References
- RapportMMGeenAAPageIHSerum vasoconstrictor, serotonin; isolation and characterizationJ Biol Chem194817631243125118100415
- ErspramerVAseroBIdentification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamineNature19521694306800801
- TwarogBMPageIHSerotonin content of some mammalian tissues and urine and a method for its determinationAm J Physiol1953175115716113114371
- SullivanPFNealeMCKendlerKSGenetic epidemiology of major depression: review and meta-analysisAm J Psychiatry20001571015526211007705
- CôtéFFlignyCFromesYMalletJVodjdaniGRecent advances in understanding serotonin regulation of cardiovascular functionTrends Mol Med200410523223815121050
- WaltherDJPeterJUBashammakhSSynthesis of serotonin by a second tryptophan hydroxylase isoformScience200329956037612511643
- NilssonTLongmoreJShawDCharacterisation of 5-HT receptors in human coronary arteries by molecular and pharmacological techniquesEur J Pharmacol19993721495610374714
- YildizOSmithJRPurdyRESerotonin and vasoconstrictor synergismLife Sci19986219172317329585103
- YusufSAl-SaadyNCammAJ5-hydroxytryptamine and atrial fibrillation: how significant is this piece in the puzzle?J Cardiovasc Electrophysiol200314220921412693508
- GershonMDTackJThe serotonin signaling system: from basic understanding to drug development for functional GI disordersGastroenterology2007132139741417241888
- KirchgessnerALLiuMTGershonMDIn situ identification and visualization of neurons that mediate enteric and enteropancreatic reflexesJ Comp Neurol199637122702868835732
- KirchgessnerALTamirHGershonMDIdentification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivityJ Neurosci19921212352481729436
- CookeHJSidhuMWangYZ5-HT activates neural reflexes regulating secretion in the guinea-pig colonNeurogastroenterol Motil1997931811869347474
- KimMCookeHJJavedNHCareyHVChristofiFRaybouldHED-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cellsGastroenterology200112161400140611729119
- SidhuMCookeHJRole for 5-HT and ACh in submucosal reflexes mediating colonic secretionAm J Physiol19952693 Pt 1G346G3517573444
- PanHGershonMDActivation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestineJ Neurosci20002093295330910777793
- BulbringECremaAObservations concerning the action of 5- hydroxytryptamine on the peristaltic reflexBr J Pharmacol Chemother195813444445713618550
- TörkIAnatomy of the serotonergic systemAnn N Y Acad Sci1990600934 discussion 34–352252340
- LeschKPAraragiNWaiderJvan den HoveDGutknechtLTargeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviourPhilos Trans R Soc Lond, B, Biol Sci201236716012426244322826343
- AndradeCSandarshSChethanKBNageshKSSerotonin reuptake inhibitor antidepressants and abnormal bleeding: a review for clinicians and a reconsideration of mechanismsJ Clin Psychiatry201071121565157521190637
- World Health OrganizationSuicide prevention (SUPRE)20122012
- Ministry of Health PromotionPrevention of Injury: Guidance DocumentToronto, ONStandards, Programs and Community Development Branch, Ministry of Health Promotion2010
- MannJJNeurobiology of suicidal behaviorNat Rev Neurosci200341081982814523381
- Practice guideline for the assessment and treatment of patients with suicidal behaviorsAm J Psychiatry2003160Suppl 11160
- FowlerJCSuicide risk assessment in clinical practice: pragmatic guidelines for imperfect assessmentsPsychotherapy (Chic)2012491819022369082
- GuzeSBRobinsESuicide and primary affective disordersBr J Psychiatry19701175394374385481206
- RunesonBMental disorder in youth suicide. DSM-III-R Axes I and IIActa Psychiatr Scand19897954904972750550
- BeautraisALJoycePRMulderRTFergussonDMDeavollBJNightingaleSKPrevalence and comorbidity of mental disorders in persons making serious suicide attempts: a case-control studyAm J Psychiatry19961538100910148678168
- SareenJCoxBJAfifiTOAnxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adultsArch Gen Psychiatry200562111249125716275812
- ClementsCMorrissRJonesSPetersSRobertsCKapurNSuicide in bipolar disorder in a national English sample, 1996–2009: frequency, trends and characteristicsPsychol Med201311023510515
