Short-term adverse effects of the apolipoprotein E ε4 allele over language function and executive function in healthy older adults

References

• Mahley RW, Apolipoprotein E. cholesterol transport protein with expanding role in cell biology. Science. 1998;240(4852):622–630. doi:10.1126/science.3283935
   Web of Science ®Google Scholar
• Nao J, Sun H, Wang Q, et al. Adverse effects of the apolipoprotein E epsilon4 allele on episodic memory, task switching and gray matter volume in healthy young adults. Front Hum Neurosci. 2017;11(19):346–355. doi:10.3389/fnhum.2017.0034628706481
   PubMed Web of Science ®Google Scholar
• Li J, Kanekiyo T, Shinohara M, et al. Differential regulation of amyloid-beta endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms. J Biol Chem. 2012;287(53):44593–44601. doi:10.1074/jbc.M112.42022423132858
   PubMed Web of Science ®Google Scholar
• Ramanan VK, Risacher SL, Nho K, et al. APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Mol Psychiatry. 2014;19(3):351–357. doi:10.1038/mp.2013.1923419831
   PubMed Web of Science ®Google Scholar
• Verhaaren BF, Vernooij MW, Koudstaal PJ, et al. Alzheimer’s disease genes and cognition in the nondemented general population. Biol Psychiatry. 2013;73(5):429–434. doi:10.1016/j.biopsych.2012.04.00922592056
   PubMed Web of Science ®Google Scholar
• Carrasquillo MM, Crook JE, Pedraza O, et al. Late-onset Alzheimer’s risk variants in memory decline, incident mild cognitive impairment, and Alzheimer’s disease. Neurobiol Aging. 2015;36(1):60–67. doi:10.1016/j.neurobiolaging.2014.07.04225189118
   PubMed Web of Science ®Google Scholar
• Arendt T, Schindler C, Bruckner MK, et al. Plastic neuronal remodeling is impaired in patients with Alzheimer’s disease carrying apolipoprotein epsilon 4 allele. J Neurosci. 1997;17(2):516–529.8987775
   PubMed Web of Science ®Google Scholar
• Foster CM, Kennedy KM. Differential aging trajectories of modulation of activation to cognitive challenge in APOE epsilon4 groups: reduced modulation predicts poorer cognitive performance. J Neurosci.2017;37(29):6894–6901. doi:10.1523/JNEUROSCI.3900-16.201728652414
   PubMed Web of Science ®Google Scholar
• Hulette CM, Welsh-Bohmer KA, Murray MG, Saunders AM, Mash DC, McIntyre LM. Neuropathological and neuropsychological changes in “normal” aging: evidence for preclinical Alzheimer disease in cognitively normal individuals. J Neuropathol Exp Neurol. 1998;57(12):1168–1174. doi:10.1097/00005072-199812000-000099862640
   PubMed Web of Science ®Google Scholar
• Bennett DA, Schneider JA, Arvanitakis Z, et al. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology. 2006;66(12):1837–1844. doi:10.1212/01.wnl.0000219668.47116.e616801647
   PubMed Web of Science ®Google Scholar
• Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):280–292. doi:10.1016/j.jalz.2011.03.00321514248
   PubMed Web of Science ®Google Scholar
• Reinvang I, Winjevoll IL, Rootwelt H, Espeseth T. Working memory deficits in healthy APOE epsilon 4 carriers. Neuropsychologia. 2010;48(2):566–573. doi:10.1016/j.neuropsychologia.2009.10.01819879282
   PubMed Web of Science ®Google Scholar
• Albert M, Soldan A, Gottesman R, et al. Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotype. Curr Alzheimer Res. 2014;11(8):773–784.25212916
   PubMed Web of Science ®Google Scholar
• Marioni RE, Campbell A. Differential effects of the APOE e4 allele on different domains of cognitive ability across the life-course. Eur J Hum Genet. 2016;24(6):919–923.26395552
   PubMed Web of Science ®Google Scholar
• Wisdom NM, Callahan JL, Hawkins KA. The effects of apolipoprotein E on non-impaired cognitive functioning: a meta-analysis. Neurobiol Aging. 2011;32(1):63–74. doi:10.1016/j.neurobiolaging.2009.02.00319285755
   PubMed Web of Science ®Google Scholar
• Luciano M, Gow AJ, Taylor MD, et al. Apolipoprotein E is not related to memory abilities at 70 years of age. Behav Genet. 2009;39(1):6–14. doi:10.1007/s10519-008-9236-x18946731
