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Review

Bridging the Gap Between Physical Health and Autism Spectrum Disorder

, , , ORCID Icon &
Pages 1605-1618 | Published online: 30 Jun 2020

References

  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: Diagnostic and Statistical Manual of Mental Disorders. Fifth Arlington, VA; 2013.
  • Whiteley P, Carr K, Shattock P, et al. Is autism inborn and lifelong for everyone? Neuropsychiatr Dis Treat. 2019;15:2885–2891. doi:10.2147/NDT.S22190131632036
  • Fein D, Barton M, Eigsti I-M, et al. Optimal outcome in individuals with a history of autism. J Child Psychol Psychiatry. 2003;54:195–205. doi:10.1111/jcpp.12037
  • Wise EA, Smith MD, Rabins PV, et al. Aging and autism spectrum disorder: a naturalistic, longitudinal study of the comorbidities and behavioural and neuropsychiatric symptoms in adults with ASD. J Autism Dev Disord. 2017;47(6):1708–1715. doi:10.1007/s10803-017-3095-328303420
  • Whiteley P. Nutritional management of (some) autism: a case for gluten- and casein-free diets? Proc Nutr Soc. 2015;74(3):202–207. doi:10.1017/S002966511400147525311313
  • Baron-Cohen S, Scott FJ, Allison C, et al. Prevalence of autism-spectrum conditions: UK school-based population study. Br J Psychiatry. 2009;194(6):500–509. doi:10.1192/bjp.bp.108.05934519478287
  • Zablotsky B, Black LI, Maenner MJ, et al. Estimated Prevalence of autism and other developmental disabilities following questionnaire changes in the 2014 National Health Interview Survey. Natl Health Stat Rep. 2015;87:1–20.
  • Baio J, Wiggins L, Christensen DL, et al. Prevalence of autism spectrum disorder among children aged 8 years — autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014. MMWR Morb Mortal Wkly Rep. 2018;67(6):1–23.29324727
  • Xu G, Strathearn L, Liu B, et al. Prevalence of autism spectrum disorder among US children and adolescents, 2014–2016. JAMA. 2018;319(1):81–82. doi:10.1001/jama.2017.1781229297068
  • Blumberg SJ, Bramlett MD, Kogan MD, et al. Changes in prevalence of parent-reported autism spectrum disorder in school-aged U.S. children: 2007 to 2011–2012. Natl Health Stat Report. 2013;65:1–11.
  • Lyall K, Croen L, Daniels J, et al. The changing epidemiology of autism spectrum disorders. Annu Rev Public Health. 2017;38(1):81–102. doi:10.1146/annurev-publhealth-031816-04431828068486
  • Waugh I. The Prevalence of Autism (Including Asperger Syndrome) in School Age Children in Northern Ireland 2019. Northern Ireland Department of Health; 5 2019.
  • Sun X, Allison C, Wei L, et al. Autism prevalence in China is comparable to Western prevalence. Mol Autism. 2019;10:7. doi:10.1186/s13229-018-0246-030858963
  • Kim YS, Leventhal BL, Koh Y-J, et al. Prevalence of autism spectrum disorders in a total population sample. Am J Psychiatry. 2011;168(9):904–912. doi:10.1176/appi.ajp.2011.1010153221558103
  • Rice CE, Rosanoff M, Dawson G, et al. Evaluating changes in the prevalence of the autism spectrum disorders (ASDs). Public Health Rev. 2012;34(2):1–22. doi:10.1007/BF0339168526236074
  • Hertz-Picciotto I, Delwiche L. The rise in autism and the role of age at diagnosis. Epidemiology. 2009;2:84–90. doi:10.1097/EDE.0b013e3181902d15
  • Russell G, Collishaw S, Golding J, et al. Changes in diagnosis rates and behavioural traits of autism spectrum disorder over time. BJPsych Open. 2015;1(2):110–115. doi:10.1192/bjpo.bp.115.00097627703734
  • Sandin S, Lichtenstein P, Kuja-Halkola R, et al. The heritability of autism spectrum disorder. JAMA. 2017;318(12):1182–1184. doi:10.1001/jama.2017.1214128973605
  • Hallmayer J, Cleveland S, Torres A, et al. Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry. 2011;68(11):1095–1102. doi:10.1001/archgenpsychiatry.2011.7621727249
  • Modabbernia A, Velthorst E, Reichenberg A, et al. Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses. Mol Autism. 2017;8:13. doi:10.1186/s13229-017-0121-428331572
  • Emberti Gialloreti L, Mazzone L, Benvenuto A, et al. Risk and protective environmental factors associated with autism spectrum disorder: evidence-based principles and recommendations. J Clin Med. 2019;8(2):217. doi:10.3390/jcm8020217
  • Getahun D, Fassett M, Peltier M, et al. Association of perinatal risk factors with autism spectrum disorder. Am J Perinatol. 2017;34(03):295–304. doi:10.1055/s-0036-159762428099978
  • Gilberg C, Coleman M. The Biology of Autistic Disorders. Clinics in Developmental Medicine. 3rd ed. London, United Kingdom: Mac Keith Press; 2000.
