedmanJHBermanRMGoetzCGOpen-label flexible- dose pilot study to evaluate the safety and tolerability of aripiprazole in patients with psychosis associated with Parkinson’s diseaseMov Disord200621122078208117013906
  • QiZMillerGWVoitEOComputational systems analysis of dopamine metabolismPLoS One200836e244418568086
  • TauscherJKüfferleBAsenbaumSTauscher-WisniewskiSKasperSStriatal dopamine-2 receptor occupancy as measured with [123I] iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidolPsychopharmacology (Berl)20021621424912107616
  • LandBRSalpeterEESalpeterMMKinetic parameters for acetylcholine interaction in intact neuromuscular junctionProc Natl Acad Sci U S A19817811720072046947281