Intraductal meibomian gland probing: background, patient selection, procedure, and perspectives

References

• Paradigm shift. Oxford Dictionary. Oxford University Press: New  York, NY; 2019.
   Google Scholar
• Lemp MA, Crews LA, Bron AJ, Foulks GN, Sullivan BD. Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea. 2012;31:472–478. doi:10.1097/ICO.0b013e318225415a
   PubMed Web of Science ®Google Scholar
• Maskin SL, Testa WR. Growth of meibomian gland tissue after intraductal meibomian gland probing in patients with obstructive meibomian gland dysfunction. Br J Ophthalmol. 2018;102:59–68. doi:10.1136/bjophthalmol-2016-310097
   Web of Science ®Google Scholar
• Maskin SL. Intraductal meibomian gland probing relieves symptoms of obstructive meibomian gland dysfunction. Cornea. 2010;29(10):1145–1152. doi:10.1097/ICO.0b013e3181d836f3
   Web of Science ®Google Scholar
• Syed ZA, Sutula FC. Dynamic intraductal meibomian probing: a modified approach to the treatment of obstructive meibomian gland dysfunction. Ophthal Plast Reconstr Surg. 2017;33:307–309. doi:10.1097/IOP.0000000000000876
   Web of Science ®Google Scholar
• Cardenas Diaz GA, Guerra Almaguer M, Hernandez Lopez I et al. Efficacy of intraductal probing in meibomian gland dysfunction. Rev Cubana De Oftalmol. 2017;30:1–12.
   Google Scholar
• Maskin SL. A paradigm shift for the successful treatment of obstructive meibomian gland dysfunction. In: Tsubota K, editor. Diagnosis and Treatment of Meibomian Gland Dysfunction. Kanehara & Co., LTD. Tokyo, Japan; 2016:149–167.
   Google Scholar
• Ma X, Lu Y. Efficacy of intraductal meibomian gland probing on tear function in patients with obstructive meibomian gland dysfunction. Cornea. 2016;35:725–730. doi:10.1097/ICO.0000000000000777
   PubMed Web of Science ®Google Scholar
• Sik Sarman Z, Cucen B, Yuksel N, Cengiz A, Caglar Y. Effectiveness of intraductal meibomian gland probing for obstructive meibomian gland dysfunction. Cornea. 2016;35:721–724. doi:10.1097/ICO.0000000000000820
   PubMed Web of Science ®Google Scholar
• Nakayama N, Kawashima M, Kaido M, et al. Analysis of meibum before and after intraductal meibomian gland probing in eyes with obstructive meibomian gland dysfunction. Cornea. 2015;34:1206–1208.
   PubMed Web of Science ®Google Scholar
• Fermon S, Zaga IH, Alvarez Melloni D. Intraductal meibomian gland probing for the treatment of blepharitis. Arch Soc Esp Oftalmol. 2015;90:76–80. doi:10.1016/j.oftal.2014.04.014
   Google Scholar
• Dongju Q, Hui L, Jianjiang X. Clinical research on intraductal meibomian gland probing in the treatment of patients with meibomian gland dysfunction. Chin J Optom Ophthalmol. 2014;16:615–621.
   Google Scholar
• Wladis EJ. Intraductal meibomian gland probing in the management of ocular rosacea. Ophthal Plast Reconstr Surg. 2012;28:416–418. doi:10.1097/IOP.0b013e3182627ebc
   PubMed Web of Science ®Google Scholar
• Hamrah P, Keirkhah A, Jamali A, et al. A Randomized Sham-Controlled Trial of Intraglandular Meibomian Gland Probing for Obstructive Meibomian Gland Dysfunction. Chicago: American Academy of Ophtalmology; 2016.
   Google Scholar
• Narayanan S, Mickles C, Conner C, et al. Evaporative Dry Eye Treatment with Retaine MGD Artificial Tears OR Intraductal Meibomian Gland Probing. A Comparision. Orlando, Florida: American Academy of Optometry; 2014.
