Radiation Retinopathy: Detection and Management Strategies

References

• Finger PT, Chin KJ, Duvall G, Palladium-103 for Choroidal Melanoma Study Group. Palladium-103 ophthalmic plaque radiation therapy for choroidal melanoma: 400 treated patients. Ophthalmology. 2009;116(4):790–6. e1. doi:10.1016/j.ophtha.2008.12.027
   PubMed Web of Science ®Google Scholar
• Finger PT. Radiation therapy for orbital tumors: concepts, current use, and ophthalmic radiation side effects. Surv Ophthalmol. 2009;54(5):545–568.
   PubMed Web of Science ®Google Scholar
• Finger PT, Pro MJ, Schneider S, Kurli M, Shapira I, Kenneth H. Visual recovery after radiation therapy for bilateral subfoveal acute myelogenous leukemia (AML). Am J Ophthalmol. 2004;138(4):659–662. doi:10.1016/j.ajo.2004.04.047
   Web of Science ®Google Scholar
• Diener-West M, Earle JD, Fine SL, et al. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma, III: initial mortality findings. COMS Report No. 18. Arch Ophthalmol. 2001;119(7):969–982.
   PubMedGoogle Scholar
• Fallico M, Raciti G, Longo A, et al. Current molecular and clinical insights into uveal melanoma. Int J Oncol. 2021;58(4):1. doi:10.3892/ijo.2021.5190
   Web of Science ®Google Scholar
• Stallard HB. Radiant energy as (a) a pathogenic and (b) therapeutic agent in ophthalmic disorders. Gifford Edmonds prize essay for. Br J Ophthalmol. 1933;6:1–126.
   Google Scholar
• Kim IK, Lane AM, Jain P, Awh C, Gragoudas ES. Ranibizumab for the prevention of radiation complications in patients treated with proton beam irradiation for choroidal melanoma (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 2016;2:114.
   Google Scholar
• Krema H, Somani S, Sahgal A, et al. Stereotactic radiotherapy for treatment of juxtapapillary choroidal melanoma: 3-year follow-up. Br J Ophthalmol. 2009;93(9):1172–1176. doi:10.1136/bjo.2008.153429
   PubMed Web of Science ®Google Scholar
• Gragoudas ES, Seddon JM, Egan K, et al. Long-term results of proton beam irradiated uveal melanomas. Ophthalmology. 1987;94(4):349–353. doi:10.1016/S0161-6420(87)33456-6
   PubMed Web of Science ®Google Scholar
• Haas A, Pinter O, Papaefthymiou G, et al. Incidence of radiation retinopathy after high-dosage single-fraction gamma knife radiosurgery for choroidal melanoma. Ophthalmology. 2002;109(5):909–913. doi:10.1016/S0161-6420(02)01011-4
   Web of Science ®Google Scholar
• Shields CL, Naseripour M, Cater J, et al. Plaque radiotherapy for large posterior uveal melanomas (≥ 8-mm thick) in 354 consecutive patients. Ophthalmology. 2002;109(10):1838–1849. doi:10.1016/S0161-6420(02)01181-8
   Web of Science ®Google Scholar
• Gündüz K, Shields CL, Shields JA, Cater J, Freire JE, Brady LW. Radiation retinopathy following plaque radiotherapy for posterior uveal melanoma. Arch Ophthalmol. 1999;117(5):609–614. doi:10.1001/archopht.117.5.609
   Google Scholar
• Melia BM, Abramson DH, Albert DM, et al. Collaborative ocular melanoma study (COMS) randomized trial of I-125 brachytherapy for medium choroidal melanoma. I. Visual acuity after 3 years COMS report no. 16. Ophthalmology. 2001;108(2):348–366.
