The modern perspective for long-acting injectables antipsychotics in the patient-centered care of schizophrenia

References

• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Association; 2013.
   Google Scholar
• DeRosse P, Nitzburg GC, Blair M, Malhotra AK. Dimensional symptom severity and global cognitive function predict subjective quality of life in patients with schizophrenia and healthy adults. Schizophr Res. 2018;195:385–390. doi:10.1016/j.schres.2017.10.01829056491
   PubMed Web of Science ®Google Scholar
• Jobe TH, Harrow M. Long-term outcome of patients with schizophrenia: a review. Can J Psychiatry. 2005;50(14):892–900. doi:10.1177/07067437050500140316494258
   PubMed Web of Science ®Google Scholar
• Wiersma D, Wanderling J, Dragomirecka E, et al. Social disability in schizophrenia: its development and prediction over 15 years in incidence cohorts in six European centres. Psychol Med. 2000;30(5):1155–1167.12027051
   PubMed Web of Science ®Google Scholar
• Brugnoli R, Rapinesi C, Kotzalidis GD, et al. Model of Management (Mo.Ma) for the patient with schizophrenia: crisis control, maintenance, relapse prevention, and recovery with long-acting injectable antipsychotics (LAIs). Riv Psichiatr. 2016;51(2):47–59. doi:10.1708/2246.2419427183509
   PubMed Web of Science ®Google Scholar
• Hasan A, Falkai P, Wobrock T, et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects. World J Biol Psychiatry. 2013;14(1):2–44.23216388
   PubMed Web of Science ®Google Scholar
• NICE Guidance. Psychosis and schizophrenia in adults: prevention and management. NICE guidelines [CG178]. Available from: https://www.nice.org.uk/guidance/cg178. Accessed March, 2014.
   Google Scholar
• Lehman A, Lieberman JA, Dixon LB, et al. Practice guideline for the treatment of patients with schizophrenia. 2004. Available from: https://psychiatryonline.org/pb/assets/raw/sitewide/practice_guidelines/guidelines/schizophrenia.pdf.
   Google Scholar
• Vita A, Barlati S. Recovery from schizophrenia: is it possible? Curr Opin Psychiatry. 2018;31(3):246–255.29474266
   PubMed Web of Science ®Google Scholar
• Mura G, Petretto DR, Bhat KM, Carta MG. Schizophrenia: from epidemiology to rehabilitation. Clin Pract Epidemiol Ment Health. 2012;8:52–66. doi:10.2174/174501790120801005222962559
   PubMedGoogle Scholar
• Lambert M, Schimmelmann BG, Naber D, et al. Prediction of remission as a combination of symptomatic and functional remission and adequate subjective well-being in 2960 patients with schizophrenia. J Clin Psychiatry. 2006;67(11):1690–1697.17196047
   PubMed Web of Science ®Google Scholar
• Chan RCH, Mak WWS, Chio FHN, Tong ACY. Flourishing with psychosis: a prospective examination on the interactions between clinical, functional, and personal recovery processes on well-being among individuals with schizophrenia spectrum disorders. Schizophr Bull. 2018;44(4):778–786. doi:10.1093/schbul/sbx12028981851
   PubMed Web of Science ®Google Scholar
• Velligan DI, Newcomer J, Pultz J, et al. Does cognitive function improve with quetiapine in comparison to haloperidol? Schizophr Res. 2002;53(3):239–248.11738537
   PubMed Web of Science ®Google Scholar
• Kreyenbuhl J, Buchanan RW, Dickerson FB, Dixon LB. Schizophrenia Patient Outcomes Research T. The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2009. Schizophr Bull. 2010;36(1):94–103. doi:10.1093/schbul/sbp13019955388
   PubMed Web of Science ®Google Scholar
