172
Views
11
CrossRef citations to date
0
Altmetric
Original Research

Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761®. Findings from a randomized controlled trial

, &
Pages 209-215 | Published online: 20 Apr 2011

References

  • TariotPNMackJLPattersonMBThe behavior rating scale for dementia of the consortium to establish a registry for Alzheimer’ disease. The Behavioral Pathology Committee of the Consortium to establish a registry for Alzheimer’s diseaseAm J Psychiatry19951529134913577653692
  • ShinISCarterMMastermannDFairbanksLCummingsJLNeuropsychiatric symptoms and quality of life in Alzheimer diseaseAm J Geriatr Psychiatry200513646947415956266
  • LyketsosCGSteinbergMTschanzJTNortonMCSteffensDCBreitnerJCSMental and behavioural disturbances in dementia: findings from the Cache Country Study on the Memory in AgingAm J Psychiatry20001575707714
  • SteinbergMSheppardJMTschanzJTThe incidence of mental and behavioral disturbances in dementia: the Cache County StudyJ Neuropsychiatry Clin Neurosci200315334034512928510
  • LyketsosCGLopezOJonesBFitzpatrickALBreitnerJDeKoskySTPrevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment. Results from the Cardiovascular Health StudyJAMA2002288121475148312243634
  • ChanDCKasperJDBlackBSRabinsPVPrevalence and correlates of behavioural and psychiatric symptoms in community-dwelling elders with dementia or mild cognitive impairment: the Memory and Medical Care StudyInt J Geriatr Psychiatry200318217418212571828
  • CummingsJLThe Neuropsychiatric Inventory: assessing psychopathology in dementia patientsNeurology199748Suppl 6S10S169153155
  • ThompsonCBrodatyHTrollorJSachdevPBehavioral and psychological symptoms associated with dementia subtype and severityInt Psychogeriat2010222300305
  • IQWiG Institut für Qualität und Wirtschaftlichkeit im GesundheitswesenGinkgohaltige Präparate bei Alzheimer Demenz Abschlussbericht. Auftrag A05-19B Version 10 [Ginkgo in Alzheimer‘s disease IQWiG Reports Commission No A05-19B Version 10].CologneIQWiG2008
  • KasperSSchubertHGinkgo-Spezialextrakt EGb 761® in der Behandlung der Demenz: Evidenz für Wirksamkeit und Verträglichkeit [Ginkgo biloba extract EGb 761® in the treatment of dementia: evidence of efficacy and tolerability]Fortschr Neurol Psychiatr200977949450619621278
  • WeinmannSRollSSchwarzbachCVauthCWillichSNEffects of Ginkgo biloba in dementia: systematic review and meta-analysisBMC Geriatrics [serial on the internet].20103 [cited 2010 Nov 15];14:[12 p.]. http://www.biomedcentral.com/content/pdf/1471-2318-10-14.pdf. Accessed November 15, 2010.
  • IhlRBachinskayaNKorczynADEfficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features. A randomized controlled trialInt J Geriatr Psychiatry Epub 2010 Dec 7.
  • HoerrRBehavioural and psychological symptoms of dementia (BPSD): effects of EGb 761®Pharmacopsychiatry200336Suppl 1S56S6113130390
  • SchneiderLSDeKoskySTFarlowMRTariotPNHoerrRKieserMA randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer’s typeCurr Alzheimer Res20052554155116375657
  • ScripnikovAKhomenkoANapryeyenkoOfor the GINDEM-NP Study GroupEffects of Ginkgo biloba extract EGb 761® on neuropsychiatric symptoms of dementia: findings from a randomised controlled trialWien Med Wochenschr200715713–1429530017704975
  • RamassamyCLongpréFChristenYGinkgo biloba extract (EGb 761®) in Alzheimer’s disease: is there any evidence?Current Alzheimer Res200743253262
  • HoyerSLannertHNöldnerMChatterjeeSSDamaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761®)J Neural Transm199910611–121171118810651112
  • WuYWuZButkoPAmyloid-β-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761® and ginkgolides in transgenic Caenorhabditis elegansJ Neurosci20062650131021311317167099
  • BastianettoSRamassamyCDoréSChristenYPoirierJQuirionRThe Ginkgo biloba extract (EGb 761®) protects hippocampal neurons against cell death induced by beta-amyloidEur J Neurosci20001261882189110886329
  • KampkötterAPielarskiTRohrigRThe Ginkgo biloba extract EGb 761® reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegansPharmacol Res200755213914717207635
  • EckertAKeilUKressmannSEffects of EGb 761® Ginkgo biloba extract on mitochondrial function and oxidative stressPharmacopsychiatry200336Suppl 1S15S2313130384
  • Abdel-KaderRHauptmannSKeilUStabilization of mitochondrial function by Ginkgo biloba extract (EGb 761®)Pharmacol Res200756649350217977008
  • KöltringerPLangstegerWEberODose-dependent hemorheological effects and microcirculatory modifications following intravenous administration of Ginkgo biloba special extract EGb 761®Clin Hemorheol1995154649656