   PubMed Web of Science ®Google Scholar
• Viebahn M, Barricks ME, Osterloh MD. Synergism between diabetic and radiation retinopathy: case report and review. Br J Ophthalmol. 1991;75(10):629–632. doi:10.1136/bjo.75.10.629
   PubMed Web of Science ®Google Scholar
• Packer S, Rotman M. Radiotherapy of choroidal melanoma with iodine-125. Ophthalmology. 1980;87(6):582–590. doi:10.1016/S0161-6420(80)35194-4
   PubMed Web of Science ®Google Scholar
• Max Conway R, Poothullil AM, Daftari IK, Weinberg V, Chung JE. Estimates of ocular and visual retention following treatment of extra-large uveal melanomas by proton beam radiotherapy. Arch Ophthalmol. 2006;124(6):838–843. doi:10.1001/archopht.124.6.838
   Google Scholar
• Rudoler SB, Corn BW, Shields CL, et al. External beam irradiation for choroid metastases: identification of factors predisposing to long-term sequelae. Int J Radiat Oncol Biol Phys. 1997;38(2):251–256. doi:10.1016/S0360-3016(97)00050-3
   PubMed Web of Science ®Google Scholar
• Wakelkamp IMMJ, Tan H, Saeed P, et al. Orbital irradiation for Graves’ ophthalmopathy: is it safe? A long-term follow-up study. Ophthalmology. 2004;111(8):1557–1562. doi:10.1016/j.ophtha.2003.12.054
   Web of Science ®Google Scholar
• Stack R, Elder M, Abdelaal A, Hidajat R, Clemett R. New Zealand experience of I125 brachytherapy for choroidal melanoma. Clin Exp Ophthalmol. 2005;33(5):490–494. doi:10.1111/j.1442-9071.2005.01067.x
   Web of Science ®Google Scholar
• Takeda A, Shigematsu N, Suzuki S, et al. Late retinal complications of radiation therapy for nasal and paranasal malignancies: relationship between irradiated-dose area and severity. Int J Radiat Oncol Biol Phys. 1999;44(3):599–605. doi:10.1016/S0360-3016(99)00057-7
   Web of Science ®Google Scholar
• Wara WM, Irvine AR, Neger RE, Howes EL, Phillips TL. Radiation retinopathy. Int J Radiat Oncol Biol Phys. 1979;5(1):81–83. doi:10.1016/0360-3016(79)90043-9
   Web of Science ®Google Scholar
• Kinyoun JL, Lawrence BS, Barlow WE. Proliferative radiation retinopathy. Arch Ophthalmol. 1996;114(9):1097–1100. doi:10.1001/archopht.1996.01100140299007
   Google Scholar
• Brown GC, Shields JA, Sanborn G, Augsburger JJ, Savino PJ, Schatz NJ. Radiation retinopathy. Ophthalmology. 1982;89(12):1494–1501. doi:10.1016/S0161-6420(82)34611-4
   PubMed Web of Science ®Google Scholar
• Chan RC, Shukovsky LJ. Effects of irradiation on the eye. Radiology. 1976;120(3):673–675. doi:10.1148/120.3.673
   Web of Science ®Google Scholar
• Krema H, Wei X, Payne D, Vasquez LM, Pavlin CJ, Simpson R. Factors predictive of radiation retinopathy post 125Iodine brachytherapy for uveal melanoma. Can J Ophthalmol. 2011;46(2):158–163. doi:10.3129/i10-111
   Web of Science ®Google Scholar
• Kumar B, Palimar P. Accelerated radiation retinopathy in diabetes and pregnancy. Eye. 2000;14(1):107–108. doi:10.1038/eye.2000.28
   Web of Science ®Google Scholar
• Parsons JT, Bova FJ, Fitzgerald CR, Mendenhall WM, Million RR. Radiation retinopathy after external-beam irradiation: analysis of time-dose factors. Int J Radiat Oncol Biol Phys. 1994;30(4):765–773. doi:10.1016/0360-3016(94)90347-6
   PubMed Web of Science ®Google Scholar
• Rodman Irvine A, Alvarado JA, Wara WM, Morris BW, Wood IS. Radiation retinopathy: an experimental model for the ischemic–proliferative retinopathies. Trans Am Ophthalmol Soc. 1981;79:103.
