Review: brain neurobiology of gambling disorder based on rodent models

References

• Lemieux A, al’Absi M. Stress psychobiology in the context of addiction medicine: from drugs of abuse to behavioral addictions. Prog Brain Res. 2016;223:43–62. doi:10.1016/bs.pbr.2015.08.00126806770
   PubMed Web of Science ®Google Scholar
• Grant JE, Odlaug BL, Chamberlain SR. Neural and psychological underpinnings of gambling disorder: a review. Prog Neuropsychopharmacol Biol Psychiatry. 2016;65:188–193. doi:10.1016/j.pnpbp.2015.10.00726497079
   PubMed Web of Science ®Google Scholar
• Alguacil LF, González-Martin C. Target identification and validation in brain reward dysfunction. Drug Discov Today. 2015;20(3):347–352. doi:10.1016/j.drudis.2014.10.01425541474
   PubMed Web of Science ®Google Scholar
• Winstanley CA, Clark L. Translational models of gambling-related decision-making. Curr Top Behav Neurosci. 2016;28:93–120. doi:10.1007/7854_2015_501427418069
   PubMedGoogle Scholar
• Norbury A, Husain M. Sensation-seeking: dopaminergic modulation and risk for psychopathology. Behav Brain Res. 2015;288:79–93. doi:10.1016/j.bbr.2015.04.01525907745
   PubMed Web of Science ®Google Scholar
• Quintero GC. A biopsychological review of gambling disorder. Neuropsychiatr Dis Treat. 2017;13:51–60. doi:10.2147/NDT.S11881828096672
   PubMed Web of Science ®Google Scholar
• Potenza MN, Kosten TR, Rounsaville BJ. Pathological gambling. Jama. 2001;286(2):141–144.11448261
   PubMed Web of Science ®Google Scholar
• National Opinion Research Center. Gambling Impact and Behavior Study. Chicago: NORC Chicago; 1999 Available from: http://www.norc.org/PDFs/publications/GIBSFinalReportApril1999.pdf. Accessed November 20, 2018.
   Google Scholar
• Lorains FK, Cowlishaw S, Thomas SA. Prevalence of comorbid disorders in problem and pathological gambling: systematic review and meta-analysis of population surveys. Addiction. 2011;106(3):490–498. doi:10.1111/j.1360-0443.2010.03300.x21210880
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: APA; 2013.
   Google Scholar
• Goulet-Kennedy J, Labbe S, Fecteau S. The involvement of the striatum in decision making. Dialogues Clin Neurosci. 2016;18(1):55–63.27069380
   PubMed Web of Science ®Google Scholar
• Banz BC, Yip SW, Yau YH, Potenza MN. Behavioral addictions in addiction medicine: from mechanisms to practical considerations. Prog Brain Res. 2016;223:311–328. doi:10.1016/bs.pbr.2015.08.00326806783
   PubMed Web of Science ®Google Scholar
• Levy DJ, Glimcher PW. The root of all value: a neural common currency for choice. Curr Opin Neurobiol. 2012;22(6):1027–1038. doi:10.1016/j.conb.2012.06.00122766486
   PubMed Web of Science ®Google Scholar
• Meng YJ, Deng W, Wang HY, et al. Reward pathway dysfunction in gambling disorder: a meta-analysis of functional magnetic resonance imaging studies. Behav Brain Res. 2014;275:243–251. doi:10.1016/j.bbr.2014.08.05725205368
   PubMed Web of Science ®Google Scholar
• Potenza MN. Neurobiology of gambling behaviors. Curr Opin Neurobiol. 2013;23(4):660–667. doi:10.1016/j.conb.2013.03.00423541597
   PubMed Web of Science ®Google Scholar
• van Den Bos R, Davies W, Dellu-Hagedorn F, et al. Cross-species approaches to pathological gambling: a review targeting sex differences, adolescent vulnerability and ecological validity of research tools. Neurosci Biobehav Rev. 2013;37(10 Pt 2):2454–2471. doi:10.1016/j.neubiorev.2013.07.00523867802
   PubMed Web of Science ®Google Scholar
• Anselme P. Dopamine, motivation, and the evolutionary significance of gambling-like behaviour. Behav Brain Res. 2013;256:1–4. doi:10.1016/j.bbr.2013.07.03923896052
   PubMed Web of Science ®Google Scholar
• Cocker PJ, Winstanley CA. Irrational beliefs, biases and gambling: exploring the role of animal models in elucidating vulnerabilities for the development of pathological gambling. Behav Brain Res. 2015;279:259–273. doi:10.1016/j.bbr.2014.10.04325446745
   PubMed Web of Science ®Google Scholar
