Photobiomodulation Therapy for Age-Related Macular Degeneration and Diabetic Retinopathy: A Review

References

• Wong WL, Su X, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Heal. 2014;2(2):e106–e116. doi:10.1016/S2214-109X(13)70145-1
   PubMed Web of Science ®Google Scholar
• Zheng Y, He M, Congdon N. The worldwide epidemic of diabetic retinopathy. Indian J Ophthalmol. 2012;60(5):428–431. doi:10.4103/0301-4738.100542
   PubMed Web of Science ®Google Scholar
• Lee R, Wong TY, Sabanayagam C. Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye Vis (London, England). 2015;2(1):17. doi:10.1186/s40662-015-0026-2
   PubMedGoogle Scholar
• Khanna S, Komati R, Eichenbaum DA, Hariprasad I, Ciulla TA, Hariprasad SM. Current and upcoming anti-VEGF therapies and dosing strategies for the treatment of neovascular AMD: a comparative review. BMJ Open Ophthalmol. 2019;4(1):e000398. doi:10.1136/bmjophth-2019-000398
   PubMed Web of Science ®Google Scholar
• Baker CW, Glassman AR, Beaulieu WT, et al. Effect of initial management with aflibercept vs laser photocoagulation vs observation on vision loss among patients with diabetic macular edema involving the center of the macula and good visual acuity: a randomized clinical trial. JAMA. 2019;321(19):1880–1894. doi:10.1001/jama.2019.5790
   PubMed Web of Science ®Google Scholar
• Bressler SB, Odia I, Glassman AR, et al. Changes in diabetic retinopathy severity when treating diabetic macular edema with ranibizumab: DRCR.net protocol I 5-year report. Retina. 2018;38(10):1896–1904. doi:10.1097/IAE.0000000000002302
   PubMed Web of Science ®Google Scholar
• Rojas-Fernandez CH, Tyber K. Benefits, potential harms, and optimal use of nutritional supplementation for preventing progression of age-related macular degeneration. Ann Pharmacother. 2017;51(3):264–270. doi:10.1177/1060028016680643
   Web of Science ®Google Scholar
• Mukhtar S, Ambati BK. The value of nutritional supplements in treating age-related macular degeneration: a review of the literature. Int Ophthalmol. 2019;39(12):2975–2983. doi:10.1007/s10792-019-01140-6
   PubMed Web of Science ®Google Scholar
• Eells JT, Henry MM, Summerfelt P, et al. Therapeutic photobiomodulation for methanol-induced retinal toxicity. Proc Natl Acad Sci U S A. 2003;100(6):3439–3444. doi:10.1073/pnas.0534746100
   PubMed Web of Science ®Google Scholar
• Eells JT, Gopalakrishnan S, Valter K. Near-infrared photobiomodulation in retinal injury and disease. Adv Exp Med Biol. 2016;854:437–441. doi:10.1007/978-3-319-17121-0_58
   Web of Science ®Google Scholar
• Ao J, Wood JP, Chidlow G, Gillies MC, Casson RJ. Retinal pigment epithelium in the pathogenesis of age-related macular degeneration and photobiomodulation as a potential therapy? Clin Experiment Ophthalmol. 2018;46(6):670–686. doi:10.1111/ceo.13121
   PubMed Web of Science ®Google Scholar
• Geneva II. Photobiomodulation for the treatment of retinal diseases: a review. Int J Ophthalmol. 2016;9(1):145–152. doi:10.18240/ijo.2016.01.24
   Web of Science ®Google Scholar
• Heinig N, Schumann U, Calzia D, et al. Photobiomodulation mediates neuroprotection against blue light induced retinal photoreceptor degeneration. Int J Mol Sci. 2020;21(7):7. doi:10.3390/ijms21072370
   Web of Science ®Google Scholar
• Muste JC, Kalur A, Iyer A, Valentim CCS, Singh RP. Photobiomodulation therapy in age-related macular degeneration. Curr Opin Ophthalmol. 2021;32(3):225–232. doi:10.1097/ICU.0000000000000742
   PubMed Web of Science ®Google Scholar
• Tao J-X, Zhou W-C, Zhu X-G. Mitochondria as potential targets and initiators of the blue light hazard to the retina. Oxid Med Cell Longev. 2019;2019:6435364. doi:10.1155/2019/6435364
   PubMed Web of Science ®Google Scholar
• Wong-Riley MTT, Liang HL, Eells JT, et al. Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase. J Biol Chem. 2005;280(6):4761–4771. doi:10.1074/jbc.M409650200
   PubMed Web of Science ®Google Scholar
• Karu TI, Pyatibrat LV, Kolyakov SF, Afanasyeva NI. Absorption measurements of a cell monolayer relevant to phototherapy: reduction of cytochrome c oxidase under near IR radiation. J Photochem Photobiol B. 2005;81(2):98–106. doi:10.1016/j.jphotobiol.2005.07.002