   Google Scholar
• Chacko DC. Considerations in the diagnosis of radiation injury. JAMA. 1981;245(12):1255–1258. doi:10.1001/jama.1981.03310370045029
   Web of Science ®Google Scholar
• Dunavoelgyi R, Zehetmayer M, Gleiss A, et al. Hypofractionated stereotactic photon radiotherapy of posteriorly located choroidal melanoma with five fractions at ten Gy–clinical results after six years of experience. Radiother Oncol. 2013;108(2):342–347. doi:10.1016/j.radonc.2013.08.004
   Web of Science ®Google Scholar
• Monroe AT, Bhandare N, Morris CG, Mendenhall WM. Preventing radiation retinopathy with hyperfractionation. Int J Radiat Oncol Biol Phys. 2005;61(3):856–864. doi:10.1016/j.ijrobp.2004.07.664
   Web of Science ®Google Scholar
• Collaborative Ocular Melanoma Study Group. Design and methods of a clinical trial for a rare condition: the Collaborative Ocular Melanoma Study: COMS Report No. 3. Control Clin Trials. 1993;14(5):362–391. doi:10.1016/0197-2456(93)90052-F
   Google Scholar
• Shields CL, Shields JA, Cater J, et al. Plaque radiotherapy for uveal melanoma: long-term visual outcome in 1106 consecutive patients. Arch Ophthalmol. 2000;118(9):1219–1228. doi:10.1001/archopht.118.9.1219
   Google Scholar
• Horgan N, Shields CL, Mashayekhi A, Teixeira LF, Materin MA, Shields JA. Early macular morphological changes following plaque radiotherapy for uveal melanoma. Retina. 2008;28(2):263–273. doi:10.1097/IAE.0b013e31814b1b75
   PubMed Web of Science ®Google Scholar
• Brewington BY, Shao YF, Davidorf FH, Cebulla CM. Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions. Clin Ophthalmol. 2018;12:925. doi:10.2147/OPTH.S129645
   PubMed Web of Science ®Google Scholar
• Takiar V, Ranh Voong K, Gombos DS, et al. A choice of radionuclide: comparative outcomes and toxicity of ruthenium-106 and iodine-125 in the definitive treatment of uveal melanoma. Pract Radiat Oncol. 2015;5(3):e169–e76. doi:10.1016/j.prro.2014.09.005
   Google Scholar
• Ghassemi F, Sheibani S, Arjmand M, et al. Comparison of iodide-125 and ruthenium-106 brachytherapy in the treatment of choroidal melanomas. Clin Ophthalmol. 2020;14:339. doi:10.2147/OPTH.S235265
   Web of Science ®Google Scholar
• Filì M, Trocme E, Bergman L, et al. Ruthenium-106 versus iodine-125 plaque brachytherapy of 571 choroidal melanomas with a thickness of ≥5.5 mm. Br J Ophthalmol. 2020;104(1):26–32. doi:10.1136/bjophthalmol-2018-313419
   PubMed Web of Science ®Google Scholar
• Seibel I, Cordini D, Hager A, et al. Predictive risk factors for radiation retinopathy and optic neuropathy after proton beam therapy for uveal melanoma. Graefe’s Arch Clin Exp Ophthalmol. 2016;254(9):1787–1792. doi:10.1007/s00417-016-3429-4
   PubMed Web of Science ®Google Scholar
• Matet A, Daruich A, Zografos L. Radiation maculopathy after proton beam therapy for uveal melanoma: optical coherence tomography angiography alterations influencing visual acuity. Inv Ophthalmol Vis Sc. 2017;58(10):3851–3861. doi:10.1167/iovs.17-22324
   PubMed Web of Science ®Google Scholar
• Guyer DR, Mukai S, Egan KM, Seddon JM, Walsh SM, Gragoudas ES. Radiation maculopathy after proton beam irradiation for choroidal melanoma. Ophthalmology. 1992;99(8):1278–1285. doi:10.1016/S0161-6420(92)31832-9
   Web of Science ®Google Scholar
• Sorour OA, Mignano JE, Duker JS. Gamma Knife radiosurgery for locally recurrent choroidal melanoma following plaque radiotherapy. Int J Retin Vitr. 2018;4(1):1–5. doi:10.1186/s40942-018-0123-1
   Google Scholar
• Bianciotto C, Shields CL, Pirondini C, Mashayekhi A, Furuta M, Shields JA. Proliferative radiation retinopathy after plaque radiotherapy for uveal melanoma. Ophthalmology. 2010;117(5):1005–1012. doi:10.1016/j.ophtha.2009.10.015
   PubMed Web of Science ®Google Scholar
• Durkin SR, Roos D, Higgs B, Casson RJ, Selva D. Ophthalmic and adnexal complications of radiotherapy. Act Ophthalmol. 2007;85(3):240–250. doi:10.1111/j.1600-0420.2006.00822.x
   Web of Science ®Google Scholar
• Archer DB, Amoaku WMK, Gardiner TA. Radiation retinopathy—clinical, histopathological, ultrastructural and experimental correlations. Eye. 1991;5(2):239–251. doi:10.1038/eye.1991.39
   PubMedGoogle Scholar
• Atebara NH, Drouilhet JH, Brown GC. Chapter 36A: Radiation Retinopathy. Duane’s ophthalmology on CD-ROM Lippincott Williams & Wilkins; 2006.
