118
Views
22
CrossRef citations to date
0
Altmetric
Review

Potential serum and urine biomarkers in patients with lupus nephritis and the unsolved problems

, &
Pages 81-91 | Published online: 19 Sep 2016

References

  • MokCCTherapeutic options for resistant lupus nephritisSemin Arthritis Rheum2006362718116884971
  • SchwartzNMichaelsonJSPuttermanCLipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritisAnn N Y Acad Sci20071109826527417785315
  • BalowJEClinical presentation and monitoring of lupus nephritisLupus2005141253015732284
  • EnghardPRiemekastenGImmunology and the diagnosis of lupus nephritisLupus200918428729019276295
  • LechMAndersHJThe pathogenesis of lupus nephritisJ Am Soc Nephrol20132491357136623929771
  • SarhsyanSASerkovaNJRennerBDetection of glomerular complement C3 fragments by magnetic resonance imaging in murine lupus nephritisKidney Int201281215215921956190
  • HookeDHHancockWWGeeDCKraftNAtkinsRCMonoclonal antibody analysis of glomerular hypercellularity in human glomeru-lonephritisClin Nephrol19842241631686391767
  • NolascoFECameronJSHartleyBCoelhoAHildrethGBeubenRIntraglomerular T cells and monocytes in nephritis: study with monoclonal antibodiesKidney Int1987315116011663496476
  • LorenzGDesaiJAndersHJLupus nephritis: update on mechanisms of systemic autoimmunity and kidney immunopathologyCurr Opin Nephrol Hypertens201423321121724662982
  • TsaiCYWuTHSunKHLinWMYuCLIncreased excretion of soluble interleukin 2 receptors and free light chain immunoglobulins in the urine of patients with active lupus nephritisAnn Rheum Dis19925121681721550398
  • TesarVMasekZRychlikICytokine and adhesion molecules in renal vasculitis and lupus nephritisNephrol Dial Transplant1998137166216679681708
  • TesarVJirsaMJrZimaTSoluble cytokine receptor in renal vaseculitis and lupus nephritisMed Sci Monit200281BR24BR2911782670
  • TsaiCYWuTHYuCLLuJYTsaiYYIncreased excretion of beta 2-microglobulin, IL-6, and IL-8 and decreased excretion of Tamm-Horsfall glycoprotein in urine of patients with active lupus nephritisNephron200085320721410867535
  • ChanRWTamLSLiEKInflammatory cytokine gene expression in the urinary sediment of patients with lupus nephritisArthritis Rheum20034851326133112746905
  • ChanRWLaiFMLiEKExpression of chemokine and fibrosing factor messenger RNA in the urinary sediment of patients with lupus nephritisArthritis Rheum20045092882289015457456
  • RovinBHSongHBirminghamDJHerbertLAYuCYNagarajaHNUrine chemokines: biomarkers of human systemic lupus erythematosus activityAm Soc Nephrol2005162467473
  • ArihingsanonYPhumesinPBenjachatTMeasurement of urinary chemokine and growth factor messenger RNAs: a noninvasive monitoring in lupus nephritisKidney Int200669474775316518330
  • LiYTucciMNarainSUrinary biomarkers in lupus nephritisAutoimmun Rev20065638338816890891
  • WuTXieCWangHWElevated urinary VCAM-1, P-selection, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritisJ Immunol2007791071667175
  • MokCCBiomarkers for lupus nephritis: a critical appraisalJ Biomed Biotechnol2010201063841320414362
  • LiaoXReihlAMLuoXMBreakdown of immune tolerance in systemic lupus erythematosus by dendritic cellsJ Immunol Res20162016626915727034965
  • Costa-ReisPSullivanKEGenetics and epigenetics of systemic lupus erythematosusCurr Rheumatol Rep201315936937723943494
  • DengYTsaoBPAdvances in lupus genetics and epigeneticsCurr Opin Rheumatol201426548249225010439
  • NiewoldTBAdvances in lupus geneticsCurr Opin Rheumatol201527544044726218512