• Schottle D, Schimmelmann BG, Ruppelt F, et al. Effectiveness of integrated care including therapeutic assertive community treatment in severe schizophrenia-spectrum and bipolar I disorders: four-year follow-up of the ACCESS II study. PLoS One. 2018;13(2):e0192929. doi:10.1371/journal.pone.019292929485988
   PubMed Web of Science ®Google Scholar
• Liberman RP. Recovery from schizophrenia: form follows functioning. World Psychiatry. 2012;11(3):161–162.23024668
   PubMed Web of Science ®Google Scholar
• Karthik MS, Kulhara P, Chakrabarti S. Attitude towards second-generation antipsychotics among patients with schizophrenia and their relatives. Hum Psychopharmacol. 2013;28(5):457–465. doi:10.1002/hup.233223784674
   PubMed Web of Science ®Google Scholar
• Potkin S, Bera R, Zubek D, Lau G. Patient and prescriber perspectives on long-acting injectable (LAI) antipsychotics and analysis of in-office discussion regarding LAI treatment for schizophrenia. BMC Psychiatry. 2013;13:261. doi:10.1186/1471-244X-13-26124131801
   PubMed Web of Science ®Google Scholar
• Naber D. Subjective effects of antipsychotic drugs and their relevance for compliance and remission. Epidemiol Psichiatr Soc. 2008;17(3):174–176.18924553
   PubMedGoogle Scholar
• Roe D, Lachman M. The subjective experience of people with severe mental illness: a potentially crucial piece of the puzzle. Isr J Psychiatry Relat Sci. 2005;42(4):223–230.16618053
   PubMed Web of Science ®Google Scholar
• Awad AG, Voruganti LN. The impact of newer atypical antipsychotics on patient-reported outcomes in schizophrenia. CNS Drugs. 2013;27(8):625–636. doi:10.1007/s40263-013-0070-123757184
   PubMed Web of Science ®Google Scholar
• Naber D. Subjective effects of antipsychotic treatment. Acta Psychiatr Scand. 2005;111(2):81–83. doi:10.1111/j.1600-0447.2004.00478.x15667426
   PubMed Web of Science ®Google Scholar
• Altamura AC, Aguglia E, Bassi M, et al. Rethinking the role of long-acting atypical antipsychotics in the community setting. Int Clin Psychopharmacol. 2012;27(6):336–349. doi:10.1097/YIC.0b013e328357727a22859065
   PubMed Web of Science ®Google Scholar
• Jakovljevic M. Long-acting injectable (depot) antipsychotics and changing treatment philosophy: possible contribution to integrative care and personal recovery of schizophrenia. Psychiatr Danub. 2014;26(4):304–307.25377363
   PubMed Web of Science ®Google Scholar
• Pietrini F, Spadafora M, Tatini L, et al. LAI versus oral: A case-control study on subjective experience of antipsychotic maintenance treatment. Eur Psychiatry. 2016;37:35–42. doi:10.1016/j.eurpsy.2016.05.00827442981
   PubMed Web of Science ®Google Scholar
• Pietrini F, D’Anna G, Tatini L, et al. Changes in attitude towards LAI antipsychotic maintenance treatment: A two-year follow-up study. Eur Psychiatry. 2018;53:58–65. doi:10.1016/j.eurpsy.2018.06.00229957369
   PubMed Web of Science ®Google Scholar
• Agius M, Butler S, Holt C. Does early diagnosis and treatment of schizophrenia lead to improved long-term outcomes?. Neuropsychiatry. 2011;1(6):553–565. doi:10.2217/npy.11.71
   Google Scholar
• Birchwood M, Todd P, Jackson C. Early intervention in psychosis. The critical period hypothesis. Br J Psychiatry Suppl. 1998;172(33):53–59.9764127
   PubMedGoogle Scholar
• Buckley PE, Evans D. First-episode schizophrenia. A window of opportunity for optimizing care and outcomes. Postgrad Med. 2006:5–19.