   PubMed Web of Science ®Google Scholar
• Bunce D, Fratiglioni L, Small BJ, Winblad B, Backman L. APOE and cognitive decline in preclinical Alzheimer disease and non-demented aging. Neurology. 2004;63(5):816–821. doi:10.1212/01.wnl.0000137041.86153.4215365129
   PubMed Web of Science ®Google Scholar
• Schiepers OJ, Harris SE, Gow AJ, et al. APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921. Mol Psychiatry. 2012;17(3):315–324. doi:10.1038/mp.2010.13721263443
   PubMed Web of Science ®Google Scholar
• de Oliveira FF, Chen ES, Smith MC, Bertolucci PH. Associations of blood pressure with functional and cognitive changes in patients with Alzheimer’s disease. Dement Geriatr Cogn Disord. 2016;41(5–6):314–323. doi:10.1159/00044758527398980
   PubMed Web of Science ®Google Scholar
• Fillenbaum GG, Landerman LR, Blazer DG, Saunders AM, Harris TB, Launer LJ. The relationship of APOE genotype to cognitive functioning in older African-American and Caucasian community residents. J Am Geriatr Soc. 2001;49(9):1148–1155.11559372
   PubMed Web of Science ®Google Scholar
• Xiao S, Li J, Tang M, et al. Methodology of China’s national study on the evaluation, early recognition, and treatment of psychological problems in the elderly: the China Longitudinal Aging Study (CLAS). Shanghai Arch Psychiatry. 2013;25(2):91–98. doi:10.3969/j.issn.1002-0829.2013.02.00524991140
   PubMedGoogle Scholar
• Pohl R, Lewis R, Niccolini R, Rubenstein R. Teaching the mental status examination: comparison of three methods. J Med Educ. 1982;57(8):626–629.7097737
   PubMedGoogle Scholar
• Schmidt H, Elster J, Eckert I, et al. Cognitive functions after spinal tap in patients with normal pressure hydrocephalus. J Neurol. 2014;261(12):2344–2350. doi:10.1007/s00415-014-7489-225239390
   PubMed Web of Science ®Google Scholar
• Trzepacz PT, Hochstetler H, Wang S, Walker B, Saykin AJ. Relationship between the montreal cognitive assessment and mini-mental state examination for assessment of mild cognitive impairment in older adults. BMC Geriatr. 2015;10(19):107–114. doi:10.1186/s12877-015-0103-3
   Web of Science ®Google Scholar
• Morris JC, Heyman A, Mohs RC, et al. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer’s disease. Neurology. 1989;39(9):1159–1165. doi:10.1212/wnl.39.9.11592771064
   PubMed Web of Science ®Google Scholar
• Woods DL, Kishiyamaa MM, Lund EW, et al. Improving digit span assessment of short-term verbal memory. J Clin Exp Neuropsychol. 2011;33(1):101–111. doi:10.1080/13803395.2010.49314920680884
   PubMed Web of Science ®Google Scholar
• Loring DW, Goldstein FC, Chen C, et al. False-positive error rates for reliable digit span and auditory verbal learning test performance validity measures in amnestic mild cognitive impairment and early Alzheimer disease. Arch Clin Neuropsychol. 2016;31(4):313–331. doi:10.1093/arclin/acw01427084732
   PubMed Web of Science ®Google Scholar
• Bhattacharya B, Marwaha RK, Malhotra S, Pershad D. Intellectual functions in childhood malignant disorders. Indian Pediatr. 1995;32(8):869–875.8635829
   PubMedGoogle Scholar
• Gao Y, Xiao Y, Miao R, et al. The characteristic of cognitive function in Type 2 diabetes mellitus. Diabetes Res Clin Pract. 2015;109(2):299–305. doi:10.1016/j.diabres.2015.05.01926004430
   PubMed Web of Science ®Google Scholar
• de Paula JJ, Paiva GCC, Costa DS. Use of a modified version of the switching verbal fluency test for the assessment of cognitive flexibility. Dement Neuropsychol. 2015;9(3):258–264. doi:10.1590/1980-57642015dn9300000829213970
   PubMedGoogle Scholar
• Ahn HJ, Chin J, Park A, et al. Seoul Neuropsychological Screening Battery-dementia version (SNSB-D): a useful tool for assessing and monitoring cognitive impairments in dementia patients. J Korean Med Sci. 2010;25(7):1071–1076. doi:10.3346/jkms.2010.25.7.107120592901
   PubMed Web of Science ®Google Scholar
