Simulated Night-Shift Schedule Disrupts the Plasma Lipidome and Reveals Early Markers of Cardiovascular Disease Risk

References

• Potter GD, Skene DJ, Arendt J, Cade JE, Grant PJ, Hardie LJ. Circadian Rhythm and Sleep Disruption: causes, Metabolic Consequences, and Countermeasures. Endocr Rev. 2016;37(6):584–608. doi:10.1210/er.2016-1083
   PubMed Web of Science ®Google Scholar
• Astiz M, Heyde I, Oster H. Mechanisms of Communication in the Mammalian Circadian Timing System. Int J Mol Sci. 2019;20(2):65. doi:10.3390/ijms20020343
   Web of Science ®Google Scholar
• Reinke H, Asher G. Crosstalk between metabolism and circadian clocks. Nat Rev Mol Cell Biol. 2019;20(4):227–241. doi:10.1038/s41580-018-0096-9
   PubMed Web of Science ®Google Scholar
• Crnko S, Du Pré BC, Sluijter JPG, Van Laake LW. Circadian rhythms and the molecular clock in cardiovascular biology and disease. Nat Rev Cardiol. 2019;16(7):437–447. doi:10.1038/s41569-019-0167-4
   PubMed Web of Science ®Google Scholar
• Hayter EA, Wehrens SMT, Van Dongen HPA, et al. Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia. Nat Commun. 2021;12(1):2472. doi:10.1038/s41467-021-22788-8
   PubMed Web of Science ®Google Scholar
• Costa G. Shift work and health: current problems and preventive actions. Saf Health Work. 2010;1(2):112–123. doi:10.5491/shaw.2010.1.2.112
   PubMedGoogle Scholar
• James SM, Honn KA, Gaddameedhi S, Van Dongen HPA. Shift Work: disrupted Circadian Rhythms and Sleep-Implications for Health and Well-Being. Curr Sleep Med Rep. 2017;3(2):104–112. doi:10.1007/s40675-017-0071-6
   PubMedGoogle Scholar
• Adamovich Y, Rousso-Noori L, Zwighaft Z, et al. Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides. Cell Metab. 2014;19(2):319–330. doi:10.1016/j.cmet.2013.12.016
   PubMed Web of Science ®Google Scholar
• Chua EC, Shui G, Cazenave-Gassiot A, Wenk MR, Gooley JJ. Changes in Plasma Lipids during Exposure to Total Sleep Deprivation. Sleep. 2015;38(11):1683–1691. doi:10.5665/sleep.5142
   PubMed Web of Science ®Google Scholar
• Chua EC, Shui G, Lee IT-G, et al. Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans. Proce National Acad Sci. 2013;110(35):14468–14473. doi:10.1073/pnas.1222647110
   PubMed Web of Science ®Google Scholar
• Loizides-Mangold U, Perrin L, Vandereycken B, et al. Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro. Proc Natl Acad Sci U S A. 2017;114(41):E8565–e8574. doi:10.1073/pnas.1705821114
   PubMed Web of Science ®Google Scholar
• Wehrens SM, Hampton SM, Finn RE, Skene DJ. Effect of total sleep deprivation on postprandial metabolic and insulin responses in shift workers and non-shift workers. J Endocrinol. 2010;206(2):205–215. doi:10.1677/joe-10-0077
   PubMed Web of Science ®Google Scholar
• Kervezee L, Cermakian N, Boivin DB. Individual metabolomic signatures of circadian misalignment during simulated night shifts in humans. PLoS Biol. 2019;17(6):e3000303. doi:10.1371/journal.pbio.3000303
   PubMed Web of Science ®Google Scholar
