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Review

Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development

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Pages 107-120 | Published online: 15 Apr 2016

References

  • JouvetMParadoxical sleep – a study of its nature and mechanismsProg Brain Res196518206214329040
  • SchenckCHBundlieSREttingerMGMahowaldMWChronic behavioral disorders of human REM sleep: a new category of parasomniaSleep198692933083505730
  • SchenckCHMontplaisirJYFrauscherBRapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy – a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study GroupSleep Med20131479580623886593
  • SforzaEZucconiMPetronelliRLugaresiECirignottaFREM sleep behavioral disordersEur Neurol1988282953003224627
  • BrooksPLPeeverJHImpaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in miceJ Neurosci2011317111712121562273
  • MattarozziKBellucciCCampiCClinical, behavioural and polysomnographic correlates of cataplexy in patients with narcolepsy/cataplexySleep Med2008942543317681883
  • KnudsenSGammeltoftSJennumPJRapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiencyBrain201013356857920129934
  • SchenckCHBoeveBFMahowaldMWDelayed emergence of a parkinsonian disorder or dementia in 81% of older males initially diagnosed with idiopathic REM sleep behavior disorder (RBD): 16 year update on a previously reported seriesSleep Med201314874474823347909
  • IranzoAFernández-ArcosATolosaENeurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patientsPLoS One20149e8974124587002
  • PostumaRBGagnonJFVendetteMFantiniMLMassicotte-MarquezJMontplaisirJQuantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorderNeurology2009721296130019109537
  • SchenckCHBundlieSRMahowaldMWDelayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorderNeurology1996463883938614500
  • TerzaghiMZucchellaCRustioniVSinforianiEManniRCognitive performances and mild cognitive impairment in idiopathic rapid eye movement sleep behavior disorder: results of a longitudinal follow-up studySleep2013361527153224082312
  • SorensenGLMehlsenJJennumPReduced sympathetic activity in idiopathic rapid-eye-movement sleep behavior disorder and Parkinson’s diseaseAuton Neurosci201317913814124021939
  • KashiharaKImamuraTShinyaTCardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson’s diseaseParkinsonism Relat Disord20101625225520097595
  • MiyamotoTMiyamotoMSuzukiKNishibayashiMIwanamiMHirataK123I-MIBG cardiac scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorderSleep20083171772318517041
  • UngerMMMöllerJCMankelKPatients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath testMov Disord2011262559256322147682
  • PetitDGagnonJFFantiniMLFerini-StrambiLMontplaisirJSleep and quantitative EEG in neurodegenerative disordersJ Psychosom Res20045648749615172204
  • PostumaRBGagnonJFMontplaisirJClinical prediction of Parkinson’s disease: planning for the age of neuroprotectionJ Neurol Neurosurg Psychiatry2010811008101320562452
  • RossGWAbbottRDPetrovitchHTannerCMWhiteLRPre-motor features of Parkinson’s disease: the Honolulu-Asia Aging Study experienceParkinsonism Relat Disord201218suppl 1S199S20222166434
  • NoyceAJBestwickJPSilveira-MoriyamaLPREDICT-PD: identifying risk of Parkinson’s disease in the community: methods and baseline resultsJ Neurol Neurosurg Psychiatry201485313723828833
  • SaperCBFullerPMPedersenNPLuJScammellTESleep state switchingNeuron2010681023104221172606
  • IberCThe American Academy Sleep Medicine Manual for the Scoring of Sleep and Associated EventsWestchester, ILAmerican Academy of Sleep Medicine2007
  • LuppiPHClementOFortPParadoxical (REM) sleep genesis by the brainstem is under hypothalamic controlCurr Opin Neurobiol201323578679223490549
  • SaperCBThe neurobiology of sleepContinuum (Minneap Minn)201319193123385692
  • SapinELaprayDBérodALocalization of the brainstem GABAergic neurons controlling paradoxical (REM) sleepPLoS One20094e427219169414
  • VerretLLegerLFortPLuppiPHCholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recoveryEur J Neurosci2005212488250415932606
  • LuJShermanDDevorMSaperCBA putative flip-flop switch for control of REM sleepNature200644158959416688184
  • SastreJPBudaCKitahamaKJouvetMImportance of the ventrolateral region of the periaqueductal gray and adjacent tegmentum in the control of paradoxical sleep as studied by muscimol microinjections in the catNeuroscience1996744154268865193
  • CrochetSOnoeHSakaiKA potent non-monoaminergic paradoxical sleep inhibitory system: a reverse microdialysis and single-unit recording studyEur J Neurosci2006241404141216987225
  • VerretLFortPGervasoniDLégerLLuppiPHLocalization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the ratJ Comp Neurol200649557358616498678
  • BoissardRGervasoniDSchmidtMHBarbagliBFortPLuppiPHThe rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical studyEur J Neurosci2002161959197312453060
  • ClementOSapinEBerodAFortPLuppiPHEvidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergicSleep20113441942321461384
  • SiegelJMThe neurobiology of sleepSemin Neurol20092927729619742406
  • LaiYYSiegelJMPontomedullary glutamate receptors mediating locomotion and muscle tone suppressionJ Neurosci199111293129371679125
  • MileykovskiyBYKiyashchenkoLIKodamaTLaiYYSiegelJMActivation of pontine and medullary motor inhibitory regions reduces discharge in neurons located in the locus coeruleus and the anatomical equivalent of the midbrain locomotor regionJ Neurosci2000208551855811069963
  • LuppiPHGervasoniDBoissardRBrainstem structures responsible for paradoxical sleep onset and maintenanceArch Ital Biol200414239741115493544
  • KrenzerMAnacletCVetrivelanRBrainstem and spinal cord circuitry regulating REM sleep and muscle atoniaPLoS One20116e2499822043278
  • RamaligamVChenMCSaperCBLuJPerspectives on the rapid eye movement sleep switch in rapid eye movement sleep behavior disorderSleep Med20131470771323768838
  • VetrivelanRFullerPMTongQLuJMedullary circuitry regulating rapid eye movement sleep and motor atoniaJ Neurosci2009299361936919625526
  • WebsterHHFriedmanLJonesBEModification of paradoxical sleep following transections of the reticular formation at the pontomedullary junctionSleep198691233961365
  • AnacletCPedersenNPFullerPMLuJBrainstem circuitry regulating phasic activation of trigeminal motoneurons during REM sleepPLoS One20105e878820098748
  • LaiYYHsiehKCNguyenDPeeverJSiegelJMNeurotoxic lesions at the ventral mesopontine junction change sleep time and muscle activity during sleep: an animal model of motor disorders in sleepNeuroscience200815443144318487021
  • VetrivelanRChangCLuJMuscle tone regulation during REM sleep: neural circuitry and clinical significanceArch Ital Biol201114934836622205588
  • HassaniOKHennyPLeeMGJonesBEGABAergic neurons intermingled with orexin and MCH neurons in the lateral hypothalamus discharge maximally during sleepEur J Neurosci20103244845720597977
  • MileykovskiyBYKiyashchenkoLISiegelJMMuscle tone facilitation and inhibition after orexin-a (hypocretin-1) microinjections into the medial medullaJ Neurophysiol2002872480248911976385
  • BraakHDel TrediciKRübUde VosRAJansen SteurENBraakEStaging of brain pathology related to sporadic Parkinson’s diseaseNeurobiol Aging2003Mar-Apr24219721112498954
  • BoeveBFSilberMHFermanTJClinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorderSleep Med20131475476223474058
  • BoeveBFREM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directionsAnn N Y Acad Sci20101184155420146689
  • BoeveBFPredicting the future in idiopathic rapid-eye movement sleep behaviour disorderLancet Neurol201091040104220869916
  • LapierreOMontplaisirJPolysomnographic features of REM sleep behavior disorder: development of a scoring methodNeurology199242137113741620348
  • FrauscherBIranzoAGaigCNormative EMG values during REM sleep for the diagnosis of REM sleep behavior disorderSleep20123583584722654203
