Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review

References

• AkibaJQuirozMATrempeCLRole of posterior vitreous detachment in idiopathic macular holesOphthalmology19909712161016132087292
   PubMed Web of Science ®Google Scholar
• JaffeNSVitreous traction at the posterior pole of the fundus due to alterations in the vitreous posteriorTrans Am Acad Ophthalmol Otolaryngol19677146426526052820
   PubMedGoogle Scholar
• RoldanMSerranoJMMacular edema and vitreous detachmentAnn Ophthalmol19892141411482729818
   PubMedGoogle Scholar
• NasrallahFPJalkhAEVan CoppenolleFThe role of the vitreous in diabetic macular edemaOphthalmology19889510133513393226682
   PubMed Web of Science ®Google Scholar
• AkibaJArzabeCWTrempeCLPosterior vitreous detachment and neovascularization in diabetic retinopathyOphthalmology19909778898912381702
   PubMed Web of Science ®Google Scholar
• AkibaJKadoMKakehashiATrempeCLRole of the vitreous in posterior segment neovascularization in central retinal vein occlusionOphthalmic Surg19912294985021945273
   PubMedGoogle Scholar
• RobisonCDKrebsIBinderSVitreomacular adhesion in active and end-stage age-related macular degenerationAm J Ophthalmol200914817982e7219327744
   PubMed Web of Science ®Google Scholar
• JohnsonMWPerifoveal vitreous detachment and its macular complicationsTrans Am Ophthalmol Soc200510353756717057817
   PubMedGoogle Scholar
• JohnsonMWPosterior vitreous detachment: evolution and complications of its early stagesAm J Ophthalmol20101493371382.e37120172065
   PubMed Web of Science ®Google Scholar
• RanchodTMGoldenbergDTTreseMTPharmacologic vitreodynamicsInt Ophthalmol Clin200949213514019349793
   PubMedGoogle Scholar
• ChuTGLopezPFCanoMRPosterior vitreoschisis. An echographic finding in proliferative diabetic retinopathyOphthalmology199610323153228594520
   PubMed Web of Science ®Google Scholar
• MachemerRBuettnerHNortonEWParelJMVitrectomy: a pars plana approachTrans Am Acad Ophthalmol Otolaryngol19717548138205566980
   PubMedGoogle Scholar
• SonodaKHSakamotoTEnaidaHResidual vitreous cortex after surgical posterior vitreous separation visualized by intravitreous triamcinolone acetonideOphthalmology2004111222623015019367
   PubMed Web of Science ®Google Scholar
• RussellSRHagemanGSOptic disc, foveal, and extrafoveal damage due to surgical separation of the vitreousArch Ophthalmol2001119111653165811709016
   PubMedGoogle Scholar
• GandorferAUlbigMKampikAPlasmin-assisted vitrectomy eliminates cortical vitreous remnantsEye (Lond)2002161959711913902
   PubMed Web of Science ®Google Scholar
• SebagJGuptaPRosenRRGarciaPSadunAAMacular holes and macular pucker: the role of vitreoschisis as imaged by optical coherence tomography/scanning laser ophthalmoscopyTrans Am Ophthalmol Soc2007105121129 discussion 129–131.18427601
   PubMedGoogle Scholar
• HanDPAbramsGWAabergTMSurgical excision of the attached posterior hyaloidArch Ophthalmol1988106799810003390064
   PubMedGoogle Scholar
• VanderJFKleinerRA method for induction of posterior vitreous detachment during vitrectomyRetina19921221721731439247
   PubMed Web of Science ®Google Scholar
• HaritoglouCEhrtOGassCAKristinNKampikAParacentral scotomata: a new finding after vitrectomy for idiopathic macular holeBr J Ophthalmol200185223123311159494
   PubMed Web of Science ®Google Scholar
• ThresherRJEhrenbergMMachemerRGas-mediated vitreous compression: an experimental alternative to mechanized vitrectomyGraefes Arch Clin Exp Ophthalmol198422151921986489766
   PubMed Web of Science ®Google Scholar
• MillerBMillerHRyanSJExperimental vitreous syneresisArch Ophthalmol19851039138513883929752
   PubMedGoogle Scholar
• LincoffHKreissigIJakobiecFIwamotoTVitoloJShapiroRGas vitrectomy in a primate modelGraefes Arch Clin Exp Ophthalmol198622432152173710176