  • CeccarelliFPerriconeCBorgianicPGenetic factors in systemic lupus erythematosus: contribution to disease phenotypeJ Immunol Res2015201574564726798662
  • Ghodke-PuranikYNiewoldTBImmunogenetics of systemic lupus erythematosus: a comprehensive reviewJ Autoimmun2015641112513626324017
  • ZhangZZhangREpigenetics in autoimmune diseases: pathogenesis and prospects for therapyAutoimmun Rev2015141085486326026695
  • RelleMWeinmann-HenkeJScorlettiECavagnaLSchwartingAGenetics and novel aspects of therapies in systemic lupus erythema-tosusAutoimmun Rev201514111005101826164648
  • BlombergSElorantaMLMagnussonMAlmGVRonnblomLExpression of the markers BDCA-2 and BDCA-4 and production of interferon-alpha by plasmacytoid dendritic cells in systemic lupus erythematosusArthritis Rheum20034892524253213130472
  • KirouKALeeCGeorgeSLoucaKPetersonMGCrowMKActivation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active diseaseArthritis Rheum20055251491150315880830
  • KwokSKLeeJYParkSHDysfunctional interferon-alpha production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosusArthritis Res Ther2008102R2918321389
  • TangYLuoXCuiHMicroRNA-146A contributes to abnormal activation of the type 1 interferon pathway in human lupus by targeting the key signaling proteinsArthritis Rheum20096041065107519333922
  • KaronitschTFeierlESteinerCWActivation of the interferon-gamma signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cellsArthritis Rheum20096051463147119404947
  • WuLQinYXiaSIdentification of cyclin-dependent kinase 1 as a novel regulator of type 1 interferon signaling in systemic lupus erythematosusArthritis Rheumatol20166851222123226663909
  • SekigawaIOkawaMOgasawaraHKanekoHHishikawaTHashi-motoHDNA methylation in systemic lupus erythematosusLupus20031227885
  • DaiYZhangLHuCZhangYGenome-wide analysis of histone H3 lysine 4 trimethylation by CHIP-chip in peripheral blood mononuclear cell of systemic lupus erythematosus patientClin Exp Rheumatol201028215816820483040
  • AbsherDMLiXWaiteLLGenome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+T-cell populationsPLoS Genet201398e100367823950730
  • ZhangYZhaoMSawalhaAHRichardsonBLuQImpaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosusJ Autoimmun2013413929823340289
  • ZhaoMLiuSLuoSDNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotypeJ Autoimmun2014541112713625091625
  • PanWZhuSYuanMMicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1J Immunol2010184126773678120483747
  • StagabisEBertsiasGVerginisPIdentification of novel microRNA signatures links to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expressionAnn Rheum Dis20117081496150621602271
  • Perez-HernandezJFornerMJPintoCChavesFJCortesRRedonJIncreased urinary exosomal microRNAs in patients with systemic lupus erythematosusPLoS One2015109e013861826390437
  • WangWMouSWangLUp-regulation of serum miR-130b-3p level is associated with renal damage in early lupus nephritisSci Rep2015581264426316103
  • Duroux-RichardICuencaJPonsollesCMicroRNA profiling of B cell subsets from systemic lupus erythematosus patients reveals promising novel biomarkersInt J Mol Sci2015168169531696526225955
  • RaiGRaiRSaeidianAHRaiMMicroarray to deep sequencing: transcriptome and miRNA profiling to elucidate molecular pathway in systemic lupus erythematosusImmunol Res2016641142426188428
  • AbulabanKMFallNNurnaRRelationship of cell-free urine microRNA with lupus nephritis childrenPediatr Rheumatol Online J201614141026762103