• Kim J, Na HK, Byun J, et al. Tracking cognitive decline in amnestic mild cognitive impairment and early-stage alzheimer dementia: mini-mental state examination versus neuropsychological battery. Dement Geriatr Cogn Disord. 2017;44(1–2):105–117. doi:10.1159/00047852028768247
   PubMed Web of Science ®Google Scholar
• Donohoe GG, Salomaki A, Lehtimaki T, Pulkki K, Kairisto V. Rapid identification of apolipoprotein E genotypes by multiplex amplification refractory mutation system PCR and capillary gel electrophoresis. Clin Chem. 1999;45(1):143–146.9895356
   PubMed Web of Science ®Google Scholar
• Anderson GD, Temkin NR, Dikmen SS, et al. Haptoglobin phenotype and apolipoprotein E polymorphism: relationship to posttraumatic seizures and neuropsychological functioning after traumatic brain injury. Epilepsy Behav. 2009;16(3):501–506. doi:10.1016/j.yebeh.2009.08.02519766540
   PubMed Web of Science ®Google Scholar
• Rodriguez FS, Schroeter ML, Arelin K, et al. APOE e4-genotype and lifestyle interaction on cognitive performance: results of the LIFE-adult-study. Health Psychol. 2018;37(2):194–205. doi:10.1037/hea000051529215900
   PubMed Web of Science ®Google Scholar
• Lancaster C, Forster S, Tabet N, Rusted J. Putting attention in the spotlight: the influence of APOE genotype on visual search in mid adulthood. Behav Brain Res. 2017;15(334):97–104. doi:10.1016/j.bbr.2017.07.015
   Web of Science ®Google Scholar
• Small BJ, Rosnick CB, Fratiglioni L, Backman L. Apolipoprotein E and cognitive performance: a meta-analysis. Psychol Aging. 2004;19(4):592–600. doi:10.1037/0882-7974.19.4.59215584785
   PubMed Web of Science ®Google Scholar
• Rawle MJ, Davis D, Bendayan R, Wong A, Kuh D, Richards M. Apolipoprotein-E (Apoe) ε4 and cognitive decline over the adult life course. Transl Psychiatry. 2018;8(1):10–18. doi:10.1038/s41398-017-0056-829317604
   PubMed Web of Science ®Google Scholar
• Dik MG, Jonker C, Bouter LM, Geerlings MI, van Kamp GJ, Deeg DJ. APOE-epsilon4 is associated with memory decline in cognitively impaired elderly. Neurology. 2000;54(7):1492–1497. doi:10.1212/wnl.54.7.149210751265
   PubMed Web of Science ®Google Scholar
• Zhao N, Liu CC, Van Ingelgom AJ, et al. Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor inthe endosomes. Neuron. 2017;96(1):115–129. doi:10.1016/j.neuron.2017.09.00328957663
   PubMed Web of Science ®Google Scholar
• Zhao Q, RO R, Ding D, et al. Diabetes is associated with worse executive function in both eastern and western populations: Shanghai aging study and Mayo clinic study of aging. J Alzheimers Dis. 2015;47(1):167–176. doi:10.3233/JAD-15007326402765
   PubMed Web of Science ®Google Scholar
• Urger SE, De Bellis MD, Hooper SR, Woolley DP, Chen SD. Provenzale, J. The superior longitudinal fasciculus in typically developing children and adolescents: diffusion tensor imaging and neuropsychological correlates. J Child Neurol 2015;30(1):9–20. doi:10.1177/0883073813520503.24556549
   PubMed Web of Science ®Google Scholar
• Zhang S, Chen Y, Liu Z, et al. Association of white matter integrity and cognitive functions in Chinese non-demented elderly with the APOE ɛ4 allele. J Alzheimers Dis. 2015;48(3):781–791. doi:10.3233/JAD-15035726402101
   PubMed Web of Science ®Google Scholar
• Lee BK, Glass TA, Wand GS, et al. Apolipoprotein E genotype, cortisol, and cognitive function in community-dwelling older adults. Am J Psychiatry. 2008;165(11):1456–1464. doi:10.1176/appi.ajp.2008.0709153218593777
   PubMed Web of Science ®Google Scholar
• Panza F, Frisardi V, Seripa D, et al. Apolipoprotein E genotypes and neuropsychiatric symptoms and syndromes in late-onset Alzheimer’s disease. Ageing Res Rev. 2012;11(1):87–103. doi:10.1016/j.arr.2011.06.00521763789
   PubMed Web of Science ®Google Scholar
• Pietrzak RH, Lim YY, Neumeister A, et al. Amyloid-β, anxiety,and cognitive decline in preclinical Alzheimer disease: amulticenter, prospective cohort study. JAMAPsychiatry. 2015;72(3):284–291.
   PubMed Web of Science ®Google Scholar