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Review

Insights into Current Management Strategies for Dysthyroid Optic Neuropathy: A Review

ORCID Icon, &
Pages 841-850 | Published online: 18 Mar 2022

References

  • Bahn RS, Heufelder AE, Heufelder AE. Pathogenesis of Graves’ ophthalmopathy. N Engl J Med. 1993;329(20):1468–1475. doi:10.1056/NEJM199311113292007
  • Bartalena L, Tanda ML. Graves’ ophthalmopathy. N Engl J Med. 2009;360(10):994–1001. doi:10.1056/NEJMcp0806317
  • Bahn RS. Graves’ ophthalmopathy. N Engl J Med. 2010;362(8):726–738. doi:10.1056/NEJMra0905750
  • Currò N, Covelli D, Vannucchi G, et al. Therapeutic outcomes of high-dose intravenous steroids in the treatment of dysthyroid optic neuropathy. Thyroid. 2014;24(5):897–905. doi:10.1089/thy.2013.0445
  • Wakelkamp IM, Baldeschi L, Saeed P, et al. Surgical or medical decompression as a first-line treatment of optic neuropathy in Graves’ ophthalmopathy? A randomized controlled trial. Clin Endocrinol (Oxf). 2005;63(3):323–328. doi:10.1111/j.1365-2265.2005.02345.x
  • Saeed P, Rad ST, Bisschop PH. Dysthyroid optic neuropathy. Ophthal Plast Reconstr Surg. 2018;34(4S):S60–S7. doi:10.1097/IOP.0000000000001146
  • Bartley GB, Fatourechi V, Kadrmas EF, et al. The treatment of Graves’ ophthalmopathy in an incidence cohort. Am J Ophthalmol. 1996;121(2):200–206. doi:10.1016/S0002-9394(14)70585-9
  • Bartalena L, Baldeschi L, Boboridis K, et al. The 2016 European Thyroid Association/European Group on Graves’ orbitopathy guidelines for the management of Graves’ orbitopathy. Eur Thyroid J. 2016;5(1):9–26. doi:10.1159/000443828
  • Tagami M, Honda S, Azumi A. Preoperative clinical factors and visual outcomes following orbital decompression with dysthyroid optic neuropathy. BMC Ophthalmol. 2020;20(1):30. doi:10.1186/s12886-020-1314-8
  • Tu Y, Wu S, Pan Z, et al. Endoscopic transconjunctival deep lateral wall decompression for thyroid-associated orbitopathy: a minimally invasive alternative: transconjunctival endoscopic with wall decompression for TAO. Am J Ophthalmol. 2021;235:71–79. doi:10.1016/j.ajo.2021.08.013
  • Singh S, Curragh DS, Selva D. Augmented endoscopic orbital apex decompression in dysthyroid optic neuropathy. Eye (Lond). 2019;33(10):1613–1618. doi:10.1038/s41433-019-0464-5
  • Carter KD, Frueh BR, Hessburg TP, Musch DC. Long-term efficacy of orbital decompression for compressive optic neuropathy of Graves’ eye disease. Ophthalmology. 1991;98(9):1435–1442. doi:10.1016/S0161-6420(91)32115-8
  • Tsui S, Naik V, Hoa N, et al. Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves’ disease. J Immunol. 2008;181:4397–4405. doi:10.4049/jimmunol.181.6.4397
  • Douglas R, Naik V, Hwang C, et al. B cells from patients with Graves’ disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. J Immunol. 2008;181:5768–5774. doi:10.4049/jimmunol.181.8.5768
  • Smith T, Janssen J. Insulin-like growth factor-I receptor and thyroid-associated ophthalmopathy. Endocr Rev. 2019;40:236–267. doi:10.1210/er.2018-00066
  • Smith T, Kahaly G, Ezra D, et al. Teprotumumab for thyroid-associated ophthalmopathy. N Engl J Med. 2017;376:1748–1761. doi:10.1056/NEJMoa1614949
  • Douglas R, Kahaly G, Patel A, et al. Teprotumumab for the treatment of active thyroid eye disease. N Engl J Med. 2020;382:341–352. doi:10.1056/NEJMoa1910434
  • Kahaly G, Douglas R, Holt R, et al. Teprotumumab for patients with active thyroid eye disease: a pooled data analysis, subgroup analyses, and off-treatment follow-up results from two randomised, double-masked, placebo-controlled, multicentre trials. Lancet Diabetes Endocrinol. 2021;9:360–372.