  • NiwaYSakaneTOzakiYKanohTTaniguchiSPhospholipid base exchange activity in the leukocyte membranes of patients with inflammatory disordersAm J Pathol198712723173263034067
  • NiwaYMiyachiYSakaneTKanohTTaniguchiSMethyltransferase and phospholipase A2 activity in the cell membrane of neutrophils and lymphocytes from patients with Behcet’s disease, systemic lupus erythematosus and rheumatoid arthritisClin Chim Acta19981741114
  • YehTMChangHCLiangCCWuJJLiuMFDeoxyribonuclease inhibitory antibodies in systemic lupus erythematosusJ Biomed Sci200310554455112928595
  • FujiiYFujiiKTanakaYAttempt to correct abnormal signal transduction in T lymphocyte from systemic lupus erythematosus patientsAutoimmun Rev20065214314416431347
  • MoultonVRLoMSTsokosGCMethods and protocols to study T cell signaling abnormalities in human systemic lupus erythemato-susMethods Mol Biol2012900256022933064
  • WuTXieCHanJMetabolic disturbances associated with systemic lupus erythematosusPLoS One201276e3721022723834
  • LiKJWuCHHsiehSCLuMCTsaiCYYuCLDeranged bioenergetics and defective redox capacity in T lymphocytes and neutrophils are related to cellular dysfunction and increased oxidative stress in patients with active systemic lupus erythematosusClin Dev Immunol2012201254851622007252
  • LeeHTLinCSLeeCSTsaiCYWeiYHIncreased 8-hydroxy-2-deoxyguanosine in plasma and decreased mRNA expression of human 8-oxoguanine DNA glycosylase 1, anti-oxidant enzymes, mitochondrial biogenesis-related proteins and glycolytic enzymes in leukocytes in patients with systemic lupus erythematosusClin Exp Immunol20141761667724345202
  • VyshkinaTSylvesterASadiqSAssociation of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosusClin Immunol20081291313518708297
  • LeeHTLinCSChenWSLiaoHTTsaiCYWeiYHLeukocyte mitochondrial DNA alteration in systemic lupus erythematosus and its relevance to the susceptibility to nephritisInt J Mol Sci20121378853886822942739
  • PeriAOxidative stress in the pathology and treatment of systemic lupus erythematosusNat Rev Rheumatol201391167468624100461
  • ShahDNahajanNSahSNathSKPaudyalBOxidative stress and its bio-markers in systemic lupus erythematosusJ Biomed Sci20141732123
  • GheitaTAKenawySAMeasurement of malondialdehyde, glutathione and glutathione peroxidase in SLE patientsMethods Mol Biol2014113419319924497363
  • JafariSMSalimiSNakhaeeAPro-oxidant-antioxidant balance in patients with systemic lupus erythematosus and its relationship with clinical and laboratory findingsAutoimmun Dis201620164343514
  • KnightJSKaplanMJLupus neutrophils: “NET” gain in understanding lupus pathogenesisCurr Opin Rheumatol201224544145022617827
  • YuYSuKNeutrophil extracellular traps and systemic lupus erythematosusJ Clin Cell Immunol20134410.4172/2155-9899.1000139
  • SmithCKVivekanandan-GiriATangCNeutrophil extracellular trap-derived enzymes oxidize high density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosusArthritis Rheumatol20146692532254424838349
  • LoodCBlancoLPPurmalekMMNeutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like diseaseNat Med201622214615326779811
  • KangYHUrbanBCSimRBKishoreUHuman complement factor H molecules C1q-mediated phagocytosis of apoptotic cellsImmunobiology2012217445546422088229
  • WalportMJDaviesKABottoMC1q and systemic lupus erythematosusImmunobiology199819922652859777411
  • RobsonMGCookHTBottoMAccelerated nephrotoxic nephritis is exacerbated in C1q-deficient miceJ Immunol2001166116820682811359841
  • LewisMJBottoMComplement deficiencies in human and animals: links to autoimmunityAutoimmunity200639536737816923536