  • Saffari A, Arno M, Nasser E, et al. RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation. Mol Autism. 2019;10:38. doi:10.1186/s13229-019-0285-131719968
  • Saxena V, Ramdas S, Ochoa CR, et al. Structural, genetic, and functional signatures of disordered neuro-immunological development in autism spectrum disorder. PLoS One. 2012;7(12):e48835. doi:10.1371/journal.pone.004883523239965
  • Castelbaum L, Sylvester CM, Zhang Y, et al. On the nature of monozygotic twin concordance and discordance for autistic trait severity: a quantitative analysis. Behav Genet. 2019. doi:10.1007/s10519-019-09987-2
  • Tamouza R, Fernell E, Eriksson MA, et al. HLA polymorphism in regressive and non-regressive autism: a preliminary study. Autism Res. 2019. doi:10.1002/aur.2217
  • Nazeen S, Palmer NP, Berger B, et al. Integrative analysis of genetic data sets reveals a shared innate immune component in autism spectrum disorder and its co-morbidities. Genome Biol. 2016;17(1):228. doi:10.1186/s13059-016-1084-z27842596
  • Croen L, Zerbo O, Qian Y, et al. The health status of adults on the autism spectrum. Autism. 2015;19(7):814–823. doi:10.1177/136236131557751725911091
  • Gurney JG, McPheeters ML, Davis MM, et al. Parental report of health conditions and health care use among children with and without autism: national Survey of Children’s Health. Arch Pediatr Adolesc Med. 2006;160(8):825–830. doi:10.1001/archpedi.160.8.82516894082
  • Bishop-Fitzpatrick L, Rubenstein E. The physical and mental health of middle aged and older adults on the autism spectrum and the impact of intellectual disability. Res Autism Spectr Disord. 2019;63:34–41. doi:10.1016/j.rasd.2019.01.00131768189
  • Fortuna RJ, Robinson L, Smith TH, et al. Health conditions and functional status in adults with autism: a cross-sectional evaluation. J Gen Intern Med. 2016;31(1):77–84. doi:10.1007/s11606-015-3509-x26361965
  • Vohra R, Madhavan S, Sambamoorthi U, et al. Comorbidity prevalence, healthcare utilization, and expenditures of Medicaid enrolled adults with autism spectrum disorders. Autism. 2017;21(8):995–1009. doi:10.1177/136236131666522227875247
  • Losh M, Esserman D, Anckarsäter H, et al. Lower birth weight indicates higher risk of autistic traits in discordant twin pairs. Psychol Med. 2012;42(5):1091–1102. doi:10.1017/S003329171100233922132806
  • Pan P-Y, Tammimies K, Bölte S, et al. The association between somatic health, autism spectrum disorder, and autistic traits. Behav Genet. 2019. doi:10.1007/s10519-019-09986-3
  • Willfors C, Carlsson T, Anderlid B-M, et al. Medical history of discordant twins and environmental etiologies of autism. Transl Psychiatry. 2017;7(1):e1014. doi:10.1038/tp.2016.26928140403
  • Dillenburger K, Jordan J-A, McKerr L, et al. The Millennium child with autism: early childhood trajectories for health, education and economic wellbeing. Dev Neurorehabil. 2015;18:37–46. doi:10.3109/17518423.2014.96437825289682
  • Smith DaWalt L, Hong J, Greenberg JS, et al. Mortality in individuals with autism spectrum disorder: predictors over a 20-year period. Autism. 2019;23(7):1732–1739. doi:10.1177/136236131982741230818975
  • Hwang YI (Jane), Srasuebkul P, Foley K-R, et al. Mortality and cause of death of Australians on the autism spectrum. Autism Res. 2019;12(5):806–815. doi:10.1002/aur.208630802364
  • Shavelle RM, Strauss DJ, Pickett J, et al. Causes of death in autism. J Autism Dev Disord. 2001;31(6):569–576. doi:10.1023/A:101324701148311814268
  • Datlow Smith M, Graveline PJ, Smith JB, et al. Autism and obstacles to medical diagnosis and treatment. Focus Autism Other Dev Disabl. 2012;27:189–195. doi:10.1177/1088357612450049
  • Vargas DL, Nascimbene C, Krishnan C, et al. Neuroglial activation and neuroinflammation in the brain of patients with autism [published correction appears in Ann Neurol. 2005 Feb;57(2):304]. Ann Neurol. 2005;57(1):67–81. doi:10.1002/ana.2031515546155
  • Rodriguez JI, Kern JK. Evidence of microglial activation in autism and its possible role in brain underconnectivity. Neuron Glia Biol. 2011;7(2–4):205–213. doi:10.1017/S1740925X1200014222874006
  • Young AM, Chakrabarti B, Roberts D, et al. From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition. Mol Autism. 2016;7:9. doi:10.1186/s13229-016-0068-x26793298
  • DiStasio MM, Nagakura I, Nadler MJ, et al. T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains. Ann Neurol. 2019;86(6):885–898. doi:10.1002/ana.2561031591744
  • Masi A, Glozier N, Dale R, et al. The immune system, cytokines, and biomarkers in autism spectrum disorder. Neurosci Bull. 2017;33(2):194–204. doi:10.1007/s12264-017-0103-828238116
  • Carlezon WA Jr., Kim W, Missig G, et al. Maternal and early postnatal immune activation produce sex-specific effects on autism-like behaviors and neuroimmune function in mice. Sci Rep. 2019;9(1):16928. doi:10.1038/s41598-019-53294-z31729416