  • Bartalena L, Kahaly GJ, Baldeschi L, et al. The 2021 European Group on Graves’ orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves’ orbitopathy. Eur J Endocrinol. 2021;185(4):G43–g67. doi:10.1530/EJE-21-0479
  • McKeag D, Lane C, Lazarus JH, et al. Clinical features of dysthyroid optic neuropathy: a European Group on Graves’ Orbitopathy (EUGOGO) survey. Br J Ophthalmol. 2007;91(4):455–458. doi:10.1136/bjo.2006.094607
  • Ohtsuka K, Nakamura Y. Results of transmedial-canthal ethmoidal decompression for severe dysthyroid optic neuropathy. Jpn J Ophthalmol. 1999;43(5):426–432. doi:10.1016/S0021-5155(99)00091-X
  • Trobe JD, Glaser JS, Laflamme P. Dysthyroid optic neuropathy. Clinical profile and rationale for management. Arch Ophthalmol. 1978;96(7):1199–1209. doi:10.1001/archopht.1978.03910060033007
  • Lazarus JH. Epidemiology of Graves’ orbitopathy (GO) and relationship with thyroid disease. Best Pract Res Clin Endocrinol Metab. 2012;26(3):273–279. doi:10.1016/j.beem.2011.10.005
  • Stan MN, Bahn RS. Risk factors for development or deterioration of Graves’ ophthalmopathy. Thyroid. 2010;20(7):777–783. doi:10.1089/thy.2010.1634
  • Okada Y, Momozawa Y, Ashikawa K, et al. Construction of a population-specific HLA imputation reference panel and its application to Graves’ disease risk in Japanese. Nat Genet. 2015;47(7):798–802. doi:10.1038/ng.3310
  • Huang X, Liu G, Mei S, et al. Human leucocyte antigen alleles confer susceptibility and progression to Graves’ ophthalmopathy in a Southern Chinese population. Br J Ophthalmol. 2021;105(10):1462–1468. doi:10.1136/bjophthalmol-2020-317091
  • Khong JJ, Finch S, De Silva C, et al. Risk factors for Graves’ orbitopathy; the Australian Thyroid-Associated Orbitopathy Research (ATOR) study. J Clin Endocrinol Metab. 2016;101(7):2711–2720. doi:10.1210/jc.2015-4294
  • Lee JH, Lee SY, Yoon JS. Risk factors associated with the severity of thyroid-associated orbitopathy in Korean patients. Korean J Ophthalmol. 2010;24(5):267–273. doi:10.3341/kjo.2010.24.5.267
  • Deng Z, Chen L, Tan J, et al. Combination model of thyrotrophin receptor antibody and volumetric orbital apex crowding index as an indicator of dysthyroid optic neuropathy. Dis Markers. 2021;2021:9964232. doi:10.1155/2021/9964232
  • Kalmann R, Mourits MP. Diabetes mellitus: a risk factor in patients with Graves’ orbitopathy. Br J Ophthalmol. 1999;83(4):463–465. doi:10.1136/bjo.83.4.463
  • Hayreh SS, Zimmerman MB. Nonarteritic anterior ischemic optic neuropathy: clinical characteristics in diabetic patients versus nondiabetic patients. Ophthalmology. 2008;115(10):1818–1825. doi:10.1016/j.ophtha.2008.03.032