  • VasilevVNoeRDragon-DureyMAFunctional characterization of autoantibodies against complement component C3 in patients with lupus nephritisJ Biol Chem201529042253432535526245903
  • BirminghamDJBitterJENdnkweEGRelationship of circulating anti-C3b and C1q IgG to lupus nephritis and its flareClin J Am Soc Nephrol2016111475326700439
  • KahlenbergJMKaplanMJThe inflammasome and lupus: another innate immune mechanism contributing to disease pathogenesis?Curr Opin Rheumatol201426547548124992143
  • YangQYuCYangZDeregulated NLRP3 and NLRP1 inflammasomes and their correlations with disease activity in systemic lupus erythematousJ Rheumatol201441344445224334646
  • YangCAHuangSTChiangBLSex-dependent differential activation of NLRP3 and AIM2 inflammasomes in SLE macrophagesRheumatology201554232433125161312
  • YangCAChiangBLInflammasomes and human autoimmunity: a comprehensive reviewJ Autoimmun20156171826005048
  • SamarkosMVaiopoulosGThe role of infections in the pathogenesis of autoimmune diseasesCurr Drug Targets Inflamm Allergy2005419910315720242
  • MuQZhangHLuoXHSLE: another autoimmune disorder influenced by microbes and diet?Front Immunol201561160870726648937
  • DeocharanBQingXLichaucoJPuttmanCAlpha-actinin is a cross-reactive renal target for pathogenic anti-DNA antibodiesJ Immunol200216863072307811884481
  • PesickovaSSRysavaRLenicekMPrognostic value of anti-CRP antibodies in lupus nephritis in long-term follow upArthritis Res Ther201517137137726704903
  • MonoriGQuagliniSRachiceAThe value of a panel of auto-antibodies for predicting the activity of lupus nephritis at time of renal biopsyJ Immunol Res2015201510690425815344
  • YungSChanTMMechanism of kidney injury in lupus nephritis: the role of anti-dsDNA antibodiesFront Immunol2015647526441980
  • LiZSchettinoEWPadlanEAIkematsuHCasaliPStructure-function analysis of a lupus anti-dsDNA autoantibody: central role of the heavy chain complementary-determining region 3 Arg in binding of double-and single-stranded DNAEur J Immunol20003072015202610940891
  • GuthAHZhangXSmithDDetanicoTWysockiLJChromatin specificity of anti-double-stranded DNA antibodies and a role for Arg residues in the third complementarity determining region of the heavy chainJ Immunol2003171116260626614634143
  • SongYCSunGHLeeTPArginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalization via electrostatic interactionsEur J Immunol200838113178319018991292
  • SunKHLiuWTTsaiCYTangSJHanSHYuCLAnti-dsDNA antibodies cross-react with the ribosomal P proteins expressed on the surface of glomerular mesangial cells to exert cytostatic effectImmunology19958522622697642215
  • SunKHLiuWTTangSLThe expression of acidic ribosomal phosphoproteins on the surface of different tissues in autoimmune and normal mice which are the target molecules for anti-dsDNA antibodiesImmunology19968733623718778020
  • LiYFangXLiQZBiomarker profiling for lupus nephritisGenomics Proteomics Bioinformatics20131115816523732627
  • TsaiCYWuTHSunKHLiaoTSLinWMYuCLPolyclonal IgG anti-dsDNA antibodies exert cytotoxic effect on cultured rat mesangial cells by binding to cell membrane and augmenting apoptosisScand J Rheumatol19932241621718356408
  • SikriKLFosterCLMac HughNMarshallRDLocalization of Tamm-Horsfall glycoprotein in the human kidney using immunofluorescence and immuno-electron microscopical techniquesJ Anal1981132Pt 4597605
  • HoyerJRSeilerHWPathophysiology of Tamm-Horsfall proteinKidney Int1979163279289393892