   Web of Science ®Google Scholar
• de Freitas LF, Hamblin MR. Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quant Elect. 2016;22:3. doi:10.1109/JSTQE.2016.2561201
   Web of Science ®Google Scholar
• Calaza KC, Kam JH, Hogg C, Jeffery G. Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light. Neurobiol Aging. 2015;36(10):2869–2876. doi:10.1016/j.neurobiolaging.2015.06.010
   PubMed Web of Science ®Google Scholar
• Rutar M, Natoli R, Albarracin R, Valter K, Provis J. 670-nm light treatment reduces complement propagation following retinal degeneration. J Neuroinflammation. 2012;9:257. doi:10.1186/1742-2094-9-257
   Web of Science ®Google Scholar
• Tang J, Kern TS. Inflammation in diabetic retinopathy. Prog Retin Eye Res. 2011;30(5):343–358. doi:10.1016/j.preteyeres.2011.05.002
   PubMed Web of Science ®Google Scholar
• Shen W, Teo KYC, Wood JPM, et al. Preclinical and clinical studies of photobiomodulation therapy for macular oedema. Diabetologia. 2020;63(9):1900–1915. doi:10.1007/s00125-020-05189-2
   PubMed Web of Science ®Google Scholar
• Saliba A, Du Y, Liu H, et al. Photobiomodulation mitigates diabetes-induced retinopathy by direct and indirect mechanisms: evidence from intervention studies in pigmented mice. PLoS One. 2015;10(10):e0139003. doi:10.1371/journal.pone.0139003
   PubMed Web of Science ®Google Scholar
• Begum R, Powner MB, Hudson N, Hogg C, Jeffery G. Treatment with 670 nm light up regulates cytochrome C oxidase expression and reduces inflammation in an age-related macular degeneration model. PLoS One. 2013;8(2):e57828. doi:10.1371/journal.pone.0057828
   PubMed Web of Science ®Google Scholar
• Tang J, Du Y, Lee CA, Talahalli R, Eells JT, Kern TS. Low-intensity far-red light inhibits early lesions that contribute to diabetic retinopathy: in vivo and in vitro. Invest Ophthalmol Vis Sci. 2013;54(5):3681–3690. doi:10.1167/iovs.12-11018
   PubMed Web of Science ®Google Scholar
• Kokkinopoulos I. 670 nm LED ameliorates inflammation in the CFH(-/-) mouse neural retina. J Photochem Photobiol B. 2013;122:24–31. doi:10.1016/j.jphotobiol.2013.03.003
   Web of Science ®Google Scholar
• Albarracin R, Valter K. 670 nm red light preconditioning supports Müller cell function: evidence from the white light-induced damage model in the rat retina. Photochem Photobiol. 2012;88(6):1418–1427. doi:10.1111/j.1751-1097.2012.01130.x
   PubMed Web of Science ®Google Scholar
• Fuma S, Murase H, Kuse Y, Tsuruma K, Shimazawa M, Hara H. Photobiomodulation with 670 nm light increased phagocytosis in human retinal pigment epithelial cells. Mol Vis. 2015;21:883–892.
   Web of Science ®Google Scholar
• Natoli R, Zhu Y, Valter K, Bisti S, Eells J, Stone J. Gene and noncoding RNA regulation underlying photoreceptor protection: microarray study of dietary antioxidant saffron and photobiomodulation in rat retina. Mol Vis. 2010;16:1801–1822.
   PubMed Web of Science ®Google Scholar
• Di Marco F, Romeo S, Nandasena C, et al. The time course of action of two neuroprotectants, dietary saffron and photobiomodulation, assessed in the rat retina. Am J Neurodegener Dis. 2013;2(3):208–220.
   Google Scholar
• Cheng Y, Du Y, Liu H, Tang J, Veenstra A, Kern TS. Photobiomodulation inhibits long-term structural and functional lesions of diabetic retinopathy. Diabetes. 2018;67(2):291–298. doi:10.2337/db17-0803
   Web of Science ®Google Scholar
• Eells J, Gopalakrishnan S, Connor T, et al. 670 nm photobiomodulation as a therapy for diabetic macular edema: a pilot study. Poster presented at: 2017 ARVO Annual Meeting; May 7-11, 2017; Baltimore, MD.,
   Google Scholar
• Tang J, Herda AA, Kern TS. Photobiomodulation in the treatment of patients with non-center-involving diabetic macular oedema. Br J Ophthalmol. 2014;98(8):1013–1015. doi:10.1136/bjophthalmol-2013-304477
   PubMed Web of Science ®Google Scholar
• Kim J. A Pilot study evaluating photobiomodulation therapy for diabetic Macular Edema (AE) ClinicalTrials.gov Identifier: NCT03866473. Other Study ID Numbers: DRCR.netProtocol AE; 2020. Available from: https://clinicaltrials.gov/ct2/show/NCT03866473. Accessed: July 19, 2020.