   PubMed Web of Science ®Google Scholar
• LunaJDArtalMNReviglioVEPelizzariMDiazHJuarezCPVitreoretinal alterations following laser in situ keratomileusis: clinical and experimental studiesGraefes Arch Clin Exp Ophthalmol2001239641642311561789
   PubMed Web of Science ®Google Scholar
• VenkateshPVajpayeeRBGargSInduction of posterior vitreous separation using LASIK suction ring may have a potential role in the management of diabetic macular edemaMed Hypotheses20066661137113916481121
   PubMed Web of Science ®Google Scholar
• SebagJPharmacologic vitreolysisRetina1998181139502274
   PubMed Web of Science ®Google Scholar
• FouldsWSIs your vitreous really necessary? The role of the vitreous in the eye with particular reference to retinal attachment, detachment and the mode of action of vitreous substitutesEye (Lond)19871Pt 66416643331605
   PubMed Web of Science ®Google Scholar
• BishopPNStructural macromolecules and supramolecular organisation of the vitreous gelProg Retin Eye Res200019332334410749380
   PubMed Web of Science ®Google Scholar
• ShuiYBHolekampNMKramerBCThe gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataractsArch Ophthalmol2009127447548219365028
   PubMedGoogle Scholar
• HolekampNMThe vitreous gel: more than meets the eyeAm J Ophthalmol20101491323619875090
   PubMed Web of Science ®Google Scholar
• BishopPNVitreous as a substrate for vitreolysisDev Ophthalmol20094471919494647
   PubMedGoogle Scholar
• HindsonVJGallagherJTHalfterWBishopPNOpticin binds to heparan and chondroitin sulfate proteoglycansInvest Ophthalmol Vis Sci200546124417442316303928
   PubMed Web of Science ®Google Scholar
• HeegaardSJensenOAPrauseJUStructure and composition of the inner limiting membrane of the retina. SEM on frozen resin-cracked and enzyme-digested retinas of Macaca mulattaGraefes Arch Clin Exp Ophthalmol198622443553603710190
   PubMed Web of Science ®Google Scholar
• KohnoTSorgenteNIshibashiTGoodnightRRyanSJImmunofluorescent studies of fibronectin and laminin in the human eyeInvest Ophthalmol Vis Sci19872835065143549611
   PubMed Web of Science ®Google Scholar
• PonsioenTLvan LuynMJvan der WorpRJvan MeursJCHooymansJMLosLICollagen distribution in the human vitreoretinal interfaceInvest Ophthalmol Vis Sci20084994089409518450587
   PubMed Web of Science ®Google Scholar
• SebagJBalazsEAMorphology and ultrastructure of human vitreous fibersInvest Ophthalmol Vis Sci1989308186718712759801
   PubMed Web of Science ®Google Scholar
• FoosRYVitreoretinal juncture; topographical variationsInvest Ophthalmol197211108018084561129
   PubMedGoogle Scholar
• WangJMcLeodDHensonDBBishopPNAge-dependent changes in the basal retinovitreous adhesionInvest Ophthalmol Vis Sci20034451793180012714607
   PubMed Web of Science ®Google Scholar
• SebagJMolecular biology of pharmacologic vitreolysisTrans Am Ophthalmol Soc200510347349417057814
   PubMedGoogle Scholar
• TerranovaVPRohrbachDHMartinGRRole of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagenCell19802237197267460011
   PubMed Web of Science ®Google Scholar
• EngvallERuoslahtiEMillerEJAffinity of fibronectin to collagens of different genetic types and to fibrinogenJ Exp Med1978147615841595567240
   PubMed Web of Science ®Google Scholar
• FoosRYWheelerNCVitreoretinal juncture. Synchysis senilis and posterior vitreous detachmentOphthalmology19828912150215127162795
   PubMed Web of Science ®Google Scholar
• SebagJThe vitreous: structure, function, and pathobiologyNew YorkSpringer-Verlag1989
   Google Scholar
• KishiSShimizuKPosterior precortical vitreous pocketArch Ophthalmol199010879799822369358
   PubMedGoogle Scholar
• SebagJAge-related changes in human vitreous structureGraefes Arch Clin Exp Ophthalmol1987225289933583000