  • Thom RP, Keary CJ, Palumbo ML, et al. Beyond the brain: A multi-system inflammatory subtype of autism spectrum disorder. Psychopharmacology (Berl). 2019;236(10):3045–3061. doi:10.1007/s00213-019-05280-631139876
  • Al-Ayadhi LY, Mostafa GA. Elevated serum levels of macrophage-derived chemokine and thymus and activation-regulated chemokine in autistic children. J Neuroinflammation. 2013;10(1):72. doi:10.1186/1742-2094-10-7223782855
  • Grigorenko EL, Han SS, Yrigollen CM, et al. Macrophage migration inhibitory factor and autism spectrum disorders. Pediatrics. 2008;122(2):e438–e445. doi:10.1542/peds.2007-360418676531
  • Heuer L, Ashwood P, Schauer J, et al. Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism Res. 2008;1(5):275–283. doi:10.1002/aur.4219343198
  • Onore C, Careaga M, Ashwood P, et al. The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun. 2012;26(3):383–392. doi:10.1016/j.bbi.2011.08.00721906670
  • Gupta S, Ellis SE, Ashar FN, et al. Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nat Commun. 2014;5(1):5748. doi:10.1038/ncomms674825494366
  • Bennabi M, Gaman A, Delorme R, et al. HLA-class II haplotypes and autism spectrum disorders. Sci Rep. 2018;8(1):7639. doi:10.1038/s41598-018-25974-929769579
  • Jung J-Y, Kohane IS, Wall DP, et al. Identification of autoimmune gene signatures in autism. Transl Psychiatry. 2011;1(12):e63. doi:10.1038/tp.2011.6222832355
  • Brown AS, Sourander A, Hinkka-Yli-Salomäki S, et al. Elevated maternal C-reactive protein and autism in a national birth cohort. Mol Psychiatry. 2014;19(2):259–264. doi:10.1038/mp.2012.19723337946
  • Chess S. Autism in children with congenital rubella. J Autism Child Schizophr. 1971;1(1):33–47. doi:10.1007/BF015377415172438
  • Maeyama K, Tomioka K, Nagase H, et al. Congenital cytomegalovirus infection in children with autism spectrum disorder: systematic review and meta-analysis. J Autism Dev Disord. 2018;48(5):1483–1491. doi:10.1007/s10803-017-3412-x29185167
  • Atladóttir HO, Pedersen MG, Thorsen P, et al. Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics. 2009;124(2):687–694. doi:10.1542/peds.2008-244519581261
  • Spann MN, Timonen-Soivio L, Suominen A, et al. Proband and familial autoimmune diseases are associated with proband diagnosis of autism spectrum disorders. J Am Acad Child Adolesc Psychiatry. 2019;58(5):496–505. doi:10.1016/j.jaac.2018.09.44430975444
  • Vinet E, Pineau CA, Clarke AE, et al. Increased risk of autism spectrum disorders in children born to women with systemic lupus erythematosus: results from a large population-based cohort. Arthritis Rheumatol. 2015;67(12):3201–3208. doi:10.1002/art.3932026315754
  • Theoharides TC, Tsilioni I, Patel AB, et al. Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders. Transl Psychiatry. 2016;6(6):e844. doi:10.1038/tp.2016.7727351598
  • Li X, Chauhan A, Sheikh AM, et al. Elevated immune response in the brain of autistic patients. J Neuroimmunol. 2009;207(1–2):111–116. doi:10.1016/j.jneuroim.2008.12.00219157572
  • Morgan JT, Chana G, Pardo CA, et al. Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biol Psychiatry. 2010;68:368–376. doi:10.1016/j.biopsych.2010.05.02420674603
  • Suzuki K, Sugihara G, Ouchi Y, et al. Microglial activation in young adults with autism spectrum disorder. JAMA Psychiatry. 2013;70(1):49–58. doi:10.1001/jamapsychiatry.2013.27223404112
  • Young AMH, Campbell E, Lynch S, et al. Aberrant NF-kappaB expression in autism spectrum condition: a mechanism for neuroinflammation. Front Psychiatry. 2011;2:27. doi:10.3389/fpsyt.2011.0002721629840
  • Adams F, Quesada JR, Gutterman JU, et al. Neuropsychiatric manifestations of human leukocyte interferon therapy in patients with cancer. JAMA. 1984;252(7):938–941. doi:10.1001/jama.1984.033500700560266748198
  • Niiranen A, Laaksonen R, livanainen M, et al. Behavioral assessment of patients treated with alpha‐interferon. Acta Psychiatr Scand. 1988;78:622–626. doi:10.1111/j.1600-0447.1988.tb06395.x3232542
  • Dada T, Rosenzweig JM, Al Shammary M, et al. Mouse model of intrauterine inflammation: sex-specific differences in long-term neurologic and immune sequelae. Brain Behav Immun. 2014;38:142–150. doi:10.1016/j.bbi.2014.01.01424486323
  • Martin LA, Ashwood P, Braunschweig D, et al. Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behav Immun. 2008;22(6):806–816. doi:10.1016/j.bbi.2007.12.00718262386
  • Filiano AJ, Xu Y, Tustison NJ, et al. Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature. 2016;535(7612):425–429. doi:10.1038/nature1862627409813
  • Rose DR, Careaga M, Van de Water J, et al. Long-term altered immune responses following fetal priming in a non-human primate model of maternal immune activation. Brain Behav Immun. 2017;63:60–70. doi:10.1016/j.bbi.2016.11.02027876552
  • Patterson P. Infectious Behaviour: Brain-Immune Connections in Autism, Schizophrenia, and Depression. MIT Press; 2012.
