Identification of key genes, pathways, and miRNA/mRNA regulatory networks of CUMS-induced depression in nucleus accumbens by integrated bioinformatics analysis

References

• AnthesEDepression: a change of mindNature2014515752618518725391944
   PubMed Web of Science ®Google Scholar
• SmithKMental health: a world of depressionNature20145157526180181
   Google Scholar
• GaynesBNWardenDTrivediMHWisniewskiSRFavaMRushAJWhat did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depressionPsychiatric Services200960111439144519880458
   PubMed Web of Science ®Google Scholar
• MaKZhangHBalochZPathogenetic and therapeutic applications of tumor necrosis factor-α (TNF-α) in major depressive disorder: a systematic reviewInt J Mol Sci2016175733751
   Web of Science ®Google Scholar
• Converge ConsortiumSparse whole-genome sequencing identifies two loci for major depressive disorderNature2015523756258859126176920
   PubMed Web of Science ®Google Scholar
• PriceJLDrevetsWCNeural circuits underlying the pathophysiology of mood disordersTrends Cogn Sci2012161617122197477
   PubMed Web of Science ®Google Scholar
• MaKGuoLXuACuiSWangJ-HMolecular mechanism for stress-induced depression assessed by sequencing miRNA and mRNA in medial prefrontal cortexPLoS One2016117e015909327427907
   PubMed Web of Science ®Google Scholar
• ZhuZWangGMaKCuiSWangJ-HGABAergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depressionOncotarget2017822359333594528415589
   PubMedGoogle Scholar
• BoppSKHeilbronnerUSchlattmannPLeptin gene polymorphisms are associated with weight gain during lithium augmentation in patients with major depressionEur Neuropsychopharmacol201929221122130554862
   PubMed Web of Science ®Google Scholar
• KangH-JBaeK-YKimS-WMethylation of the glucocorticoid receptor gene associated with depression in patients with acute coronary syndromePsychoneuroendocrinology2019101424930408722
   PubMed Web of Science ®Google Scholar
• PanDXuYZhangLGene expression profile in peripheral blood mononuclear cells of postpartum depression patientsSci Rep2018811013929973662
   PubMed Web of Science ®Google Scholar
• KnowlandDLimBKCircuit-based frameworks of depressive behaviors: the role of reward circuitry and beyondPharmacol Biochem Behav2018174425229309799
   PubMed Web of Science ®Google Scholar
• RussoSJNestlerEJThe brain reward circuitry in mood disordersNat Rev Neurosci201314960962523942470
   PubMed Web of Science ®Google Scholar
• FrancisTCLoboMKEmerging role for nucleus accumbens medium spiny neuron subtypes in depressionBiol Psychiatry201781864565327871668
   PubMed Web of Science ®Google Scholar
• KravitzAVTyeLDKreitzerACDistinct roles for direct and indirect pathway striatal neurons in reinforcementNat Neurosci201215681681822544310
   PubMed Web of Science ®Google Scholar
• AnackerCScholzJO’DonnellKJNeuroanatomic differences associated with stress susceptibility and resilienceBiol Psychiatry2016791084084926422005
   PubMed Web of Science ®Google Scholar
• ChandraRLenzJDGancarzAMOptogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1Front Mol Neurosci201361323745104
   PubMed Web of Science ®Google Scholar
• ChandraRFrancisTCKonkalmattPOpposing role for EGR3 in nucleus accumbens cell subtypes in cocaine actionJ Neurosci201535207927793725995477
   PubMed Web of Science ®Google Scholar
• FrancisTCChandraRFriendDMNucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stressBiol Psychiatry201577321222225173629
   PubMed Web of Science ®Google Scholar
• DelaloyeSHoltzheimerPEDeep brain stimulation in the treatment of depressionDialogues Clin Neurosci2014161839124733973
   PubMed Web of Science ®Google Scholar
• FriedmanAKWalshJJJuarezBEnhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilienceScience2014344618131331924744379
   PubMed Web of Science ®Google Scholar