   PubMed Web of Science ®Google Scholar
• O’MalleyPThe pattern of vitreous syneresis: a study of 800 autopsy eyesIrvineARO’MalleyCAdvances in vitreous surgerySpringfield, ILThomas19761733
   Google Scholar
• LarssonLOsterlinSPosterior vitreous detachment. A combined clinical and physiochemical studyGraefes Arch Clin Exp Ophthalmol1985223292954007512
   PubMed Web of Science ®Google Scholar
• LinderBAcute posterior vitreous detachment and its retinal complicationsActa Ophthalmol196687Suppl1108
   Google Scholar
• SebagJAnomalous posterior vitreous detachment: a unifying concept in vitreo-retinal diseaseGraefes Arch Clin Exp Ophthalmol2004242869069815309558
   PubMed Web of Science ®Google Scholar
• KlotiRExperimental occlusion of retinal and ciliary vessels in owl monkeys. I. Technique and clinical observations of selective embolism of the central retinal artery systemExp Eye Res1967643933996060551
   PubMed Web of Science ®Google Scholar
• SebagJAge-related differences in the human vitreoretinal interfaceArch Ophthalmol199110979669712064577
   PubMedGoogle Scholar
• SebagJIs pharmacologic vitreolysis brewing?Retina20022211311884870
   PubMed Web of Science ®Google Scholar
• UenoNSebagJHirokawaHChakrabartiBEffects of visible-light irradiation on vitreous structure in the presence of a photosensitizerExp Eye Res19874468638703653277
   PubMed Web of Science ®Google Scholar
• AkibaJUenoNChakrabartiBMechanisms of photo-induced vitreous liquefactionCurr Eye Res19941375055127924415
   PubMed Web of Science ®Google Scholar
• KakehashiAUenoNChakrabartiBMolecular mechanisms of photochemically induced posterior vitreous detachmentOphthalmic Res199426151598134089
   PubMed Web of Science ®Google Scholar
• BrownDJBishopPHamdiHKenneyMCCleavage of structural components of mammalian vitreous by endogenous matrix metalloproteinase-2Curr Eye Res19961544394458717491
   PubMed Web of Science ®Google Scholar
• Vaughan-ThomasAGilbertSJDuanceVCElevated levels of proteolytic enzymes in the aging human vitreousInvest Ophthalmol Vis Sci200041113299330411006217
   PubMed Web of Science ®Google Scholar
• LosLIvan der WorpRJvan LuynMJHooymansJMAge-related liquefaction of the human vitreous body: LM and TEM evaluation of the role of proteoglycans and collagenInvest Ophthalmol Vis Sci20034472828283312824219
   PubMed Web of Science ®Google Scholar
• MoorheadLCChuHHGarciaCAEnzyme-assisted vitrectomy with bacterial collagenase. Time course and toxicity studiesArch Ophthalmol198310122652746297438
   PubMedGoogle Scholar
• MoorheadLCRadtkeNEnzyme-assisted vitrectomy with bacterial collagenase. Pilot human studiesRetina198552981002996104
   PubMed Web of Science ®Google Scholar
• MoorheadLCRedburnDAKirkpatrickDSKretzerFBacterial collagenase. Proposed adjunct to vitrectomy with membranectomyArch Ophthalmol19809810182918396252879
   PubMedGoogle Scholar
• VerstraetenTCChapmanCHartzerMWinklerBSTreseMTWilliamsGAPharmacologic induction of posterior vitreous detachment in the rabbitArch Ophthalmol199311168498548512489
   PubMedGoogle Scholar
• HarooniMMcMillanTRefojoMEfficacy and safety of enzymatic posterior vitreous detachment by intravitreal injection of hyaluronidaseRetina199818116229502276
   PubMed Web of Science ®Google Scholar
• TezelTHDel PrioreLVKaplanHJPosterior vitreous detachment with dispaseRetina19981817159502275
   PubMed Web of Science ®Google Scholar
• TreseMTEnzymatic-assisted vitrectomyEye (Lond)200216436536812101442
   PubMed Web of Science ®Google Scholar
• TreseMTEnzymatic vitreous surgerySemin Ophthalmol200015211612111309736
   PubMedGoogle Scholar
• GandorferAPharmacologic vitreolysisDev Ophthalmol20073914915617245084
   PubMedGoogle Scholar