   Google Scholar
• Groenewald C, Konstantinidis L, Damato B. Effects of radiotherapy on uveal melanomas and adjacent tissues. Eye. 2013;27(2):163–171. doi:10.1038/eye.2012.249
   PubMed Web of Science ®Google Scholar
• Archer DB, Gardiner TA. Ionizing radiation and the retina. Curr Opin Ophthalmol. 1994;5(3):59–65. doi:10.1097/00055735-199406000-00011
   PubMedGoogle Scholar
• Kinyoun JL, Chittum ME, Wells CG. Photocoagulation treatment of radiation retinopathy. Am J Ophthalmol. 1988;105(5):470–478. doi:10.1016/0002-9394(88)90237-1
   Web of Science ®Google Scholar
• Midena G, Parrozzani R, Frizziero L, Midena E. Chorioretinal Side Effects of Therapeutic Ocular Irradiation: a Multimodal Imaging Approach. J Clin Med. 2020;9(11):3496. doi:10.3390/jcm9113496
   PubMed Web of Science ®Google Scholar
• Li M, Qiu G, Luo W, Ou J, Li X. Clinical investigation of radiation retinopathy fundus and fluorescein angiographic features. Yan Ke Xue Bao. 1999;15(3):183–186.
   Google Scholar
• Zamber RW, Kinyoun JL. Radiation retinopathy. West J Med. 1992;157(5):530–533.
   Google Scholar
• Spaide RF, Borodoker N, Shah V. Atypical choroidal neovascularization in radiation retinopathy. Am J Ophthalmol. 2002;133(5):709–711. doi:10.1016/S0002-9394(02)01331-4
   PubMed Web of Science ®Google Scholar
• De Salvo G, Hannan SR, James N, Lotery AJ. Retinal angiomatous proliferation occurring after radiotherapy. Eye. 2013;27(3):447–449. doi:10.1038/eye.2012.274
   Web of Science ®Google Scholar
• Pang CE, Bailey Freund K. Intravitreal polypoidal choroidal vasculopathy in radiation retinopathy. Ophthalmic Surg Lasers Imaging Retina. 2014;45(6):585–588. doi:10.3928/23258160-20141008-04
   Web of Science ®Google Scholar
• Brown GC, Shields JA, Sanborn G, Augsburger JJ, Savino PJ, Schatz NJ. Radiation optic neuropathy. Ophthalmology. 1982;89(12):1489–1493. doi:10.1016/S0161-6420(82)34612-6
   Web of Science ®Google Scholar
• Konstantinidis L, Groenewald C, Coupland SE, Damato B. Trans-scleral local resection of toxic choroidal melanoma after proton beam radiotherapy. Br J Ophthalmol. 2014;98(6):775–779. doi:10.1136/bjophthalmol-2013-304501
   Web of Science ®Google Scholar
• Gupta A, Dhawahir-Scala F, Smith A, Young L, Charles S. Radiation retinopathy: case report and review. BMC Ophthalmol. 2007;7(1):1–5. doi:10.1186/1471-2415-7-6
   Google Scholar
• Mukai SGD, Gragoudas ES. Radiation retinopathy. In: Albert DMJF, editor. Principles and Practice of Ophthalmology. Vol. 2. Philadelphia: WB Saunders; 1994:1038–1041.