   Web of Science ®Google Scholar
• Fleischhacker WW. The first-episode of schizophrenia: a challenge for treatment. Eur Psychiatry. 2002;17(Suppl 4):371s–375s.23573607
   PubMed Web of Science ®Google Scholar
• Tanskanen S, Morant N, Hinton M, et al. Service user and carer experiences of seeking help for a first episode of psychosis: a UK qualitative study. BMC Psychiatry. 2011;11:157. doi:10.1186/1471-244X-11-15721961829
   PubMed Web of Science ®Google Scholar
• Tindall R, Francey S, Hamilton B. Factors influencing engagement with case managers: perspectives of young people with a diagnosis of first episode psychosis. Int J Ment Health Nurs. 2015;24(4):295–303. doi:10.1111/inm.1213325976922
   PubMed Web of Science ®Google Scholar
• van Schalkwyk GI, Davidson L, Srihari V. Too late and too little: narratives of treatment disconnect in early psychosis. Psychiatr Q. 2015;86(4):521–532. doi:10.1007/s11126-015-9348-425663602
   PubMed Web of Science ®Google Scholar
• Berge D, Mane A, Salgado P, et al. Predictors of relapse and functioning in first-episode psychosis: a two-year follow-up study. Psychiatr Serv. 2016;67(2):227–233. doi:10.1176/appi.ps.20140031626467909
   PubMed Web of Science ®Google Scholar
• Robinson DG, Woerner MG, Alvir JM, Bilder RM, Hinrichsen GA, Lieberman JA. Predictors of medication discontinuation by patients with first-episode schizophrenia and schizoaffective disorder. Schizophr Res. 2002;57(2–3):209–219.12223252
   PubMed Web of Science ®Google Scholar
• Gutierrez-Casares JR, Canas F, Rodriguez-Morales A, Hidalgo-Borrajo R, Alonso-Escolano D. Adherence to treatment and therapeutic strategies in schizophrenic patients: the ADHERE study. CNS Spectr. 2010;15(5):327–337.20448523
   PubMed Web of Science ®Google Scholar
• Subotnik KL, Casaus LR, Ventura J, et al. Long-acting injectable risperidone for relapse prevention and control of breakthrough symptoms after a recent first episode of schizophrenia. A randomized clinical trial. JAMA Psychiatry. 2015;72(8):822–829. doi:10.1001/jamapsychiatry.2015.027026107752
   PubMed Web of Science ®Google Scholar
• Chung W, Chang HS, Oh SM, Yoon CW. Factors associated with long-stay status in patients with schizophrenia: an analysis of national databases covering the entire Korean population. Int J Soc Psychiatry. 2013;59(3):207–216. doi:10.1177/002076401143179422222848
   PubMed Web of Science ®Google Scholar
• Olfson M, Marcus SC, Wilk J, West JC. Awareness of illness and nonadherence to antipsychotic medications among persons with schizophrenia. Psychiatr Serv. 2006;57(2):205–211. doi:10.1176/appi.ps.57.2.20516452697
   PubMed Web of Science ®Google Scholar
• Jackson H, McGorry P, Edwards J, et al. Cognitively-oriented psychotherapy for early psychosis (COPE). Preliminary results. Br J Psychiatry Suppl. 1998;172(33):93–100.9764134
   PubMedGoogle Scholar
• McCay E, Beanlands H, Zipursky R, et al. A randomised controlled trial of a group intervention to reduce engulfment and self-stigmatisation in first episode schizophrenia. Aust E J Adv Mental Health. 2007;6:212–220. doi:10.5172/jamh.6.3.212
   Google Scholar
• Biagi E, Capuzzi E, Colmegna F, et al. Long-acting injectable antipsychotics in schizophrenia: literature review and practical perspective, with a focus on aripiprazole once-monthly. Adv Ther. 2017;34(5):1036–1048. doi:10.1007/s12325-017-0507-x28382557
   PubMed Web of Science ®Google Scholar
• Karson C, Duffy RA, Eramo A, Nylander AG, Offord SJ. Long-term outcomes of antipsychotic treatment in patients with first-episode schizophrenia: a systematic review. Neuropsychiatr Dis Treat. 2016;12:57–67. doi:10.2147/NDT.S9639226792993
   PubMed Web of Science ®Google Scholar
• Nandra KS, Agius M. The difference between typical and atypical antipsychotics: the effects on neurogenesis. Psychiatr Danub. 2012;24(Suppl 1):S95–S99.22945197
   PubMed Web of Science ®Google Scholar
• Sheehan JJ, Reilly KR, Fu DJ, Alphs L. Comparison of the peak-to-trough fluctuation in plasma concentration of long-acting injectable antipsychotics and their oral equivalents. Innov Clin Neurosci. 2012;9(7–8):17–23.
   PubMedGoogle Scholar
• Jeong HG, Lee MS. Long-acting injectable antipsychotics in first-episode schizophrenia. Clin Psychopharmacol Neurosci. 2013;11(1):1–6. doi:10.9758/cpn.2013.11.1.123678347
   PubMed Web of Science ®Google Scholar
• Taylor M, Ng KY. Should long-acting (depot) antipsychotics be used in early schizophrenia? A systematic review. Aust N Z J Psychiatry. 2013;47(7):624–630. doi:10.1177/000486741247001023209308
   PubMed Web of Science ®Google Scholar
• Seeman MV. Drawbacks of Long-Acting Intramuscular Antipsychotic Injections. J Clin Pract Nursing. 2017;1(1):12–22.