• GandorferAEnzymatic vitreous disruptionEye (Lond)200822101273127718292784
   PubMed Web of Science ®Google Scholar
• BhisitkulRBAnticipation for enzymatic vitreolysisBr J Ophthalmol20018511211133700
   PubMed Web of Science ®Google Scholar
• BenzMSPackoKHGonzalezVA placebo-controlled trial of microplasmin intravitreous injection to facilitate posterior vitreous detachment before vitrectomyOphthalmology2010117479179720138368
   PubMed Web of Science ®Google Scholar
• HermelMPrennerJAlabdulrazzakMDaileyWHartzerMEffect of intravitreal plasmin on vitreous removal through a 25-gauge cutting system in the rabbit in vivoGraefes Arch Clin Exp Ophthalmol2009247333133419034484
   PubMed Web of Science ®Google Scholar
• EckardtCTransconjunctival sutureless 23-gauge vitrectomyRetina200525220821115689813
   PubMed Web of Science ®Google Scholar
• FujiiGYDe JuanEJrHumayunMSA new 25-gauge instrument system for transconjunctival sutureless vitrectomy surgeryOphthalmology20021091018071812 discussion 1813.12359598
   PubMed Web of Science ®Google Scholar
• RamkissoonYDAslamSAShahSPWongSCSullivanPMRisk of iatrogenic peripheral retinal breaks in 20-G pars plana vitrectomyOphthalmology201011791825183020471685
   PubMed Web of Science ®Google Scholar
• TanHSMuraMde SmetMDIatrogenic retinal breaks in 25-gauge macular surgeryAm J Ophthalmol2009148342743019477712
   PubMed Web of Science ®Google Scholar
• HubschmanJPGuptaABourlaDHCuljatMYuFSchwartzSD20-, 23-, and 25-gauge vitreous cutters: performance and characteristics evaluationRetina200828224925718301030
   PubMed Web of Science ®Google Scholar
• TeixeiraAChongLPMatsuokaNVitreoretinal traction created by conventional cutters during vitrectomyOphthalmology2010117713871392.e138220176400
   PubMed Web of Science ®Google Scholar
• AsamiTTerasakiHKachiSUltrastructure of internal limiting membrane removed during plasmin-assisted vitrectomy from eyes with diabetic macular edemaOphthalmology2004111223123715019368
   PubMed Web of Science ®Google Scholar
• BonnetMThe development of severe proliferative vitreoretinopathy after retinal detachment surgery. Grade B: a determining risk factorGraefes Arch Clin Exp Ophthalmol198822632012053402740
   PubMed Web of Science ®Google Scholar
• CapeansCLorenzoJSantosLComparative study of incomplete posterior vitreous detachment as a risk factor for proliferative vitreoretinopathyGraefes Arch Clin Exp Ophthalmol199823674814859672792
   PubMed Web of Science ®Google Scholar
• GandorferARohlederMGrosselfingerSHaritoglouCUlbigMKampikAEpiretinal pathology of diffuse diabetic macular edema associated with vitreomacular tractionAm J Ophthalmol2005139463865215808159
   PubMed Web of Science ®Google Scholar
• TakahashiMTrempeCLMaguireKMcMeelJWVitreoretinal relationship in diabetic retinopathy. A biomicroscopic evaluationArch Ophthalmol19819922412457469858
   PubMedGoogle Scholar
• JalkhATakahashiMTopilowHWTrempeCLMcMeelJWPrognostic value of vitreous findings in diabetic retinopathyArch Ophthalmol198210034324347199900
   PubMedGoogle Scholar
• KadoMTrempeCLRole of the vitreous in branch retinal vein occlusionAm J Ophthalmol1988105120242447780
   PubMed Web of Science ®Google Scholar
• HikichiTKonnoSTrempeCLRole of the vitreous in central retinal vein occlusionRetina199515129337754244
   PubMed Web of Science ®Google Scholar
• AvundukAMCetinkayaKKapiciogluZKayaCThe effect of posterior vitreous detachment on the prognosis of branch retinal vein occlusionActa Ophthalmol Scand19977544414429374257
   PubMedGoogle Scholar
• KrebsIBrannathWGlittenbergCZeilerFSebagJBinderSPosterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration?Am J Ophthalmol2007144574174617884003
   PubMed Web of Science ®Google Scholar
