Real-world retrospective comparison of 0.19 mg fluocinolone acetonide and 0.7 mg dexamethasone intravitreal implants for the treatment of diabetic macular edema in vitrectomized eyes

References

• International Diabetes Federation. IDF diabetes atlas - 8th Edition. Available from: http://diabetesatlas.org/resources/2017-atlas.html Accessed November 13, 2018.
   Google Scholar
• Lee R, Wong TY, Sabanayagam C. Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye Vis (Lond). 2015;2:17. doi:10.1186/s40662-015-0026-2
   PubMedGoogle Scholar
• Klein R, Klein BE, Moss SE, Cruickshanks KJ. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XV. The long-term incidence of macular edema. Ophthalmology. 1995;102(1):7–16. doi:10.1016/s0161-6420(95)31052-4
   PubMed Web of Science ®Google Scholar
• El-Ghrably I, Steel DHW, Habib M, Vaideanu-Collins D, Manvikar S, Hillier RJ. Diabetic macular edema outcomes in eyes treated with fluocinolone acetonide 0.2 microg/d intravitreal implant: real-world UK experience. Eur J Ophthalmol. 2017;27(3):357–362. doi:10.5301/ejo.5000929
   PubMed Web of Science ®Google Scholar
• Wells JA, Glassman AR, Ayala AR, et al.; Diabetic Retinopathy Clinical Research N. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. N Engl J Med. 2015;372(13):1193–1203. doi:10.1056/NEJMoa1414264
   PubMed Web of Science ®Google Scholar
• Campochiaro PA, Brown DM, Pearson A, et al. Sustained delivery fluocinolone acetonide vitreous inserts provide benefit for at least 3 years in patients with diabetic macular edema. Ophthalmology. 2012;119(10):2125–2132. doi:10.1016/j.ophtha.2012.04.030
   PubMed Web of Science ®Google Scholar
• Boyer DS, Yoon YH, Belfort R Jr., et al. Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema. Ophthalmology. 2014;121(10):1904–1914. doi:10.1016/j.ophtha.2014.04.024
   PubMed Web of Science ®Google Scholar
• Schmidt-Erfurth U, Garcia-Arumi J, Bandello F, et al. Guidelines for the management of diabetic macular Edema by the European Society of Retina Specialists (EURETINA). Ophthalmologica. 2017;237(4):185–222. doi:10.1159/000458539
   PubMed Web of Science ®Google Scholar
• Hussain RM, Ciulla TA. Treatment strategies for refractory diabetic macular edema: switching anti-VEGF treatments, adopting corticosteroid-based treatments, and combination therapy. Expert Opin Biol Ther. 2016;16(3):365–374. doi:10.1517/14712598.2016.1131265
   PubMed Web of Science ®Google Scholar
• Campochiaro PA, Brown DM, Pearson A, et al. Long-term benefit of sustained-delivery fluocinolone acetonide vitreous inserts for diabetic macular edema. Ophthalmology. 2011;118(4):626–35 e2. doi:10.1016/j.ophtha.2010.12.028
   PubMed Web of Science ®Google Scholar
• Danis RP, Sadda S, Li XY, Cui H, Hashad Y, Whitcup SM. Anatomical effects of dexamethasone intravitreal implant in diabetic macular oedema: a pooled analysis of 3-year phase III trials. Br J Ophthalmol. 2016;100(6):796–801. doi:10.1136/bjophthalmol-2015-306823
   PubMed Web of Science ®Google Scholar
• Quhill F. BA. Cost advantage of fluocinolone Acetonide Implant (ILUVIEN® versus Ranibizumab in the treatment of chronic disbetic macular oedema. Glob Reg Health Technol Assess. 2017;4(1):e155–64.
   Web of Science ®Google Scholar
• Campochiaro PA, Nguyen QD, Hafiz G, et al. Aqueous levels of fluocinolone acetonide after administration of fluocinolone acetonide inserts or fluocinolone acetonide implants. Ophthalmology. 2013;120(3):583–587. doi:10.1016/j.ophtha.2012.09.014
   PubMed Web of Science ®Google Scholar
• Alimera Sciences Limited. Iluvien summary of product characteristics. Available from: https://www.medicines.org.uk/emc/product/3061/smpc Accessed November 13, 2018.
   Google Scholar
• Bucolo C, Gozzo L, Longo L, Mansueto S, Vitale DC, Drago F. Long-term efficacy and safety profile of multiple injections of intravitreal dexamethasone implant to manage diabetic macular edema: a systematic review of real-world studies. J Pharmacol Sci. 2018;138(4):219–232. doi:10.1016/j.jphs.2018.11.001
   PubMed Web of Science ®Google Scholar
• Nurozler Tabakci B, Unlu N. Corticosteroid treatment in diabetic macular edema. Turk J Ophthalmol. 2017;47(3):156–160. doi:10.4274/tjo.56338
   PubMedGoogle Scholar
• Alfaqawi F, Lip PL, Elsherbiny S, Chavan R, Mitra A, Mushtaq B. Report of 12-months efficacy and safety of intravitreal fluocinolone acetonide implant for the treatment of chronic diabetic macular oedema: a real-world result in the United Kingdom. Eye (Lond). 2017;31(4):650–656. doi:10.1038/eye.2016.301
   PubMed Web of Science ®Google Scholar
• Bailey C, Chakravarthy U, Lotery A, Menon G, Talks J, Medisoft Audit G. Real-world experience with 0.2 mug/day fluocinolone acetonide intravitreal implant (ILUVIEN) in the United Kingdom. Eye (Lond). 2017;31(12):1707–1715. doi:10.1038/eye.2017.125
   PubMed Web of Science ®Google Scholar
• Fusi-Rubiano W, Mukherjee C, Lane M, et al. Treating Diabetic Macular Oedema (DMO): real world UK clinical outcomes for the 0.19mg Fluocinolone Acetonide intravitreal implant (Iluvien) at 2 years. BMC Ophthalmol. 2018;18(1):62. doi:10.1186/s12886-018-0726-1
   PubMed Web of Science ®Google Scholar
• Holden SE, Currie CJ, Owens DR. Evaluation of the clinical effectiveness in routine practice of fluocinolone acetonide 190 microg intravitreal implant in people with diabetic macular edema. Curr Med Res Opin. 2017;33(sup2):5–17. doi:10.1080/03007995.2017.1366645
   PubMed Web of Science ®Google Scholar
• Lam WC, Albiani DA, Yoganathan P, et al. Real-world assessment of intravitreal dexamethasone implant (0.7 mg) in patients with macular edema: the CHROME study. Clin Ophthalmol. 2015;9:1255–1268. doi:10.2147/OPTH.S80500
   PubMed Web of Science ®Google Scholar
• Singer MA, Dugel PU, Fine HF, Capone A Jr., Maltman J. Real-world assessment of dexamethasone intravitreal implant in DME: findings of the prospective, multicenter REINFORCE study. Ophthalmic Surg Lasers Imaging Retina. 2018;49(6):425–435. doi:10.3928/23258160-20180601-07
   Web of Science ®Google Scholar