Administration of troxerutin and cerebroprotein hydrolysate injection alleviates cerebral ischemia/reperfusion injury by down-regulating caspase molecules

References

• Wang M, Zhang Y, Feng L, et al. Compound porcine cerebroside and ganglioside injection attenuates cerebral ischemia-reperfusion injury in rats by targeting multiple cellular processes. Neuropsychiatr Dis Treat. 2017;13:927–935. doi:10.2147/NDT.S12952228392696
   PubMed Web of Science ®Google Scholar
• Zhang WJ, Liu XG, Li QY. Protective effects of oleuropein against cerebral ischemia/reperfusion by inhibiting neuronal apoptosis. Med Sci Monit. 2018;24:6587–6598. doi:10.12659/MSM.91233630230477
   PubMed Web of Science ®Google Scholar
• Broussalis E, Killer M, McCoy M, Harrer A, Trinka E, Kraus J. Current therapies in ischemic stroke. Part A. Recent developments in acute stroke treatment and in stroke prevention. Drug Discov Today. 2012;17:296–309. doi:10.1016/j.drudis.2011.11.00522134007
   PubMed Web of Science ®Google Scholar
• Dong Q, Lin X, Shen L, Feng Y. The protective effect of herbal polysaccharides on ischemia-reperfusion injury. Int J Biol Macromol. 2016;92:431–440. doi:10.1016/j.ijbiomac.2016.07.05227431791
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang Y, Ma W, Lu S, Chen J, Cao L. Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect. Neuropsychiatr Dis Treat. 2018;14:871–877. doi:10.2147/NDT.S16179229636612
   PubMed Web of Science ®Google Scholar
• Lansberg MG, Bluhmki E, Thijs VN. Efficacy and safety of tissue plasminogen activator 3 to 4.5 hrs after acute ischemic stroke: a meta analysis. Stroke. 2009;40:2438–2441. doi:10.1161/STROKEAHA.109.55254719478213
   PubMed Web of Science ®Google Scholar
• Fan W, Dai Y, Xu H, et al. Caspase-3 modulates regenerative response after stroke. Stem Cells. 2014;32:473–486. doi:10.1002/stem.150323939807
   PubMed Web of Science ®Google Scholar
• Zhong M, Ma W, Zhang X, Wang Y, Gao X. Tetramethyl pyrazine protects hippocampal neurons against anoxia/reoxygenation injury through inhibiting apoptosis mediated by JNK/MARK signal pathway. Med Sci Monit. 2016;22:5082–5090. doi:10.12659/msm.89892128009855
   PubMed Web of Science ®Google Scholar
• Yan RY, Wang SJ, Yao GT, Liu Z-G, Xiao N. The protective effect and its mechanism of 3-n-butylphthalide pretreatment on cerebral ischemia reperfusion injury in rats. Eur Rev Med Pharmacol Sci. 2017;21:5275–5282. doi:10.26355/eurrev_201711_1385229228445
   PubMed Web of Science ®Google Scholar
• Mokhtari B, Badalzadeh R, Alihemmati A, Mohammadi M. Phosphorylation of GSK-3 beta and reduction of apoptosis as targets of troxerutin effect on reperfusion injury of diabetic myocardium. Eur J Pharmacol. 2015;765:316–321. doi:10.1016/j.ejphar.2015.08.05626341011
   PubMed Web of Science ®Google Scholar
• Zhao H, Liu Y, Zeng J, et al. Troxerutin and cerebroprotein hydrolysate injection protects neurovascular units from oxygen-glucose deprivation and reoxygenation-induced injury in vitro. Evid Based Complement Alternat Med. 2018;2018:9859672. doi:10.1155/2018/956706129853981
   PubMed Web of Science ®Google Scholar
• Zhao H, Liu Y, Zeng J, Li D, Huang Y. Troxerutin cerebroprotein hydrolysate injection ameliorates neurovascular injury induced by traumatic brain injury, via endothelial nitric oxide synthase pathway regulation. Int J Neurosci. 2018;128:1118–1127. doi:10.1080/00207454.2018.148682829883225