• Silveira MM, Malcolm E, Shoaib M, Winstanley CA. Scopolamine and amphetamine produce similar decision-making deficits on a rat gambling task via independent pathways. Behav Brain Res. 2015;281:86–95. doi:10.1016/j.bbr.2014.12.02925529186
   PubMed Web of Science ®Google Scholar
• Yates JR, Batten SR, Bardo MT, Beckmann JS. Role of ionotropic glutamate receptors in delay and probability discounting in the rat. Psychopharmacology. 2015;232(7):1187–1196. doi:10.1007/s00213-014-3747-325270726
   PubMed Web of Science ®Google Scholar
• Gueye AB, Trigo JM, Vemuri KV, Makriyannis A, Le Foll B. Effects of various cannabinoid ligands on choice behaviour in a rat model of gambling. Behav Pharmacol. 2016;27(2–3Spec Issue):258–269. doi:10.1097/FBP.000000000000022226905189
   PubMed Web of Science ®Google Scholar
• Le Foll B, Goldberg SR. Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence. J Pharmacol Exp Ther. 2005;312(3):875–883. doi:10.1124/jpet.104.07797415525797
   PubMed Web of Science ®Google Scholar
• Gamaleddin I, Zvonok A, Makriyannis A, Goldberg SR, Le Foll B. Effects of a selective cannabinoid CB2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking. PLoS One. 2012;7(1):e29900. doi:10.1371/journal.pone.002990022291896
   PubMed Web of Science ®Google Scholar
• Navarrete F, Rodriguez-Arias M, Martin-Garcia E, et al. Role of CB2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotine. Neuropsychopharmacol. 2013;38(12):2515–2524. doi:10.1038/npp.2013.157
   PubMed Web of Science ®Google Scholar
• Melis M, Pistis M. Endocannabinoid signaling in midbrain dopamine neurons: more than physiology? Curr Neuropharmacol. 2007;5(4):268–277. doi:10.2174/15701590778279361219305743
   PubMed Web of Science ®Google Scholar
• Maldonado R, Valverde O, Berrendero F. Involvement of the endocannabinoid system in drug addiction. Trends Neurosci. 2006;29(4):225–232. doi:10.1016/j.tins.2006.01.00816483675
   PubMed Web of Science ®Google Scholar
• Maldonado R, Berrendero F, Ozaita A, Robledo P. Neurochemical basis of cannabis addiction. Neuroscience. 2011;181:1–17. doi:10.1016/j.neuroscience.2011.02.03521334423
   PubMed Web of Science ®Google Scholar
• Gong JP, Onaivi ES, Ishiguro H, et al. Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res. 2006;1071(1):10–23. doi:10.1016/j.brainres.2005.11.03516472786
   PubMed Web of Science ®Google Scholar
• Zhang HY, Gao M, Liu QR, et al. Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proc Natl Acad Sci U S A. 2014;111(46):E5007–E5015. doi:10.1073/pnas.141321011125368177
   PubMed Web of Science ®Google Scholar
• Di Ciano P, Pushparaj A, Kim A, et al. The impact of selective dopamine D2, D3 and D4 ligands on the rat gambling task. PLoS One. 2015;10(9):e0136267. doi:10.1371/journal.pone.013626726352802
   PubMed Web of Science ®Google Scholar
• Cohen AI, Todd RD, Harmon S, O’Malley KL. Photoreceptors of mouse retinas possess D4 receptors coupled to adenylate cyclase. Proc Natl Acad Sci USA. 1992;89(24):12093–12097. doi:10.1073/pnas.89.24.120931334557
   PubMed Web of Science ®Google Scholar
• Valerio A, Belloni M, Gorno ML, Tinti C, Memo M, Spano P. Dopamine D2, D3, and D4 receptor mRNA levels in rat brain and pituitary during aging. Neurobiol Aging. 1994;15(6):713–719.7891826
   PubMed Web of Science ®Google Scholar
• O’Malley KL, Harmon S, Tang L, Todd RD. The rat dopamine D4 receptor: sequence, gene structure, and demonstration of expression in the cardiovascular system. New Biol. 1992;4(2):137–146.1554689
   PubMedGoogle Scholar
• Meador-Woodruff JH, Grandy DK, Van Tol HH, et al. Dopamine receptor gene expression in the human medial temporal lobe. Neuropsychopharmacol. 1994;10(4):239–248. doi:10.1038/npp.1994.27
   Web of Science ®Google Scholar
• Meador-Woodruff JH, Haroutunian V, Powchik P, Davidson M, Davis KL, Watson SJ. Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia. Arch Gen Psychiatry. 1997;54(12):1089–1095.9400344
   PubMed Web of Science ®Google Scholar