  • FletcherAPNeubergerARatcliffeeWATamm-Horsfall urinary glycoprotein: the chemical compositionBiochem J197012024174245493864
  • StevensonFKKentPWSubunits of Tamm-Horsfall glycoproteinBiochem J197011657917965441368
  • TammIHorsfallFLJrCharacterization and separation of an inhibitor of viral hemagglutination present in urineProc Soc Exp Biol Med195074110610815430405
  • PakJPuYZhongZTHastyDLWuXRTamm-Horsfall protein binds to type I fimbriated Escherichia coli and prevents E. coli binding to uroplakin 1b receptorsJ Biol Chem2001276139924993011134021
  • WuTHHsiehSCYuCYLeeYFTsaiCYYuCLIntact protein core-structure is essential for protein binding, mononuclear cell proliferation and neutrophil phagocytosis-enhancing activities of normal human Tamm-Horsfall glycoproteinInt Immunopharmacol200881909918068104
  • WuTHLiKJSiaoSCThe binding affinity and molecular basis of the structure-functional relationship between urinary Tamm-Horsfall glycoprotein and tumor neurosis factor-aMolecules20121710119781198923060289
  • KurogiYMesangial cell proliferation inhibitors for the treatment of proliferative glomerular diseaseMed Res Rev2003231153112424751
  • ScindiaYMDeshmukhUSBagavantHMesangial pathology in glomerular disease: targets for therapeutic interventionAdv Drug Deliv Rev201062141337134320828589
  • StrikerLJDoiTElliotSStrikerGEThe contribution of glomerular mesangial cells to progressive glomerulosclerosisSemin Nephrol1989943183282688008
  • SterzelRBSchulze-LohoffEWeberMGoodmanSLInteractions between glomerular mesangial cells, cytokines, and extracellular matrixJ Am Soc Nephrol1992210 SupplS126S1311600127
  • BoenischMHurstRHuberSKoehnJKrapfenbauerKImproved prognostic diagnosis of systemic lupus erythematosus in an early stage of disease by a combination of different predictive biomarkers identified by proteome analysisEBMA J2014515
  • YangCCHsiehSCLiKJUrinary neutrophil gelatinase-associated lipocalin is a potent biomarker for renal damage in patients with systemic lupus erythematosusJ Biomed Biotechnol2012201275931322500106
  • CowlandJBBorregaardNMolecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humanGenomics199745117239339356
  • TongZWuXOvcharenkoDZhuJChenCSKehrerJPNeutrophil gelatinase associated lipocalin as survival factorBiochem J2005391Pt 244144816060857
  • BolignanoDDonatoVCoppolinoGNeutrophil gelatinase-associated lipocalin (NGAL) as a marker for kidney damageAm J Kidney Dis200852359560518725016
  • RubinsteinTPitashnyMPuttermanCThe novel role of neutrophil gelatinase-B associated lipocalin (NGAL)/lipocalin-2 as a biomarker for lupus nephritisAutoimmun Rev20087322923418190883
  • StypinskaBParadowska-GoryckaACytokines and microRNAs as candidate biomarkers for systemic lupus erythematosusInt J Mol Sci20151610241942421826473848
  • SuzukiMRossGFWiersKIdentification of a urinary proteomic signature for lupus nephritis in childrenPediatr Nephrol200722122047205717901988
  • ErdenerDAksuKBicerIDoganavsargilEKutayFZUrinary N-acetyl-b-D-glucosaminidase (NAG) in lupus nephritis and rheumatoid arthritisJ Clin Lab Anal200519417217616025478
  • SkalovaSThe diagnostic role of urinary N-acetyl-b-D-glucosaminidase (NAG) activity in the detection of renal tubular impairmentActa Medica (Hradec Kralove)2005482758016259316
  • MasudaTAkimotoTAndoYChanges in the urinary excretion of β2-microglbulin (β2-MG) and N-acetyl-β-D-glucosaminidase (NAG) during treatment for lupus nephritisIntern Med200847428729018277031