• LeeSJLeeCSKohHJPosterior vitreomacular adhesion and risk of exudative age-related macular degeneration: paired eye studyAm J Ophthalmol20091474621626.e62119159862
   PubMed Web of Science ®Google Scholar
• KuppermannBDThomasELde SmetMDGrilloneLRPooled efficacy results from two multinational randomized controlled clinical trials of a single intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhageAm J Ophthalmol2005140457358416125661
   PubMed Web of Science ®Google Scholar
• KuppermannBDThomasELde SmetMDGrilloneLRSafety results of two phase III trials of an intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhageAm J Ophthalmol2005140458559716226510
   PubMed Web of Science ®Google Scholar
• SebagJPharmacologic vitreolysis – premise and promise of the first decadeRetina200929787187419584647
   PubMed Web of Science ®Google Scholar
• MandlICollagenaseScience1970169951123412384317926
   PubMed Web of Science ®Google Scholar
• O’NeillRSheaMThe effects of bacterial collagenase in rabbit vitreousCan J Ophthalmol1973823663704350501
   PubMed Web of Science ®Google Scholar
• QuirozHBuzneySMFurukawaHEnzymatically induced posterior vitreous detachment [abstract]Invest Ophthalmol Vis Sci (Suppl)198425307
   Google Scholar
• PrabhakarVRamanRCapilaIBosquesCJPojasekKSasisekharanRBiochemical characterization of the chondroitinase ABC I active siteBiochem J2005390Pt 239540516108757
   PubMed Web of Science ®Google Scholar
• HagemanGSRussellSRChondroitinase-mediated disinsertion of the primate vitreous body [abstract]Invest Ophthalmol Vis Sci (Suppl)1994351260
   Web of Science ®Google Scholar
• BishopPNMcLeodDReardonAEffects of hyaluronan lyase, hyaluronidase, and chondroitin ABC lyase on mammalian vitreous gelInvest Ophthalmol Vis Sci199940102173217810476780
   PubMed Web of Science ®Google Scholar
• StaubachFNoberVJanknechtPEnzyme-assisted vitrectomy in enucleated pig eyes: a comparison of hyaluronidase, chondroitinase, and plasminCurr Eye Res2004294–526126815590471
   PubMed Web of Science ®Google Scholar
• HermelMSchrageNFEfficacy of plasmin enzymes and chondroitinase ABC in creating posterior vitreous separation in the pig: a masked, placebo-controlled in vivo studyGraefes Arch Clin Exp Ophthalmol2007245339940616900357
   PubMed Web of Science ®Google Scholar
• LudowiegJVenneslandBDorfmanAThe mechanism of action of hyaluronidaseJ Biol Chem196123633333913764073
   PubMed Web of Science ®Google Scholar
• MenzelEJFarrCHyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic usesCancer Lett199813113119839614
   PubMed Web of Science ®Google Scholar
• FouldsWSAllanDMoseleyHKylePMEffect of intravitreal hyaluronidase on the clearance of tritiated water from the vitreous to the choroidBr J Ophthalmol19856975295324016049
   PubMed Web of Science ®Google Scholar
• GottliebJLAntoszykANHatchellDLSaloupisPThe safety of intravitreal hyaluronidase. A clinical and histologic studyInvest Ophthalmol Vis Sci19903111234523522242999
   PubMed Web of Science ®Google Scholar
• KangSWHyungSMChoiMYLeeJInduction of vitreolysis and vitreous detachment with hyaluronidase and perfluoropropane gasKorean J Ophthalmol19959269788818320
   PubMedGoogle Scholar
• HikichiTKadoMYoshidaAIntravitreal injection of hyaluronidase cannot induce posterior vitreous detachment in the rabbitRetina200020219519810783954
   PubMed Web of Science ®Google Scholar
• WangZ-LZhangXXuXSunX-DWangFPVD following plasmin but not hyaluronidase: implications for combination pharmacologic vitreolysis therapyRetina2005251384315655439
   PubMed Web of Science ®Google Scholar
• StennKSLinkRMoellmannGMadriJKuklinskaEDispase, a neutral protease from Bacillus polymyxa, is a powerful fibronectinase and type IV collagenaseJ Invest Dermatol19899322872902546994
   PubMed Web of Science ®Google Scholar