  • Allard M-J, Bergeron JD, Baharnoori M, et al. A sexually dichotomous, autistic‐like phenotype is induced by Group B Streptococcus maternofetal immune activation. Autism Res. 2017;10:233–245. doi:10.1002/aur.164727220806
  • Schwartzer JJ, Careaga M, Chang C, et al. Allergic fetal priming leads to developmental, behavioral and neurobiological changes in mice. Transl Psychiatry. 2015;5(4):e543. doi:10.1038/tp.2015.4025849982
  • Chen SW, Zhong XS, Jiang LN, et al. Maternal autoimmune diseases and the risk of autism spectrum disorders in offspring: a systematic review and meta-analysis. Behav Brain Res. 2016;296:61–69. doi:10.1016/j.bbr.2015.08.03526327239
  • Gata-Garcia A, Diamond B. Maternal antibody and ASD: clinical data and animal models. Front Immunol. 2019;10:1129. doi:10.3389/fimmu.2019.0112931191521
  • Brimberg L, Sadiq A, Gregersen PK, et al. Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder. Mol Psychiatry. 2013;18(11):1171–1177. doi:10.1038/mp.2013.10123958959
  • Piras IS, Haapanen L, Napolioni V, et al. Anti-brain antibodies are associated with more severe cognitive and behavioural profiles in Italian children with Autism Spectrum Disorder. Brain Behav Immun. 2014;38:91–99. doi:10.1016/j.bbi.2013.12.02024389156
  • Bauman MD, Iosif A-M, Smith SEP, et al. Activation of the maternal immune system during pregnancy alters behavioural development of rhesus monkey offspring. Biol Psychiatry. 2014;75(4):332–341. doi:10.1016/j.biopsych.2013.06.02524011823
  • Mostafa GA, Al-Ayadhi LY. The relationship between the increased frequency of serum antineuronal antibodies and the severity of autism in children. Eur J Paediatr Neurol. 2012;16(5):464–468. doi:10.1016/j.ejpn.2011.12.01022226851
  • Frye RE, Sequeira JM, Quadros EV, et al. Cerebral folate receptor autoantibodies in autism spectrum disorder. Mol Psychiatry. 2013;18(3):369–381. doi:10.1038/mp.2011.17522230883
  • Mostafa GA, El-Sherif DF, Al-Ayadhi LY, et al. Systemic auto-antibodies in children with autism. J Neuroimmunol. 2014;272(1–2):94–98. doi:10.1016/j.jneuroim.2014.04.01124837704
  • Goncalves MVM, Harger R, Braatz V, et al. Pediatric acute-onset neuropsychiatric syndrome (PANS) misdiagnosed as autism spectrum disorder. Immunol Lett. 2018;203:52–53. doi:10.1016/j.imlet.2018.09.00930222991
  • Orlovska S, Vestergaard CH, Bech BH, et al. Association of streptococcal throat infection with mental disorders: testing key aspects of the PANDAS hypothesis in a Nationwide Study. JAMA Psychiatry. 2017;74(7):740–746. doi:10.1001/jamapsychiatry.2017.099528538981
  • Barger BD, Campbell JM, McDonough JD, et al. Prevalence and onset of regression within autism spectrum disorders: a meta-analytic review. J Autism Dev Disord. 2013;43(4):817–828. doi:10.1007/s10803-012-1621-x22855372
  • Goin-Kochel RP, Esler AN, Kanne SM, et al. Developmental regression among children with autism spectrum disorder: onset, duration, and effects on functional outcomes. Res Autism Spectr Disord. 2014;8(7):890–898. doi:10.1016/j.rasd.2014.04.002
  • Scott O, Shi D, Andriashek D, et al. Clinical clues for autoimmunity and neuroinflammation in patients with autistic regression. Dev Med Child Neurol. 2017;59(9):947–951. doi:10.1111/dmcn.1343228383115
  • Thompson L, Gillberg C, Landberg S, et al. Autism with and without regression: a two-year prospective longitudinal study in two population-derived swedish cohorts. J Autism Dev Disord. 2019;49(6):2281–2290. doi:10.1007/s10803-018-03871-430734177
  • DeLong GR, Bean SC, Brown FR, et al. Acquired reversible autistic syndrome in acute encephalopathic illness in children. Arch Neurol. 1981;38(3):191–194. doi:10.1001/archneur.1981.005100300850136162440
  • Akcakaya NH, Tekturk P, Cagatay A, et al. Atypical enterovirus encephalitis causing behavioral changes and autism-like clinical manifestations: case report. Acta Neurol Belg. 2016;116(4):679–681. doi:10.1007/s13760-016-0614-526895551
  • Marques F, Brito MJ, Conde M, et al. Autism spectrum disorder secondary to enterovirus encephalitis. J Child Neurol. 2014;29(5):708–714. doi:10.1177/088307381350831424782421
  • Mankoski RE, Collins M, Ndosi NK, et al. Etiologies of autism in a case-series from Tanzania. J Autism Dev Disord. 2006;36(8):1039. doi:10.1007/s10803-006-0143-916897390
  • Gillberg C. Onset at age 14 of a typical autistic syndrome. A case report of a girl with herpes simplex encephalitis. J Autism Dev Disord. 1986;16(3):369–375. doi:10.1007/BF015316653558293
  • Gillberg IC. Autistic syndrome with onset at age 31 years: herpes encephalitis as a possible model for childhood autism. Dev Med Child Neurol. 1991;33:920–924. doi:10.1111/j.1469-8749.1991.tb14804.x1743418
  • Baldaçara L, Diniz T, Parreira B, et al. Organic mental disorder after pneumococcal meningoencephalitis with autism-like symptoms. Braz J Psychiatry. 2011;33(4):410–411. doi:10.1590/S1516-4446201100040001622189932