   Google Scholar
• Nik Ruzyanei NJ, Hazli Z, Chong YS, Marhani M. A case series on the use of atypical long acting injectable as first-line antipsychotic treatment in Malaysia: Who benefits and how?. Malaysian Journal of Psychiatry 2013;22(1):61-65.
   Google Scholar
• Brissos S, Veguilla MR, Taylor D, Balanza-Martinez V. The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal. Ther Adv Psychopharmacol. 2014;4(5):198–219. doi:10.1177/204512531454029725360245
   PubMedGoogle Scholar
• Heres S, Lambert M, Vauth R. Treatment of early episode in patients with schizophrenia: the role of long acting antipsychotics. Eur Psychiatry. 2014;29(Suppl 2):1409–1413. doi:10.1016/S0924-9338(14)70001-X25455704
   PubMed Web of Science ®Google Scholar
• Viala A, Cornic F, Vacheron MN. Treatment adherence with early prescription of long-acting injectable antipsychotics in recent-onset schizophrenia. Schizophr Res Treatment. 2012;2012:368687.22966435
   PubMedGoogle Scholar
• Moritz S, Berna F, Jaeger S, Westermann S, Nagel M. The customer is always right? Subjective target symptoms and treatment preferences in patients with psychosis. Eur Arch Psychiatry Clin Neurosci. 2017;267(4):335–339. doi:10.1007/s00406-016-0694-527194554
   PubMed Web of Science ®Google Scholar
• Chue P, Chue J. A critical appraisal of paliperidone long-acting injection in the treatment of schizoaffective disorder. Ther Clin Risk Manag. 2016;12:109–116.26869795
   PubMed Web of Science ®Google Scholar
• Prikryl R, Prikrylova Kucerova H, Vrzalova M, Ceskova E. Role of long-acting injectable second-generation antipsychotics in the treatment of first-episode schizophrenia: a clinical perspective. Schizophr Res Treatment. 2012;2012:764769.22966444
   PubMedGoogle Scholar
• Osborne RH, Dalton A, Hertel J, Schrover R, Smith DK. Health-related quality of life advantage of long-acting injectable antipsychotic treatment for schizophrenia: a time trade-off study. Health Qual Life Outcomes. 2012;10:35. doi:10.1186/1477-7525-10-3522472127
   PubMed Web of Science ®Google Scholar
• Malla A, Tibbo P, Chue P, et al. Long-acting injectable antipsychotics: recommendations for clinicians. Can J Psychiatry. 2013;58(5Suppl 1):30S–35S.23945065
   PubMed Web of Science ®Google Scholar
• World Health Organization. Adherence to Long-Term Therapies: Evidence for Action. Geneva: World Health Organization; 2003.
   Google Scholar
• Kane JM, Kishimoto T, Correll CU. Non-adherence to medication in patients with psychotic disorders: epidemiology, contributing factors and management strategies. World Psychiatry. 2013;12(3):216–226.24096780
   PubMed Web of Science ®Google Scholar
• Juckel G, de Bartolomeis A, Gorwood P, et al. Towards a framework for treatment effectiveness in schizophrenia. Neuropsychiatr Dis Treat. 2014;10:1867–1878.25285010
   PubMed Web of Science ®Google Scholar
• Revicki DA. Patient assessment of treatment satisfaction: methods and practical issues. Gut. 2004;53(Suppl 4):iv40–iv44.15082613
   PubMedGoogle Scholar
• Weaver M, Patrick DL, Markson LE, Martin D, Frederic I, Berger M. Issues in the measurement of satisfaction with treatment. Am J Manag Care. 1997;3(4):579–594.10169526
   PubMed Web of Science ®Google Scholar
• Zhang M, Brenneman SK, Carter CT, et al. Patient-reported treatment satisfaction and choice of dosing frequency with biologic treatment for moderate to severe plaque psoriasis. Patient Prefer Adherence. 2015;9:777–784.26124643
   PubMed Web of Science ®Google Scholar
• Karow A, Czekalla J, Dittmann RW, et al. Association of subjective well-being, symptoms, and side effects with compliance after 12 months of treatment in schizophrenia. J Clin Psychiatry. 2007;68(1):75–80.17284133
   PubMed Web of Science ®Google Scholar
• Lambert M, Naber D, Schacht A, et al. Rates and predictors of remission and recovery during 3 years in 392 never-treated patients with schizophrenia. Acta Psychiatr Scand. 2008;118(3):220–229.18699954
   PubMed Web of Science ®Google Scholar
