104
Views
4
CrossRef citations to date
0
Altmetric
STUDY PROTOCOL

A study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study

, , , , , & show all
Pages 897-904 | Published online: 28 May 2019

References

  • Hotta Y, Fujiki K, Hayakawa M, et al. Clinical features of Japanese Leber‘s hereditary optic neuropathy with 11778 mutation of mitochondrial DNA. Jpn J Ophthalmol. 1995;39(1):96–108.
  • Ueda K, Morizane Y, Shiraga F, et al. Nationwide epidemiological survey of Leber hereditary optic neuropathy in Japan. J Epidemiol. 2017;27(9):447–450. doi:10.1016/j.je.2017.02.001
  • Man PY, Griffiths PG, Brown DT, Howell N, Turnbull DM, Chinnery PF. The epidemiology of Leber hereditary optic neuropathy in the North East of England. Am J Hum Genet. 2003;72(2):333–339. doi:10.1086/346066
  • Mackey DA, Oostra RJ, Rosenberg T, et al. Primary pathogenic mtDNA mutations in multigeneration pedigrees with Leber hereditary optic neuropathy. Am J Hum Genet. 1996;59(2):481–485.
  • Klopstock T, Metz G, Yu-Wai-Man P, et al. Persistence of the treatment effect of idebenone in Leber‘s hereditary optic neuropathy. Brain. 2013;136(Pt 2):e230. doi:10.1093/brain/aws279
  • Klopstock T, Yu-Wai-Man P, Dimitriadis K, et al. A randomized placebo-controlled trial of idebenone in Leber‘s hereditary optic neuropathy. Brain. 2011;134(Pt 9):2677–2686. doi:10.1093/brain/awr170
  • Sadun AA, Chicani CF, Ross-Cisneros FN, et al. Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy. Arch Neurol. 2012;69(3):331–338. doi:10.1001/archneurol.2011.2972
  • Guy J, Feuer WJ, Davis JL, et al. Gene therapy for Leber hereditary optic neuropathy: low- and medium-dose visual results. Ophthalmology. 2017;124(11):1621–1634. doi:10.1016/j.ophtha.2017.05.016
  • Morimoto T, Miyoshi T, Matsuda S, Tano Y, Fujikado T, Fukuda Y. Transcorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF-1 system. Invest Ophthalmol Vis Sci. 2005;46(6):2147–2155. doi:10.1167/iovs.04-1339
  • Fujikado T, Morimoto T, Matsushita K, Shimojo H, Okawa Y, Tano Y. Effect of transcorneal electrical stimulation in patients with nonarteritic ischemic optic neuropathy or traumatic optic neuropathy. Jpn J Ophthalmol. 2006;50(3):266–273. doi:10.1007/s10384-005-0304-y
  • Schatz A, Rock T, Naycheva L, et al. Transcorneal electrical stimulation for patients with retinitis pigmentosa: a prospective, randomized, sham-controlled exploratory study. Invest Ophthalmol Vis Sci. 2011;52(7):4485–4496. doi:10.1167/iovs.10-6932
  • Schatz A, Pach J, Gosheva M, et al. Transcorneal electrical stimulation for patients with retinitis pigmentosa: a prospective, randomized, sham-controlled follow-up study over 1 year. Invest Ophthalmol Vis Sci. 2017;58(1):257–269. doi:10.1167/iovs.16-19906
  • Inomata K, Shinoda K, Ohde H, et al. Transcorneal electrical stimulation of retina to treat longstanding retinal artery occlusion. Graefes Arch Clin Exp Ophthalmol. 2007;245(12):1773–1780. doi:10.1007/s00417-007-0610-9
  • Naycheva L, Schatz A, Willmann G, et al. Transcorneal electrical stimulation in patients with retinal artery occlusion: a prospective, randomized, sham-controlled pilot study. Ophthalmol Ther. 2013;2(1):25–39. doi:10.1007/s40123-013-0012-5
  • Delbeke J, Pins D, Michaux G, Wanet-Defalque MC, Parrini S, Veraart C. Electrical stimulation of anterior visual pathways in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2001;42(1):291–297.
  • Hwang TJ, Karanjia R, Moraes-Filho MN, et al. Natural history of conversion of Leber‘s hereditary optic neuropathy: a prospective case series. Ophthalmology. 2017. doi:10.1016/j.ophtha.2017.01.002
  • Naycheva L, Schatz A, Rock T, et al. Phosphene thresholds elicited by transcorneal electrical stimulation in healthy subjects and patients with retinal diseases. Invest Ophthalmol Vis Sci. 2012;53(12):7440–7448. doi:10.1167/iovs.12-9612
  • Koilkonda R, Yu H, Talla V, et al. LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile. Invest Ophthalmol Vis Sci. 2014;55(12):7739–7753. doi:10.1167/iovs.14-15388
  • Tagami Y, Kurimoto T, Miyoshi T, Morimoto T, Sawai H, Mimura O. Axonal regeneration induced by repetitive electrical stimulation of crushed optic nerve in adult rats. Jpn J Ophthalmol. 2009;53(3):257–266. doi:10.1007/s10384-009-0657-8