Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment

References

• KesslerRCSonnegaABrometEHughesMNelsonCBPosttraumatic stress disorder in the National Comorbidity SurveyArch Gen Psychiatry19955212104810607492257
   PubMed Web of Science ®Google Scholar
• BoscarinoJAAdamsREPTSD onset and course following the World Trade Center disaster: findings and implications for future researchSoc Psychiatry Psychiatr Epidemiol2009441088789819277439
   PubMed Web of Science ®Google Scholar
• BreslauNKesslerRCChilcoatHDSchultzLRDavisGCAndreskiPTrauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of TraumaArch Gen Psychiatry19985576266329672053
   PubMed Web of Science ®Google Scholar
• SteinMBJangKLTaylorSVernonPALivesleyWJGenetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin studyAm J Psychiatry2002159101675168112359672
   PubMed Web of Science ®Google Scholar
• BinderEBBradleyRGLiuWAssociation of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adultsJAMA2008299111291130518349090
   PubMed Web of Science ®Google Scholar
• KoenenKCGenetics of posttraumatic stress disorder: review and recommendations for future studiesJ Trauma Stress200720573775017955543
   PubMed Web of Science ®Google Scholar
• NemeroffCBBremnerJDFoaEBMaybergHSNorthCSSteinMBPosttraumatic stress disorder: a state-of-the-science reviewJ Psychiatr Res200640112116242154
   PubMed Web of Science ®Google Scholar
• BroekmanBFOlffMBoerFThe genetic background to PTSDNeurosci Biobehav Rev200731334836217126903
   PubMed Web of Science ®Google Scholar
• BoscarinoJAErlichPMHoffmanSNRukstalisMStewartWFAssociation of FKBP5, COMT and CHRNA5 polymorphisms with PTSD among outpatients at risk for PTSDPsychiatry Res2011188117317421440309
   PubMed Web of Science ®Google Scholar
• SkeltonKResslerKJNorrholmSDJovanovicTBradley-DavinoBPTSD and gene variants: new pathways and new thinkingNeuropharmacology201262262863721356219
   PubMed Web of Science ®Google Scholar
• RauchSLDrevetsWCNeuroimaging and neuroanatomy of stress-induced and fear circuitry disordersAndrewsGCharneyDSSirovatkaPJRegierDAStress-Induced and Fear Circuitry Disorders: Refining the Research Agenda for DSM-VArlington, VAAmerican Psychiatric Association2009215254
   Google Scholar
• McFarlaneACThe long-term costs of traumatic stress: intertwined physical and psychological consequencesWorld Psychiatry20109131020148146
   PubMed Web of Science ®Google Scholar
• StillCDWoodGCChuXHigh allelic burden of four obesity SNPs is associated with poorer weight loss outcomes following gastric bypass surgeryObesity20111981676168321311511
   PubMed Web of Science ®Google Scholar
• BoscarinoJARukstalisMHoffmanSNRisk factors for drug dependence among out-patients on opioid therapy in a large US healthcare systemAddiction2010105101776178220712819
   PubMed Web of Science ®Google Scholar
• BoscarinoJAAdamsREFigleyCRMental health service use after the World Trade Center disaster: utilization trends and comparative effectivenessJ Nerv Ment Dis20111992919921278537
   PubMed Web of Science ®Google Scholar
• GaleaSAhernJResnickHPsychological sequelae of the September 11 terrorist attacks in New York CityN Engl J Med20023461398298711919308
   PubMed Web of Science ®Google Scholar
• ResnickHSKilpatrickDGDanskyBSSaundersBEBestCLPrevalence of civilian trauma and posttraumatic stress disorder in a representative national sample of womenJ Consult Clin Psychol19936169849918113499
   PubMed Web of Science ®Google Scholar
• CraddockNOwenMJO’DonovanMCThe catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessonsMol Psychiatry200611544645816505837
   PubMed Web of Science ®Google Scholar
• MontagCBuckholtzJWHartmannPCOMT genetic variation affects fear processing: psychophysiological evidenceBehav Neurosci2008122490190918729643
   PubMed Web of Science ®Google Scholar
• GillespieCFPhiferJBradleyBResslerKJRisk and resilience: genetic and environmental influences on development of the stress responseDepress Anxiety2009261198499219750552
   PubMed Web of Science ®Google Scholar
• SpitzMRAmosCIDongQLinJWuXThe CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancerJ Natl Cancer Inst2008100211552155618957677
   PubMedGoogle Scholar
• ThorgeirssonTEGellerFSulemPA variant associated with nicotine dependence, lung cancer and peripheral arterial diseaseNature2008452718763864218385739
   PubMed Web of Science ®Google Scholar
• ErlichPMHoffmanSNRukstalisMNicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severityHum Genet2010128549149920725741
   PubMed Web of Science ®Google Scholar
• von WolffGAvrabosCStepanJVoltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formationJ Psychiatr Res201145225626120619419
   PubMed Web of Science ®Google Scholar
• BeckJGClappJDA different kind of co-morbidity: understanding posttraumatic stress disorder and chronic painPsychol Trauma20113210110821765966
   PubMed Web of Science ®Google Scholar
• PhiferJSkeltonKWeissTPain symptomatology and pain medication use in civilian PTSDPain2011152102233224021665366
   PubMed Web of Science ®Google Scholar
• KesslerRCWangPSThe descriptive epidemiology of commonly occurring mental disorders in the United StatesAnnu Rev Public Health20082911512918348707
   PubMed Web of Science ®Google Scholar
• SpinelliSCheferSSuomiSJHigleyJDBarrCSSteinEEarly-life stress induces long-term morphologic changes in primate brainArch Gen Psychiatry200966665866519487631
   PubMed Web of Science ®Google Scholar
• DongMGilesWHFelittiVJInsights into causal pathways for ischemic heart disease: adverse childhood experiences studyCirculation2004110131761176615381652
   PubMed Web of Science ®Google Scholar
• FelittiVJAndaRFNordenbergDRelationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) StudyAm J Prev Med19981442452589635069
   PubMed Web of Science ®Google Scholar
• RosenbergMConceiving the SelfNew York, NYBasic Books1979
   Google Scholar
• CoxBJMacPhersonPSEnnsMWMcWilliamsLANeuroticism and self-criticism associated with posttraumatic stress disorder in a nationally representative sampleBehav Res Ther200442110511414744527
   PubMed Web of Science ®Google Scholar
• CostaPTJrWidigerTAPersonality Disorders and the Five-Factor Model of Personality2nd edArlington, VAAmerican Psychological Association2002
   Google Scholar
• ChapmanDPWhitfieldCLFelittiVJDubeSREdwardsVJAndaRFAdverse childhood experiences and the risk of depressive disorders in adulthoodJ Affect Disord200482221722515488250
   PubMed Web of Science ®Google Scholar
• BoscarinoJAAdamsREFigleyCRMental health service use 1-year after the World Trade Center disaster: implications for mental health careGen Hosp Psychiatry200426534635815474634
   PubMed Web of Science ®Google Scholar
• BlascovichJTomakaJMeasures of self-esteemRobinsonJPShaverPRWrightsmanLSMeasures of Personality and Social Psychological Attitudes1San Diego, CAAcademic Press1991115160
   Google Scholar
• GoodwinRDFriedmanHSHealth status and the five-factor personality traits in a nationally representative sampleJ Health Psychol200611564365416908463
   PubMed Web of Science ®Google Scholar
• TaylorMDWhitemanMCFowkesGRLeeAJAllerhandMDearyIJFive Factor Model personality traits and all-cause mortality in the Edinburgh Artery Study cohortPsychosom Med200971663164119483118
   PubMed Web of Science ®Google Scholar
• CostaPTJrMcCraeRRRevised NEO Personality Inventory (NEO PI-R) and NEO Five Factor Inventory (NEO-FFI): Professional ManualLutz, FLPsychological Assessment Resources Inc1992
   Google Scholar
• CleelandCSRyanKMPain assessment: global use of the Brief Pain InventoryAnn Acad Med Singapore19942321291388080219
   PubMedGoogle Scholar
• TanGJensenMPThornbyJIShantiBFValidation of the Brief Pain Inventory for chronic nonmalignant painJ Pain20045213313715042521
   PubMed Web of Science ®Google Scholar
• ZieglerAKonigIRA Statistical Approach to Genetic Epidemiology2nd edWeinheimWiley-VCH2010
   Google Scholar
• GabrielSBSchaffnerSFNguyenHThe structure of haplotype blocks in the human genomeScience200229655762225222912029063
   PubMed Web of Science ®Google Scholar
• de BakkerPIYelenskyRPe’erIGabrielSBDalyMJAltshulerDEfficiency and power in genetic association studiesNat Genet200537111217122316244653
   PubMed Web of Science ®Google Scholar
• StrachanTReadAPHuman Molecular Genetics4th edNew York, NYGarland Science2011
   Google Scholar
• ZhengSLSunJWiklundFCumulative association of five genetic variants with prostate cancerN Engl J Med2008358991091918199855
   PubMed Web of Science ®Google Scholar
• ThomasDCStatistical Methods in Genetic EpidemiologyNew York, NYOxford University Press2004
   Google Scholar
• XiePKranzlerHRPolingJInteraction of FKBP5 with childhood adversity on risk for post-traumatic stress disorderNeuropsychopharmacology20103581684169220393453
   PubMed Web of Science ®Google Scholar
• AmstadterABNugentNRKoenenKCAssociation between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic samplePsychiatry200972436036920070134
   PubMed Web of Science ®Google Scholar
• FuSSMcFallMSaxonAJPost-traumatic stress disorder and smoking: a systematic reviewNicotine Tob Res20079111071108417978982