• FrenzelEMNeelyKAWalshAWCameronJDGregersonDSA new model of proliferative vitreoretinopathyInvest Ophthalmol Vis Sci19983911215721649761295
   PubMed Web of Science ®Google Scholar
• KralingerMTKieselbachGFVoigtMExperimental model for proliferative vitreoretinopathy by intravitreal dispase: limited by zonulolysis and cataractOphthalmologica2006220421121616785750
   PubMed Web of Science ®Google Scholar
• OliveiraLBTatebayashiMMahmoudTHBlackmonSMWongFMcCuenBW2ndDispase facilitates posterior vitreous detachment during vitrectomy in young pigsRetina200121432433111508877
   PubMed Web of Science ®Google Scholar
• JorgeROyamaguchiEKCardilloJAGobbiALaicineEMHaddadAIntravitreal injection of dispase causes retinal hemorrhages in rabbit and human eyesCurr Eye Res200326210711212815529
   PubMed Web of Science ®Google Scholar
• ZhuDChenHXuXEffects of intravitreal dispase on vitreoretinal interface in rabbitsCurr Eye Res2006311193594617114119
   PubMed Web of Science ®Google Scholar
• WangFWangZSunXXuXZhangXSafety and efficacy of dispase and plasmin in pharmacologic vitreolysisInvest Ophthalmol Vis Sci20044593286329015326153
   PubMed Web of Science ®Google Scholar
• SumiHHamadaHTsushimaHMiharaHMurakiHA novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese dietExperientia19874310111011113478223
   PubMedGoogle Scholar
• SumiHHamadaHNakanishiKHirataniHEnhancement of the fibrinolytic activity in plasma by oral administration of nattokinaseActa Haematol19908431391432123064
   PubMed Web of Science ®Google Scholar
• UranoTIharaHUmemuraKThe profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1J Biol Chem200127627246902469611325965
   PubMed Web of Science ®Google Scholar
• TakanoAHirataAOgasawaraKPosterior vitreous detachment induced by nattokinase (subtilisin NAT): a novel enzyme for pharmacologic vitreolysisInvest Ophthalmol Vis Sci20064752075207916639018
   PubMed Web of Science ®Google Scholar
• LiottaLAGoldfarbRHBrundageRSiegalGPTerranovaVGarbisaSEffect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membraneCancer Res19814111 Pt 1462946366458354
   PubMed Web of Science ®Google Scholar
• UemuraANakamuraMKachiSEffect of plasmin on laminin and fibronectin during plasmin-assisted vitrectomyArch Ophthalmol2005123220921315710817
   PubMedGoogle Scholar
• LiXShiXFanJPosterior vitreous detachment with plasmin in the isolated human eyeGraefes Arch Clin Exp Ophthalmol20022401566211954782
   PubMed Web of Science ®Google Scholar
• TakanoAHirataAInomataYIntravitreal plasmin injection activates endogenous matrix metalloproteinase-2 in rabbit and human vitreousAm J Ophthalmol2005140465466016140249
   PubMed Web of Science ®Google Scholar
• BaramovaENBajouKRemacleAInvolvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activationFEBS Lett199740521571629089282
   PubMed Web of Science ®Google Scholar
• WachtfogelYTAbramsWKucichUWeinbaumGSchapiraMColmanRWFibronectin degradation products containing the cytoadhesive tetrapeptide stimulate human neutrophil degranulationJ Clin Invest1988815131013162966812
   PubMed Web of Science ®Google Scholar
• HikichiTYanagiyaNKadoMAkibaJYoshidaAPosterior vitreous detachment induced by injection of plasmin and sulfur hexafluoride in the rabbit vitreousRetina1999191555810048374
   PubMed Web of Science ®Google Scholar
• GandorferAPutzEWelge-LussenUGruterichMUlbigMKampikAUltrastructure of the vitreoretinal interface following plasmin assisted vitrectomyBr J Ophthalmol200185161011133703
   PubMed Web of Science ®Google Scholar
• GandorferAPriglingerSSchebitzKVitreoretinal morphology of plasmin-treated human eyesAm J Ophthalmol2002133115615911755861
   PubMed Web of Science ®Google Scholar