   Google Scholar
• Mickles C, Connor C, Brinkley D, et al. Unplugged: A Comparision of Intraductal Meibomian Gland Probing and Conventional Meibomian Gland Dysfunction Treatment. Denver, Colorado: American Academy of Optometry; 2014.
   Google Scholar
• Maskin SL. Intraductal meibomian gland probing relieves symptoms of obstructive MGD. Invest Ophthalmol Vis Sci. 2009;50:1.
   Google Scholar
• Maskin SL. Intraductal Meibomian Gland Probing and Distinct Visual Analog Scale Response Profiles for Symptoms of Meibomian Gland Dysfunction. Chicago: American Academy of Ophthalmology (AAO); 2010.
   Google Scholar
• Maskin SL, Kantor K. Intraductal meibomian gland probing with adjunctive intraductal microtube steroid injection (MGPs) for Meibomian Gland Dysfunction (MGD). Invest Ophthalmol Vis Sci. 2011;52:1.
   Google Scholar
• Maskin SL. Intraductal Meibomian Gland Probing to Restore Gland Functionality for Obstructive Meibomian Gland Dysfunction. Orlando, Florida: American Academy of Ophthalmology; 2011.
   Google Scholar
• Maskin SL. Meibomian gland probing findings suggest fibrotic obstruction is a major cause of Obstructive Meibomian Gland Dysfunction (O-MGD). Invest Ophthalmol Vis Sci. 2012;53:1.
   Google Scholar
• Incekalan TK, Harbiyeli II, Yagmur M, Erdem E. Effectiveness of intraductal meibomian gland probing in addition to the conventional treatment in patients with obstructive meibomian gland dysfunction AU - Incekalan, Tuğba Kurumoglu. Ocul Immunol Inflamm. Epub 2018 Sep 20.
   Google Scholar
• Nirupama D, Hymavathi B, Prathima L, et al. Meibomian gland probing in patients with meibomian gland dysfunction. Indian Journal of Clinical and Experimental Ophthalmology. 2019;5(1):78–81.
   Google Scholar
• Knop E, Knop N, Millar T, Obata H, Sullivan DA. The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Invest Ophthalmol Vis Sci. 2011;52:1938–1978. doi:10.1167/iovs.10-6997c
   PubMed Web of Science ®Google Scholar
• Maskin SL, Alluri S. Expressible meibomian glands have occult fixed obstructions: findings from meibomian gland probing to restore intraductal integrity. Cornea. 2019;38:880–887.
   Web of Science ®Google Scholar
• Cher I. Meibomian marginal dimples: clinical indicants of reactive pathogenic processes. In: Lass J, editor. Advances in Corneal Research: Selected Transections of the World Congress on the Cornea. Vol IV. New York: Plenum Press; 1997:27–35.
   Google Scholar
• Foulks GN, Bron AJ. Meibomian gland dysfunction: a clinical scheme for description, diagnosis, classification, and grading. Ocul Surf. 2003;1:107–126.
   PubMedGoogle Scholar
• Matsumoto Y, Sato EA, Ibrahim OMA, Dogru M, Tsubota K. The application of in vivo laser confocal microscopy to the diagnosis and evaluation of meibomian gland dysfunction. Mol Vis. 2008;14:1263–1271.
   PubMed Web of Science ®Google Scholar
• Maskin SL. When meds are not enough: surgical considerations fo rchronic dry eye. Ophthalmol Manage. 2009;45–50.
   Google Scholar
• Maskin SL. Dry eye relief: peeling back layers to reveal root causes, select right tools and improve tear quality. Ophthalmol Manage. 2011;19–23.