• Mrzljak L, Bergson C, Pappy M, Huff R, Levenson R, Goldman-Rakic PS. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature. 1996;381(6579):245–248. doi:10.1038/381245a08622768
   PubMed Web of Science ®Google Scholar
• Khaled MA, Pushparaj A, Di Ciano P, Diaz J, Le Foll B. Dopamine D3 receptors in the basolateral amygdala and the lateral habenula modulate cue-induced reinstatement of nicotine seeking. Neuropsychopharmacol. 2014;39(13):3049–3058. doi:10.1038/npp.2014.158
   Web of Science ®Google Scholar
• Heidbreder C. Novel pharmacotherapeutic targets for the management of drug addiction. Eur J Pharmacol. 2005;526(1–3):101–112. doi:10.1016/j.ejphar.2005.09.03816253234
   PubMed Web of Science ®Google Scholar
• Bouthenet ML, Souil E, Martres MP, Sokoloff P, Giros B, Schwartz JC. Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA. Brain Res. 1991;564(2):203–219.1839781
   PubMed Web of Science ®Google Scholar
• Diaz J, Pilon C, Le Foll B, et al. Dopamine D3 receptors expressed by all mesencephalic dopamine neurons. J Neurosci. 2000;20(23):8677–8684.11102473
   PubMed Web of Science ®Google Scholar
• Nakajima S, Gerretsen P, Takeuchi H, et al. The potential role of dopamine D(3) receptor neurotransmission in cognition. Eur Neuropsychopharmacol. 2013;23(8):799–813. doi:10.1016/j.euroneuro.2013.05.00623791072
   PubMed Web of Science ®Google Scholar
• Le Foll B, Goldberg SR, Sokoloff P. The dopamine D3 receptor and drug dependence: effects on reward or beyond? Neuropharmacology. Sep. 2005;49(4):525–541.
   Google Scholar
• Pes R, Godar SC, Fox AT, et al. Pramipexole enhances disadvantageous decision-making: lack of relation to changes in phasic dopamine release. Neuropharmacology. 2017;114:77–87. doi:10.1016/j.neuropharm.2016.11.01427889491
   PubMed Web of Science ®Google Scholar
• Fitoussi A, Le Moine C, De Deurwaerdere P, et al. Prefronto-subcortical imbalance characterizes poor decision-making: neurochemical and neural functional evidences in rats. Brain Struct Funct. 2015;220(6):3485–3496. doi:10.1007/s00429-014-0868-825134683
   PubMed Web of Science ®Google Scholar
• Tremblay M, Cocker PJ, Hosking JG, Zeeb FD, Rogers RD, Winstanley CA. Dissociable effects of basolateral amygdala lesions on decision making biases in rats when loss or gain is emphasized. Cogn Affect Behav Neurosci. 2014;14(4):1184–1195. doi:10.3758/s13415-014-0271-124668615
   PubMed Web of Science ®Google Scholar
• Zeeb FD, Winstanley CA. Functional disconnection of the orbitofrontal cortex and basolateral amygdala impairs acquisition of a rat gambling task and disrupts animals’ ability to alter decision-making behavior after reinforcer devaluation. J Neurosci. 2013;33(15):6434–6443. doi:10.1523/JNEUROSCI.3971-12.201323575841
   PubMed Web of Science ®Google Scholar
• Bhatti M, Jang H, Kralik JD, Jeong J. Rats exhibit reference-dependent choice behavior. Behav Brain Res. 2014;267:26–32. doi:10.1016/j.bbr.2014.03.01224657593
   PubMed Web of Science ®Google Scholar
• Cocker PJ, Hosking JG, Murch WS, Clark L, Winstanley CA. Activation of dopamine D4 receptors within the anterior cingulate cortex enhances the erroneous expectation of reward on a rat slot machine task. Neuropharmacology. 2016;105:186–195. doi:10.1016/j.neuropharm.2016.01.01926775821
   PubMed Web of Science ®Google Scholar
• Zeeb FD, Baarendse PJ, Vanderschuren LJ, Winstanley CA. Inactivation of the prelimbic or infralimbic cortex impairs decision-making in the rat gambling task. Psychopharmacology. 2015;232(24):4481–4491. doi:10.1007/s00213-015-4075-y26387517
   PubMed Web of Science ®Google Scholar
• Pittaras E, Callebert J, Chennaoui M, Rabat A, Granon S. Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice. Brain Struct Funct. 2016;221(9):4615–4629. doi:10.1007/s00429-016-1192-226860089
   PubMed Web of Science ®Google Scholar
• Koot S, Baars A, Hesseling P, van Den Bos R, Joels M. Time-dependent effects of corticosterone on reward-based decision-making in a rodent model of the Iowa gambling task. Neuropharmacology. 2013;70:306–315. doi:10.1016/j.neuropharm.2013.02.00823474014