• MargherioARMargherioRRHartzerMTreseMTWilliamsGAFerronePJPlasmin enzyme-assisted vitrectomy in traumatic pediatric macular holesOphthalmology19981059161716209754166
   PubMed Web of Science ®Google Scholar
• WuWCDrenserKATreseMTWilliamsGACaponeAPediatric traumatic macular hole: results of autologous plasmin enzyme-assisted vitrectomyAm J Ophthalmol2007144566867217870044
   PubMed Web of Science ®Google Scholar
• TsukaharaYHondaSImaiHAutologous plasmin-assisted vitrectomy for stage 5 retinopathy of prematurity: a preliminary trialAm J Ophthalmol2007144113914117601440
   PubMed Web of Science ®Google Scholar
• WuW-CDrenserKALaiMCaponeATreseMTPlasmin enzyme-assisted vitrectomy for primary and reoperated eyes with stage 5 retinopathy of prematurityRetina200828Suppl 3S75S8018317350
   PubMed Web of Science ®Google Scholar
• WuW-CDrenserKACaponeAWilliamsGATreseMTPlasmin enzyme-assisted vitreoretinal surgery in congenital X-linked retinoschisis: surgical techniques based on a new classification systemRetina20072781079108518040249
   PubMed Web of Science ®Google Scholar
• TreseMTWilliamsGAHartzerMKA new approach to stage 3 macular holesOphthalmology200010781607161110919918
   PubMed Web of Science ®Google Scholar
• RizzoSPellegriniGBenocciFBeltingCBaicchiUVispiMAutologous plasmin for pharmacologic vitreolysis prepared 1 hour before surgeryRetina200626779279616963853
   PubMed Web of Science ®Google Scholar
• SakumaTTanakaMInoueMMizotaASouriMIchinoseAEfficacy of autologous plasmin for idiopathic macular hole surgeryEur J Ophthalmol200515678779416329067
   PubMed Web of Science ®Google Scholar
• AzzoliniCD’AngeloAMaestranziGIntrasurgical plasmin enzyme in diabetic macular edemaAm J Ophthalmol2004138456056615488781
   PubMed Web of Science ®Google Scholar
• SakumaTTanakaMInoueJMizotaASouriMIchinoseAUse of autologous plasmin during vitrectomy for diabetic maculopathyEur J Ophthalmol200616113814016496258
   PubMed Web of Science ®Google Scholar
• HirataATakanoAInomataYYonemuraNSagaraNTaniharaHPlasmin-assisted vitrectomy for management of proliferative membrane in proliferative diabetic retinopathy: a pilot studyRetina20072781074107818040248
   PubMed Web of Science ®Google Scholar
• UdaondoPDiaz-LlopisMGarcia-DelpechSSalomDRomeroFJIntravitreal plasmin without vitrectomy for macular edema secondary to branch retinal vein occlusionArch Ophthalmol2011129328328721402982
   PubMedGoogle Scholar
• KameiMEstafanousMLewisHTissue plasminogen activator in the treatment of vitreoretinal diseasesSemin Ophthalmol2000151445010749314
   PubMedGoogle Scholar
• Glacet-BernardAKuhnDVineAKOubrahamHCoscasGSoubraneGTreatment of recent onset central retinal vein occlusion with intravitreal tissue plasminogen activator: a pilot studyBr J Ophthalmol200084660961310837386
   PubMed Web of Science ®Google Scholar
• Le MerYKorobelnikJFMorelCUllernMBerrodJPTPA-assisted vitrectomy for proliferative diabetic retinopathy: results of a double-masked, multicenter trialRetina199919537838210546931
   PubMed Web of Science ®Google Scholar
• EsserPHeimannKBartz-SchmidtKUWalterPKrottRWellerMPlasminogen in proliferative vitreoretinal disordersBr J Ophthalmol19978175905949290376
   PubMed Web of Science ®Google Scholar
• HesseLNebelingBSchroederBHellerGKrollPInduction of posterior vitreous detachment in rabbits by intravitreal injection of tissue plasminogen activator following cryopexyExp Eye Res2000701313910644418
   PubMed Web of Science ®Google Scholar
• UnalMPeymanGAThe efficacy of plasminogen-urokinase combination in inducing posterior vitreous detachmentRetina2000201697510696751
   PubMed Web of Science ®Google Scholar
• MenGPeymanGAGenaidyMThe role of recombinant lysine-plasminogen and recombinant urokinase and sulfur hexafluoride combination in inducing posterior vitreous detachmentRetina200424219920915097878
