Safety and efficacy of incobotulinumtoxinA as a potential treatment for poststroke spasticity

References

• WalleschC-WMaesELecomtePBartelsCFeasibility study on pharmacoeconomics of botulinum toxin A (Botox) in spasticity following stroke3rd Eur Botulinum Toxin Symp Abstr199714
   Google Scholar
• WatkinsCLLeathleyMJGregsonJMMooreAPSmithTLSharmaAKPrevalence of spasticity post strokeClin Rehabil20021651552212194622
   PubMed Web of Science ®Google Scholar
• LundströmETeréntABorgJPrevalence of disabling spasticity 1 year after first-ever strokeEur J Neurol200815653353918355307
   PubMed Web of Science ®Google Scholar
• SommerfeldDKEekEUSvenssonAKWiden HolmqvistLvon ArbinMHSpasticity after stroke: its occurrence and association with motor impairments and activity limitationsStroke200435113413914684785
   PubMed Web of Science ®Google Scholar
• WelmerAKvon ArbinMHWiden HolmqvistLSommerfeldDKSpasticity and its association with functioning and health-related quality of life 18 months after strokeCerebrovasc Dis20062124725316446538
   PubMed Web of Science ®Google Scholar
• TennigloMJNederhandMJPrinsenECNeneAVRietmanJSBuurkeJHEffect of chemodenervation of the rectus femoris muscle in adults with a stiff knee gait due to spastic paresis: a systematic review with a meta-analysis in patients with strokeArch Phys Med Rehabil201495357658724309072
   PubMed Web of Science ®Google Scholar
• WardABSpasticity treatment with botulinum toxinsJ Neural Transm2008115460761618389166
   PubMed Web of Science ®Google Scholar
• SmaniaNPicelliAMunariDRehabilitation procedures in the management of spasticityEur J Phys Rehabil Med201046342343820927008
   PubMed Web of Science ®Google Scholar
• HulmeAMacLennanWJRitchieRTJohnVAShottonPABaclofen in the elderly stroke patient its side-effects and pharmacokineticsEur J Clin Pharmacol19852944674693912190
   PubMed Web of Science ®Google Scholar
• DvorakEMKetchumNCMcGuireJRThe underutilization of intrathecal baclofen in poststroke spasticityTop Stroke Rehabil201118319520221642057
   PubMed Web of Science ®Google Scholar
• DahmLSBericADimitrijevicMRWallPDDirect spinal effect of a benzodiazepine (midazolam) on spasticity in manStereotact Funct Neurosurg198953285942626605
   PubMed Web of Science ®Google Scholar
• CutterNCScottDDJohnsonJCWhiteneckGGabapentin effect on spasticity in multiple sclerosis: a placebo-controlled, randomized trialArch Phys Med Rehabil200081216416910668769
   PubMed Web of Science ®Google Scholar
• MalangaGReiterRDGarayEUpdate on tizanidine for muscle spasticity and emerging indicationsExpert Opin Pharmacother20089122209221518671474
   PubMed Web of Science ®Google Scholar
• JoyntRLDantrolene sodium: long-term effects in patients with muscle spasticityArch Phys Med Rehabil1976575212217776122
   PubMed Web of Science ®Google Scholar
• LakhanSERowlandMWhole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic reviewBMC Neurol200995919961570
   PubMed Web of Science ®Google Scholar
• MalhotraSRosewilliamSHermensHRoffeCJonesPPandyanADA randomized controlled trial of surface neuromuscular electrical stimulation applied early after acute stroke: effects on wrist pain, spasticity and contracturesClin Rehabil201327757959023129814
   PubMed Web of Science ®Google Scholar
• Bovend’EerdtTJNewmanMBarkerKDawesHMinelliCWadeDTThe effects of stretching in spasticity: a systematic reviewArch Phys Med Rehabil20088971395140618534551
   PubMed Web of Science ®Google Scholar
• MazarakisNKUghratdarIVloeberghsMHExcellent functional outcome following selective dorsal rhizotomy in a child with spasticity secondary to transverse myelitisChilds Nerv Syst201531112189219126077594
   PubMed Web of Science ®Google Scholar
• EppingerMABermanCMMazzolaCASelective dorsal rhizotomy for spastic diplegia secondary to stroke in an adult patientSurg Neurol Int2015611126167363
   PubMedGoogle Scholar
• CardaSBertoniMZerbinatiPRossiniMMagoniLMolteniFGait changes after tendon functional surgery for equinovarus foot in patients with stroke: assessment of temporo-spatial, kinetic, and kinematic parameters in 177 patientsAm J Phys Med Rehabil200988429230119190482
   PubMed Web of Science ®Google Scholar
• GraciesJMElovicEMcGuireJSimpsonDMTraditional pharmacological treatments for spasticity. Part I: local treatmentsMuscle Nerve Suppl19976S61S919826983
   PubMedGoogle Scholar