- DiaconuGTureckiGObsessive-compulsive personality disorder and suicidal behavior: evidence for a positive association in a sample of depressed patientsJ Clin Psychiatry200970111551155619607764
- MandelliLSerrettiAGene environment interaction studies in depression and suicidal behavior: an updateNeurosci Biobehav Rev Epub July 22, 2013
- PaykelESLife stress, depression and attempted suicideJ Human Stress197623312
- World Health OrganizationPrevention of Mental Disorders: Effective Interventions and Policy Options, Summary ReportGeneva, SwitzerlandWorld Health Organization2004
- LinkowskaKDacaPSykuteraMPufalEBloch-BogusławskaEGrzybowskiTSearch for association between suicide and 5-HTT, MAOA and DAT polymorphism in Polish malesArch Med Sadowej Kryminol2010602–311211721516943
- RoyAFamily history of suicideArch Gen Psychiatry19834099719746615160
- RoyASegalNLSarchiaponeMAttempted suicide among living co-twins of twin suicide victimsAm J Psychiatry19951527107510767793447
- GouldMSFisherPParidesMFloryMShafferDPsychosocial risk factors of child and adolescent completed suicideArch Gen Psychiatry19965312115511628956682
- BrentDAMannJJFamily genetic studies, suicide, and suicidal behaviorAm J Med Genet C Semin Med Genet2005133C1132415648081
- MannJJBrentDAArangoV2001The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic systemNeuropsychopharmacology2446747711282247
- StanleyMMannJJSuicide and serotonin receptorsLancet1984183723496141420
- StanleyMMannJJIncreased serotonin-2 binding sites in frontal cortex of suicide victimsLancet1983183182142166130248
- StanleyMVirgilioJGershonSTritiated imipramine binding sites are decreased in the frontal cortex of suicidesScience19822164552133713397079769
- HughesJHDunneFYoungAHEffects of acute tryptophan depletion on mood and suicidal ideation in bipolar patients symptomatically stable on lithiumBr J Psychiatry200017744745111059999
- McCloskeyMSBen-ZeevDLeeRBermanMECoccaroEFAcute tryptophan depletion and self-injurious behavior in aggressive patients and healthy volunteersPsychopharmacology (Berl)20092031536118946662
- SubletteMEGalfalvyHCFuchsDPlasma kynurenine levels are elevated in suicide attempters with major depressive disorderBrain Behav Immun20112561272127821605657
- De PontiFToniniMIrritable bowel syndrome: new agents targeting serotonin receptor subtypesDrugs200161331733211293643
- WongDTBymasterFPDevelopment of antidepressant drugs. Fluoxetine (Prozac) and other selective serotonin uptake inhibitorsAdv Exp Med Biol199536377957618533
- HammadTALaughrenTRacoosinJSuicidality in pediatric patients treated with antidepressant drugsArch Gen Psychiatry200663333233916520440
- GunnellDSaperiaJAshbyDSelective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA’s safety reviewBMJ2005330748838515718537
- HetrickSEMcKenzieJECoxGRSimmonsMBMerrySNNewer generation antidepressants for depressive disorders in children and adolescentsCochrane Database Syst Rev201211CD00485123152227
- TondoLBaldessariniRJLong-term lithium treatment in the prevention of suicidal behavior in bipolar disorder patientsEpidemiol Psichiatr Soc200918317918320034193
- GibbonsRMannJJProper studies of selective serotonin reuptake inhibitors are needed for youth with depressionCMAJ2009180327027119188617
- NakagawaAGrunebaumMFEllisSPAssociation of suicide and antidepressant prescription rates in Japan, 1999–2003J Clin Psychiatry200768690891617592916
- CastelpietraGMorsanuttoAPascolo-FabriciEIsacssonGAntidepressant use and suicide prevention: a prescription database study in the region Friuli Venezia Giulia, ItalyActa Psychiatr Scand2008118538238818754835
- BachHArangoVChapter 2: Neuroanatomy of serotonergic abnormalities in suicideDwivediYThe Neurobiological Basis of SuicideBoca Raton, FLCRC Press2012 Available online: http://www.ncbi.nlm.nih.gov.libaccess.lib.mcmaster.ca/books/NBK107204/
- YoonHKKimYKTPH2-703G/T SNP may have important effect on susceptibility to suicidal behavior in major depressionProg Neuropsychopharmacol Biol Psychiatry200933340340919162119
- PatelPDPontrelloCBurkeSRobust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal glandBiol Psychiatry200455442843314960297
- KatzungBGBasic and Clinical PharmacologyNew York, NYMcGraw-Hill Medical2007