  • FerriRManconiMPlazziGA quantitative statistical analysis of the submentalis muscle EMG amplitude during sleep in normal controls and patients with REM sleep behavior disorderJ Sleep Res2008178910018275559
  • MontplaisirJGagnonJFFantiniMLPolysomnographic diagnosis of idiopathic REM sleep behavior disorderMov Disord2010252044205120818653
  • FrandsenRNikolicMZoetmulderMKempfnerLJennumPAnalysis of automated quantification of motor activity in REM sleep behaviour disorderJ Sleep Res201524558359025923472
  • KempfnerJSorensenGLNikolicMFrandsenRSorensenHBJennumPRapid eye movement sleep behavior disorder as an outlier detection problemJ Clin Neurophysiol201431869324492451
  • StefaniAGabeliaDHöglBLong-term follow-up investigation of isolated rapid eye movement sleep without atonia without rapid eye movement sleep behavior disorder: a pilot studyJ Clin Sleep Med201511111273127926156949
  • KangSHYoonIYLeeSDHanJWKimTHKimKWREM sleep behavior disorder in the Korean elderly population: prevalence and clinical characteristicsSleep2013361147115223904674
  • TerzaghiMArnaldiDRizzettiMCAnalysis of video-polysomnographic sleep findings in dementia with Lewy bodiesMov Disord2013281416142323744574
  • HilkerRBurghausLRazaiNJacobsAHSzeliesBHeissWDFunctional brain imaging in combined motor and sleep disordersJ Neurol Sci200624822322616753181
  • HappeSPirkerWKloschGSauterCZeitlhoferJPeriodic leg movements in patients with Parkinson’s disease are associated with reduced striatal dopamine transporter bindingJ Neurol2003250838612527997
  • SasaiTInoueYMatsuuraMClinical significance of periodic leg movements during sleep in rapid eye movement sleep behavior disorderJ Neurol20112581971197821509428
  • ShouseMNSiegelJMPontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleepBrain Res199257150631611494
  • KimYEYangHJYunJYKimHJLeeJYJeonBSREM sleep behavior disorder in Parkinson disease: association with abnormal ocular motor findingsParkinsonism Relat Disord20142044444624495707
  • ChristensenJAKochHFrandsenRClassification of iRBD and Parkinson’s disease patients based on eye movements during sleepConf Proc IEEE Eng Med Biol Soc2013201344144424109718
  • FantiniMLGagnonJFPetitDSlowing of electroencephalogram in rapid eye movement sleep behavior disorderAnn Neurol20035377478012783424
  • Massicotte-MarquezJCarrierJDécaryASlow-wave sleep and delta power in rapid eye movement sleep behavior disorderAnn Neurol20055727728215668971
  • HanyuHInoueYSakuraiHRegional cerebral blood flow changes in patients with idiopathic REM sleep behavior disorderEur J Neurol20111878478821143707
  • IranzoAIsettaVMolinuevoJLElectroencephalographic slowing heralds mild cognitive impairment in idiopathic REM sleep behavior disorderSleep Med20101153453920462792
  • SasaiTMatsuuraMInoueYElectroencephalographic findings related with mild cognitive impairment in idiopathic rapid eye movement sleep behavior disorderSleep2013361893189924293764
  • BonanniLThomasATiraboschiPPerfettiBVaraneseSOnofrjMEEG comparisons in early Alzheimer’s disease, dementia with Lewy bodies and Parkinson’s disease with dementia patients with a 2-year follow-upBrain200813169070518202105
  • MoritaAKameiSMizutaniTRelationship between slowing of the EEG and cognitive impairment in Parkinson diseaseJ Clin Neurophysiol20112838438721811128
  • LatreilleVCarrierJMontplaisirJLafortuneMGagnonJFNon-rapid eye movement sleep characteristics in idiopathic REM sleep behavior disorderJ Neurol Sci201131015916221714973
  • ChristensenJAKempfnerJZoetmulderMDecreased sleep spindle density in patients with idiopathic REM sleep behavior disorder and patients with Parkinson’s diseaseClin Neurophysiol201412551251924125856
  • ChristensenJANikolicMWarbySCSleep spindle alterations in patients with Parkinson’s diseaseFront Hum Neurosci2015923325983685
  • LatreilleVCarrierJLafortuneMSleep spindles in Parkinson’s disease may predict the development of dementiaNeurobiol Aging2015361083109025442116
  • WebsterHHJonesBENeurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-cholinergic cell area in the cat. II Effects upon sleep-waking statesBrain Res19884582853022905197