   Google Scholar
• Hayreh SS. Post-radiation retinopathy. A Fluorescence Fundus Angiographic Study. Br J Ophthalmol. 1970;54:705.
   PubMed Web of Science ®Google Scholar
• Cogan DG. Lesions of the eye from radiant energy. JAMA. 1950;142(3):145–151. doi:10.1001/jama.1950.02910210001001
   Web of Science ®Google Scholar
• Amoaku WMK, Archer DB. Fluorescein angiographic features, natural course and treatment of radiation retinopathy. Eye. 2021;4(5):657–667. doi:10.1038/eye.1990.93
   Web of Science ®Google Scholar
• Finger PT, Kurli M. Laser photocoagulation for radiation retinopathy after ophthalmic plaque radiation therapy. Br J Ophthalmol. 2005;89(6):730–738. doi:10.1136/bjo.2004.052159
   PubMed Web of Science ®Google Scholar
• Shields CL, Say EAT, Samara WA, Khoo CTL, Mashayekhi A, Shields JA. Optical coherence tomography angiography of the macula after plaque radiotherapy of choroidal melanoma. Retina. 2016;36(8):1493–1505. doi:10.1097/IAE.0000000000001021
   Web of Science ®Google Scholar
• Sellam A, Coscas F, Lumbroso-le Rouic L, et al. Optical coherence tomography angiography of macular features after proton beam radiotherapy for small choroidal melanoma. Am J Ophthalmol. 2017;181:12–19. doi:10.1016/j.ajo.2017.06.008
   PubMed Web of Science ®Google Scholar
• Skalet AH, Liu L, Binder C, et al. Quantitative OCT angiography evaluation of peripapillary retinal circulation after plaque brachytherapy. Ophthalmol Retina. 2018;2(3):244–250. doi:10.1016/j.oret.2017.06.005
   Google Scholar
• Maguire AM. Radiation retinopathy. Retina. 1994;2:1500–1514.
   Google Scholar
• Chaudhuri PR, Austin DAVIDJ, Rosenthal ARALPH. Treatment of radiation retinopathy. Br J Ophthalmol. 1981;65(9):623–625. doi:10.1136/bjo.65.9.623
   PubMed Web of Science ®Google Scholar
• Amoaku WMK, Archer DB. Fluorescein angiographic features, natural course and treatment of radiation retinopathy. Eye. 1990;4(5):657–667.
   Web of Science ®Google Scholar
• Hykin PG, Shields CL, Shields JA, Fernando Arevalo J. The efficacy of focal laser therapy in radiation-induced macular edema. Ophthalmology. 1998;105(8):1425–1429. doi:10.1016/S0161-6420(98)98023-X
   Web of Science ®Google Scholar
• Mason JO, Albert MA, Persaud TO, Vail RS. Intravitreal bevacizumab treatment for radiation macular edema after plaque radiotherapy for choroidal melanoma. Retina. 2007;27(7):903–907. doi:10.1097/IAE.0b013e31806e6042
   PubMed Web of Science ®Google Scholar
• Gupta A, Muecke JS. Treatment of radiation maculopathy with intravitreal injection of bevacizumab (Avastin). Retina. 2008;28(7):964–968. doi:10.1097/IAE.0b013e3181706302
   PubMed Web of Science ®Google Scholar
• Finger PT, Chin KJ. High-dose (2.0 mg) intravitreal ranibizumab for recalcitrant radiation retinopathy. Eur J Ophthalmol. 2013;23(6):850–856. doi:10.5301/ejo.5000333
   PubMed Web of Science ®Google Scholar
• Schefler AC, Fuller D, Anand R, et al. Randomized Trial of Monthly Versus As-Needed Intravitreal Ranibizumab for Radiation Retinopathy–Related Macular Edema: 1-Year Outcomes. Am J Ophthalmol. 2020;216:165–173. doi:10.1016/j.ajo.2020.03.045
   PubMed Web of Science ®Google Scholar
• Fallico M, Reibaldi M, Avitabile T, et al. Intravitreal aflibercept for the treatment of radiation-induced macular edema after ruthenium 106 plaque radiotherapy for choroidal melanoma. Graefe’s Arch Clin Exp Ophthalmol. 2019;257(7):1547–1554. doi:10.1007/s00417-019-04347-6
   PubMed Web of Science ®Google Scholar
• Murray TG, Latiff A, Villegas VM, Gold AS. Aflibercept for radiation maculopathy study: a prospective, randomized clinical study. Ophthalmol Retina. 2019;3(7):561–566. doi:10.1016/j.oret.2019.02.009
   PubMedGoogle Scholar
• Finger PT, Chin K. Anti–vascular endothelial growth factor bevacizumab (Avastin) for radiation retinopathy. Arch Ophthalmol. 2007;125(6):751–756. doi:10.1001/archopht.125.6.751
   PubMedGoogle Scholar