- NielsenDAJenkinsGLStefaniskoKMJeffersonKKGoldmanDSequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7Brain Res Mol Brain Res19974511451489105682
- NielsenDAGoldmanDVirkkunenMTokolaRRawlingsRLinnoilaMSuicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphismArch Gen Psychiatry199451134387506517
- BennettPJMcMahonWMWatabeJTryptophan hydroxylase polymorphisms in suicide victimsPsychiatr Genet2000101131710909123
- GeijerTFrischAPerssonMLSearch for association between suicide attempt and serotonergic polymorphismsPsychiatr Genet2000101192610909124
- KollerGEngelRRPreussUWTryptophan hydroxylase gene 1 polymorphisms are not associated with suicide attempts in alcohol-dependent individualsAddict Biol200510326927316109589
- SaetrePLundmarkPWangA2010The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: a multi-centre case-control study and meta-analysisAm J Med Genet B Neuropsychiatr Genet153B38739619526457
- CourtetPJollantFCastelnauDAstrucBBuresiCMalafosseAImplication of genes of the serotonergic system on vulnerability to suicidal behaviorJ Psychiatry Neurosci2004295350359 French15534946
- YoonHKKimYKAssociation between serotonin-related gene polymorphisms and suicidal behavior in depressive patientsProg Neuropsychopharmacol Biol Psychiatry20083251293129718502553
- TsaiSJHongCJWangYCTryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviorsNeuroreport199910183773377510716208
- RujescuDGieglingISatoTHartmannAMMöllerHJGenetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysisBiol Psychiatry200354446547312915291
- BellivierFChastePMalafosseAAssociation between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysisAm J Med Genet B Neuropsychiatr Genet2004124B1879114681922
- DuLFaludiGPalkovitsMBakishDHrdinaPDSerotonergic genes and suicidalityCrisis2001222546011727894
- RotondoASchuebelKBergenAIdentification of four variants in the tryptophan hydroxylase promoter and association to behaviorMol Psychiatry19994436036810483053
- TureckiGZhuZTzenovaJTPH and suicidal behavior: a study in suicide completersMol Psychiatry2001619810211244493
- BrunLNguLHKengWTClinical and biochemical features of aromatic L-amino acid decarboxylase deficiencyNeurology2010751647120505134
- Sumi-IchinoseCIchinoseHTakahashiEHoriTNagatsuTMolecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesisBiochemistry1992318222922381540578
- SpeightGTuricDAustinJComparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorderMol Psychiatry20005332733110889538
- GieglingIMoreno-De-LucaDRujescuDDopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behaviorAm J Med Genet B Neuropsychiatr Genet2008147330831517948905
- SurrattCKPersicoAMYangXDA human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPsFEBS Lett199331833253308095030
- PeterDFinnJPKlisakIChromosomal localization of the human vesicular amine transporter genesGenomics19931837207237905859
- GlattCEDeYoungJADelgadoSScreening a large reference sample to identify very low frequency sequence variants: comparisons between two genesNat Genet200127443543811279528
- BurmanJTranCHGlattCFreimerNBEdwardsRHThe effect of rare human sequence variants on the function of vesicular monoamine transporter 2Pharmacogenetics200414958759415475732
- TrowbridgeSNarboux-NêmeNGasparPGenetic models of serotonin (5-HT) depletion: what do they tell us about the developmental role of 5-HT?Anat Rec (Hoboken)2011294101615162320818612
- OzeliusLHsuYPBrunsGHuman monoamine oxidase gene (MAOA): chromosome position (Xp21-p11) and DNA polymorphismGenomics19883153582906043
- ClaydenRCZarukAMeyreDThabaneLSamaanZThe association of attempted suicide with genetic variants in the SLC6A4 and TPH genes depends on the definition of suicidal behavior: a systematic review and meta-analysisTransl Psychiatry20122e16623032942
- HungCFLungFWHungTHMonoamine oxidase A gene polymorphism and suicide: an association study and meta-analysisJ Affect Disord2012136364364922041522
- MannJJStanleyMPostmortem monoamine oxidase enzyme kinetics in the frontal cortex of suicide victims and controlsActa Psychiatr Scand19846921351396702476
