Hyperuricemia Among Egyptian Rheumatoid Arthritis Patients. Is It an Association or an Inflammatory Marker? A Cross-Sectional Observational Study

References

• McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365(23):2205–2219. doi:10.1056/NEJMra1004965
   PubMed Web of Science ®Google Scholar
• Jebakumar AJ, Udayakumar PD, Crowson CS, Matteson EL. Occurrence of gout in rheumatoid arthritis: it does happen! A population‐based study. Int J Clin Rheumatol. 2013;8:433–437.
   Google Scholar
• Petsch C, Araujo EG, Englbrecht M, et al. Prevalence of monosodium urate deposits in a population of rheumatoid arthritis patients with hyperuricemia. Semin Arthritis Rheum. 2016;45:663–668.
   Web of Science ®Google Scholar
• Cleophas MC, Crisan TO, Joosten LA. Factors modulating the inflammatory response in acute gouty arthritis. Curr Opin Rheumatol. 2017;29:163–170.
   Web of Science ®Google Scholar
• Schett G, Schauer C, Hoffmann M, Herrmann M. Why does the gout attack stop? A roadmap for the immune pathogenesis of gout. RMD Open. 2015;1(Suppl 1):e000046.
   Google Scholar
• Terkeltaub R. What makes gouty inflammation so variable? BMC Med. 2017;15:158.
   PubMed Web of Science ®Google Scholar
• Choi HK, Curhan G. Independent impact of gout on mortality and risk for coronary heart disease. Circulation. 2007;116:894–900.
   PubMed Web of Science ®Google Scholar
• Meek IL, Vonkeman HE, van de Laar MA. Hyperuricaemia: a marker of increased cardiovascular risk in rheumatic patients: analysis of the ACT‐CVD cohort. BMC Musculoskelet Disord. 2014;15:174.
   Web of Science ®Google Scholar
• Kang DH, Nakagawa T, Feng L, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002;13:2888–2897.
   PubMed Web of Science ®Google Scholar
• Daoussis D, Panoulas V, Toms T, et al. Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis. Arthritis Res Ther. 2009;11:R116.
   PubMed Web of Science ®Google Scholar
• Kuo D, Crowson CS, Gabriel SE, Matteson EL. Hyperuricemia and incident cardiovascular disease and non-cardiac vascular events in patients with rheumatoid arthritis. Int J Rheumatol. 2014;2014:523897.
   PubMedGoogle Scholar
• JAVA. Declaration of Helsinki World Medical Association Declaration of Helsinki. Bull World Health Organ. 2013;79:373–374.
   Google Scholar
• Von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg. 2014;12:1495–1499.
   PubMed Web of Science ®Google Scholar
• Aletaha D, Neogi T, Silman AJ, et al. The 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League against rheumatism collaborative initiative. Ann Rheum Dis. 2010;62(9):2569–2581.
   Google Scholar
• Prevoo ML, Van ‘T Hof MA, Kuper HH, et al. Modified disease activity scores that include twenty-eight joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38(1):44–48.
   PubMed Web of Science ®Google Scholar
• Maska L, Anderson J, Michaud K. Measures of functional status and quality of life in rheumatoid arthritis. Arthritis Care Res. 2011;63(11):S4–13.
   Web of Science ®Google Scholar
• Ruggiero C, Cherubini A, Ble A, et al. Uric acid and inflammatory markers. Eur Heart J. 2006;27(10):1174–1181.
   PubMed Web of Science ®Google Scholar
• Masson C. Rheumatoid anemia. Joint Bone Spine. 2011;78(2):131–137.
   Web of Science ®Google Scholar
• Yildirim K, Karatay S, Melikoglu MA, et al. Associations between acute phase reactant levels and disease activity score (DAS28) in patients with rheumatoid arthritis. Ann Clin Lab Sci. 2004;34(4):423–426.
   Web of Science ®Google Scholar
• De Rycke L, Peene I, Hoffman IE, et al. Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations. Ann Rheum Dis. 2004;63(12):1587–1593.
   PubMed Web of Science ®Google Scholar
• Wei S-T, Sun Y-H, Zong S-H, Xiang Y-B. Serum levels of IL-6 and TNF-α may correlate with activity and severity of rheumatoid arthritis. Med Sci Monit. 2015;21:4030–4038.
   PubMed Web of Science ®Google Scholar
• Ory PA. Radiography in the assessment of musculoskeletal conditions. Best Pract Res Clin Rheumatol. 2003;17(3):495–512.
   Web of Science ®Google Scholar
• Wang Q, Huang QH, Yeow JTW, Pickering MR, Saarakkala S. Quantitative analysis of musculoskeletal ultrasound: techniques and clinical applications. Biomed Res Int. 2017;1:1–2.
   Google Scholar
• Dawson-Saunders B, Trapp R. Basic and Clinical Biostatistics. 2nd ed. Lange Medical Book, Prentice- Hall International Inc; 1994.
   Google Scholar
• Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007–2008. Arthritis Rheum. 2011;63(10):3136–3141.