   Google Scholar
• Korb DR, Blackie CA. Restoration of meibomian gland functionality with novel thermodynamic treatment device-a case report. Cornea. 2010;29:930–933. doi:10.1097/ICO.0b013e3181ca36d6
   Web of Science ®Google Scholar
• Lane SS, DuBiner HB, Epstein RJ, et al. A new system, the LipiFlow, for the treatment of meibomian gland dysfunction. Cornea. 2012;31:396–404. doi:10.1097/ICO.0b013e318239aaea
   PubMed Web of Science ®Google Scholar
• Toyos R, McGill W, Briscoe D. Intense pulsed light treatment for dry eye disease due to meibomian gland dysfunction; a 3-year retrospective study. Photomed Laser Surg. 2015;33:41–46. doi:10.1089/pho.2014.3819
   PubMed Web of Science ®Google Scholar
• Vegunta S, Patel D, Shen JF. Combination therapy of Intense Pulsed Light Therapy and Meibomian Gland Expression (IPL/MGX) can improve dry eye symptoms and meibomian gland function in patients with refractory dry eye: a retrospective analysis. Cornea. 2016;35:318–322. doi:10.1097/ICO.0000000000000735
   PubMed Web of Science ®Google Scholar
• Qazi Y, Kheirkhah A, Blackie C, et al. In vivo detection of clinically non-apparent ocular surface inflammation in patients with meibomian gland dysfunction-associated refractory dry eye symptoms: a pilot study. Eye. 2015;29:1099. doi:10.1038/eye.2015.28
   Web of Science ®Google Scholar
• Matsumoto Y, Shigeno Y, Sato EA, et al. The evaluation of the treatment response in obstructive meibomian gland disease by in vivo laser confocal microscopy. Graefe‘S Arch Clin Exp Ophthalmol. 2009;247:821–829. doi:10.1007/s00417-008-1017-y
   PubMed Web of Science ®Google Scholar
• Korb DR, Blackie CA. Meibomian gland therapeutic expression: quantifying the applied pressure and the limitation of resulting pain. Eye Contact Lens. 2011;37:298–301. doi:10.1097/ICL.0b013e31821bc7c5
   PubMed Web of Science ®Google Scholar
• Fermon S, Zaga IH, Alvarez Melloni D. [Intraductal meibomian gland probing for the treatment of blepharitis]. Arch Soc Esp Oftalmol. 2015;90(2):76–80. Spanish.
   Google Scholar
• Maskin SL, Tseng SC. Culture of rabbit meibomian gland using collagen gel. Invest Ophthalmol Vis Sci. 1991;32:214–223.
   PubMed Web of Science ®Google Scholar
• Maskin SL, Tseng SC. Clonal growth and differentiation of rabbit meibomian gland epithelium in serum-free culture: differential modulation by EGF and FGF. Invest Ophthalmol Vis Sci. 1992;33:205–217.
   Web of Science ®Google Scholar
• Maskin SL. Reversing Dry Eye Syndrome: Practival Ways to Improve Your Comfort, Vision and Appearance. New Haven, CT: Yale University Press; 2007.
   Google Scholar
• Obata H. Anatomy and histopathology of human meibomian gland. Cornea. 2002;21:S70–S74.
   PubMed Web of Science ®Google Scholar
• Blackie CA, Korb DR, Knop E, Bedi R, Knop N, Holland EJ. Nonobvious obstructive meibomian gland dysfunction. Cornea. 2010;29:1333–1345. doi:10.1097/ICO.0b013e3181d4f366
   PubMed Web of Science ®Google Scholar
• Flora MR. Intraductal drug delivery effective in meibomian gland dysfunction. Primary Care Optometry News. 2014;19:1–4.