  • Hayreh SS. Neovascular glaucoma. Prog Retin Eye Res. 2007;26(5):470–485. doi:10.1016/j.preteyeres.2007.06.001
  • Neigel JM, Rootman J, Belkin RI, et al. Dysthyroid optic neuropathy. The crowded orbital apex syndrome. Ophthalmology. 1988;95(11):1515–1521. doi:10.1016/S0161-6420(88)32978-7
  • Mensah A, Vignal-Clermont C, Mehanna C, et al. Dysthyroid optic neuropathy: atypical initial presentation and persistent visual loss. Orbit. 2009;28(6):354–362. doi:10.3109/01676830903104728
  • Kendler DL, Lippa J, Rootman J. The initial clinical characteristics of Graves’ orbitopathy vary with age and sex. Arch Ophthalmol. 1993;111(2):197–201. doi:10.1001/archopht.1993.01090020051022
  • Miśkiewicz P, Rutkowska B, Jabłońska A, et al. Complete recovery of visual acuity as the main goal of treatment in patients with dysthyroid optic neuropathy. Endokrynol Pol. 2016;67(2):166–173. doi:10.5603/EP.a2016.0018
  • Bahn RS. Current insights into the pathogenesis of Graves’ ophthalmopathy. Horm Metab Res. 2015;47(10):773–778. doi:10.1055/s-0035-1555762
  • Ponto KA, Diana T, Binder H, et al. Thyroid-stimulating immunoglobulins indicate the onset of dysthyroid optic neuropathy. J Endocrinol Invest. 2015;38(7):769–777. doi:10.1007/s40618-015-0254-2
  • Iyer S, Bahn R. Immunopathogenesis of Graves’ ophthalmopathy: the role of the TSH receptor. Best Pract Res Clin Endocrinol Metab. 2012;26(3):281–289. doi:10.1016/j.beem.2011.10.003
  • Walasik-Szemplińska D, Pauk-Domańska M, Sanocka U, Sudoł-Szopińska I. Doppler imaging of orbital vessels in the assessment of the activity and severity of thyroid-associated orbitopathy. J Ultrason. 2015;15(63):388–397. doi:10.15557/JoU.2015.0036
  • Mourits MP, Prummel MF, Wiersinga WM, Koornneef L. Clinical activity score as a guide in the management of patients with Graves’ ophthalmopathy. Clin Endocrinol (Oxf). 1997;47(1):9–14. doi:10.1046/j.1365-2265.1997.2331047.x
  • Soares-Welch CV, Fatourechi V, Bartley GB, et al. Optic neuropathy of Graves disease: results of transantral orbital decompression and long-term follow-up in 215 patients. Am J Ophthalmol. 2003;136(3):433–441. doi:10.1016/S0002-9394(03)00233-2
  • Garip Kuebler A, Halfter K, Reznicek L, et al. A pathological indicator for dysthyroid optic neuropathy: tritan color vision deficiency. Graefes Arch Clin Exp Ophthalmol. 2021;259(11):3421–3426. doi:10.1007/s00417-021-05227-8
  • Kirsch E, von Arx G, Hammer B. Imaging in Graves’ orbitopathy. Orbit. 2009;28(4):219–225.