   PubMed Web of Science ®Google Scholar
• Mizoguchi H, Katahira K, Inutsuka A, et al. Insular neural system controls decision-making in healthy and methamphetamine-treated rats. Proc Natl Acad Sci U S A. 2015;112(29):E3930–E3939. doi:10.1073/pnas.141801411226150496
   PubMed Web of Science ®Google Scholar
• Ishii H, Ohara S, Tobler PN, Tsutsui K, Iijima T. Inactivating anterior insular cortex reduces risk taking. J Neurosci. 2012;32(45):16031–16039. doi:10.1523/JNEUROSCI.2278-12.201223136439
   PubMed Web of Science ®Google Scholar
• Ishii H, Ohara S, Tobler PN, Tsutsui K, Iijima T. Dopaminergic and serotonergic modulation of anterior insular and orbitofrontal cortex function in risky decision making. Neurosci Res. 2015;92:53–61. doi:10.1016/j.neures.2014.11.00925481848
   PubMed Web of Science ®Google Scholar
• Pushparaj A, Kim AS, Musiol M, et al. Differential involvement of the agranular vs granular insular cortex in the acquisition and performance of choice behavior in a rodent gambling task. Neuropsychopharmacol. 2015;40(12):2832–2842. doi:10.1038/npp.2015.133
   Web of Science ®Google Scholar
• Peak JN, Turner KM, Burne TH. The effect of developmental vitamin D deficiency in male and female Sprague-Dawley rats on decision-making using a rodent gambling task. Physiol Behav. 2015;138:319–324. doi:10.1016/j.physbeh.2014.09.00725447469
   PubMed Web of Science ®Google Scholar
• Roitman JD, Loriaux AL. Nucleus accumbens responses differentiate execution and restraint in reward-directed behavior. J Neurophysiol. 2014;111(2):350–360. doi:10.1152/jn.00350.201324174652
   PubMed Web of Science ®Google Scholar
• Lobo DS, Aleksandrova L, Knight J, et al. Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models. Mol Psychiatry. 2015;20(8):1002–1010. doi:10.1038/mp.2014.11325266122
   PubMed Web of Science ®Google Scholar
• Boileau I, Payer D, Chugani B, et al. The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]-(+)-propyl-hexahydro-naphtho-oxazin and [11C]raclopride. Addiction. 2013;108(5):953–963. doi:10.1111/add.1206623167711
   PubMed Web of Science ®Google Scholar
• Paine TA, Asinof SK, Diehl GW, Frackman A, Leffler J. Medial prefrontal cortex lesions impair decision-making on a rodent gambling task: reversal by D1 receptor antagonist administration. Behav Brain Res. 2013;243:247–254. doi:10.1016/j.bbr.2013.01.01823354057
   PubMed Web of Science ®Google Scholar
• Paine TA, O’Hara A, Plaut B, Lowes DC. Effects of disrupting medial prefrontal cortex GABA transmission on decision-making in a rodent gambling task. Psychopharmacology. 2015;232(10):1755–1765. doi:10.1007/s00213-014-3816-725420610
   PubMed Web of Science ®Google Scholar
• Baarendse PJ, Counotte DS, O’Donnell P, Vanderschuren LJ. Early social experience is critical for the development of cognitive control and dopamine modulation of prefrontal cortex function. Neuropsychopharmacol. 2013;38(8):1485–1494. doi:10.1038/npp.2013.47
   Web of Science ®Google Scholar
• Cocker PJ, Dinelle K, Kornelson R, Sossi V, Winstanley CA. Irrational choice under uncertainty correlates with lower striatal D(2/3) receptor binding in rats. J Neurosci. 2012;32(44):15450–15457. doi:10.1523/JNEUROSCI.0626-12.201223115182
   PubMed Web of Science ®Google Scholar
• Gadziola MA, Wesson DW. The neural representation of goal-directed actions and outcomes in the Ventral Striatum’s olfactory tubercle. J Neurosci. 2016;36(2):548–560. doi:10.1523/JNEUROSCI.3328-15.2016
   Google Scholar
• Phillips D, Choleris E, Ervin KS, et al. Cage-induced stereotypic behaviour in laboratory mice covaries with nucleus accumbens FosB/DeltaFosB expression. J Neurosci. 2016;301:238–242.
   Google Scholar
• Aleksandrova LR, Creed MC, Fletcher PJ, Lobo DS, Hamani C, Nobrega JN. Deep brain stimulation of the subthalamic nucleus increases premature responding in a rat gambling task. Behav Brain Res. 2013;245:76–82. doi:10.1016/j.bbr.2013.02.01123434606
   PubMed Web of Science ®Google Scholar