  • BraakHDel TrediciKRübUde VosRAJansen SteurENBraakEStaging of brain pathology related to sporadic Parkinson’s diseaseNeurobiol Aging20032419721112498954
  • ChristensenJAJennumPKochHSleep stability and transitions in patients with idiopathic REM sleep behavior disorder and patients with Parkinson’s diseaseClin Neurophysiol2015127153754325843013
  • LanfranchiPAFradetteLGagnonJFColomboRMontplaisirJCardiac autonomic regulation during sleep in idiopathic REM sleep behavior disorderSleep2007301019102517702272
  • SorensenGLKempfnerJZoetmulderMSorensenHBJennumPAttenuated heart rate response in REM sleep behavior disorder and Parkinson’s diseaseMov Disord20122788889422555939
  • ValappilRABlackJEBroderickMJExploring the electrocardiogram as a potential tool to screen for premotor Parkinson’s diseaseMov Disord2010252296230320976736
  • MiyamotoTMiyamotoMInoueYUsuiYSuzukiKHirataKReduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorderNeurology2006672236223817190953
  • MiyamotoTMiyamotoMIwanamiMHirataKFollow-up study of cardiac 123 I-MIBG scintigraphy in idiopathic REM sleep behavior disorderEur J Neurol2011181275127821914050
  • OguriTTachibanaNMitakeSKawanishiTFukuyamaHDecrease in myocardial 123I-MIBG radioactivity in REM sleep behavior disorder: two patients with different clinical progressionSleep Med2008958358517921052
  • PostumaRBLanfranchiPABlaisHGagnonJFMontplaisirJYCardiac autonomic dysfunction in idiopathic REM sleep behavior disorderMov Disord2010252304231020669316
  • BassoMAEvingerCAn explanation for reflex blink hyperexcitability in Parkinson’s disease. II Nucleus raphe magnusJ Neurosci199616731873308929438
  • ValldeoriolaFValls-SoléJTolosaENobbeFAMuñozJEMartíJThe acoustic startle response is normal in patients with multiple system atrophyMov Disord1997126977009380050
  • KoflerMMüllerJWenningGKThe auditory startle reaction in parkinsonian disordersMov Disord200116627111215594
  • PeterAHansenMLMerklAVoigtländerSBajboujMDanker-HopfeHREM sleep behavior disorder and excessive startle reaction to visual stimuli in a patient with pontine lesionsSleep Med2008969770018060836
  • ZoetmulderMBiernatHBNikolicMKorboLFribergLJennumPJPrepulse inhibition is associated with attention, processing speed, and 123I-FP-CIT SPECT in Parkinson’s diseaseJ Parkinsons Dis20144778724366928
  • ZoetmulderMBiernatHBNikolicMKorboLJennumPJSensorimotor gating deficits in multiple system atrophy: comparison with Parkinson’s disease and idiopathic REM sleep behavior disorderParkinsonism Relat Disord20142029730224355363
  • AlbinRLKoeppeRAChervinRDDecreased striatal dopaminergic innervation in REM sleep behavior disorderNeurology2000551410141211087796
  • IranzoAValldeoriolaFLomeñaFSerial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective studyLancet Neurol20111079780521802993
  • MiyamotoMMiyamotoTNeuroimaging of rapid eye movement sleep behavior disorder: transcranial ultrasound, single-photon emission computed tomography, and positron emission tomography scan dataSleep Med20131473974323648146
  • EisensehrILinkeRNoachtarSSchwarzJGildehausFJTatschKReduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson’s disease and controlsBrain2000123pt 61155116010825354
  • IranzoAValldeoriolaFLomeñaFSerial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective studyLancet Neurol2011910979780521802993
  • NurmiERuottinenHMBergmanJRate of progression in Parkinson’s disease: a 6-[18F]fluoro-L-dopa PET studyMov Disord20011660861511481683
  • MiyamotoTOrimoSMiyamotoMFollow-up PET studies in case of idiopathic REM sleep behavior disorderSleep Med20101110010119592301
  • KimYKYoonIYKimJMThe implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorderEur J Neurol20101748749219968708
  • García-LorenzoDLongo-Dos SantosCEwenczykCThe coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s diseaseBrain20131362120212923801736