  • Ghaziuddin M, Al-Khouri I, Ghaziuddin N, et al. Autistic symptoms following herpes encephalitis. Eur Child Adolesc Psychiatry. 2002;11(3):142–146. doi:10.1007/s00787-002-0271-512369775
  • Hacohen Y, Wright S, Gadian J, et al. N-methyl-d-aspartate (NMDA) receptor antibodies encephalitis mimicking an autistic regression. Dev Med Child Neurol. 2016;58(10):1092–1094. doi:10.1111/dmcn.1316927255282
  • González-Toro MC, Jadraque-Rodríguez R, Sempere-Pérez Á, et al. Encefalitis antirreceptor de NMDA: dos casos pediátricos [Anti-NMDA receptor encephalitis: two paediatric cases]. Rev Neurol. 2013;57(11):504–508.24265144
  • Scott O, Richer L, Forbes K, et al. Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis: an unusual cause of autistic regression in a toddler. J Child Neurol. 2014;29(5):691–694. doi:10.1177/088307381350187524092894
  • Matoq AA, Rappoport AS, Yang Y, et al. Anti-NMDA-receptor antibody encephalitis in infants. Epilepsy Behav Case Rep. 2015;4:99–101. doi:10.1016/j.ebcr.2015.07.00526744696
  • Schieveld JNM. Case reports with a child psychiatric exploration of catatonia, autism, and delirium. Int Rev Neurobiol. 2006;72:195–206.16697299
  • Khandaker GM, Zammit S, Lewis G, et al. A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence. Schizophr Res. 2014;152(1):139–145. doi:10.1016/j.schres.2013.09.02124268471
  • Chang HY, Seo J-H, Kim HY, et al. Allergic diseases in preschoolers are associated with psychological and behavioural problems. Allergy Asthma Immunol Res. 2013;5(5):315–321. doi:10.4168/aair.2013.5.5.31524003389
  • Dahl RE, Bernhisel-Broadbent J, Scanlon-Holdford S, et al. Sleep disturbances in children with atopic dermatitis. Arch Pediatr Adolesc Med. 1995;149(8):856–860. doi:10.1001/archpedi.1995.021702100300057633537
  • Goodwin RD, Galea S, Perzanowski M, et al. Impact of allergy treatment on the association between allergies and mood and anxiety in a population sample. Clin Exp Allergy. 2012;42(12):1765–1771. doi:10.1111/j.1365-2222.2012.04042.x23181792
  • Xu G, Snetselaar LG, Jing J, et al. Association of food allergy and other allergic conditions with autism spectrum disorder in children. JAMA Netw Open. 2018;1(2):e180279. doi:10.1001/jamanetworkopen.2018.027930646068
  • Mostafa GA, Hamza RT, El-Shahawi HH, et al. Allergic manifestations in autistic children: relation to disease severity. J Paediatr Neurol. 2008;6:115–123.
  • Shibata A, Hitomi Y, Kambayashi Y, et al. Epidemiological study on the involvements of environmental factors and allergy in child mental health using the Autism Screening Questionnaire. Res Autism Spectr Disord. 2013;7(1):132–140. doi:10.1016/j.rasd.2012.06.003
  • Lyall K, Van de Water J, Ashwood P, et al. Asthma and allergies in children with autism spectrum disorders: results from the CHARGE study. Autism Res. 2015;8(5):567–574. doi:10.1002/aur.147125722050
  • Boris M, Goldblatt A. Pollen exposure as a cause for the deterioration of neurobehavioural function in children with autism and attention deficit hyperactive disorder: nasal pollen challenge. J Nutr Environ Med. 2004;14:47–54. doi:10.1080/13590840410001695176
  • Jyonouchi H. Autism spectrum disorders and allergy: observation from a pediatric allergy/immunology clinic. Expert Rev Clin Immunol. 2010;6(3):397–411. doi:10.1586/eci.10.1820441426
  • Angelidou A, Alysandratos K-D, Asadi S, et al. Brief report: “allergic symptoms” in children with autism spectrum disorders. More than meets the eye? J Autism Dev Disord. 2011;41(11):1579–1585. doi:10.1007/s10803-010-1171-z21210299
  • Theoharides TC. Is a subtype of autism an allergy of the brain? Clin Ther. 2013;35(5):584–591. doi:10.1016/j.clinthera.2013.04.00923688533
  • Yadama AP, Kelly RS, Lee-Sarwar K, et al. Allergic disease and low ASQ communication score in children. Brain Behav Immun. 2020;83:293–297. doi:10.1016/j.bbi.2019.10.00831606476
  • Kordulewska NK, Kostyra E, Chwała B, et al. A novel concept of immunological and allergy interactions in autism spectrum disorders: molecular, anti-inflammatory effect of osthole. Int Immunopharmacol. 2019;72:1–11. doi:10.1016/j.intimp.2019.01.05830953868
  • de Theije CGM, Wu J, Koelink PJ, et al. Autistic-like behavioural and neurochemical changes in a mouse model of food allergy. Behav Brain Res. 2014;261:265–274. doi:10.1016/j.bbr.2013.12.00824333575
  • Liezmann C, Klapp B, Peters E, et al. Stress, atopy and allergy: A re-evaluation from a psychoneuroimmunologic perspective. Dermatoendocrinol. 2011;3:37–40. doi:10.4161/derm.3.1.1461821519408
  • Lefter R, Ciobica A, Timofte D, et al. A descriptive review on the prevalence of gastrointestinal disturbances and their multiple associations in autism spectrum disorder. Medicina (Kaunas). 2019;56(1):E11. doi:10.3390/medicina5601001131892195
  • Lee M, Krishnamurthy J, Susi A, et al. Association of autism spectrum disorders and inflammatory bowel disease. J Autism Dev Disord. 2018;48(5):1523–1529. doi:10.1007/s10803-017-3409-529170940
