236
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

CACNA1C Gene rs1006737 Polymorphism Affects Cognitive Performance in Chinese Han Schizophrenia

ORCID Icon, &
Pages 1697-1704 | Received 12 May 2022, Accepted 27 Jul 2022, Published online: 10 Aug 2022

References

  • McGrath J, Saha S, Chant D, et al. Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol Rev. 2008;30:67–76. doi:10.1093/epirev/mxn001
  • Howes OD, Murray RM. Schizophrenia: an integrated sociodevelopmental-cogniti- ve model. Lancet. 2014;10(9929):1677–1687. doi:10.1016/S0140-6736(13)62036-X
  • Olfson M, Stroup TS, Huang C, et al. Suicide risk in medicare patients with schizophrenia across the life span. JAMA Psychiatry. 2021;78(8):876–885. doi:10.1001/jamapsychiatry.2021.0841
  • Charlson FJ, Ferrari AJ, Santomauro DF, et al. Global epidemiology and burden of schizophrenia: findings from the global burden of disease study 2016. Schizophr Bull. 2018;44(6):1195–1203. doi:10.1093/schbul/sby058
  • GBD 2019 Mental Disorders Collaborators. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis from the global burden of disease study 2019. Lancet Psychiatry. 2022;9(2):137–150. doi:10.1016/S2215-0366(21)00395-3
  • Jauhar S, Johnstone M, McKenna PJ. Schizophrenia. Lancet. 2022;399(10323):473–486. doi:10.1016/S0140-6736(21)01730-X
  • Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Genome-wide association study identifies five new Schizophrenia loci. Nat Genet. 2011;43(10):969–976. doi:10.1038/ng.940
  • De Jesús-Cortés H, Rajadhyaksha AM, Pieper AA. Cacna1c: protecting young hippocampal neurons in the adult brain. Neurogenesis. 2016;3(1):e1231160. doi:10.1080/23262133.2016.1231160
  • Jiang M, Swann JW. A role for L-type calcium channels in the maturation of parvalbumin-containing hippocampal interneurons. Neuroscience. 2005;135(3):839–850. doi:10.1016/j.neuroscience.2005.06.073
  • Bigos KL, Mattay VS, Callicott JH, et al. Genetic variation in CACNA1C affects brain circuitries related to mental illness. Arch Gen Psychiatry. 2010;67(9):939–945. doi:10.1001/archgenpsychiatry.2010.96
  • Bhat S, Dao DT, Terrillion CE, et al. CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease. Prog Neurobiol. 2012;99(1):1–14. doi:10.1016/j.pneurobio.2012.06.001
  • Takahashi S, Glatt SJ, Uchiyama M, et al. Meta-analysis of data from the psychiatric genomics consortium and additional samples supports association of CACNA1C with risk for schizophrenia. Schizophr Res. 2015;168(1–2):429–433. doi:10.1016/j.schres.2015.07.033
  • Zhu D, Yin J, Liang C, et al. CACNA1C (rs1006737) may be a susceptibility gene for schizophrenia: an updated meta-analysis. Brain Behav. 2019;9(6):e01292. doi:10.1002/brb3.1292
  • Jiang H, Qiao F, Li Z, et al. Evaluating the association between CACNA1C rs1006737 and schizophrenia risk: a meta-analysis. Asia Pac Psychiatry. 2015;7(3):260–267. doi:10.1111/appy.12173
  • Liu YP, Wu X, Xia X, et al. The genome-wide supported CACNA1C gene polymorphisms and the risk of schizophrenia: an updated meta-analysis. BMC Med Genet. 2020;21(2):159. doi:10.1186/s12881-020-01084-0
  • Yang L, Zhou C, Fang L, et al. Meta-analysis of l-type calcium channel α1C gene polymorphism and schizophrenia. J China Med Univ. 2014;39(6):858–863. doi:10.13406/j.cnki.cyxb.000119
  • Kowalec K, Lu Y, Sariaslan A, et al. Increased schizophrenia family history burden and reduced premorbid IQ in treatment-resistant schizophrenia: a Swedish national register and genomic study. Mol Psychiatry. 2021;26(8):4487–4495. doi:10.1038/s41380-019-0575-1
  • Zheng F, Cui Y, Yan H, et al. The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects. Sci Rep. 2016;09–29(6):34298. doi:10.1038/srep34298
  • Zheng F, Zhang Y, Xie W, et al. Further evidence for genetic association of CACNA1C and schizophrenia: new risk loci in a Han Chinese population and a meta-analysis. Schizophr Res. 2014;52(1):105–110. doi:10.1016/j.schres.2013.12.003
  • Zhang Q, Shen Q, Xu Z, et al. The effects of CACNA1C gene polymorphism on spatial working memory in both healthy controls and patients with schizophrenia or bipolar disorder. Neuropsychopharmacology. 2012;37(3):677–684. doi:10.1038/npp.2011.242