   PubMed Web of Science ®Google Scholar
• HesseLKrollPTPA-assisted vitrectomy for proliferative diabetic retinopathyRetina200020331731810872945
   PubMed Web of Science ®Google Scholar
• MurakamiTTakagiHOhashiHRole of posterior vitreous detachment induced by intravitreal tissue plasminogen activator in macular edema with central retinal vein occlusionRetina20072781031103718040240
   PubMed Web of Science ®Google Scholar
• NagaiNDemarsinEVan HoefBRecombinant human microplasmin: production and potential therapeutic propertiesJ Thromb Haemost20031230731312871505
   PubMed Web of Science ®Google Scholar
• GandorferARohlederMSethiCPosterior vitreous detachment induced by microplasminInvest Ophthalmol Vis Sci200445264164714744909
   PubMed Web of Science ®Google Scholar
• SakumaTTanakaMMizotaAInoueJPakolaSSafety of in vivo pharmacologic vitreolysis with recombinant microplasmin in rabbit eyesInvest Ophthalmol Vis Sci20054693295329916123432
   PubMed Web of Science ®Google Scholar
• ChenWHuangXMaXWMoWWangWJSongHYEnzymatic vitreolysis with recombinant microplasminogen and tissue plasminogen activatorEye (Lond)200822230030717704761
   PubMed Web of Science ®Google Scholar
• de SmetMDValmaggiaCZarranz-VenturaJWillekensBMicroplasmin: ex vivo characterization of its activity in porcine vitreousInvest Ophthalmol Vis Sci200950281481918806295
   PubMed Web of Science ®Google Scholar
• de SmetMDGandorferAStalmansPMicroplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy: the MIVI I trialOphthalmology20091167134913551355.e1341e134219447497
   PubMed Web of Science ®Google Scholar
• StalmansPDelaeyCde SmetMDvan DijkmanEPakolaSIntravitreal injection of microplasmin for treatment of vitreomacular adhesion: results of a prospective, randomized, sham-controlled phase II trial (the MIVI-IIT trial)Retina20103071122112720616687
   PubMed Web of Science ®Google Scholar
• DugelPUGroupM-TSA single injection of ocriplasmin for the treatment of symptomatic vitreomacular adhesion (sVMA): results of the Phase III MIVI-TRUST Program [abstract]Invest Ophthalmol Vis Sci (Suppl)2011526628
   Google Scholar
• HynesROIntegrins: versatility, modulation, and signaling in cell adhesionCell199269111251555235
   PubMed Web of Science ®Google Scholar
• GehlsenKRArgravesWSPierschbacherMDRuoslahtiEInhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptidesJ Cell Biol198810639259302450101
   PubMed Web of Science ®Google Scholar
• BremRBRobbinsSGWilsonDJImmunolocalization of integrins in the human retinaInvest Ophthalmol Vis Sci1994359346634748056522
   PubMed Web of Science ®Google Scholar
• OliveiraLBMeyerCHKumarJRGD peptide-assisted vitrectomy to facilitate induction of a posterior vitreous detachment: a new principle in pharmacological vitreolysisCurr Eye Res200225633334012789539
   PubMed Web of Science ®Google Scholar
• KarageozianHLDetermine the safety and efficacy of Vitreosolve® administered intravitreally to induce a complete posterior vitreous detachment (PVD) in non proliferative diabetic retinopathy human subjectsInvest Ophthalmol Vis Sci (Suppl)2005465453
   Web of Science ®Google Scholar
• McLaughlinPSMcLaughlinBGChemical analysis of bovine and porcine vitreous humors: correlation of normal values with serum chemical values and changes with time and temperatureAm J Vet Res19874834674733565904
   PubMed Web of Science ®Google Scholar
• GandorferAKampikAPharmacologic vitreolysis combining the two enzymes plasmin and hyaluronidaseRetina2005255674 author reply 674–675.16077373
   PubMed Web of Science ®Google Scholar
• Zhi-LiangWWo-DongSMinLXiao-PingBJinJPharmacologic vitreolysis with plasmin and hyaluronidase in diabetic ratsRetina200929226927419050667
   PubMed Web of Science ®Google Scholar