Cordycepin Nanoencapsulated in Poly(Lactic-Co-Glycolic Acid) Exhibits Better Cytotoxicity and Lower Hemotoxicity Than Free Drug

References

• Shi P, Huang Z, Tan X, Chen G. Proteomic detection of changes in protein expression induced by cordycepin in human hepatocellular carcinoma BEL-7402 cells. Methods Find Exp Clin Pharmacol. 2008;30:347–353. doi:10.1358/mf.2008.30.5.118608518806893
   PubMedGoogle Scholar
• Li G, Nakagome I, Hirono S, Itoh T, Fujiwara R. Inhibition of adenosine deaminase (ADA) mediated metabolism of cordycepin by natural substances. Pharmacol Res Perspect. 2015;3:e00121. doi:10.1002/prp2.12126038697
   PubMed Web of Science ®Google Scholar
• Cao T, Xu R, Xu Y, Liu Y, Qi D, Wan Q. The protective effect of Cordycepin on diabetic nephropathy through autophagy induction in vivo and in vitro. Int Urol Nephrol. 2019;51:1883–1892. doi:10.1007/s11255-019-02241-y31359358
   PubMed Web of Science ®Google Scholar
• Ashraf S, Radhi M, Gowler P, et al. The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis. Sci Rep. 2019;9:4696. doi:10.1038/s41598-019-41140-130886197
   PubMed Web of Science ®Google Scholar
• Cho HJ, Cho JY, Rhee MH, Kim HS, Lee HS, Park HJ. Inhibitory effects of cordycepin (3ʹ-deoxyadenosine), a component of Cordyceps militaris, on human platelet aggregation induced by thapsigargin. J Microbiol Biotechnol. 2007;17:1134–1138.18051324
   PubMed Web of Science ®Google Scholar
• Tian X, Li Y, Shen Y, Li Q, Wang Q, Feng L. Apoptosis and inhibition of proliferation of cancer cells induced by cordycepin. Oncology Lett. 2015;10:595–599. doi:10.3892/ol.2015.3273
   Web of Science ®Google Scholar
• Lee HJ, Burger P, Vogel M, Friese K, Bruning A. The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells. Invest New Drugs. 2012;30:1917–1925. doi:10.1007/s10637-012-9859-x22821173
   PubMed Web of Science ®Google Scholar
• Liu C, Qi M, Li L, Yuan Y, Wu X, Fu J. Natural cordycepin induces apoptosis and suppresses metastasis in breast cancer cells by inhibiting the Hedgehog pathway. Food Funct. 2020;11:2107–2116. doi:10.1039/C9FO02879J32163051
   PubMed Web of Science ®Google Scholar
• Jo E, Jang HJ, Yang KE, et al. Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation. BMC Complement Med Ther. 2020;20:1. doi:10.1186/s12906-019-2780-532020859
   PubMedGoogle Scholar
• Nakamura K, Shinozuka K, Yoshikawa N. Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis. J Pharmacol Sci. 2015;127:53–56. doi:10.1016/j.jphs.2014.09.00125704018
   PubMed Web of Science ®Google Scholar
• Guan H, Qi S, Liu W, Ma C, Wang C. A rapid assay to screen adenosine deaminase inhibitors from Ligustri Lucidi Fructus against metabolism of cordycepin utilizing ultra high performance liquid chromatography–tandem mass spectrometry. Biomed Chromatogr. 2020;34:e4779. doi:10.1002/bmc.477931845520
   PubMed Web of Science ®Google Scholar
• Aghaei M, Karami-Tehrani F, Salami S, Atri M. Diagnostic value of adenosine deaminase activity in benign and malignant breast tumors. Arch Med Res. 2010;41:14–18. doi:10.1016/j.arcmed.2009.10.01220430249
   PubMed Web of Science ®Google Scholar
• Blackburn MR, Kellems RE. Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation. Adv Immunol. 2005;86:1–41. doi:10.1016/S0065-2776(04)86001-215705418
   PubMed Web of Science ®Google Scholar
• Wu PK, Tao Z, Ouyang Z, et al. The anti-tumor effects of cordycepin-loaded liposomes on the growth of hepatoma 22 tumors in mice and human hepatoma BEL-7402 cells in culture. Drug Dev Ind Pharm. 2016;42:1424–1433. doi:10.3109/03639045.2016.114193026984179
   PubMed Web of Science ®Google Scholar
• Tsai Y-J, Lin L-C, Tsai T-H. Pharmacokinetics of adenosine and cordycepin, a bioactive constituent of Cordyceps sinensis in rat. J Agric Food Chem. 2010;58:4638–4643. doi:10.1021/jf100269g20302371
   PubMed Web of Science ®Google Scholar
• Marslin G, Sheeba CJ, Kalaichelvan VK, Manavalan R, Reddy PN, Franklin G. Poly(D,L-lactic-co-glycolic acid) nanoencapsulation reduces erlotinib-induced subacute toxicity in rat. J Biomed Nanotechnol. 2009;5:464–471. doi:10.1166/jbn.2009.107520201419
   PubMed Web of Science ®Google Scholar
• Marslin G, Revina AM, Khandelwal VK, Balakumar K, Sheeba CJ, Franklin G. PEGylated ofloxacin nanoparticles render strong antibacterial activity against many clinically important human pathogens. Colloids Surf B. 2015;132:62–70. doi:10.1016/j.colsurfb.2015.04.050
   PubMed Web of Science ®Google Scholar
• Karanam V, Marslin G, Krishnamoorthy B, et al. Poly (e-caprolactone) nanoparticles of carboplatin: preparation, characterization and in vitro cytotoxicity evaluation in U-87 MG cell lines. Colloids Surf B. 2015;130:48–52. doi:10.1016/j.colsurfb.2015.04.005