- SherifFMarcussonJOrelandLBrain gamma-aminobutyrate transaminase and monoamine oxidase activities in suicide victimsEur Arch Psychiatry Clin Neurosci199124131391441790159
- LanNCHeinzmannCGalAHuman monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie diseaseGenomics1989445525592744764
- SabolSZHuSHamerDA functional polymorphism in the monoamine oxidase A gene promoterHum Genet199810332732799799080
- LungFWTzengDSHuangMFLeeMBAssociation of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorderBMC Med Genet2011127421605465
- OnoHShirakawaONishiguchiNNo evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicidesAm J Med Genet2002114334034211920860
- AsbergMNeurotransmitters and suicidal behavior. The evidence from cerebrospinal fluid studiesAnn N Y Acad Sci19978361581819616798
- AsbergMTräskmanLThorénP5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor?Arch Gen Psychiatry1976331011931197971028
- MannJJCurrierDA review of prospective studies of biologic predictors of suicidal behavior in mood disordersArch Suicide Res200711131617178639
- JokinenJNordströmALNordströmPCerebrospinal fluid mono-amine metabolites and suicideNord J Psychiatry200963427627919034712
- SamuelssonMJokinenJNordströmALNordströmPCSF 5-HIAA, suicide intent and hopelessness in the prediction of early suicide in male high-risk suicide attemptersActa Psychiatr Scand20061131444716390368
- TräskmanLAsbergMBertilssonLSjöstrandLMonoamine metabolites in CSF and suicidal behaviorArch Gen Psychiatry19813866316366166274
- LinnoilaMVirkkunenMScheininMNuutilaARimonRGoodwinFKLow cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behaviorLife Sci19833326260926146198573
- NordstömPAsgårdUSuicide risk by age and birth cohort in SwedenCrisis19867275803780276
- OquendoMAPlacidiGPMaloneKMPositron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depressionArch Gen Psychiatry2003601142212511168
- MilakMSParseyRVKeilpJOquendoMAMaloneKMMannJJNeuroanatomic correlates of psychopathologic components of major depressive disorderArch Gen Psychiatry200562439740815809407
- RaymondJRMukhinYVGelascoAMultiplicity of mechanisms of serotonin receptor signal transductionPharmacol Ther2001922–317921211916537
- BlierPListaADe MontignyCDifferential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperoneJ Pharmacol Exp Ther199326517158474032
- KobilkaBKFrielleTCollinsSAn intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteinsNature1987329613475793041227
- DavidSPMurthyNVRabinerEAA functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humansJ Neurosci200525102586259015758168
- HettemaJMAnSSvan den OordEJNealeMCKendlerKSChenXAssociation study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disordersAm J Med Genet B Neuropsychiatr Genet2008147B566166618163385
- GöthertMProppingPBönischHBrüssMNöthenMMGenetic variation in human 5-HT receptors: potential pathogenetic and pharmacological roleAnn N Y Acad Sci199886126309928235
- WassermanDGeijerTSokolowskiMRozanovVWassermanJThe serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attemptBehav Brain Funct200621416626484
- SerrettiAMandelliLGieglingIHTR2C and HTR1A gene variants in German and Italian suicide attempters and completersAm J Med Genet B Neuropsychiatr Genet2007144B329129917192951
- VideticAZupancTPregeljPBalazicJTomoriMKomelRSuicide, stress and serotonin receptor 1A promoter polymorphism -1019C>G in Slovenian suicide victimsEur Arch Psychiatry Clin Neurosci2009259423423819224112
- JinHOksenbergDAshkenaziCharacterization of the human 5-hydroxytryptamine 1B receptorJ Biol Chem19922679573557381348246
- SandersARCaoQTaylorJGenetic diversity of the human serotonin receptor 1B (HTR1B) geneGenomics200172111411247661
- KielSBrüssMBönischHGöthertMPharmacological properties of the naturally occurring Phe-124-Cys variant of the human 5-HT1B receptor: changes in ligand binding, G-protein coupling and second messenger formationPharmacogenetics200010765566611037806
- SandersARDuanJGejmanPVDNA variation and psychopharmacology of the human serotonin receptor 1B (HTR1B) genePharmacogenomics20023674576212437478
- HuangYYGrailheRArangoVHenRMannJJRelationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissueNeuropsychopharmacology199921223824610432472