  • He K, An Z, Wang Q, et al. CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population. Br J Psychiatry. 2014;204(1):36–39. doi:10.1192/bjp.bp.113.126979
  • Guan F, Zhang B, Yan T, et al. MIR137 gene and target gene CACNA1C of miR-137 contribute to schizophrenia susceptibility in Han Chinese. Schizophr Res. 2013;152(1):97–104. doi:10.1016/j.schres.2013.11.004
  • Pasparakis E, Koiliari E, Zouraraki C, et al. The effects of the CACNA1C rs1006737 A/G on affective startle modulation in healthy males. Eur Psychiatry. 2015;30(4):492–498. doi:10.1016/j.eurpsy.2015.03.004
  • Meller T, Schmitt S, Stein F, et al. Associations of schizophrenia risk genes ZNF804A and CACNA1C with schizotypy and modulation of attention in healthy subjects. Schizophr Res. 2019;208:67–75. doi:10.1016/j.schres.2019.04.018
  • Lancaster TM, Heerey EA, Mantripragada K, et al. CACNA1C risk variant affects reward responsiveness in healthy individuals. Transl Psychiatry. 2014;4:e461. doi:10.1038/tp.2014.100
  • Wang Z, Chen W, Cao Y, et al. An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia. Aust N Z J Psychiatry. 2022;56(4):385–397. doi:10.1177/00048674211009595
  • Wolf C, Mohr H, Schneider-Axmann T, et al. CACNA1C genotype explains interindividual differences in amygdala volume among patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2014;264(2):93–102. doi:10.1007/s00406-013-0427-y
  • Mallas E, Carletti F, Chaddock CA, et al. The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder1. Genes Brain Behav. 2017;16(4):479–488. doi:10.1111/gbb.12355
  • Erk S, Meyer-Lindenberg A, Schmierer P, et al. Hippocampal and frontolimbic function as intermediate phenotype for psychosis: evidence from healthy relatives and a common risk variant in CACNA1C. Biol Psychiatry. 2014;76(6):466–475. doi:10.1016/j.biopsych.2013.11.025
  • Paulus FM, Bedenbender J, Krach S, et al. Association of rs1006737 in CACNA1C with alterations in prefrontal activation and fronto-hippocampal connectivity. Hum Brain Mapp. 2014;35(4):1190–1200. doi:10.1002/hbm.22244
  • Lancaster TM, Foley S, Tansey KE, et al. CACNA1C risk variant is associated with increased amygdala volume. Eur Arch Psychiatry Clin Neurosci. 2016;266(3):269–275. doi:10.1007/s00406-015-0609-x
  • Takeuchi H, Tomita H, Taki Y, et al. A common CACNA1C gene risk variant has sex-dependent effects on behavioral traits and brain functional activity. Cereb Cortex. 2019;29(8):3211–3219. doi:10.1093/cercor/bhy189
  • Merinder LB. Patient education in schizophrenia: a review. Acta Psychiatr Scand. 2000;102(2):98–106. doi:10.1034/j.1600-0447.2000.102002098.x
  • Schwartz BL, Fay MM, Kendrick K, et al. Effects of nifedipine, a calcium channel antagonist, on cognitive function in schizophrenic patients with tardive dyskinesia. Clin Neuropharmacol. 1997;20(4):364–370. doi:10.1097/00002826-199708000-00009
  • Van DP, Thomas KL. Concomitant calcium channel blocker and antipsychotic therapy in patients with schizophrenia: efficacy analysis of the CATIE-Sz Phase 1 data. Ann Clin Psychiatry. 2018;30(1):6–16.
  • Porcelli S, Lee SJ, Han C, et al. CACNA1C gene and schizophrenia: a case–control and pharmacogenetic study. Psychiatr Genet. 2015;25(4):163–167. doi:10.1097/YPG.0000000000000092
  • Mosheva M, Serretti A, Stukalin Y, et al. Association between CANCA1C Gene rs1034936 polymorphism and alcohol dependence in bipolar disorder. J Affect Disord. 2020;261:181–186. doi:10.1016/j.jad.2019.10.015
  • Zhu D, Zhang J, Wu J, et al. Paliperidone Protects SH-SY5Y cells against MK- 801-induced neuronal damage through inhibition of Ca(2+) influx and regulation of SIRT1/miR-134 signal pathway. Mol Neurobiol. 2016;53(4):2498–2509. doi:10.1007/s12035-015-9217-z
  • Kamijo S, Ishii Y, Horigane SI, et al. A critical neurodevelopmental role for L-type voltage-gated calcium channels in neurite extension and radial migration. J Neurosci. 2018;38(24):5551–5566. doi:10.1523/JNEUROSCI.2357-17.2018
  • Khalid M, Driessen TM, Lee JS, et al. Association of CACNA1C with bipolar disorder among the Pakistani population. Gene. 2018;664:119–126. doi:10.1016/j.gene.2018.04.061