• Lambert M, Schimmelmann BG, Schacht A, et al. Long-term patterns of subjective wellbeing in schizophrenia: cluster, predictors of cluster affiliation, and their relation to recovery criteria in 2842 patients followed over 3 years. Schizophr Res. 2009;107(2–3):165–172.18842393
   PubMed Web of Science ®Google Scholar
• Naber D. A self-rating to measure subjective effects of neuroleptic drugs, relationships to objective psychopathology, quality of life, compliance and other clinical variables. Int Clin Psychopharmacol. 1995;10(Suppl 3):133–138.8866775
   PubMed Web of Science ®Google Scholar
• Vothknecht S, Schoevers RA, de Haan L. Subjective well-being in schizophrenia as measured with the subjective well-being under neuroleptic treatment scale: a review. Aust N Z J Psychiatry. 2011;45(3):182–192.21438745
   PubMed Web of Science ®Google Scholar
• de Haan L, Lavalaye J, Linszen D, Dingemans PM, Booij J. Subjective experience and striatal dopamine D(2) receptor occupancy in patients with schizophrenia stabilized by olanzapine or risperidone. Am J Psychiatry. 2000;157(6):1019–1020.10831489
   PubMed Web of Science ®Google Scholar
• de Haan L, Lavalaye J, van Bruggen M, et al. Subjective experience and dopamine D2 receptor occupancy in patients treated with antipsychotics: clinical implications. Can J Psychiatry. 2004;49(5):290–296.15198464
   PubMed Web of Science ®Google Scholar
• de Haan L, van Bruggen M, Lavalaye J, Booij J, Dingemans PM, Linszen D. Subjective experience and D2 receptor occupancy in patients with recent-onset schizophrenia treated with low-dose olanzapine or haloperidol: a randomized, double-blind study. Am J Psychiatry. 2003;160(2):303–309.12562577
   PubMed Web of Science ®Google Scholar
• Lataster J, van Os J, de Haan L, et al. Emotional experience and estimates of D2 receptor occupancy in psychotic patients treated with haloperidol, risperidone, or olanzapine: an experience sampling study. J Clin Psychiatry. 2011;72(10):1397–1404.21208588
   PubMed Web of Science ®Google Scholar
• Mizrahi R, Mamo D, Rusjan P, Graff A, Houle S, Kapur S. The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychotics. Int J Neuropsychopharmacol. 2009;12(5):715–721.19366489
   PubMed Web of Science ®Google Scholar
• Mizrahi R, Rusjan P, Agid O, et al. Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophrenia. Am J Psychiatry. 2007;164(4):630–637.17403977
   PubMed Web of Science ®Google Scholar
• Murray RM, Quattrone D, Natesan S, et al. Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics?. Br J Psychiatry. 2016;209(5):361–365.27802977
   PubMed Web of Science ®Google Scholar
• Wu HE, Okusaga OO. Antipsychotic medication-induced dysphoria: its meaning, association with typical vs. atypical medications and impact on adherence. Psychiatr Q. 2015;86(2):199–205.25164199
   PubMed Web of Science ®Google Scholar
• Nasrallah HA. The case for long-acting antipsychotic agents in the post-CATIE era. Acta Psychiatr Scand. 2007;115(4):260–267.17355516
   PubMed Web of Science ®Google Scholar
• Fujikawa M, Togo T, Yoshimi A, et al. Evaluation of subjective treatment satisfaction with antipsychotics in schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(3):755–760.18226436
   PubMed Web of Science ®Google Scholar
• Hargarter L, Cherubin P, Bergmans P, et al. Intramuscular long-acting paliperidone palmitate in acute patients with schizophrenia unsuccessfully treated with oral antipsychotics. Prog Neuropsychopharmacol Biol Psychiatry. 2015;58:1–7.25448776
   PubMed Web of Science ®Google Scholar
• Kwon JS, Kim SN, Han J, et al. Satisfaction of immediate or delayed switch to paliperidone palmitate in patients unsatisfied with current oral atypical antipsychotics. Int Clin Psychopharmacol. 2015;30(6):320–328.26196188
   PubMed Web of Science ®Google Scholar
• Nordon C, Rouillon F, Barry C, Gasquet I, Falissard B. Determinants of treatment satisfaction of schizophrenia patients: results from the ESPASS study. Schizophr Res. 2012;139(1–3):211–217.22704996
   PubMed Web of Science ®Google Scholar
• Pietrini F, Spadafora M, Talamba GA, et al. The effects of switching from oral to LAI antipsychotic treatment on subjective experience of schizophrenic and schizoaffective patients: preliminary results. Int J Psychiatry Clin Pract. 2015;19(2):106–113.25410156
