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Original Research

Effect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in Brazil: a randomized clinical trial

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Pages 1523-1531 | Published online: 09 Aug 2019

References

  • Bandello F, Battaglia Parodi M, Lanzetta P, et al. Diabetic macular edema. Dev Ophthalmol. 2010;47:73–110.
  • Williams R, Airey M, Baxter H, Forrester J, tKennedy-Marin T, Girach A. Epidemiology of diabetic retinopathy and macular oedema: a systematic review. Eye (Lond). 2004;18(10):963–983. doi:10.1038/sj.eye.6701476
  • Das A, McGuire PG, Rangasamy S. Diabetic macular edema: pathophysiology and novel therapeutic targets. Ophthalmology. 2015;122(7):1375–1394. doi:10.1016/j.ophtha.2015.03.024
  • Daruich A, Matet A, Moulin A, et al. Mechanisms of macular edema: beyond the surface. Prog Retin Eye Res. 2018;63(3):20–68. doi:10.1016/j.preteyeres.2017.10.006
  • Urias EA, Urias GA, Monickaraj F, McGuire P, Das A. Novel therapeutic targets in diabetic macular edema: beyond VEGF. Vision Research. 2017;139:221–227. doi:10.1016/j.visres.2017.06.015
  • Zhang X, Wang N, Schachat AP, Bao S, Gillies MC. Glucocorticoids: structure, signaling and molecular mechanisms in the treatment of diabetic retinopathy and diabetic macular edema. Curr Mol Med. 2014;14:376–384.
  • Elman MJ, Aiello LP, Beck RW, et al. Diabetic retinopathy clinical research network. randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2010;117(6):1064–1077. doi:10.1016/j.ophtha.2010.02.031
  • Nguyen QD, Brown DM, Marcus DM, et al. RISE and RIDE research group. Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology. 2012;119(4):789–801. doi:10.1016/j.ophtha.2011.12.039
  • Mitchell P, Bandello F, Schmidt-Erfurth U, et al. RESTORE study group. The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology. 2011;118(4):615–625. doi:10.1016/j.ophtha.2011.01.031
  • Korobelnik JF, Do DV, Schmidt-Erfurth U, et al. Intravitreal aflibercept for diabetic macular edema. Ophthalmology. 2014;121(11):2247–2254. doi:10.1016/j.ophtha.2014.05.006
  • Massin P, Bandello F, Garweg JG, et al. Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE study). Diabetes Care. 2010;33:2399–2405. doi:10.2337/dc10-0493
  • Nguyen QD, Shah SM, Khwaja AA, et al. Two-year outcomes of the ranibizumab for edema of the macula in diabetes (READ-2) study. Ophthalmology. 2010;117(11):2146–2151. doi:10.1016/j.ophtha.2010.08.016
  • Sohn HJ, Han DH, Kim IT, et al. Changes in aqueous concentrations of various cytokines after intravitreal triamcinolone versus bevacizumab for diabetic macular edema. Am J Ophthalmol. 2011;152:686–694. doi:10.1016/j.ajo.2011.03.033
  • Vujosevic S, Torresin T, Bini S, et al. Imaging retinal inflammatory biomarkers after intravitreal steroid and anti-VEGF treatment in diabetic macular oedema. Acta Ophthalmol. 2017;95:464–471. doi:10.1111/aos.13294
  • Elman MJ, Bressler NM, Qin H, et al. Diabetic retinopathy clinical research network. Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2011;118:609–614. doi:10.1016/j.ophtha.2010.12.033
  • Ciulla TA, Harris A, McIntyre N, Jonescu-Cuypers C. Treatment of diabetic macular edema with sustained-release glucocorticoids: intravitreal triamcinolone acetonide, dexamethasone implant, and fluocinolone acetonide implant. Expert Opin Pharmacother. 2014;15:953–959. doi:10.1517/14656566.2014.896899
  • Boyer DS, Yoon YH, Bellfort R Jr, et al. Ozurdex MEAD study group. Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema. Ophthalmology. 2014;121(10):1904–1914. doi:10.1016/j.ophtha.2014.04.024