• Forooghian F, Kertes PJ, Eng KT, Agrón E, Chew EY. Alterations in the intraocular cytokine milieu after intravitreal bevacizumab. Inv Ophthalmol Vis Sc. 2010;51(5):2388–2392. doi:10.1167/iovs.09-4065
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang N, Schachat AP, Bao S, Gillies MC. Glucocorticoids: structure, signaling and molecular mechanisms in the treatment of diabetic retinopathy and diabetic macular edema. Curr Mol Med. 2014;14(3):376–384. doi:10.2174/1566524014666140128114414
   PubMed Web of Science ®Google Scholar
• Gillies MC. Regulators of vascular permeability: potential sites for intervention in the treatment of macular edema. Doc Ophthalmol. 1999;97(3):251–260. doi:10.1023/A:1002196930726
   Web of Science ®Google Scholar
• Jeon S, Lee WK. Effect of intravitreal triamcinolone in diabetic macular edema unresponsive to intravitreal bevacizumab. Retina. 2014;34(8):1606–1611. doi:10.1097/IAE.0000000000000109
   PubMed Web of Science ®Google Scholar
• Horgan N, Shields CL, Mashayekhi A, et al. Periocular triamcinolone for prevention of macular edema after iodine 125 plaque radiotherapy of uveal melanoma. Retina. 2008;28(7):987–995. doi:10.1097/IAE.0b013e31816b3192
   PubMed Web of Science ®Google Scholar
• Shields CL, Demirci H, Dai V, et al. Intravitreal triamcinolone acetonide for radiation maculopathy after plaque radiotherapy for choroidal melanoma. Retina. 2005;25(7):868–874. doi:10.1097/00006982-200510000-00009
   PubMed Web of Science ®Google Scholar
• Russo A, Avitabile T, Uva M, et al. Radiation macular edema after Ru-106 plaque brachytherapy for choroidal melanoma resolved by an intravitreal dexamethasone 0.7-mg implant. Case Rep Ophthalmol. 2012;3(1):71–76. doi:10.1159/000337144
   PubMedGoogle Scholar
• Baillif S, Maschi C, Gastaud P, Caujolle JP. Intravitreal dexamethasone 0.7-mg implant for radiation macular edema after proton beam therapy for choroidal melanoma. Retina. 2013;33(9):1784–1790. doi:10.1097/IAE.0b013e31829234fa
   PubMed Web of Science ®Google Scholar
• Finger PT, Chin KJ. Intravitreous ranibizumab (Lucentis) for radiation maculopathy. Arch Ophthalmol. 2010;128(2):249–252. doi:10.1001/archophthalmol.2009.376
   PubMedGoogle Scholar
• Finger PT, Chin KJ, Semenova EA. Intravitreal anti-VEGF therapy for macular radiation retinopathy: a 10-year study. Eur J Ophthalmol. 2016;26(1):60–66. doi:10.5301/ejo.5000670
   PubMed Web of Science ®Google Scholar
• Meyer CH, Krohne TU, Holz FG. Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans. Retina. 2011;31(9):1877–1884. doi:10.1097/IAE.0b013e318217373c
   PubMed Web of Science ®Google Scholar
• Kaplan RI, Chaugule SS, Finger PT. Intravitreal triamcinolone acetate for radiation maculopathy recalcitrant to high-dose intravitreal bevacizumab. Br J Ophthalmol. 2017;101(12):1694–1698. doi:10.1136/bjophthalmol-2017-310315
   PubMed Web of Science ®Google Scholar
• Eleni Loukianou, Georgia Loukianou. Intravitreal aflibercept in recalcitrant radiation maculopathy due to external beam radiotherapy for nasopharyngeal cancer: a first case report. Case Rep Ophthalmol. 2017;8(1):87–90. doi:10.1159/000456535
   Web of Science ®Google Scholar
• Corradetti G, Corvi F, Juhn A. Short-term outcomes following treatment of recalcitrant cystoid macular edema secondary to radiation maculopathy using intravitreal brolucizumab. Am J Ophthalmol Case Rep. 2020;20:100981. doi:10.1016/j.ajoc.2020.100981
   PubMedGoogle Scholar
• Seibel I, Hager A, Riechardt AI, Davids AM, Böker A, Joussen AM. Antiangiogenic or corticosteroid treatment in patients with radiation maculopathy after proton beam therapy for uveal melanoma. Am J Ophthalmol. 2016;168:31–39. doi:10.1016/j.ajo.2016.04.024
   PubMed Web of Science ®Google Scholar
• US National Library of Medicine. Intravitreal aflibercept injection for radiation retinopathy trial (ARRT); 2018. Available from: https://clinicaltrials.gov/ct2/show/NCT03085784. Accessed June 26, 2021.