   PubMed Web of Science ®Google Scholar
• ValenteNLValladaHCordeiroQCatechol-O-methyltransferase (COMT) val158 met polymorphism as a risk factor for PTSD after urban violenceJ Mol Neurosci201143351652321080103
   PubMed Web of Science ®Google Scholar
• TyrkaARPriceLHGelernterJSchepkerCAndersonGMCarpenterLLInteraction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivityBiol Psychiatry200966768168519596121
   PubMed Web of Science ®Google Scholar
• DeYoungCGCicchettiDRogoschFAModeration of the association between childhood maltreatment and neuroticism by the corticotropin-releasing hormone receptor 1 geneJ Child Psychol Psychiatry201152889890621438878
   PubMed Web of Science ®Google Scholar
• BoscarinoJAForsbergCWGoldbergJA twin study of the association between PTSD symptoms and rheumatoid arthritisPsychosom Med201072548148620410244
   PubMed Web of Science ®Google Scholar
• BoscarinoJAA prospective study of PTSD and early-age heart disease mortality among Vietnam veterans: implications for surveillance and preventionPsychosom Med200870666867618596248
   PubMed Web of Science ®Google Scholar
• KubzanskyLDKoenenKCIs posttraumatic stress disorder related to development of heart disease? An updateCleve Clin J Med.200976Suppl 2S606519376986
   PubMedGoogle Scholar
• GlaesmerHBrahlerEGundelHRiedel-HellerSGThe association of traumatic experiences and posttraumatic stress disorder with physical morbidity in old age: a German population-based studyPsychosom Med201173540140621636658
   PubMed Web of Science ®Google Scholar
• BenyaminiYSolomonZCombat stress reactions, posttraumatic stress disorder, cumulative life stress, and physical health among Israeli veterans twenty years after exposure to combatSoc Sci Med20056161267127715970236
   PubMed Web of Science ®Google Scholar
• O’TooleBICattsSVTrauma, PTSD, and physical health: an epidemiological study of Australian Vietnam veteransJ Psychosom Res2008641334018157997
   PubMed Web of Science ®Google Scholar
• AhmadiNHajsadeghiFMirshkarloHBBudoffMYehudaREbrahimiRPost-traumatic stress disorder, coronary atherosclerosis, and mortalityAm J Cardiol20111081293321530936
   PubMed Web of Science ®Google Scholar
• BoscarinoJAPosttraumatic stress disorder and physical illness: results from clinical and epidemiologic studiesAnn N Y Acad Sci2004103214115315677401
   PubMed Web of Science ®Google Scholar
• HeimCEhlertUHellhammerDHThe potential role of hypocortisolism in the pathophysiology of stress-related bodily disordersPsychoneuroendocrinology200025113510633533
   PubMed Web of Science ®Google Scholar
• SmithAKConneelyKNKilaruVDifferential immune system DNA methylation and cytokine regulation in post-traumatic stress disorderAm J Med Genet B Neuropsychiatr Genet.2011156B670070821714072
   PubMed Web of Science ®Google Scholar
• UddinMAielloAEWildmanDEEpigenetic and immune function profiles associated with posttraumatic stress disorderProc Natl Acad Sci U S A2010107209470947520439746
   PubMed Web of Science ®Google Scholar
• GanderMLvon KanelRMyocardial infarction and post-traumatic stress disorder: frequency, outcome, and atherosclerotic mechanismsEur J Cardiovasc Prev Rehabil200613216517216575268
   PubMedGoogle Scholar
• SpitzerCBarnowSVolzkeHAssociation of posttraumatic stress disorder with low-grade elevation of C-reactive protein: evidence from the general populationJ Psychiatr Res2010441152119628221
   PubMed Web of Science ®Google Scholar
• von KanelRHeppUKraemerBEvidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorderJ Psychiatr Res200741974475216901505
   PubMed Web of Science ®Google Scholar
• BoscarinoJAVietnam veterans, postwar experiences and health outcomesFinkGEncyclopedia of Stress32nd edSan Diego, CAAcademic Press2007830838
   Google Scholar
• BoscarinoJAKirchnerHLHoffmanSNSartoriusJAdamsREPTSD and alcohol use after the World Trade Center attacks: a longitudinal studyJ Trauma Stress201124551552521882246
   PubMed Web of Science ®Google Scholar
• VlahovDGaleaSResnickHIncreased use of cigarettes, alcohol, and marijuana among Manhattan, New York, residents after the September 11th terrorist attacksAm J Epidemiol20021551198899612034577
   PubMed Web of Science ®Google Scholar
• HungRJMcKayJDGaborieauVA susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25Nature2008452718763363718385738
   PubMed Web of Science ®Google Scholar
• WeissTSkeltonKPhiferJPosttraumatic stress disorder is a risk factor for metabolic syndrome in an impoverished urban populationGen Hosp Psychiatry201133213514221596206
   PubMed Web of Science ®Google Scholar