   Google Scholar
• Bristlecone Health, Inc. Photobiomodulation & ketogenic diet for treatment of mid-periphery retinal disorders for Alzheimer’s disease prevention. ClinicalTrials.gov Identifier: NCT03859245; 2019. Available from: https://clinicaltrials.gov/ct2/show/NCT03859245. Accessed May 30, 2021.
   Google Scholar
• Kim J. Photobiomodulation for the Treatment of Diabetic Macular Edema (PTDME). ClinicalTrials.gov Identifier: NCT02457975; 2019. Available from: https://clinicaltrials.gov/ct2/show/NCT02457975. Accessed May 30, 2021.
   Google Scholar
• Eells JT. Mitochondrial dysfunction in the aging retina. Biology (Basel). 2019;8:2. doi:10.3390/biology8020031
   Web of Science ®Google Scholar
• Ennis S, Gibson J, Cree AJ, Collins A, Lotery AJ. Support for the involvement of complement factor I in age-related macular degeneration. Eur J Hum Genet. 2010;18(1):15–16. doi:10.1038/ejhg.2009.113
   Web of Science ®Google Scholar
• Keenan TDL, Clemons TE, Domalpally A, et al. Retinal specialist versus artificial intelligence detection of retinal fluid from OCT: age-related eye disease study 2: 10-year follow-on study. Ophthalmology. 2021;128(1):100–109. doi:10.1016/j.ophtha.2020.06.038
   Web of Science ®Google Scholar
• Ivandic BT, Ivandic T. Low-level laser therapy improves vision in patients with age-related macular degeneration. Photomed Laser Surg. 2008;26(3):241–245. doi:10.1089/pho.2007.2132
   PubMed Web of Science ®Google Scholar
• Merry G, Dotson R, Devenyi R, Markowitz SRS. Photobiomodulation as a new treatment for dry age related macular degeneration RESULTS from the Toronto and Oak Ridge Photobimodulation study in AMD (TORPA). Invest Ophthalmol Vis Sci. 2012;53:2049.
   Google Scholar
• Merry GF, Munk MR, Dotson RS, Walker MG, Devenyi RG. Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age-related macular degeneration. Acta Ophthalmol. 2017;95(4):e270–e277. doi:10.1111/aos.13354
   PubMed Web of Science ®Google Scholar
• Markowitz SN, Devenyi RG, Munk MR, et al. A double-masked, randomized, sham-controlled, single-center study with photobiomodulation for the treatment of dry age-related macular degeneration. Retina. 2019;40:1471. doi:10.1097/IAE.0000000000002632
   Web of Science ®Google Scholar
• Pinelli R. Photobiomodulation Shows the Power of Light: study results demonstrate effectiveness in treating dry-age related macular degeneration. Ophthalmol Times. 2020;45(13).
   Google Scholar
• Kaymak H, Schwahn H Photobiomodulation as a treatment in dry AMD. Retina Today: May/June Special Edition; 2020. Available from: https://retinatoday.com/articles/2020-may-june/photobiomodulation-as-a-treatment-in-dry-amd. Accessed May 30, 2021.
   Google Scholar
• LumiThera, Inc., Study of photobiomodulation to treat non-exudative age-related macular degeneration (LIGHTSITE II). ClinicalTrials.gov Identifier: NCT03878420; 2020. Available from: https://clinicaltrials.gov/ct2/show/NCT03878420. Accessed July 19, 2020.
   Google Scholar
• LumiThera, Inc. Study of photobiomodulation to treat non-exudative age-related macular degeneration (LIGHTSITE III). ClinicalTrials.gov Identifier: NCT04065490; 2020. Available from: https://clinicaltrials.gov/ct2/show/NCT04065490. Accessed July 19, 2020.
   Google Scholar
• LumiThera, Inc.Study of photobiomodulation effect on electroretinogram outcomes in dry age-related macular degeneration (ELECTROLIGHT). ClinicalTrials.gov Identifier: NCT04522999; 2020. Available from: https://clinicaltrials.gov/ct2/show/NCT04522999. Accessed October 19, 2020.
   Google Scholar
• Grewal MK, Sivapathasuntharam C, Chandra S, et al. A pilot study evaluating the effects of 670 nm photobiomodulation in healthy ageing and age-related macular degeneration. J Clin Med. 2020;9(4):1001. doi:10.3390/jcm9041001
   Web of Science ®Google Scholar
• Samanta A, Aziz AA, Jhingan M, et al. Emerging therapies in nonexudative age-related macular degeneration in 2020. Asia Pac J Ophthalmol. 2021. doi:10.1097/APO.0000000000000355
   Web of Science ®Google Scholar