- StefuljJBüttnerASkavicJSerotonin 1B (5HT-1B) receptor polymorphism (G861C) in suicide victims: association studies in German and Slavic populationAm J Med Genet B Neuropsychiatr Genet2004127B1485015108179
- RujescuDGieglingISatoTMöllerHJLack of association between serotonin 5-HT1B receptor gene polymorphism and suicidal behaviorAm J Med Genet B Neuropsychiatr Genet2003116B1697112497617
- NishiguchiNShirakawaOOnoHNo evidence of an association between 5HT1B receptor gene polymorphism and suicide victims in a Japanese populationAm J Med Genet2001105434334511378847
- Cornea-HébertVRiadMWuCSinghSKDescarriesLCellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult ratJ Comp Neurol1999409218720910379914
- BarnesNMSharpTA review of central 5-HT receptors and their functionNeuropharmacology19993881083115210462127
- ZhangJShenYHeGLack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patientsProg Neuropsychopharmacol Biol Psychiatry200832246747117964050
- ErtugrulAKennedyJLMasellisMBasileVSJayathilakeKMeltzerHYNo association of the T102C polymorphism of the serotonin 2A receptor gene (HTR2A) with suicidality in schizophreniaSchizophr Res2004692–330130515469201
- PooleyECHoustonKHawtonKHarrisonPJDeliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genesPsychol Med200333577578312877392
- RamamoorthySLeibachFHMaheshVBGanapathyVPartial purification and characterization of the human placental serotonin transporterPlacenta19931444494618248037
- HeilsATeufelAPetriSAllelic variation of human serotonin transporter gene expressionJ Neurochem1996666262126248632190
- LeschKPBengelDHeilsAAssociation of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory regionScience19962745292152715318929413
- MergenHDemirelBAkarTSenolELack of association between the serotonin transporter and tryptophan hydroxylase gene polymorphisms and completed suicidePsychiatr Genet20061625316538180
- OwensMJNemeroffCBRole of serotonin in the pathophysiology of depression: focus on the serotonin transporterClin Chem19944022882957508830
- ResslerKJNemeroffCBRole of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disordersDepress Anxiety200012Suppl 121911098410
- AsbergMNordströmPTräskman-BendzLCerebrospinal fluid studies in suicide. An overviewAnn N Y Acad Sci19864872432552436537
- HrdinaPDDemeterEVuTBSótónyiPPalkovitsM5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdalaBrain Res19936141–237448348328
- TureckiGBrièreRDewarKPrediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicideAm J Psychiatry199915691456145810484964
- ArangoVErnsbergerPMarzukPMAutoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victimsArch Gen Psychiatry19904711103810472173513
- Gonzalez-CastroTBTovilla-ZarateCAJuarez-RojopIPoolGarcia SGenisA2013Association of 5HTR1A gene variants with suicidal behavior: Case-control study and updated meta-analysisJ Psychiatr Res
- AnguelovaMBenkelfatCTureckiG2003A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behaviorMol Psychiatry864665312874600
- MannJJArangoVAAvenevoliSCandidate endopheno-types for genetic studies of suicidal behaviorBiol Psychiatry200965755656319201395
- BrezoJKlempanTTureckiGThe genetics of suicide: a critical review of molecular studiesPsychiatr Clin North Am200831217920318439443
- PerasonTAManolioTAHow to interpret a genome-wide association studyJAMA2008299111335134418349094
- DuLFaludiGPalkovitsMBakishDHrdinaPDTryptophan hydroxylase gene 218A/C polymorphism is not associated with depressed suicideInt J Neuropsychopharmacol20003321522011343598
- ZalsmanGFrischAKingRACase control and family-based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescentsAm J Med Genet2001105545145711449398
- SerrettiACalatiRGieglingIHartmannAMMöllerHJRujescuDSerotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controlsJ Psychiatr Res200943551952518715570
- StefuljJKubatMBalijaMSkavicJJernejBVariability of the tryptophan hydroxylase gene: study in victims of violent suicidePsychiatry Res20051341677315808291
- VideticAZupancTPregeljPBalazicJTomoriM2009Suicide, stress and serotonin receptor 1A promoter polymorphism -1019C>G in Slovenian suicide victimsEur Arch Psychiatry Clin Neurosci25923423819224112