   Google Scholar
• Arita R, Itoh K, Inoue K, Amano S. Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population. Ophthalmology. 2008;115:911–915. doi:10.1016/j.ophtha.2007.06.031
   PubMed Web of Science ®Google Scholar
• Arita R, Itoh K, Inoue K, et al. Noncontact meibography detects changes in meibomian glands in the aging process in a normal population and patients with meibomian gland dysfunction. Cornea. 2009;28:S75–S79. doi:10.1097/ICO.0b013e3181ae6bec
   Web of Science ®Google Scholar
• Galor A, Zlotcavitch L, Walter SD, et al. Dry eye symptom severity and persistence are associated with symptoms of neuropathic pain. Br J Ophthalmol. 2015;99:665–668. doi:10.1136/bjophthalmol-2014-306057
   Web of Science ®Google Scholar
• Rosenthal P, Borsook D. Ocular neuropathic pain. Br J Ophthalmol. 2016;100:128–134. doi:10.1136/bjophthalmol-2014-306280
   Web of Science ®Google Scholar
• Kozak I, Bron AJ, Kucharova K, et al. Morphologic and volumetric studies of the meibomian glands in elderly human eyelids. Cornea. 2007;26:610–614. doi:10.1097/ICO.0b013e318041f0d2
   PubMed Web of Science ®Google Scholar
• Milz S, Neufang J, Higashiyama I, Putz R, Benjamin M. An immunohistochemical study of the extracellular matrix of the tarsal plate in the upper eyelid in human beings. J Anat. 2005;206:37–45. doi:10.1111/j.0021-8782.2005.00363.x
   PubMed Web of Science ®Google Scholar
• Vu CHV, Kawashima M, Yamada M, et al. Influence of meibomian gland dysfunction and friction-related disease on the severity of dry eye. Ophthalmology. 2018;125:1181–1188. doi:10.1016/j.ophtha.2018.01.025
   PubMed Web of Science ®Google Scholar
• Cochener B, Cassan A, Omiel L. Prevalence of meibomian gland dysfunction at the time of cataract surgery. J Cataract Refract Surg. 2018;44:144–148. doi:10.1016/j.jcrs.2017.10.050
   PubMed Web of Science ®Google Scholar
• Maskin SL. Effect of ocular surface reconstruction by using amniotic membrane transplant for symptomatic conjunctivochalasis on fluorescein clearance test results. Cornea. 2008;27:644–649. doi:10.1097/QAI.0b013e31815e723f
   Web of Science ®Google Scholar
• Osei KA, Ovenseri-Ogbomo G, Kyei S, Ntodie M. The effect of caffeine on tear secretion. Optom Vis Sci. 2014;91:171–177. doi:10.1097/OPX.0000000000000129
   Web of Science ®Google Scholar
• Jester JV, Nicolaides N, Kiss-Palvolgyi I, et al. Meibomian gland dysfunction. II. The role of keratinization in a rabbit model of MGD. Invest Ophthalmol Vis Sci. 1989;30:936–945.
   PubMed Web of Science ®Google Scholar
• Trope GE, Rumley AG. Catecholamine concentrations in tears. Exp Eye Res. 1984;39:247–250.
   PubMed Web of Science ®Google Scholar
• Dao AH, Spindle JD, Harp BA, Jacob A, Chuang AZ, Yee RW. Association of dyslipidemia in moderate to severe meibomian gland dysfunction. Am J Ophthalmol. 2010;150:371–375.e371. doi:10.1016/j.ajo.2010.04.016
   PubMed Web of Science ®Google Scholar
• Han JY, Kang B, Eom Y, Kim HM, Song JS. Comparing the effects of particulate matter on the ocular surfaces of normal eyes and a dry eye rat model. Cornea. 2017;36:605–610. doi:10.1097/ICO.0000000000001171
   Web of Science ®Google Scholar
• Hornick MK Evaluating exposures to inhalable dust among dairy parlor workers. MS (Master of Science) thesis, University of Iowa. 2013.
   Google Scholar
• Dieckmann G, Goyal S, Hamrah P. Neuropathic corneal pain: approaches for management. Ophthalmology. 2017;124:S34–S47. doi:10.1016/j.ophtha.2017.08.004
   PubMed Web of Science ®Google Scholar
• Stiles J, Krohne S, Rankin A, Chang M. The efficacy of 0.5% proparacaine stored at room temperature. Vet Ophthalmol. 2001;4:205–207.
   Google Scholar