• FatemiSHFolsomTDRooneyRJThurasPDExpression of GABAA α2-, β1- and ε-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorderTransl Psychiatry201339e30324022508
   PubMed Web of Science ®Google Scholar
• LopizzoNBocchio ChiavettoLCattaneNGene–Environment Interaction in Major Depression: Focus on Experience-Dependent Biological SystemsFront Psychiatry2015686826005424
   PubMed Web of Science ®Google Scholar
• MaheuMLopezJPCrapperLDavoliMATureckiGMechawarNMicroRNA regulation of central glial cell line-derived neurotrophic factor (GDNF) signalling in depressionTransl Psychiatry201552e51125689572
   PubMed Web of Science ®Google Scholar
• SausESoriaVEscaramísGGenetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomniaHum Mol Genet201019204017402520656788
   PubMed Web of Science ®Google Scholar
• DwivediYRoyBLugliGRizaviHZhangHSmalheiserNRChronic corticosterone-mediated dysregulation of microRNA network in prefrontal cortex of rats: relevance to depression pathophysiologyTransl Psychiatry2015511e68226575223
   PubMed Web of Science ®Google Scholar
• XuACuiSWangJ-HIncoordination among subcellular compartments is associated with depression-like behavior induced by chronic mild stressInt J Neuropsychopharmacol2016195pyv12226506857
   PubMed Web of Science ®Google Scholar
• TangJXueWXiaBInvolvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed miceScientific Reports2015511357326315757
   PubMed Web of Science ®Google Scholar
• SeoJ-SWeiJQinLKimYYanZGreengardPCellular and molecular basis for stress-induced depressionMol Psychiatry201722101440144727457815
   PubMed Web of Science ®Google Scholar
• MaKXuACuiSSunM-RXueY-CWangJ-HImpaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stressTransl Psychiatry2016610e91027701406
   PubMed Web of Science ®Google Scholar
• BagotRCPariseEMPeñaCJVentral hippocampal afferents to the nucleus accumbens regulate susceptibility to depressionNat Comm2015617062
   Web of Science ®Google Scholar
• NestlerEJRole of the brain’s reward circuitry in depression: transcriptional mechanismsInt Rev Neurobiol201512415117026472529
   PubMed Web of Science ®Google Scholar
• GoldenSAChristoffelDJHeshmatiMEpigenetic regulation of Rac1 induces synaptic remodeling in stress disorders and depressionNat Med201319333734423416703
   PubMed Web of Science ®Google Scholar
• RobisonAJVialouVSunH-SFluoxetine epigenetically alters the CaMKIIα promoter in nucleus accumbens to regulate ΔFosB binding and antidepressant effectsNeuropsychopharmacology20143951178118624240473
   PubMed Web of Science ®Google Scholar
• HorschigJMSmoldersRBonnefondMDirected communication between nucleus accumbens and neocortex in humans is differentially supported by synchronization in the theta and alpha bandPLoS One2015109e013868526394404
   PubMed Web of Science ®Google Scholar
• SchlaepferTECohenMXFrickCDeep brain stimulation to reward circuitry alleviates anhedonia in refractory major depressionNeuropsychopharmacology200833236837717429407
   PubMed Web of Science ®Google Scholar
• KohnomiSKonishiSMultiple actions of a D3 dopamine receptor agonist, PD128907, on GABAergic inhibitory transmission between medium spiny neurons in mouse nucleus accumbens shellNeurosci Lett2015600172126033184
   PubMed Web of Science ®Google Scholar
• YuJYanYLiK-LNucleus accumbens feedforward inhibition circuit promotes cocaine self-administrationProc Nat Acad Sci201711441E8750E875928973852
   PubMed Web of Science ®Google Scholar
• AdermarkLSöderpalmBBurkhardtJMBrain region specific modulation of ethanol-induced depression of GABAergic neurons in the brain reward system by the nicotine receptor antagonist mecamylamineAlcohol201448545546124961541
   PubMed Web of Science ®Google Scholar
• ChristoffelDJGoldenSADumitriuDIκB kinase regulates social defeat stress-induced synaptic and behavioral plasticityJ Neurosci201131131432121209217
   PubMed Web of Science ®Google Scholar