  • Kushak RI, Lauwers GY, Winter HS, et al. Intestinal disaccharidase activity in patients with autism: effect of age, gender, and intestinal inflammation. Autism. 2011;15(3):285–294. doi:10.1177/136236131036914221415091
  • de Magistris L, Familiari V, Pascotto A, et al. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J Pediatr Gastroenterol Nutr. 2010;51(4):418–424. doi:10.1097/MPG.0b013e3181dcc4a520683204
  • Hughes HK, Rose D, Ashwood P, et al. The gut microbiota and dysbiosis in autism spectrum disorders. Curr Neurol Neurosci Rep. 2018;18(11):81. doi:10.1007/s11910-018-0887-630251184
  • Torrente F, Anthony A, Heuschkel RB, et al. Focal-enhanced gastritis in regressive autism with features distinct from Crohn’s and Helicobacter pylori gastritis. Am J Gastroenterol. 2004;99(4):598–605. doi:10.1111/j.1572-0241.2004.04142.x15089888
  • Walker SJ, Fortunato J, Gonzalez LG, et al. Identification of unique gene expression profile in children with regressive autism spectrum disorder (ASD) and ileocolitis. PLoS One. 2013;8(3):e58058. doi:10.1371/journal.pone.005805823520485
  • Gorrindo P, Williams KC, Lee EB, et al. Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors. Autism Res. 2012;5(2):101–108. doi:10.1002/aur.23722511450
  • Chaidez V, Hansen RL, Hertz-Picciotto I, et al. Gastrointestinal problems in children with autism, developmental delays or typical development. J Autism Dev Disord. 2014;44(5):1117–1127. doi:10.1007/s10803-013-1973-x24193577
  • Mazurek MO, Vasa RA, Kalb LG, et al. Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders. J Abnorm Child Psychol. 2013;41(1):165–176. doi:10.1007/s10802-012-9668-x22850932
  • Prosperi M, Santocchi E, Muratori F, et al. Vocal and motor behaviours as a possible expression of gastrointestinal problems in preschoolers with autism spectrum disorder. BMC Pediatr. 2019;19(1):466. doi:10.1186/s12887-019-1841-831779607
  • Ding HT, Taur Y, Walkup JT, et al. Gut microbiota and autism: key concepts and findings. J Autism Dev Disord. 2017;47(2):480–489. doi:10.1007/s10803-016-2960-927882443
  • Yap IKS, Angley M, Veselkov KA, et al. Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. J Proteome Res. 2010;9(6):2996–3004. doi:10.1021/pr901188e20337404
  • Williams BL, Hornig M, Parekh T, et al. Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. MBio. 2012;3(1):e00261–11. doi:10.1128/mBio.00261-1122233678
  • Ng QX, Loke W, Venkatanarayanan N, et al. A systematic review of the role of prebiotics and probiotics in autism spectrum disorders. Medicina (Kaunas). 2019;55(5):129. doi:10.3390/medicina55050129
  • Kang D-W, Adams JB, Coleman DM, et al. Long-term benefit of microbiota transfer therapy on autism symptoms and gut microbiota. Sci Rep. 2019;9(1):5821. doi:10.1038/s41598-019-42183-030967657
  • Mangiola F, Ianiro G, Franceschi F, et al. Gut microbiota in autism and mood disorders. World J Gastroenterol. 2016;22(1):361–368. doi:10.3748/wjg.v22.i1.36126755882
  • Furuta GT, Williams K, Kooros K, et al. Management of constipation in children and adolescents with autism spectrum disorders. Pediatrics. 2012;130(Suppl 2):S98–S105. doi:10.1542/peds.2012-0900H23118260
  • Coury DL, Ashwood P, Fasano A, et al. Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda. Pediatrics. 2012;130(Suppl 2):S160–S168. doi:10.1542/peds.2012-0900N23118247
  • Goodwin MS, Goodwin TC, Cowen MA. Malabsorption and cerebral dysfunction: a multivariate and comparative study of autistic children. J Autism Child Schizophr. 1971;1(1):48–62. doi:10.1007/BF015377425172439
  • Herbert MR, Buckley JA. Autism and dietary therapy: case report and review of the literature. J Child Neurol. 2013;28(8):975–982. doi:10.1177/088307381348866823666039
  • El-Rashidy O, El-Baz F, El-Gendy Y, et al. Ketogenic diet versus gluten free casein free diet in autistic children: a case-control study. Metab Brain Dis. 2017;32(6):1935–1941. doi:10.1007/s11011-017-0088-z28808808
  • Whiteley P, Shattock P, Knivsberg AM, et al. Gluten- and casein-free dietary intervention for autism spectrum conditions. Front Hum Neurosci. 2013;6:344. doi:10.3389/fnhum.2012.0034423316152
  • Pedersen L, Parlar S, Kvist K, et al. Data mining the ScanBrit study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders: behavioural and psychometric measures of dietary response. Nutr Neurosci. 2014;17(5):207–213. doi:10.1179/1476830513Y.000000008224075141
  • Calderoni S, Santocchi E, Del Bianco T, et al. Serological screening for celiac disease in 382 pre-schoolers with autism spectrum disorder. Ital J Pediatr. 2016;42(1):98. doi:10.1186/s13052-016-0308-x27852289
  • Genuis SJ, Bouchard TP. Celiac disease presenting as autism. J Child Neurol. 2010;25(1):114–119. doi:10.1177/088307380933612719564647
  • Sapone A, Bai JC, Ciacci C, et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med. 2012;10(1):13. doi:10.1186/1741-7015-10-1322313950