   PubMed Web of Science ®Google Scholar
• Adamopoulos D, Vlassopoulos C, Seitanides B, Contoyiannis P, Vassilopoulos P. The relationship of sex steroids to uric acid levels in plasma and urine. Acta Endocrinol (Copenh). 1977;85(1):198–208.
   Google Scholar
• Choe JY, Lee GH, Kim SK. Radiographic bone damage in chronic Gout is negatively associated with the inflammatory cytokines soluble interleukin 6 receptor and osteoprotegerin. J Rheumatol. 2011;38(3):485–491.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Pandya BJ, Choi HK. Comorbidities of Gout and hyperuricemia in the US general population: NHANES 2007–2008. Am J Med. 2012;125(7):679–687.
   PubMed Web of Science ®Google Scholar
• Rosangela S, Maria AM, Elettra M, et al. Uric acid is associated with inflammatory biomarkers and induces inflammation via activating the NF-κB signaling pathway in HepG2 cells. Arterioscler Thromb Vasc Biol. 2017;37:1241–1249.
   Web of Science ®Google Scholar
• Anker SD, Doehner W, Rauchhaus M, et al. Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging. Circulation. 2003;107:1991–1997.
   PubMed Web of Science ®Google Scholar
• Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol. 2005;16:3553–3562.
   PubMed Web of Science ®Google Scholar
• Choe Y, Kim SK. Association between serum uric acid and inflammation in rheumatoid arthritis: perspective on lowering serum uric acid of leflunomide. Clin Chim Acta. 2015;438:29–34.
   Web of Science ®Google Scholar
• Kanellis J, Watanabe S, Li JH, et al. Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension. 2003;416:1287–1293.
   Web of Science ®Google Scholar
• Puddu P, Puddu GM, Cravero E, Vizioli L, Muscari A. Relationships among hyperuricemia, endothelial dysfunction and cardiovascular disease: molecular mechanisms and clinical implications. J Cardiol. 2012;59:235–242.
   PubMed Web of Science ®Google Scholar
• Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin angiotensin system. J Hypertens. 2008;26:269–275.
   PubMed Web of Science ®Google Scholar
• Meneshian A, Bulkley GB. The physiology of endothelial xanthine oxidase: from urate catabolism to reperfusion injury to inflammatory signal transduction. Microcirculation. 2002;9:161–175.
   PubMed Web of Science ®Google Scholar
• Vorbach C, Harrison R, Capecchi MR. Xanthine oxidoreductase is central to the evolution and function of the innate immune system. Trends Immunol. 2003;24:512–517.
   PubMed Web of Science ®Google Scholar
• Gersch C, Palii SP, Kim KM, Angerhofer A, Johnson RJ, Henderson GN. Inactivation of nitric oxide by uric acid. Nucleosides Nucleotides Nucleic Acids. 2008;27:967–978.
   PubMed Web of Science ®Google Scholar
• Miesel R, Zuber M. Elevated levels of xanthine oxidase in serum of patients with inflammatory and autoimmune rheumatic diseases. Inflammation. 1993;17:551–561.
   PubMed Web of Science ®Google Scholar
• Andrew C, Bryant RE, Harlan S, et al. Coexistent hyperuricemia and Gout in rheumatoid arthritis: associations with comorbidities, disease activity, and mortality. Arthritis Care Res. 2020;72(7):950–958.
   Web of Science ®Google Scholar
• Carlos AA, Robert AT, Marguerite P, Edward P. Does hyperuricemia protect from rheumatoid inflammation? A clinical study. Arthritis Rheum. 1984;27:4.
   Google Scholar
• Lussier A, De Medicis R. Coexistent Gout and rheumatoid arthritis: “a red marker?” (letter). Arthritis Rheum. 1979;22:939–940.
   Web of Science ®Google Scholar
• Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci USA. 1981;78:6858–6862.
   PubMed Web of Science ®Google Scholar
• Elkhouly T, Elnady B, Rageh E. Validity of Doppler subclinical synovitis as an activity marker associated with bone erosions in rheumatoid arthritis patients during clinical remission. Egypt J Radiol Nucl Med. 2016;47(3):985–990.
   Google Scholar
• Abdel Sattar M, Alsherbini H. Assessment of synovitis in rheumatoid arthritis by enhanced magnetic resonance imaging (OMERACT RAMRIS score) and power Doppler ultrasound: a comparative study. Kasr Al Ainy Med J. 2017;23(2):96–103.
   Google Scholar
• Choi HK, Ford ES. Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med. 2007;120:442–447.
   PubMed Web of Science ®Google Scholar
• Edwards NL. The role of hyperuricemia in vascular disorders. Curr Opin Rheumatol. 2009;21:132–137.
   PubMed Web of Science ®Google Scholar
• George J, Carr E, Davies J, Belch JJ, Struthers A. High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation. 2006;114:2508–2516.
   PubMed Web of Science ®Google Scholar
• McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365:2205–2219.
   PubMed Web of Science ®Google Scholar