• LimBKHuangKWGrueterBARothwellPEMalenkaRCAnhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbensNature2012487740618318922785313
   PubMed Web of Science ®Google Scholar
• LuscherBFuchsTGABAergic control of depression-related brain statesAdvances in pharmacology2015739714425637439
   PubMedGoogle Scholar
• GaoS-FKlompAWuJ-LSwaabDFBaoA-MReduced GAD(65/67) immunoreactivity in the hypothalamic paraventricular nucleus in depression: a postmortem studyJ Affect Disord20131491–342242523312397
   PubMed Web of Science ®Google Scholar
• ProulxCDHikosakaOMalinowRReward processing by the lateral habenula in normal and depressive behaviorsNat Neurosci20141791146115225157511
   PubMed Web of Science ®Google Scholar
• ElizaldeNPastorPMGarcia-García ÁlvaroLRegulation of markers of synaptic function in mouse models of depression: chronic mild stress and decreased expression of VGlut1J Neurochem20101951314
   Google Scholar
• MalemudCJMillerAHPro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugsExpert Opin Ther Targets200812217118318208366
   PubMed Web of Science ®Google Scholar
• CollinsLMDownerEJToulouseANolanYMMitogen-Activated Protein Kinase Phosphatase (MKP)-1 in nervous system development and diseaseMol Neurobiol20155131158116724957007
   PubMed Web of Science ®Google Scholar
• LippielloPHoxhaESperanzaLThe 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPKNeuropharmacology201610142643826482421
   PubMed Web of Science ®Google Scholar
• KériSSzabóCKelemenOBlood biomarkers of depression track clinical changes during cognitive-behavioral therapyJ Affect Disord201416411812224856564
   PubMed Web of Science ®Google Scholar
• RichterFMeurersBHZhuCMedvedevaVPChesseletM-FNeurons express hemoglobin alpha- and beta-chains in rat and human brainsJ Comp Neurol2009515553854719479992
   PubMed Web of Science ®Google Scholar
• SchelshornDWSchneiderAKuschinskyWExpression of hemoglobin in rodent neuronsJ Cereb Blood Flow Metab200929358559519116637
   PubMed Web of Science ®Google Scholar
• GelmanJSSironiJCastroLMFerroESFrickerLDHemopressins and other hemoglobin-derived peptides in mouse brain: comparison between brain, blood, and heart peptidome and regulation in Cpefat/fat miceJ Neurochem2010113487188020202081
   PubMed Web of Science ®Google Scholar
• HeYHuaYLiuWHuHKeepRFXiGEffects of cerebral ischemia on neuronal hemoglobinJ Cereb Blood Flow Metab200929359660519066615
   PubMed Web of Science ®Google Scholar
• SarlusHWangXCedazo-MinguezASchultzbergMOpricaMChronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responsesJ Neuroinflammation20131019923915208
   PubMed Web of Science ®Google Scholar
• InceBGuloksuzSAltınbaşKOralETAlpkanLRAltinozMAMinor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against postpartum episodesJ Affect Disord2013151140540823856286
   PubMed Web of Science ®Google Scholar
• TavakolizadehJRoshanaeiKSalmaninejadAMicroRNAs and exosomes in depression: potential diagnostic biomarkersJ Cell Biochem201811953783379729236313
   PubMed Web of Science ®Google Scholar
• DwivediYmicroRNAs as biomarker in depression pathogenesisAnn Psychiatry Ment Health201311100326894231
   PubMedGoogle Scholar
• SaavedraKMolina-MárquezASaavedraNZambranoTSalazarLEpigenetic modifications of major depressive disorderInt J Mol Sci20161781279
   Web of Science ®Google Scholar
• SerafiniGPompiliMHansenKFThe involvement of microR-NAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3pCell Mol Neurobiol2014341173024213247
   PubMed Web of Science ®Google Scholar
• BritesDFernandesANeuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulationFront Cell Neurosci2015947626733805
   PubMed Web of Science ®Google Scholar
• MaffiolettiETarditoDGennarelliMBocchio-ChiavettoLMicro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disordersFront Cell Neurosci20148827524653674
   PubMed Web of Science ®Google Scholar
• DwivediYEmerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implicationsDialogues in Clin Neurosci20141614361
   PubMed Web of Science ®Google Scholar
• MiaoZMaoFLiangJSzyfMWangYSunZSAnxiety-related behaviours associated with microRNA-206-3p and BDNF expression in pregnant female mice following psychological social stressMol Neurobiol20185521097111128092086
   PubMed Web of Science ®Google Scholar
• YanHFangMLiuX-YRole of microRNAs in stroke and poststroke depressionSci World J20132013416
   Google Scholar
• LiuQSunNNZzWFanDHCaoMQChaihu-Shugan-San exerts an antidepressive effect by downregulating miR-124 and releasing inhibition of the MAPK14 and GRIA3 signaling pathwaysNeural Regener Res2018135837845
   PubMed Web of Science ®Google Scholar
• HiguchiFUchidaSYamagataHHippocampal microRNA-124 enhances chronic stress resilience in miceJ Neurosci201636277253726727383599
   PubMed Web of Science ®Google Scholar
• RoyBDunbarMSheltonRCDwivediYIdentification of MicroRNA-124-3p as a putative epigenetic signature of major depressive disorderNeuropsychopharmacology201742486487527577603
   PubMed Web of Science ®Google Scholar
• HussainNZhuWJiangCDown-regulation of miR-10a-5p in synoviocytes contributes to TBX5-controlled joint inflammationJ Cell Mol Med201822124125028782180
   PubMed Web of Science ®Google Scholar
• Pienimaeki-RoemerAKonovalovaTMusriMMTranscriptomic profiling of platelet senescence and platelet extracellular vesiclesTransfusion201757114415628026009
   PubMed Web of Science ®Google Scholar
• LiuB-BLuoLLiuX-LGengDLiuQYiL-T7-chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stressPsychopharmacology2015232354155025034119
   PubMed Web of Science ®Google Scholar
• GiridharanVVThandavarayanRAFriesGRNewer insights into the role of miRNA a tiny genetic tool in psychiatric disorders: focus on post-traumatic stress disorderTransl Psychiatry2016611e95427845777
   PubMed Web of Science ®Google Scholar
• LanFYuHHuMXiaTYueXmiR-144-3p exerts anti-tumor effects in glioblastoma by targeting c-MetJ Neurochem2015135227428626250785
   PubMed Web of Science ®Google Scholar
• FengYLiNMaHBeiBHanYChenGUndescribed phenylethyl flavones isolated from Patrinia villosa show cytoprotective properties via the modulation of the mir-144-3p/Nrf2 pathwayPhytochemistry2018153283529859331
   PubMed Web of Science ®Google Scholar
• LiJSunPYueZZhangDYouKWangJmiR-144-3p induces cell cycle arrest and apoptosis in pancreatic cancer cells by targeting proline-rich protein 11 expression via the mitogen-activated protein kinase signaling pathwayDNA and Cell Biology201736861962628574724
   PubMed Web of Science ®Google Scholar
• PersengievSKondovaIOttingNKoeppenAHBontropREGenome-wide analysis of miRNA expression reveals a potential role for miR-144 in brain aging and spinocerebellar ataxia pathogenesisNeurobiol Aging201132122316e17-2
   Web of Science ®Google Scholar
• DananMSchwartzSEdelheitSSorekRTranscriptome-wide discovery of circular RNAs in ArchaeaNucleic Acids Res20124073131314222140119
   PubMed Web of Science ®Google Scholar
• MemczakSJensMElefsiniotiACircular RNAs are a large class of animal RNAs with regulatory potencyNature2013495744133333823446348
   PubMed Web of Science ®Google Scholar
• ScalaGMarwahVKinaretPSundJFortinoVGrecoDIntegration of genome-wide mRNA and miRNA expression, and DNA methylation data of three cell lines exposed to ten carbon nanomaterialsData in Brief2018191046105730228994
   PubMed Web of Science ®Google Scholar
• SijenTMolecular approaches for forensic cell type identification: on mRNA, miRNA, DNA methylation and microbial markersForensic Sci Int Genet201518213225488609
   PubMed Web of Science ®Google Scholar
• DoeckeJDWangYBaggerlyKCo-localized genomic regulation of miRNA and mRNA via DNA methylation affects survival in multiple tumor typesCancer Genetics20162091046347327810075
   PubMed Web of Science ®Google Scholar