  • Pacella E, Vestri AR, Muscella R, et al. Preliminary results of an intravitreal dexamethasone implant (Ozurdex) in patients with persistent diabetic macular edema. Clin Ophthalmol. 2013;7:1423–1428. doi:10.2147/OPTH.S48364
  • Lazic R, Lukic M, Boras I, et al. Treatment of anti-vascular endothelial growth factor-resistant diabetic macular edema with dexamethasone intravitreal implant. Retina. 2014;34(4):719–724. doi:10.1097/IAE.0b013e3182a48958
  • Cicinelli MV, Cavalleri M, Querques L, Rabiolo A, Bandello F, Querques G. Early response to ranibizumab predictive of functional outcome after dexamethasone for unresponsive diabetic macular edema. Br J Ophthalmol. 2017;101:1689–1693. doi:10.1136/bjophthalmol-2017-310242
  • Boyer DS, Faber D, Gupta S, et al. Ozurdex champlain study group. Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients. Retina. 2011;31(5):915–923. doi:10.1097/IAE.0b013e318206d18c
  • Bucolo C, Gozzo L, Longo L, Mansueto S, Vitale DC, Drago F. Long-term efficacy and safety profile of multiple injections of intravitreal dexamethasone implant to manage diabetic macular edema: a systematic review of real-world studies. Journal of Pharmacological Sciences. 2018;138:219–232. doi:10.1016/j.jphs.2018.11.001
  • Whitcup SM, Cidlowski JA, Csaky KG, Ambati J. Pharmacology of corticosteroids for DME. Invest Ophthalmol Vis Sci. 2018;59:1–12. doi:10.1167/iovs.17-22259
  • Thakur A, Kadam R, Kompella UB. Trabecular meshwork and lens partitioning of corticosteroids: implications for elevated intraocular pressure and cataracts. Arch Ophthalmol. 2011;129(7):914–920. doi:10.1001/archophthalmol.2011.39
  • Maturi RK, Glassman AR, Liu D, et al. Diabetic retinopathy clinical research network. Effect of adding dexamethasone to continued ranibizumab treatment in patients with persistent diabetic macular edema: a DRCR network phase 2 randomized clinical trial. JAMA Ophthalmol. 2018;136(1):29–38. doi:10.1001/jamaophthalmol.2017.4914
  • Iglicki M, Zur D, Busch C, Mali O, Loewenstein A. Progression of diabetic retinopathy severity after treatment with dexamethasone implant: a 24 month cohort study the “DR- pro DEX study”. Acta Diabetologica. 2018;55:541–547. doi:10.1007/s00592-018-1117-z
  • Wykoff CC, Chakravarthy U, Campochiaro PA, Bailey C, Green K, Cunha-Vaz J. Long term effects of intravireal 0,19 mg fluocinolone acetonide implanto n progression and regression of diabetic retinopathy. Ophthalmology. 2017;124:440–449. doi:10.1016/j.ophtha.2016.11.034
  • Chang-lin JE, Attar M, Acheampong AA, et al. Pharmacokinetics and pharmacodynamics of a sustained release dexamethasone intravitreal implant. IOVS. 2011;52(1):80–86.
  • Escobar-Barranco JJ, Pina-Marín B, Fernandez-Bonet M. Dexamethasone implants in patients with naïve or or refractory diffuse diabetic macular edema. Opthalmologica. 2015;233:176–185. doi:10.1159/000371770
  • Yilmaz T, Weaver CD, Gallagher MJ, et al. Intravitreal triamcinolone acetonide injection for treatment of refractory diabetic macular edema: a systematic review. Ophthalmology. 2009;116(5):902–911. doi:10.1016/j.ophtha.2009.02.002
  • Elman MJ, Raden RZ, Sloan MD, et al. Diabetic retinopathy clinical research network. A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema. Ophthalmology. 2008;115(9):1447–1449. doi:10.1016/j.ophtha.2008.06.015
  • Kwak HW, D’Amico DJ. Evaluation of the retinal toxicity and phamacokinetics of dexamethasone after intravitreal injection. Arch Ophthalmol. 1992;110(2):259–266. doi:10.1001/archopht.1992.01080140115038