   Google Scholar
• Tara A, Colin A. Iodine 125 brachytherapy with vitrectomy and silicone oil in the treatment of uveal melanoma: 1-to-1 matched case-control series. Int J Radiat Oncol Biol Phys. 2014;89(2):347–352. doi:10.1016/j.ijrobp.2014.02.021
   Web of Science ®Google Scholar
• Fallico M, Chronopoulos A, Schutz JS, Reibaldi M. Treatment of radiation maculopathy and radiation-induced macular edema: a systematic review. Surv Ophthalmol. 2020;1:854.
   Google Scholar
• Russo A, Reibaldi M, Avitabile T, et al. Dexamethasone intravitreal implant vs ranibizumab in the treatment of macular edema secondary to brachytherapy for choroidal melanoma. Retina. 2018;38(4):788–794. doi:10.1097/IAE.0000000000001585
   PubMed Web of Science ®Google Scholar
• Finger PT, Kurli M. Laser photocoagulation for radiation retinopathy after ophthalmic plaque radiation therapy. Br J Ophthalmol. 2005;89:6.
   Web of Science ®Google Scholar
• Shah SU, Shields CL, Bianciotto CG, et al. Intravitreal bevacizumab at 4-month intervals for prevention of macular edema after plaque radiotherapy of uveal melanoma. Ophthalmology. 2014;121(1):269–275. doi:10.1016/j.ophtha.2013.08.039
   PubMed Web of Science ®Google Scholar
• Shields CL, Dalvin LA, Chang M, et al. Visual outcome at 4 years following plaque radiotherapy and prophylactic intravitreal bevacizumab (every 4 months for 2 years) for uveal melanoma: comparison with nonrandomized historical control individuals. JAMA Ophthalmol. 2020;138(2):136–146. doi:10.1001/jamaophthalmol.2019.5132
   PubMed Web of Science ®Google Scholar
• Seibel I, Vollhardt D, Riechardt AI, et al. Influence of Ranibizumab versus laser photocoagulation on radiation retinopathy (RadiRet)-a prospective randomized controlled trial. Graefe’s Arch Clin Exp Ophthalmol. 2020;258(4):869–878. doi:10.1007/s00417-020-04618-7
   PubMed Web of Science ®Google Scholar
• Horgan N, Shields CL, Mashayekhi A, et al. Periocular triamcinolone for prevention of macular edema after plaque radiotherapy of uveal melanoma: a randomized controlled trial. Ophthalmology. 2009;116(7):1383–1390. doi:10.1016/j.ophtha.2009.01.051
   PubMed Web of Science ®Google Scholar
• Materin MA, Bianciotto CG, Chengqing W, Shields CL. Sector laser photocoagulation for the prevention of macular edema after plaque radiotherapy for uveal melanoma: a pilot study. Retina. 2012;32(8):1601–1607. doi:10.1097/IAE.0b013e3182437e70
   PubMed Web of Science ®Google Scholar