• Skene DJ, Skornyakov E, Chowdhury NR, et al. Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism. Proc Natl Acad Sci U S A. 2018;115(30):7825–7830. doi:10.1073/pnas.1801183115
   PubMed Web of Science ®Google Scholar
• Duffy JF, Dijk DJ. Getting through to circadian oscillators: why use constant routines? J Biol Rhythms. 2002;17(1):4–13. doi:10.1177/074873002129002294
   PubMed Web of Science ®Google Scholar
• Khalyfa A, Gaddameedhi S, Crooks E, et al. Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues. Int J Mol Sci. 2020;21(17):65. doi:10.3390/ijms21176396
   Web of Science ®Google Scholar
• Fretts AM, Jensen PN, Hoofnagle A, et al. Plasma Ceramide Species Are Associated with Diabetes Risk in Participants of the Strong Heart Study. J Nutr. 2019;150(5):1214–1222. doi:10.1093/jn/nxz259
   Web of Science ®Google Scholar
• Havulinna AS, Sysi-Aho M, Hilvo M, et al. Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort. Arterioscler Thromb Vasc Biol. 2016;36(12):2424–2430. doi:10.1161/atvbaha.116.307497
   PubMed Web of Science ®Google Scholar
• Miller M, Stone NJ, Ballantyne C, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011;123(20):2292–2333. doi:10.1161/CIR.0b013e3182160726
   PubMed Web of Science ®Google Scholar
• McMahon WR, Ftouni S, Phillips AJK, et al. The impact of structured sleep schedules prior to an in-laboratory study: individual differences in sleep and circadian timing. PLoS One. 2020;15(8):e0236566. doi:10.1371/journal.pone.0236566
   PubMed Web of Science ®Google Scholar
• Folch J, Lees M, Sloane stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957;226(1):497–509.
   PubMed Web of Science ®Google Scholar
• Nakayasu ES, Nicora CD, Sims AC, et al. MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses. mSystems. 2016;1(3):315. doi:10.1128/mSystems.00043-16
   Web of Science ®Google Scholar
• Bowden JA, Heckert A, Ulmer CZ, et al. Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma. J Lipid Res. 2017;58(12):2275–2288. doi:10.1194/jlr.M079012
   PubMed Web of Science ®Google Scholar
• Kyle JE, Crowell KL, Casey CP, et al. LIQUID: an-open source software for identifying lipids in LC-MS/MS-based lipidomics data. Bioinformatics. 2017;33(11):1744–1746. doi:10.1093/bioinformatics/btx046
   PubMed Web of Science ®Google Scholar
• Pluskal T, Castillo S, Villar-Briones A, Oresic M. MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinform. 2010;11:395. doi:10.1186/1471-2105-11-395
   PubMed Web of Science ®Google Scholar
• Matzke MM, Waters KM, Metz TO, et al. Improved quality control processing of peptide-centric LC-MS proteomics data. Bioinformatics. 2011;27(20):2866–2872. doi:10.1093/bioinformatics/btr479
   PubMed Web of Science ®Google Scholar
• Cornelissen G. Cosinor-based rhythmometry. Theor Biol Med Model. 2014;11:16. doi:10.1186/1742-4682-11-16
   PubMed Web of Science ®Google Scholar
• Team RDC. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing; 2019.