   PubMed Web of Science ®Google Scholar
• Schreiner A, Bergmans P, Cherubin P, et al. Paliperidone palmitate in non-acute patients with schizophrenia previously unsuccessfully treated with risperidone long-acting therapy or frequently used conventional depot antipsychotics. J Psychopharmacol. 2015;29(8):910–922.25999398
   PubMed Web of Science ®Google Scholar
• Keith SJ, Pani L, Nick B, et al. Practical application of pharmacotherapy with long-acting risperidone for patients with schizophrenia. Psychiatr Serv. 2004;55(9):997–1005.15345759
   PubMed Web of Science ®Google Scholar
• Llorca PM, Abbar M, Courtet P, Guillaume S, Lancrenon S, Samalin L. Guidelines for the use and management of long-acting injectable antipsychotics in serious mental illness. BMC Psychiatry. 2013;13:340.24359031
   PubMed Web of Science ®Google Scholar
• Gardner KN, Nasrallah HA. Managing first-episode psychosis: rationale and evidence for nonstandard first-line treatments for schizophrenia. Curr Psychiatry. 2015;14(7):38–45.
   Google Scholar
• Weiden PJ, Kim E, Bermak J, Turkoz I, Gopal S, Berwaerts J. Does half-life matter after antipsychotic discontinuation? A relapse comparison in schizophrenia with 3 different formulations of paliperidone. J Clin Psychiatry. 2017;78(7):e813–e820.28640988
   PubMed Web of Science ®Google Scholar
• Yeo SU, Park JI, Jang JM, et al. Acceptance rate of long-acting injection after short information: a survey in patients with first- and multiple-episode psychoses and their caregivers. Early Interv Psychiatry. 2017;11(6):509–516.26256465
   PubMed Web of Science ®Google Scholar
• Galderisi S, Rossi A, Rocca P, et al. The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia. World Psychiatry. 2014;13(3):275–287.25273301
   PubMed Web of Science ®Google Scholar
• Livingston JD, Boyd JE. Correlates and consequences of internalized stigma for people living with mental illness: a systematic review and meta-analysis. Soc Sci Med. 2010;71(12):2150–2161.21051128
   PubMed Web of Science ®Google Scholar
• Rossi A, Galderisi S, Rocca P, et al. The relationships of personal resources with symptom severity and psychosocial functioning in persons with schizophrenia: results from the Italian Network for Research on Psychoses study. Eur Arch Psychiatry Clin Neurosci. 2017;267(4):285–294.27381016
   PubMed Web of Science ®Google Scholar
• Wahl OF. Stigma as a barrier to recovery from mental illness. Trends Cogn Sci. 2012;16(1):9–10.22153582
   PubMed Web of Science ®Google Scholar
• Pinna F, Deriu L, Lepori T, et al. Is it true remission? A study of remitted patients affected by schizophrenia and schizoaffective disorders. Psychiatry Res. 2013;210(3):739–744.24007858
   PubMed Web of Science ®Google Scholar
• Pinna F, Tusconi M, Bosia M, Cavallaro R, Carpiniello B; Cagliari Recovery Group S. Criteria for symptom remission revisited: a study of patients affected by schizophrenia and schizoaffective disorders. BMC Psychiatry. 2013;13:235.24294839
   PubMed Web of Science ®Google Scholar
• Buizza C, Schulze B, Bertocchi E, Rossi G, Ghilardi A, Pioli R. The stigma of schizophrenia from patients’ and relatives’ view: A pilot study in an Italian rehabilitation residential care unit. Clin Pract Epidemiol Ment Health. 2007;3:23.17967165
   PubMedGoogle Scholar
• Dixon LB, Holoshitz Y, Nossel I. Treatment engagement of individuals experiencing mental illness: review and update. World Psychiatry. 2016;15(1):13–20.26833597
   PubMed Web of Science ®Google Scholar
• Clemmensen L, Dl V, Hc S. A systematic review of the long-term outcome of early onset schizophrenia. BMC Psychiatry. 2012;12:150.22992395
   PubMed Web of Science ®Google Scholar
• Lasalvia A, Penta E, Sartorius N, Henderson S. Should the label “schizophrenia” be abandoned? Schizophr Res. 2015;162(1–3):276–284.25649288
   PubMed Web of Science ®Google Scholar
• Carpiniello B, Pinna F. Critical appraisal of 3-monthly paliperidone depot injections in the treatment of schizophrenia. Drug Des Devel Ther. 2016;10:1731–1742.