• DollyJOAokiKRThe structure and mode of action of different botulinum toxinsEur J Neurol200613suppl 41917112344
   PubMed Web of Science ®Google Scholar
• SantamatoAMicelloMFPanzaFCan botulinum toxin type A injection technique influence the clinical outcome of patients with post-stroke upper limb spasticity? A randomized controlled trial comparing manual needle placement and ultrasound-guided injection techniquesJ Neurol Sci20143471–2394325263601
   PubMed Web of Science ®Google Scholar
• FranceschiniMIoccoMMolteniFSantamatoASmaniaNItalian Spasticity Study GroupManagement of stroke patients submitted to botulinum toxin type A therapy: a Delphi survey of an Italian expert panel of specialist injectorsEur J Phys Rehabil Med201450552553324963604
   PubMed Web of Science ®Google Scholar
• DasTKParkDMEffect of treatment with botulinum toxin on spasticityPostgrad Med J1989652082102594595
   PubMed Web of Science ®Google Scholar
• BrashearAGordonMFElovicEBotox Post-Stroke Spasticity Study Group. Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after a strokeN Engl J Med200234739540012167681
   PubMed Web of Science ®Google Scholar
• SimpsonDMAlexanderDNO’BrienCFBotulinum toxin type A in the treatment of upper extremity spasticity: a randomized, double-blind, placebo-controlled trialNeurology1996465130613108628472
   PubMed Web of Science ®Google Scholar
• WisselJWardABErztgaardPEuropean consensus table on the use of botulinum toxin type A in adult spasticityJ Rehabil Med2009411132519197564
   PubMed Web of Science ®Google Scholar
• SheeanGLanninNATurner-StokesLRawickiBSnowBJBotulinum toxin assessment, intervention and after-care for upper limb hypertonicity in adults: international consensus statementEur J Neurol201017suppl 2749320633180
   PubMed Web of Science ®Google Scholar
• SimpsonDMGraciesJMGrahamHKAssessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of NeurologyNeurology200870191691169818458229
   PubMed Web of Science ®Google Scholar
• SantamatoAPanzaFRanieriMEfficacy and safety of higher doses of botulinum toxin type A NT 201 free from complexing proteins in the upper and lower limb spasticity after strokeJ Neural Transm2013120346947622955957
   PubMed Web of Science ®Google Scholar
• SantamatoAMicelloMFRanieriMEmployment of higher doses of botulinum toxin type A to reduce spasticity after strokeJ Neurol Sci20153501–21625684341
   PubMed Web of Science ®Google Scholar
• AlbaneseATerminology for preparations of botulinum neurotoxins: what a difference a name makesJAMA20113058990
   PubMed Web of Science ®Google Scholar
• DresslerDManderGJFinkKEquivalent potency of Xeomin® and Botox®Mov Disord2008123 supplS20S21
   Google Scholar
• DresslerDManderGFinkKMeasuring the potency labelling of onabotulinumtoxinA (Botox(®)) and incobotulinumtoxinA (Xeomin(®)) in an LD50 assayJ Neural Transm2012119131521971766
   PubMed Web of Science ®Google Scholar
• OdergrenTHjaltasonHKaakkolaSA double blind, randomised, parallel group study to investigate the dose equivalence of Dysport® and Botox® in the treatment of cervical dystoniaJ Neurol Neurosurg Psychiatry199864612
   PubMed Web of Science ®Google Scholar
• FrevertJContent of botulinum neurotoxin in Botox®/Vistabel®, Dysport®/Azzalure®, and Xeomin®/Bocouture®Drugs R D20101026773
   PubMedGoogle Scholar
• GreinSManderGJFinkKStability of botulinum neurotoxin type A, devoid of complexing proteinsBotulinum J2011214957
   Google Scholar
• EiseleKHFinkKVeyMTaylorHVStudies on the dissociation of botulinum neurotoxin type A complexesToxicon2011574555565
   Web of Science ®Google Scholar
• CarliLMontecuccoCRossettoOAssay of diffusion of different botulinum neurotoxin type a formulations injected in the mouse legMuscle Nerve200940337438019618426
   PubMed Web of Science ®Google Scholar
• SantamatoARanieriMPanzaFEffectiveness of switching therapy from complexing protein-containing botulinum toxin type A to a formulation with low immunogenicity in spasticity after stroke: a case reportJ Rehabil Med201244979579722915045
   PubMed Web of Science ®Google Scholar
• Merz Pharmaceuticals GmbH [webpage on the Internet]Xeomin® US Prescribing Information [updated July 2011] Available from http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/125360s045lbl.pdfAccessed October 13, 2014
   Google Scholar
• KanovskýPSlawekJDenesZEfficacy and safety of botulinum neurotoxin NT 201 in poststroke upper limb spasticityClin Neuropharmacol200932525926519644361