   Google Scholar
• Mikulich SK, Zerbe GO, Jones RH, Crowley TJ. Comparing linear and nonlinear mixed model approaches to cosinor analysis. Stat Med. 2003;22(20):3195–3211. doi:10.1002/sim.1560
   PubMed Web of Science ®Google Scholar
• Scargle JD. Studies in astronomical time series analysis. II. Statistical aspects of spectral analysis of unevenly spaced data. Astrophys J. 1982;263:835–853. doi:10.1086/160554
   Web of Science ®Google Scholar
• Hosack DA, Dennis G, Sherman BT, Lane HC, Lempicki RA. Identifying biological themes within lists of genes with EASE. Genome Biol. 2003;4(10):R70. doi:10.1186/gb-2003-4-10-r70
   PubMed Web of Science ®Google Scholar
• Clair G, Reehl S, Stratton KG, et al. Lipid Mini-On: mining and ontology tool for enrichment analysis of lipidomic data. Bioinformatics. 2019;35(21):4507–4508. doi:10.1093/bioinformatics/btz250
   PubMed Web of Science ®Google Scholar
• Figueiro MG, White RD. Health consequences of shift work and implications for structural design. J Perinatol. 2013;33(1):S17–S23. doi:10.1038/jp.2013.7
   PubMed Web of Science ®Google Scholar
• Antunes LC, Levandovski R, Dantas G, Caumo W, Hidalgo MP. Obesity and shift work: chronobiological aspects. Nutr Res Rev. 2010;23(1):155–168. doi:10.1017/s0954422410000016
   PubMed Web of Science ®Google Scholar
• De Bacquer D, Van Risseghem M, Clays E, Kittel F, De Backer G, Braeckman L. Rotating shift work and the metabolic syndrome: a prospective study. Int J Epidemiol. 2009;38(3):848–854. doi:10.1093/ije/dyn360
   PubMed Web of Science ®Google Scholar
• Knutsson A, Kempe A. Shift work and diabetes–a systematic review. Chronobiol Int. 2014;31(10):1146–1151. doi:10.3109/07420528.2014.957308
   PubMed Web of Science ®Google Scholar
• Nojkov B, Rubenstein JH, Chey WD, Hoogerwerf WA. The impact of rotating shift work on the prevalence of irritable bowel syndrome in nurses. Am J Gastroenterol. 2010;105(4):842–847. doi:10.1038/ajg.2010.48
   PubMed Web of Science ®Google Scholar
• Haupt CM, Alte D, Dörr M, et al. The relation of exposure to shift work with atherosclerosis and myocardial infarction in a general population. Atherosclerosis. 2008;201(1):205–211. doi:10.1016/j.atherosclerosis.2007.12.059
   PubMed Web of Science ®Google Scholar
• Rizza S, Neri A, Capanna A, et al. Night Shift Working Is Associated With an Increased Risk of Thyroid Nodules. J Occup Environ Med. 2020;62(1):1–3. doi:10.1097/jom.0000000000001711
   PubMed Web of Science ®Google Scholar
• Straif K, Baan R, Grosse Y, et al. Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncol. 2007;8(12):1065–1066. doi:10.1016/s1470-2045(07
   PubMed Web of Science ®Google Scholar
• Jacobson TA, Ito MK, Maki KC, et al. National Lipid Association recommendations for patient-centered management of dyslipidemia: part 1 - executive summary. J Clin Lipidol. 2014;8(5):473–488. doi:10.1016/j.jacl.2014.07.007
   PubMed Web of Science ®Google Scholar
• Mundra PA, Barlow CK, Nestel PJ, et al. Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention. JCI Insight. 2018;3(17):555. doi:10.1172/jci.insight.121326
   Web of Science ®Google Scholar
• Calder PC. Functional Roles of Fatty Acids and Their Effects on Human Health. JPEN J Parenter Enteral Nutr. 2015;39(1Suppl):18s–32s. doi:10.1177/0148607115595980
   PubMed Web of Science ®Google Scholar
• Ding M, Rexrode KM. A Review of Lipidomics of Cardiovascular Disease Highlights the Importance of Isolating Lipoproteins. Metabolites. 2020;10(4):5149. doi:10.3390/metabo10040163
   Web of Science ®Google Scholar