  • GeJWuPPengSAssessing cerebral glucose metabolism in patients with idiopathic rapid eye movement sleep behavior disorderJ Cereb Blood Flow Metab201535122062206926219593
  • DauvilliersYBoudousqVLopezRIncreased perfusion in supplementary motor area during a REM sleep behaviour episodeSleep Med20111253153221489868
  • MayerGBitterlichMKuwertTRittPStefanHIctal SPECT in patients with rapid eye movement sleep behaviour disorderBrain20151381263127025732183
  • De CockVCVidailhetMLeuSRestoration of normal motor control in Parkinson’s disease during REM sleepBrain200713045045617235126
  • SternMBThe preclinical detection of Parkinson’s disease: ready for prime time?Ann Neurol20045616917115293267
  • OlssonBConstantinescuRHolmbergBAndreasenNBlennowKZetterbergHThe glial marker YKL-40 is decreased in synucleinopathiesMov Disord2013281882188523847144
  • MagdalinouNKPatersonRWSchottJMA panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromesJ Neurol Neurosurg Psychiatry2015861240124725589779
  • WennströmMSurovaYHallSThe inflammatory marker YKL-40 is elevated in cerebrospinal fluid from patients with Alzheimer’s but not Parkinson’s disease or dementia with Lewy bodiesPLoS One201510e013545826270969
  • AndersonKNVincentASmithIEShneersonJMCerebrospinal fluid hypocretin levels are normal in idiopathic REM sleep behaviour disorderEur J Neurol2010171105110720113337
  • BaumannCRDauvilliersYMignotEBassettiCLNormal CSF hypocretin-1 (orexin A) levels in dementia with Lewy bodies associated with excessive daytime sleepinessEur Neurol200452737615256827
  • ThannickalTCLaiYYSiegelJMHypocretin (orexin) cell loss in Parkinson’s diseaseBrain20071301586159517491094
  • FronczekROvereemSLeeSYHypocretin (orexin) loss in Parkinson’s diseaseBrain20071301577158517470494
  • AuroraRNZakRSMagantiRKStandards of Practice CommitteeAmerican Academy of Sleep MedicineBest practice guide for the treatment of REM sleep behavior disorder (RBD)J Clin Sleep Med20106859520191945
  • KunzDMahlbergRA two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorderJ Sleep Res20101959159620561180
  • AndersonKNShneersonJMDrug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepamJ Clin Sleep Med2009523523919960644
  • ShneersonJMSuccessful treatment of REM sleep behavior disorder with sodium oxybateClin Neuropharmacol20093215815919483483
  • OnofrjMLucianoALThomasAIaconoDD’AndreamatteoGMirtazapine induces REM sleep behavior disorder (RBD) in parkinsonismNeurology20036011311512525729
  • SchapiraAHOlanowCWGreenamyreJTBezardESlowing of neurodegeneration in Parkinson’s disease and Huntington’s disease: future therapeutic perspectivesLancet201438454555524954676
  • HenchcliffeCSevertWLDisease modification in Parkinson’s diseaseDrugs Aging20112860561521812497
  • CruickshankTMReyesARZimanMRA systematic review and meta-analysis of strength training in individuals with multiple sclerosis or Parkinson diseaseMedicine (Baltimore)201594e41125634170
  • TomlinsonCLHerdCPClarkeCEPhysiotherapy for Parkinson’s disease: a comparison of techniquesCochrane Database Syst Rev20146CD00281524936965
  • ShanahanJMorrisMEBhriainONSaundersJCliffordAMDance for people with Parkinson disease: what is the evidence telling us?Arch Phys Med Rehabil20159614115325223491
  • Sixel-DoringFTrautmannEMollenhauerBTrenkwalderCRapid eye movement sleep behavioral events: a new marker for neurodegeneration in early Parkinson disease?Sleep20143743143824587564
  • Sixel-DoringFSchweitzerMMollenhauerBTrenkwalderCIntraindividual variability of REM sleep behavior disorder in Parkinson’s disease: a comparative assessment using a new REM sleep behavior disorder severity scale (RBDSS) for clinical routineJ Clin Sleep Med20117758021344049
  • MayerGKesperKPlochTQuantification of tonic and phasic muscle activity in REM sleep behavior disorderJ Clin Neurophysiol200825485518303560
  • JensenPSSorensenHBLeonthinHLJennumPAutomatic sleep scoring in normals and in individuals with neurodegenerative disorders according to new international sleep scoring criteriaJ Clin Neurophysiol20102729630220634706