   PubMed Web of Science ®Google Scholar
• KaňovskýPSlawekJDenesZEfficacy and safety of treatment with incobotulinum toxin A (botulinum neurotoxin type A free from complexing proteins; NT 201) in post-stroke upper limb spasticityJ Rehabil Med201143648649221533328
   PubMed Web of Science ®Google Scholar
• BarnesMSchnitzlerAMedeirosLAguilarMLehnert-BatarAMinnaschPEfficacy and safety of NT 201 for upper limb spasticity of various etiologies – a randomized parallel-group studyActa Neurol Scand2010122429530220456248
   PubMed Web of Science ®Google Scholar
• ElovicEPMuninMCKaňovskýPHanschmannAHiersemenzelRMarciniakCRandomized, placebo-controlled trial of incobotulinumtoxinA for upper-limb post-stroke spasticityMuscle Nerve Epub2015722
   PubMed Web of Science ®Google Scholar
• SantamatoAMicelloMFPanzaFSafety and efficacy of incobotulinum toxin type A (NT 201-Xeomin) for the treatment of post-stroke lower limb spasticity: a prospective open-label studyEur J Phys Rehabil Med201349448348923480980
   PubMed Web of Science ®Google Scholar
• FiorePSantamatoARanieriMTreatment of upper limb spasticity after stroke: one-year safety and efficacy of botulinum toxin type A NT201Int J Immunopathol Pharmacol2012251 suppl57S62S22652163
   PubMed Web of Science ®Google Scholar
• HesseSMachHFrohlichSBehrendSWernerCMelzerIAn early botulinum toxin A treatment in subacute stroke patients may prevent a disabling finger flexor stiffness six months later: a randomized controlled trialClin Rehabil201226323724521971750
   PubMed Web of Science ®Google Scholar
• DresslerDSaberiFAKolleweKSchraderCSafety aspects of incobotulinumtoxinA high-dose therapyJ Neural Transm20151222327333
   PubMed Web of Science ®Google Scholar
• InvernizziMCardaSMolinariCStagnoDCisariCBaricichAHeart rate variability (HRV) modifications in adult hemiplegic patients after botulinum toxin type A (nt-201) injectionEur J Phys Rehabil Med201551435335925051207
   PubMed Web of Science ®Google Scholar
• SantamatoAMicelloMFPanzaFAdhesive taping vs daily manual muscle stretching and splinting after botulinum toxin type A injection for wrist and fingers spastic overactivity in stroke patients: a randomized controlled trialClin Rehabil20152915058
   PubMed Web of Science ®Google Scholar
• BaricichAGranaECardaSSantamatoACisariCInvernizziMHigh doses of onabotulinumtoxinA in post-stroke spasticity: a retrospective analysisJ Neural Transm201512291283128725724294
   PubMed Web of Science ®Google Scholar
• BergfeldtUSköldCJulinPShort Form 36 assessed health-related quality of life after focal spasticity therapyJ Rehabil Med2009414279281
   Web of Science ®Google Scholar
• CatyGDDetrembleurCBleyenheuftCDeltombeTLejeuneTMEffect of upper limb botulinum toxin injections on impairment, activity, participation, and quality of life among stroke patientsStroke20094072589259119407231
   PubMed Web of Science ®Google Scholar
• McCroryPTurner-StokesLBaguleyIJBotulinum toxin A for treatment of upper limb spasticity following stroke: a multi-centre randomized placebo-controlled study of the effects on quality of life and other person-centred outcomesJ Rehabil Med200941753654419543664
   PubMed Web of Science ®Google Scholar
• BensmailDHanschmannAWisselJSatisfaction with botulinum toxin treatment in post-stroke spasticity: results from two cross-sectional surveys (patients and physicians)J Med Econ201417961862524841450
   PubMedGoogle Scholar
• LieberRLSteinmanSBarashIAChambersHStructural and functional changes in spastic skeletal muscleMuscle Nerve200429561562715116365
   PubMed Web of Science ®Google Scholar
• Hafer-MackoCERyanASIveyFMMackoRFSkeletal muscle changes after hemiparetic stroke and potential beneficial effects of exercise intervention strategiesJ Rehabil Res Dev200845226127218566944
   PubMed Web of Science ®Google Scholar
• FortunaRHorisbergerMVazMAHerzogWDo skeletal muscle properties recover following repeat onabotulinum toxin A injections?J Biomech201346142426243323953503
   PubMed Web of Science ®Google Scholar
• FortunaRVazMASawatskyAHartDAHerzogWA clinically relevant BTX-A injection protocol leads to persistent weakness, contractile material loss, and an altered mRNA expression phenotype in rabbit quadriceps musclesJ Biomech201548101700170626087882
   PubMed Web of Science ®Google Scholar