• Wang Z, Park HG, Wang DH, Kitano R, Kothapalli KSD, Brenna JT. Fatty acid desaturase 2 (FADS2) but not FADS1 desaturates branched chain and odd chain saturated fatty acids. Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865(3):158572. doi:10.1016/j.bbalip.2019.158572
   PubMed Web of Science ®Google Scholar
• Shi L, Brunius C, Lehtonen M, et al. Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort. Diabetologia. 2018;61(4):849–861. doi:10.1007/s00125-017-4521-y
   PubMed Web of Science ®Google Scholar
• Martín-Timón I, Sevillano-Collantes C, Segura-Galindo A, Del Cañizo-Gómez FJ. Type 2 diabetes and cardiovascular disease: have all risk factors the same strength? World J Diabetes. 2014;5(4):444–470. doi:10.4239/wjd.v5.i4.444
   PubMedGoogle Scholar
• Lambert JE, Parks EJ. Postprandial metabolism of meal triglyceride in humans. Biochim Biophys Acta. 2012;1821(5):721–726. doi:10.1016/j.bbalip.2012.01.006
   PubMed Web of Science ®Google Scholar
• Jenkins B, West JA, Koulman A. A review of odd-chain fatty acid metabolism and the role of pentadecanoic Acid (c15:0) and heptadecanoic Acid (c17:0) in health and disease. Molecules. 2015;20(2):2425–2444. doi:10.3390/molecules20022425
   PubMed Web of Science ®Google Scholar
• Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB. Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem. 2010;285(15):11348–11356. doi:10.1074/jbc.M109.075184
   PubMed Web of Science ®Google Scholar
• Suryawan A, Hawes JW, Harris RA, Shimomura Y, Jenkins AE, Hutson SM. A molecular model of human branched-chain amino acid metabolism. Am J Clin Nutr. 1998;68(1):72–81. doi:10.1093/ajcn/68.1.72
   PubMed Web of Science ®Google Scholar
• Wang Z, Wang DH, Goykhman Y, et al. The elongation of very long-chain fatty acid 6 gene product catalyses elongation of n-13: 0 and n-15: 0 odd-chain SFA in human cells. Br J Nutr. 2019;1:1–8. doi:10.1017/s0007114518003185
   Web of Science ®Google Scholar
• Grant AD, Wolf GI. Free-Living Humans Cross Cardiovascular Disease Risk Categories Due to Daily Rhythms in Cholesterol and Triglycerides. J Circadian Rhythms. 2019;17:3. doi:10.5334/jcr.178
   PubMedGoogle Scholar
• Isherwood CM, Van der Veen DR, Johnston JD, Skene DJ. Twenty-four-hour rhythmicity of circulating metabolites: effect of body mass and type 2 diabetes. FASEB j. 2017;31(12):5557–5567. doi:10.1096/fj.201700323R
   PubMed Web of Science ®Google Scholar
• Grant LK, Czeisler CA, Lockley SW, Rahman SA. Time-of-day and Meal Size Effects on Clinical Lipid Markers. J Clin Endocrinol Metab. 2021;106(3):e1373–e1379. doi:10.1210/clinem/dgaa739
   PubMed Web of Science ®Google Scholar
• Grant LK, St Hilaire MA, Brainard GC, Czeisler CA, Lockley SW, Rahman SA. Endogenous circadian regulation and phase resetting of clinical metabolic biomarkers. J Pineal Res. 2021;1:e12752. doi:10.1111/jpi.12752
   Web of Science ®Google Scholar
• Kent BA, Rahman SA, St. Hilaire MA, et al. Circadian lipid and hepatic protein rhythms shift with a phase response curve different than melatonin. Nat Commun. 2022;13(1):681. doi:10.1038/s41467-022-28308-6
   PubMed Web of Science ®Google Scholar
• Kuang J, Chen L, Tang Q, Zhang J, Li Y, He J. The Role of Sirt6 in Obesity and Diabetes. Front Physiol. 2018;9:135. doi:10.3389/fphys.2018.00135
   PubMed Web of Science ®Google Scholar
• Masri S, Rigor P, Cervantes M, et al. Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell. 2014;158(3):659–672. doi:10.1016/j.cell.2014.06.050
   PubMed Web of Science ®Google Scholar
• Kyle JE. How lipidomics can transform our understanding of virus infections. Expert Rev Proteomics. 2021;18(5):329–332. doi:10.1080/14789450.2021.1929177
   PubMed Web of Science ®Google Scholar