   PubMed Web of Science ®Google Scholar
• Longa EZ, Weinstein PR, Carlason S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84–91.2643202
   PubMed Web of Science ®Google Scholar
• Garcia JH, Wagner S, Liu KF, Hu XJ. Neurological deficit and extent of neuronal necreosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 1995;26:627–634.7709410
   PubMed Web of Science ®Google Scholar
• Pan JY, Cai RX, Chen Y, et al. Analysis the effect of hyperbaric oxygen preconditioning on neuronal apoptosis, Ca2+ concentration and caspases expression after spinal cord injury in rats. Eur Rev Med Pharmacol Sci. 2018;22:3467–3473. doi:10.26355/eurrev_201806_1517229917200
   PubMed Web of Science ®Google Scholar
• Baluchnejadmojarad T, Jamali-Raeufy N, Zabihnejad S, Rabiee N, Roghani M. Troxerutin exerts neuroprotection in 6-hydroxydopamine lesion rat model of Parkinson’s disease: possible involvement of PI3K/ER-beta signaling. Eur J Pharmacol. 2017;810:72–78. doi:10.1016/j.ejphar.2017.03.002
   Web of Science ®Google Scholar
• An L, Han X, Li H, et al. Effects of mechanism of cerebroprotein dydrolysate on learning and memory ability in mice. Genet Mol Res. 2016;15:15038804. doi:10.4238/gmr.15038804
   Web of Science ®Google Scholar
• Stornetta RL. Identification of neurotransmitters and co-localization of transmitters in brain stem respiratory neurons. Respir Physiol Neurobiol. 2008;164:18–27. doi:10.1016/j.resp.2008.07.02418722563
   PubMed Web of Science ®Google Scholar
• Wang G, Han T, Nijhawan D, et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell. 2014;158:1324–1334. doi:10.1016/j.cell.2014.07.04025215490
   PubMed Web of Science ®Google Scholar
• Quillinan N, Herson PS, Traystman RJ. Neuropathophysiology of brain injury. Anesthesiol Clin. 2016;34:453–464. doi:10.1016/j.anclin.2016.04.01127521191
   PubMedGoogle Scholar
• Chen CH, Jiang Z, Yan JH, et al. The involvement of programmed cell death 5 (PDCD5) in the regulation of apoptosis in cerebral ischemia/reperfusion injury. CNS Neurosci Ther. 2013;19:566–576. doi:10.1111/cns.1211423638963
   PubMed Web of Science ®Google Scholar
• Nijboer CH, Heijnen CJ, Groenendaal F, May MJ, van Bel F, Kavelaars A. A dual role of the NF-kappa B pathway in neonatal hypoxic-ischemic brain damage. Stroke. 2008;39:2578–2586. doi:10.1161/STROKEAHA.108.51640118420947
   PubMed Web of Science ®Google Scholar
• Wang GH, Lan R, Zhen XD, Zhang W, Xiang J, Cai D-F. An-Gong-Niu-Huang Wan protects against cerebral ischemia induced apoptosis in rats: up-regulation of Bcl-2 and down-regulation of Bax and caspaase-3. J Ethnopharmacol. 2014;154:156–162. doi:10.1016/j.jep.2014.03.05724690773
   PubMed Web of Science ®Google Scholar
• Shabanzadeh AP, D’Onofrio PM, Monnier PP, Koeberle PD. Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke. Cell Death Dis. 2015;6:e1967. doi:10.1038/cddis.2015.27226539914
   PubMed Web of Science ®Google Scholar
• Akpan N, Troy CM. Caspases inhibitors: prospective therapeutic for stroke. Neuroscientist. 2013;19:129–136. doi:10.1177/107385841244787522645109
   PubMed Web of Science ®Google Scholar
• Shan Q, Zhuang J, Zheng G, et al. Troxerutin reduces kindey damage against BDE-47-induced apoptosis via inhibiting NOX2 activity and increasing Nrf2 activity. Oxid Med Cell Longev. 2017;2017:6034692. doi:10.1155/2017/603469229163754
   PubMed Web of Science ®Google Scholar