   PubMed Web of Science ®Google Scholar
• Kaplan G, Casoy J, Zummo J. Impact of long-acting injectable antipsychotics on medication adherence and clinical, functional, and economic outcomes of schizophrenia. Patient Prefer Adherence. 2013;7:1171–1180. doi:10.2147/PPA.S5379524265549
   PubMed Web of Science ®Google Scholar
• Montemagni C, Frieri T, Rocca P. Second-generation long-acting injectable antipsychotics in schizophrenia: patient functioning and quality of life. Neuropsychiatr Dis Treat. 2016;12:917–929. doi:10.2147/NDT.S8863227143893
   PubMed Web of Science ®Google Scholar
• Schreiner A, Bergmans P, Cherubin P, et al. A prospective flexible-dose study of paliperidone palmitate in nonacute but symptomatic patients with schizophrenia previously unsuccessfully treated with oral antipsychotic agents. Clin Ther. 2014;36(10):1372–1388 e1371. doi:10.1016/j.clinthera.2014.08.01425444566
   PubMed Web of Science ®Google Scholar
• McCay E, Ryan K. Meeting the patient’s emotional needs In: Zipursky RB, Carpenter W, editors. First Episode Psychosis. Washington, DC: American Psychiatric Publishing, Inc.; 2002:107–127.
   Google Scholar
• Kane JM, Robinson DG, Schooler NR, et al. Comprehensive versus usual community care for first-episode psychosis: 2-year outcomes from the NIMH RAISE early treatment program. Am J Psychiatry. 2016;173(4):362–372. doi:10.1176/appi.ajp.2015.1505063226481174
   PubMed Web of Science ®Google Scholar
• Lloyd K, Latif MA, Simpson S, Shrestha KL. Switching stable patients with schizophrenia from depot and oral antipsychotics to long-acting injectable risperidone: efficacy, quality of life and functional outcome. Hum Psychopharmacol. 2010;25(3):243–252. doi:10.1002/hup.110820373476
   PubMed Web of Science ®Google Scholar
• Rosa F, Schreiner A, Thomas P, Sherif T. Switching patients with stable schizophrenia or schizoaffective disorder from olanzapine to risperidone long-acting injectable. Clin Drug Investig. 2012;32(4):267–279. doi:10.2165/11599080-000000000-00000
   PubMed Web of Science ®Google Scholar
• Chen WY, Lin SK. Comparison of subjective experiences and effectiveness of first-generation long-acting injectable antipsychotics and risperidone long-acting injectables in patients with schizophrenia. J Clin Psychopharmacol. 2016;36(5):492–495. doi:10.1097/JCP.000000000000055527580495
   PubMed Web of Science ®Google Scholar
• Correll CU, Citrome L, Haddad PM, et al. The use of long-acting injectable antipsychotics in schizophrenia: evaluating the evidence. J Clin Psychiatry. 2016;77(suppl 3):1–24. doi:10.4088/JCP.15032su127732772
   PubMed Web of Science ®Google Scholar
• Stahl SM. Long-acting injectable antipsychotics: shall the last be first? CNS Spectr. 2014;19(1):3–5. doi:10.1017/S109285291300101624512639
   PubMed Web of Science ®Google Scholar
• Stevens GL, Dawson G, Zummo J. Clinical benefits and impact of early use of long-acting injectable antipsychotics for schizophrenia. Early Interv Psychiatry. 2016;10(5):365–377. doi:10.1111/eip.1227826403538
   PubMed Web of Science ®Google Scholar