   Web of Science ®Google Scholar
• Lee SS, Lee YB, Oh IJ. Cellular uptake of poly(dl-lactide-co-glycolide) nanoparticles: effects of drugs and surface characteristics of nanoparticles. J Pharm Investig. 2015;45:659–667. doi:10.1007/s40005-015-0221-0
   Google Scholar
• Aramwit P, Porasuphatana S, Srichana T, Nakpheng T. Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity. Nanoscale Res Lett. 2015;10:015–0851. doi:10.1186/s11671-015-0851-1
   Web of Science ®Google Scholar
• Xia C, Chen P, Mei S, et al. Photo-crosslinked HAMA hydrogel with cordycepin encapsulated chitosan microspheres for osteoarthritis treatment. Oncotarget. 2017;8(2):2835–2849. doi:10.18632/oncotarget.1374827926509
   PubMedGoogle Scholar
• Bi YE, Zhou Y, Wang M, et al. Targeted delivery of cordycepin to liver cancer cells using transferrin-conjugated liposomes. Anticancer Res. 2017;37:5207–5214. doi:10.21873/anticanres.1194428870956
   PubMed Web of Science ®Google Scholar
• Makadia HK, Siegel SJ. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers. 2011;3:1377–1397. doi:10.3390/polym303137722577513
   PubMed Web of Science ®Google Scholar
• Danhier F, Ansorena E, Silva JM, Coco R, Le Breton A, Preat V. PLGA-based nanoparticles: an overview of biomedical applications. J Control Release. 2012;161:505–522. doi:10.1016/j.jconrel.2012.01.04322353619
   PubMed Web of Science ®Google Scholar
• Vasir JK, Labhasetwar V. Biodegradable nanoparticles for cytosolic delivery of therapeutics. Adv Drug Deliver Rev. 2007;59:718–728. doi:10.1016/j.addr.2007.06.003
   PubMed Web of Science ®Google Scholar
• Rafiei P, Haddadi A. Docetaxel-loaded PLGA and PLGA-PEG nanoparticles for intravenous application: pharmacokinetics and biodistribution profile. Int J Nanomedicine. 2017;12:935–947. doi:10.2147/IJN.S12188128184163
   PubMed Web of Science ®Google Scholar
• Mayol L, Serri C, Menale C, et al. Curcumin loaded PLGA-poloxamer blend nanoparticles induce cell cycle arrest in mesothelioma cells. Eur J Pharm Biopharm. 2015;93:37–45. doi:10.1016/j.ejpb.2015.03.00525794477
   PubMed Web of Science ®Google Scholar
• Zhu L, Liang Y, Lao D, Zhang T, Ito Y. Preparative separation of high-purity cordycepin from Cordyceps militaris(L.) Link by high-speed countercurrent chromatography. J Liq Chromatogr Relat Technol. 2011;37:491‐499. doi:10.1080/10826076.2011.556965
   Google Scholar
• Ramanlal Chaudhari K, Kumar A, Megraj Khandelwal VK, et al. Bone metastasis targeting: a novel approach to reach bone using zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel. J Control Release. 2012;158:470–478. doi:10.1016/j.jconrel.2011.11.02022146683
   PubMed Web of Science ®Google Scholar
• Rawat S, Gupta P, Kumar A, Garg P, Suri CR, Sahoo DK. Molecular mechanism of poly(vinyl alcohol) mediated prevention of aggregation and stabilization of insulin in nanoparticles. Mol Pharm. 2015;12:1018–1030. doi:10.1021/mp500365325644480
   PubMed Web of Science ®Google Scholar
• Bohrey S, Chourasiya V, Pandey A. Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study. Nano Converg. 2016;3:3. doi:10.1186/s40580-016-0061-228191413
   PubMed Web of Science ®Google Scholar
• Mainardes RM, Evangelista RC. PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution. Int J Pharm. 2005;290:137–144. doi:10.1016/j.ijpharm.2004.11.02715664139
   PubMed Web of Science ®Google Scholar
• Mittal G, Sahana DK, Bhardwaj V, Ravi Kumar MN. Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. J Control Release. 2007;119:77–85. doi:10.1016/j.jconrel.2007.01.01617349712
   PubMed Web of Science ®Google Scholar
• Chaudhari KR, Kumar A, Khandelwal VKM, Mishra AK, Monkkonen J, Murthy RSR. Targeting efficiency and biodistribution of zoledronate conjugated docetaxel loaded pegylated PBCA nanoparticles for bone metastasis. Adv Funct Mater. 2012;22:4101–4114. doi:10.1002/adfm.201102357
   Web of Science ®Google Scholar
• Xiong S, Zhao X, Heng BC, Ng KW, Loo JS. Cellular uptake of Poly-(D,L-lactide-co-glycolide) (PLGA) nanoparticles synthesized through solvent emulsion evaporation and nanoprecipitation method. Biotechnol J. 2011;6(5):501–508. doi:10.1002/biot.20100035121259442
   PubMed Web of Science ®Google Scholar
• Lui JCK, Wong JWY, Suen YK, Kwok TT, Fung KP, Kong SK. Cordycepin induced eryptosis in mouse erythrocytes through a Ca2+-dependent pathway without caspase-3 activation. Arch Toxicol. 2007;81:859–865. doi:10.1007/s00204-007-0214-517541556
   PubMed Web of Science ®Google Scholar