  • HeidenreichUMayerGHeroldMKlotzWAl-JazrawiKSLhottaKSensitivity and specificity of autoantibody tests in the differential diagnosis of lupus nephritisLupus200918141276128019854810
  • Torres-SalidoMTCortes-HernandezJVidalXPedrosaAVilardell-TarresMOrdi-RosJNeutrophil gelatinase-associated lipocalin as a biomarker for lupus nephritisNephrol Dial Transplant20142991740174924711435
  • Abdel GawasERMansourAIAbdel AzizYASolimanAFFawzyRMRole of anti-nucleosome antibodies in the diagnosis of systemic lupus erythematosus and as a marker for lupus nephritisEgypt J Immunol2014211576525204045
  • El-ShehabyADarweeshHEL-KhatibMCorrelations of urinary biomarkers, TNF-like weak inducer of apoptosis (TWEAK), osteoprotegerin (OPG), monocyte chemoattractant protein-1 (MCP-1) and IL-8 with lupus nephritisJ Clin Immunol201131584885621691937
  • SoleCCortes-HernandezJFelipMLVidalMOrdi-RosJMiR-29c in urinary exosomes as a predictor of early renal fibrosis in lupus nephritisNephrol Dial Transplant20153091488149626040904
  • WuCYangMZhouZUrinary soluble intercellular adhesion molecule-1 and vascular adhesion molecule-1: potential biomarkers of active lupus nephritisNan Fang Yi Ke Da Xue Xue Bao201535912721276 Chinese26403737
  • SusiantiHIrianeVMDharmanataSAnalysis of urinary TGFb1, MCP-1, NGAL, and IL-17 as biomarkers for lupus nephritisPathophysiology2015221657125595582
  • EastonRLPatankarMSClarkGFMorrisHRDellAPregnancy associated changes in the glycosylation of Tamm-Horsfall glycoprotein. Expression of sialyl Lewis(x) sequences on core 2 type O-glycans derived from uromodulinJ Biol Chem200027529219282193810770931
  • FairleyJKOwenJEBirchDFProtein composition of urinary casts from healthy subjects and patients with glomerulonephritisBr Med J (Clin Res Ed)1983287640818381840
  • OlczakTOlczakMKubiczADulawaJKokotFComposition of the sugar moiety of Tamm-Horsfall protein in patients with urinary diseasesInt J Clin Lab Res1999292687410436264
  • Serafini-CessiFMalagoliniNCavalloneDTamm-Horsfall glycoprotein: biology and clinical relevanceAm J Kidney Dis200342465867614520616
  • WuTHHsiehSCLiKJAltered glycosylation of Tamm-Horsfall glycoprotein derived from renal allograft recipients lead to changes in the biological functionTranspl Immunol200818323724518047931
  • ArgadeSPVanichsamCChenowethMParsonsCLAbnormal glycosylation of Tamm-Horsfall protein in patients with interstitial cystitisBJU Int200910381085108919007360
  • IoremberFNVehaskariVMUromodulin: old friend with new roles in health and diseasePediatr Nephrol20142971151115823880785
  • EkiciABHackenbeckTMoriniereVRenal fibrosis is the common feature of autosomal dominant tubulointerstitial kidney diseases caused by mutations in mucin 1 or uromodulinKidney Int201486358959924670410
  • ScolariFIzziCGhiggeriGMUromodulin: from monogenic to multifactorial diseasesNephrol Dial Transplant20153081250125625228753
  • Venkat RamanGGastCMarinakiAFairbanksLFrom juvenile hyperuricemia to dysfunctional uromodulin: an ongoing metamorphosisPediatr Nephrol Epub2016212
  • SaemannMDWeichhartTZeydaMTamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanismJ Clin Invest2005115246847515650774
  • PeiserLMukhopadhyaySGoedenSScavenger receptors in innate immunityCurr Opin Immunol200214112312811790542
  • PfistershammerKKlauserCLeitnerJIdentification of the scavenger receptors SREC-1, Cla-1 (Sr-B1), and SR-A1 as cellular receptors for Tamm-Horsfall proteinJ Leukoc Biol200883113113817928461
  • AbulabanKMSongHZhangXPredicting decline of kidney function in lupus nephritis using urine biomarkersLupus20162591012101826873651