  • RamassamyCChristenYClostreFCostentinJThe Ginkgo biloba extract, EGb 761®, increases synaptosomal uptake of 5-hydroxytryptamine: in-vitro and ex-vivo studiesJ Pharmacy Pharmacol19924411943945
  • YoshitakeTYoshitakeSKehrJThe Ginkgo biloba extract EGb 761® and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortexBr J Pharmacol2010159365966820105177
  • FehskeCJLeunerKMüllerWEGinkgo biloba extract (EGb 761®) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatmentPharmacol Res2009601687319427589
  • RapinJRLamproglouIDrieuKDeFeudisFVDemonstration of the “anti-stress” activity of an extract of Ginkgo biloba (EGb 761®) using a discrimination learning taskGen Pharmacol1994255100910167835617
  • MarcilhacADakineNBourhimNEffect of chronic administration of Ginkgo biloba extract or Ginkgolide on the hypothalamic-pituitary-adrenal axis in the ratLife Sci199825 62:232923409651122
  • JezovaDDunckoRLassanovaMKriskaMMoncekFReduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGb 761®) in healthy volunteersJ Physiol Pharmacol200253333734812369732
  • ICH International Conference on Harmonisation of Technical Requirements for the Registration of Pharmaceuticals for Human UseGood Clinical Practice: Consolidated GuidelineGenevaICH1996
  • McKhannGDrachmanDFolsteinMKatzmanRPriceDStadlanEMClinical diagnosis of Alzheimer‘s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer‘s DiseaseNeurology19843479399446610841
  • RománGCTatemichiTKErkinjunttiTVascular Dementia: Diagnostic criteria for research studies. Report of the NINDS-AIREN International WorkshopNeurology19934322502608094895
  • MahoneyRJohnstonKKatonaCMaxminKLivingstonGThe TE4D-Cog: a new test for detecting early dementia in English-speaking populationsInt J Geriatr Psychiatry200520121172117916315149
  • KimYSNibbelinkDWOverallJEFactor structure and scoring of the SKT test batteryJ Clin Psychol199349161718425936
  • ErzigkeitHSKT Manual A Short Cognitive Performance Test for Assessing Memory and Attention Concise versionCastrop-RauxelGeromed1992
  • SunderlandTHillJMellowAClock drawing in Alzheimer’s disease: a novel measure of dementia severityJ Am Geriatr Soc19893787257292754157
  • HamiltonMA rating scale for depressionJ Neurol Neurosurg Psychiatry196023566214399272
  • MegaMSMastermanDMO’ConnorSMBarclayTRCummingsJLThe spectrum of behavioural responses to cholinesterase inhibitor therapy in Alzheimer’s diseaseArch Neurol199956111388139310555660
  • NapryeyenkoOBorzenkoIfor the GINDEM-NP Study GroupGinkgo biloba special extract in dementia with neuropsychiatric features. A randomized, placebo-controlled, double-blind clinical trialArzneimittelforschung200757141117341003
  • CummingsJLMackellJKauferDBehavioral effects of current Alzheimer’s disease treatments: a descriptive reviewAlzheimers Dement200841496018631950
  • GauthierSLoftHCummingsJImprovement in behavioural symptoms in patients with moderate to severe Alzheimer’s disease by memantine: a pooled data analysisInt J Geriat Psychiatry2008235537545
  • RoddaJMorganSWalkerZAre cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer’s disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamineInt Psychogeriat2009215813824
  • BanerjeeSSmithSCLampingDLQuality of life in dementia: more than just cognition. An analysis of associations with quality of life in dementiaJ Neurol Neurosurg Psychiatry200677214614816421113
  • BanerjeeSSamsiKPetrieCDWhat do we know about quality of life in dementia? A review of the emerging evidence on the predictive and explanatory value of disease specific measures of health related quality of life in people with dementiaInt J Geriatr Psychiatry2009241152418727132
  • Conde-SalaJLGarre-OlmoJGTurró-GarrigaOLópez-PousaSVilalta-FranchJFactors related to perceived quality of life in patients with Alzheimer’s disease: the patient’s perception compared with that of caregiversInt J Geriatr Psychiatry200924658559419031477
  • Agüera-OrtizLFrank-GarcíaAGilPMorenoAon behalf of the 5E Study GroupClinical progression of moderate-to-severe Alzheimer’s disease and caregiver burden: a 12-month multicenter prospective observational studyInt Psychogeriatr20102281265127920849672
  • GilleyDWBieniasJLWilsonRSBennettDABeckTLEvansDAInfluence of behavioral symptoms on rates of institutionalization for persons with Alzheimer‘s diseasePsychol Med20043461129113515554582
  • De VugtMEStevensFAaltenPLousbergRJaspersNVerheyFRJA prospective study of the effects of behavioral symptoms on the institutionalization of patients with dementiaInt Psychogeriatr200517411315945587