  • Ludvigsson JF, Reichenberg A, Hultman CM, et al. A nationwide study of the association between celiac disease and the risk of autistic spectrum disorders. JAMA Psychiatry. 2013;70(11):1224–1230. doi:10.1001/jamapsychiatry.2013.204824068245
  • Lau NM, Green PHR, Taylor AK, et al. Markers of celiac disease and gluten sensitivity in children with autism. PLoS One. 2013;8(6):e66155. doi:10.1371/journal.pone.006615523823064
  • de Magistris L, Picardi A, Siniscalco D, et al. Antibodies against food antigens in patients with autistic spectrum disorders. Biomed Res Int. 2013;2013:729349. doi:10.1155/2013/72934923984403
  • Caio G, Volta U, Tovoli F, et al. Effect of gluten free diet on immune response to gliadin in patients with non-celiac gluten sensitivity. BMC Gastroenterol. 2014;14(1):26. doi:10.1186/1471-230X-14-2624524388
  • Massari S, Liso M, De Santis L, et al. Occurrence of nonceliac gluten sensitivity in patients with allergic disease. Int Arch Allergy Immunol. 2011;155(4):389–394. doi:10.1159/00032119621346369
  • Carroccio A, Mansueto P, Iacono G, et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Am J Gastroenterol. 2012;107(12):1898–1907. doi:10.1038/ajg.2012.23622825366
  • Ashwood P, Murch SH, Anthony A, et al. Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology. J Clin Immunol. 2003;23(6):504–517. doi:10.1023/B:JOCI.0000010427.05143.bb15031638
  • Chen B, Girgis S, El-Matary W, et al. Childhood autism and eosinophilic colitis. Digestion. 2010;81(2):127–129. doi:10.1159/00025276520068312
  • Hadjivassiliou M, Duker AP, Sanders DS. Gluten-related neurologic dysfunction. Handb Clin Neurol. 2014;120:607–619.24365341
  • Peters SL, Biesiekierski JR, Yelland GW, et al. Randomised clinical trial: gluten may cause depression in subjects with non-coeliac gluten sensitivity - an exploratory clinical study. Aliment Pharmacol Ther. 2014;39(10):1104–1112. doi:10.1111/apt.1273024689456
  • Besag FM. Epilepsy in patients with autism: links, risks and treatment challenges. Neuropsychiatr Dis Treat. 2017;14:1–10. doi:10.2147/NDT.S12050929296085
  • Lewine JD, Andrews R, Chez M, et al. Magnetoencephalographic patterns of epileptiform activity in children with regressive autism spectrum disorders. Pediatrics. 1999;104(3 Pt 1):405–418. doi:10.1542/peds.104.3.40510469763
  • Ertürk Çetin Ö, Korkmaz B, Alev G, et al. EEG abnormalities and long term seizure outcome in high functioning autism. Acta Neurol Belg. 2017;117(3):729–732. doi:10.1007/s13760-017-0785-828447214
  • Strasser L, Downes M, Kung J, et al. Prevalence and risk factors for autism spectrum disorder in epilepsy: a systematic review and meta-analysis. Dev Med Child Neurol. 2018;60(1):19–29. doi:10.1111/dmcn.1359829119560
  • García-Peñas JJ. Tratamiento con fármacos antiepilépticos en los sindromes de regresión autista [Antiepileptic drugs in the treatment of autistic regression syndromes]. Rev Neurol. 2005;40(Suppl 1):S173–S176.15736083
  • Ko C, Kim N, Kim E, et al. The effect of epilepsy on autistic symptom severity assessed by the social responsiveness scale in children with autism spectrum disorder. Behav Brain Funct. 2016;12(1):20. doi:10.1186/s12993-016-0105-027350381
  • Wang M, Jiang L, Tang X, et al. Levetiracetam is associated with decrease in subclinical epileptiform discharges and improved cognitive functions in pediatric patients with autism spectrum disorder. Neuropsychiatr Dis Treat. 2017;13:2321–2326. doi:10.2147/NDT.S14396628919764
  • Veerappan VD, Sweetha B, Kavitha HR, et al. Two-year follow-up of isolated epileptiform discharges in autism: an endophenotypic biomarker? [published correction appears in Indian J Psychol Med. 2018 Nov-Dec;40(6):602]. Indian J Psychol Med. 2018;40(3):219–224. doi:10.4103/IJPSYM.IJPSYM_555_1729875528
  • Swatzyna RJ, Tarnow JD, Turner RP, et al. Integration of EEG into psychiatric practice: a step toward precision medicine for autism spectrum disorder. J Clin Neurophysiol. 2017;34(3):230–235. doi:10.1097/WNP.000000000000036527893495
  • Kokoszka MA, McGoldrick PE, La Vega-talbott M, et al. Epilepsy surgery in patients with autism. J Neurosurg Pediatr. 2017;19(2):196–207. doi:10.3171/2016.7.PEDS165127885946
  • Shuper A, Mimouni M. Problems of differentiation between epilepsy and non-epileptic paroxysmal events in the first year of life. Arch Dis Child. 1995;73(4):342–344. doi:10.1136/adc.73.4.3427492200
  • Zheng Z, Zhang L, Li S, et al. Association among obesity, overweight and autism spectrum disorder: a systematic review and meta-analysis. Sci Rep. 2017;7(1):11697. doi:10.1038/s41598-017-12003-428916794
  • Kim E-K, Neggers YH, Shin C-S, et al. Alterations in lipid profile of autistic boys: a case control study. Nutr Res. 2010;30(4):255–260. doi:10.1016/j.nutres.2010.04.00220534328
  • Hill AP, Zuckerman KE, Fombonne E. Obesity and autism. Pediatrics. 2015;136(6):1051–1061. doi:10.1542/peds.2015-143726527551
