Advanced search
Publication Cover
Open Access Rheumatology: Research and Reviews Volume 13, 2021 - Issue
Submit an article Journal homepage
164
Views
1
CrossRef citations to date
0
Altmetric
Original Research

Analysis of Serum Immune Markers in Seropositive and Seronegative Rheumatoid Arthritis Among Sudanese Patients and the Relation Between the Serotype and Joint Involvement: A Cohort Study

Ahmed Seri1 Department of Clinical Immunology, Royal Care International Hospital, Khartoum, Sudan;2 Department of Immunology, Institute of Endemic Disease, University of Khartoum, Khartoum, SudanView further author information
,
Hala Kamal Ali Mohamed3 Department of Microbiology, Faculty of Medicine, African International University (AIU), Khartoum, Sudan;4 Department of Clinical Immunology, Sudan Medical Specialization Board (SMSB), Khartoum, Sudan;5 Faculty of Medicine, Sudan University of Science and Technology, Khartoum, SudanView further author information
,
Mohammed Elmujtba Adam Essa6 Department of Clinical Medicine, Medical and Cancer Research Institute, Nyala, SudanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1050-2771View further author information
ORCID Icon,
Elnour Mohammed Elagib7 Department of Rheumatology, Omdurman Military Hospital, Khartoum, Sudan;8 Department of Medicine, Faculty of Medicine, Karary University, Khartoum, SudanView further author information
,
Noha Ibrahim Ahmed Eltahirm7 Department of Rheumatology, Omdurman Military Hospital, Khartoum, Sudan;8 Department of Medicine, Faculty of Medicine, Karary University, Khartoum, SudanView further author information
,
Salma Mohammed Alfatih Mansour9 Department of Medicine, Faculty of Medicine, University of Khartoum, Khartoum, SudanView further author information
&
Abdelkareem A Ahmed6 Department of Clinical Medicine, Medical and Cancer Research Institute, Nyala, SudanView further author information
 show all
Pages 325-332 | Published online: 30 Nov 2021

References

  • Guo Q, Wang Y, Xu D, Nossent J, Pavlos NJ, Xu J. Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. Bone Res. 2018;6(1):15. PubMed PMID: 29736302. Pubmed Central PMCID: 5920070. doi:10.1038/s41413-018-0016-9
  • Matsushita M, Yamaji K, Tamura N. Extra-articular manifestations of rheumatoid arthritis. Juntendo Med J. 2020;66(1):21–26. doi:10.14789/jmj.2020.66.JMJ19-R01
  • Zhang L, Zhang Y, Pan J. Immunopathogenic mechanisms of rheumatoid arthritis and the use of anti-inflammatory drugs. Intractable Rare Dis Res. 2021;10(3):154–164. doi:10.5582/irdr.2021.01022
  • Vecellio M, Hake VX, Davidson C, Carena MC, Wordsworth P, Selmi C. The IL-17/IL-23 axis and its genetic contribution to psoriatic Arthritis. Front Immunol. 2020;11:3418.
  • Syversen SW, Goll GL, van der Heijde D, et al. Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a 10-year prospective study. Ann Rheum Dis. 2010;69(2):345–351. PubMed PMID: 19648126. doi:10.1136/ard.2009.113092
  • Bay-Jensen AC, Siebuhr AS, Damgaard D, et al. Objective and noninvasive biochemical markers in rheumatoid arthritis: where are we and where are we going? Expert Rev Proteomics. 2021;18(3):159–175. doi:10.1080/14789450.2021.1908892
  • Park E-J, Jeong W, Kim J. Prognostic factors for radiographic progression in patients with seronegative rheumatoid arthritis. J Pers Med. 2021;11(3):184. doi:10.3390/jpm11030184
  • de Punder YM, Hendrikx J, den Broeder AA, Pascual EV, van Riel PL, Fransen J. Should we redefine treatment targets in rheumatoid arthritis? Low disease activity is sufficiently strict for patients who are anticitrullinated protein antibody-negative. J Rheumatol. 2013;40(8):1268–1274. doi:10.3899/jrheum.121438
  • Nordberg LB, Lillegraven S, Lie E, et al. Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-naïve patients classified according to the 2010 ACR/EULAR criteria. Ann Rheum Dis. 2017;76(2):341–345. doi:10.1136/annrheumdis-2015-208873
  • Fujita Y, Asano T, Matsuoka N, et al. Differential regulation and correlation between galectin-9 and anti-CCP antibody (ACPA) in rheumatoid arthritis patients. Arthritis Res Ther. 2020;22(1):1–9. doi:10.1186/s13075-020-02158-3
  • Ouédraogo -D-D, Singbo J, Diallo O, Sawadogo SA, Tiéno H, Drabo YJ. Rheumatoid arthritis in Burkina Faso: clinical and serological profiles. Clin Rheumatol. 2011;30(12):1617–1621. doi:10.1007/s10067-011-1831-1
  • Elshafie AI, Elkhalifa AD, Elbagir S, et al. Active rheumatoid arthritis in central Africa: a comparative study between Sudan and Sweden. J Rheumatol. 2016;43(10):1777–1786. PubMed PMID: 27481904. doi:10.3899/jrheum.160303
  • Vander Cruyssen B, Nogueira L, Van Praet J, et al. Do all anti-citrullinated protein/peptide antibody tests measure the same? Evaluation of discrepancy between anti-citrullinated protein/peptide antibody tests in patients with and without rheumatoid arthritis. Ann Rheum Dis. 2008;67(4):542–546. doi:10.1136/ard.2007.071654
  • Abdel‐Nasser A, Mahmoud M, El Mansoury T, Osman A. Anti‐CCP2 is an adjunct to, not a surrogate for, rheumatoid factor in the diagnosis of rheumatoid arthritis: diagnostic utility of anti‐CCP2 antibodies in Egyptian patients with rheumatoid arthritis. Scand J Rheumatol. 2008;37(5):329–336. doi:10.1080/03009740802116208
  • Zabsonré WJT, Kaboré F, Nanema D, et al. Frequency and factors associated with depression in rheumatoid arthritis in African black patients: case-control study. Open J Rheumatol Autoimmune Dis. 2019;9(2):35–41. doi:10.4236/ojra.2019.92004
  • Zemri K, Sellam F, Harir N, et al. Is there an association between anti-citrullinated peptide antibodies and the severity of rheumatoid arthritis parameters in Algerian patients? J Drug Deliv Therapeut. 2020;10(4):17–24. doi:10.22270/jddt.v10i4.4201
  • Barra L, Pope JE, Orav JE, et al. Prognosis of seronegative patients in a large prospective cohort of patients with early inflammatory arthritis. J Rheumatol. 2014;41(12):2361–2369. doi:10.3899/jrheum.140082
  • Elshafie AI, Elbagir S, Aledrissy MI, Elagib EM, Nur MA, Rönnelid J. Occurrence of anti-CCP2 and RF isotypes and their relation to age and disease severity among Sudanese patients with rheumatoid arthritis. Clin Rheumatol. 2019;38(6):1545–1553. doi:10.1007/s10067-019-04431-6
  • Yacoub YI, Amine B, Laatiris A, Hajjaj-Hassouni N. Rheumatoid factor and antibodies against citrullinated peptides in Moroccan patients with rheumatoid arthritis: association with disease parameters and quality of life. Clin Rheumatol. 2012;31(2):329–334. doi:10.1007/s10067-011-1820-4

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.