  • Sanchez CE, Barry C, Sabhlok A, et al. Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis. Obes Rev. 2018;19(4):464–484. doi:10.1111/obr.1264329164765
  • Wang Y, Tang S, Xu S, et al. Maternal body mass index and risk of autism spectrum disorders in offspring: a meta-analysis. Sci Rep. 2016;6(1):34248. doi:10.1038/srep3424827687989
  • Delzenne NM, Neyrinck AM, Bäckhed F, et al. Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat Rev Endocrinol. 2011;7(11):639–646. doi:10.1038/nrendo.2011.12621826100
  • Weissman JR, Kelley RI, Bauman ML, et al. Mitochondrial disease in autism spectrum disorder patients: a cohort analysis. PLoS One. 2008;3(11):e3815. doi:10.1371/journal.pone.000381519043581
  • Goh S, Dong Z, Zhang Y, et al. Mitochondrial dysfunction as a neurobiological subtype of autism spectrum disorder: evidence from brain imaging. JAMA Psychiatry. 2014;71(6):665–671. doi:10.1001/jamapsychiatry.2014.17924718932
  • Rose S, Niyazov DM, Rossignol DA, et al. Clinical and molecular characteristics of mitochondrial dysfunction in autism spectrum disorder. Mol Diagn Ther. 2018;22(5):571–593. doi:10.1007/s40291-018-0352-x30039193
  • Rose S, Frye RE, Slattery J, et al. Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort. PLoS One. 2014;9(1):e85436. doi:10.1371/journal.pone.008543624416410
  • Alabdali A, Al-Ayadhi L, El-Ansary A, et al. A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders. Behav Brain Funct. 2014;10(1):14. doi:10.1186/1744-9081-10-1424776096
  • Hollis F, Kanellopoulos AK, Bagni C, et al. Mitochondrial dysfunction in autism spectrum disorder: clinical features and perspectives. Curr Opin Neurobiol. 2017;45:178–187. doi:10.1016/j.conb.2017.05.01828628841
  • Hadjixenofontos A, Schmidt MA, Whitehead PL, et al. Evaluating mitochondrial DNA variation in autism spectrum disorders. Ann Hum Genet. 2013;77(1):9–21. doi:10.1111/j.1469-1809.2012.00736.x23130936
  • Tang G, Rios PG, Kuo SH, et al. Mitochondrial abnormalities in temporal lobe of autistic brain. Neurobiol Dis. 2013;54:349–361. doi:10.1016/j.nbd.2013.01.00623333625
  • Palmieri L, Persico AM. Mitochondrial dysfunction in autism spectrum disorders: cause or effect? Biochim Biophys Acta. 2010;1797(6–7):1130–1137. doi:10.1016/j.bbabio.2010.04.01820441769
  • Ming X, Stein TP, Barnes V, et al. Metabolic perturbance in autism spectrum disorders: a metabolomics study. J Proteome Res. 2012;11(12):5856–5862. doi:10.1021/pr300910n23106572
  • Lasselin J, Capuron L. Chronic low-grade inflammation in metabolic disorders: relevance for behavioural symptoms. Neuroimmunomodulation. 2014;21(2–3):95–101. doi:10.1159/00035653524557041
  • Spilioti M, Evangeliou AE, Tramma D, et al. Evidence for treatable inborn errors of metabolism in a cohort of 187 Greek patients with autism spectrum disorder (ASD). Front Hum Neurosci. 2013;7:858. doi:10.3389/fnhum.2013.0085824399946
  • Krsička D, Geryk J, Vlčková M, et al. Identification of likely associations between cerebral folate deficiency and complex genetic- and metabolic pathogenesis of autism spectrum disorders by utilization of a pilot interaction modeling approach. Autism Res. 2017;10(8):1424–1435. doi:10.1002/aur.178028339176
  • Kanner L. Autistic disturbances of affective contact. Nerv Child. 1943;2:217–250.
  • Bell L, Wittkowski A, Hare DJ, et al. Movement disorders and syndromic autism: a systematic review. J Autism Dev Disord. 2019;49(1):54–67. doi:10.1007/s10803-018-3658-y30014250
  • Bal VH, Fok M, Lord C, et al. Predictors of longer-term development of expressive language in two independent longitudinal cohorts of language-delayed preschoolers with Autism Spectrum Disorder [published online ahead of print, 2019 Aug 19]. J Child Psychol Psychiatry. 2019. doi:10.1111/jcpp.13117
  • Cederlöf M, Larsson H, Lichtenstein P, et al. Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings. BMC Psychiatry. 2016;16:207. doi:10.1186/s12888-016-0922-627377649
  • Baum SH, Stevenson RA, Wallace MT, et al. Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder. Prog Neurobiol. 2015;134:140–160. doi:10.1016/j.pneurobio.2015.09.00726455789
  • O’Nions E, Happé F, Evers K, et al. How do parents manage irritability, challenging behaviour, non-compliance and anxiety in children with autism spectrum disorders? A meta-synthesis. J Autism Dev Disord. 2018;48(4):1272–1286. doi:10.1007/s10803-017-3361-429222612
  • Goldschmidt J. What happened to Paul? Manifestation of abnormal pain response for individuals with autism spectrum disorder. Qual Health Res. 2017;27(8):1133–1145. doi:10.1177/104973231664441527117957
  • Breau LM, Finley GA, McGrath PJ, et al. Validation of the non-communicating children’s pain checklist-postoperative version [published correction appears in Anesthesiology 2002 Sep;97(3):769]. Anesthesiology. 2002;96(3):528–535. doi:10.1097/00000542-200203000-0000411873023