  • Hu H, Xu XQ, Wu FY, et al. Diagnosis and stage of Graves’ ophthalmopathy: efficacy of quantitative measurements of the lacrimal gland based on 3-T magnetic resonance imaging. Exp Ther Med. 2016;12(2):725–729. doi:10.3892/etm.2016.3389
  • Mayer EJ, Fox DL, Herdman G, et al. Signal intensity, clinical activity and cross-sectional areas on MRI scans in thyroid eye disease. Eur J Radiol. 2005;56(1):20–24. doi:10.1016/j.ejrad.2005.03.027
  • Yokoyama N, Nagataki S, Uetani M, et al. Role of magnetic resonance imaging in the assessment of disease activity in thyroid-associated ophthalmopathy. Thyroid. 2002;12(3):223–227. doi:10.1089/105072502753600179
  • Feldon SE, Muramatsu S, Weiner JM. Clinical classification of Graves’ ophthalmopathy: identification of risk factors for optic neuropathy. Arch Ophthalmol. 1984;102(10):1469–1472. doi:10.1001/archopht.1984.01040031189015
  • Leung CK-S, Cheung CYL, Weinreb RN, et al. Evaluation of retinal nerve fiber layer progression in glaucoma: a study on optical coherence tomography guided progression analysis. Invest Ophthalmol Vis Sci. 2010;51(1):217–222. doi:10.1167/iovs.09-3468
  • Amini N, Nowroozizadeh S, Cirineo N, et al. Influence of the disc–fovea angle on limits of rnfl variability and glaucoma discrimination. Invest Ophthalmol Vis Sci. 2014;55(11):7332–7342. doi:10.1167/iovs.14-14962
  • Kanamori A, Nakamura M, Escano MF, et al. Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography. Am J Ophthalmol. 2003;135(4):513–520. doi:10.1016/S0002-9394(02)02003-2
  • Kanamori A, Nakamura M, Matsui N, et al. Optical coherence tomography detects characteristic retinal nerve fiber layer thickness corresponding to band atrophy of the optic discs. Ophthalmology. 2004;111(12):2278–2283. doi:10.1016/j.ophtha.2004.05.035
  • Park KA, Kim YD, In woo K, et al. Optical coherence tomography measurements in compressive optic neuropathy associated with dysthyroid orbitopathy. Graefes Arch Clin Exp Ophthalmol. 2016;254(8):1617–1624. doi:10.1007/s00417-016-3335-9
  • Park KA, Kim YD, Woo KI. Changes in optical coherence tomography measurements after orbital wall decompression in dysthyroid optic neuropathy. Eye (Lond). 2018;32(6):1123–1129. doi:10.1038/s41433-018-0051-1
  • Cheng S, Yu Y, You Y, et al. Retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after orbital decompression for dysthyroid optic neuropathy. Int Ophthalmol. 2021;41(9):3121–3133. doi:10.1007/s10792-021-01877-z
  • Gillespie EF, Smith TJ, Douglas RS. Thyroid eye disease: towards an evidence base for treatment in the 21st century. Curr Neurol Neurosci Rep. 2012;12(3):318–324. doi:10.1007/s11910-012-0256-9
  • Zang S, Ponto K, Pitz S, Kahaly G. Dose of intravenous steroids and therapy outcome in Graves’ orbitopathy. J Endocrinol Invest. 2011;34:876–880. doi:10.1007/BF03346732
  • Blandford AD, Zhang D, Chundury RV, Perry JD. Dysthyroid optic neuropathy: update on pathogenesis, diagnosis, and management. Expert Rev Ophthalmol. 2017;12(2):111–121. doi:10.1080/17469899.2017.1276444
  • Bartalena L. Graves’ disease: complications. In: Feingold KR, Anawalt B, Boyce A, editors. Endotext. South Dartmouth (MA): MDText.com, Inc. Copyright © 2000–2021, MDText.com, Inc.; 2000.
  • Perumal B, Meyer DR. Treatment of severe thyroid eye disease: a survey of the American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS). Ophthalmic Plast Reconstr Surg. 2015;31(2):127–131. doi:10.1097/IOP.0000000000000216
  • Ito M, Takahashi Y, Katsuda E, et al. Predictive factors of prognosis after radiation and steroid pulse therapy in thyroid eye disease. Sci Rep. 2019;9(1):2027. doi:10.1038/s41598-019-38640-5
  • Bartalena L, Krassas G, Wiersinga W, et al. Efficacy and safety of three different cumulative doses of intravenous methylprednisolone for moderate to severe and active Graves’ orbitopathy. J Clin Endocrinol Metab. 2012;97:4454–4463. doi:10.1210/jc.2012-2389
  • Mourits M, van Kempen-harteveld M, Garcia M, et al. Radiotherapy for Graves’ orbitopathy: randomised placebo-controlled study. Lancet. 2000;355:1505–1509. doi:10.1016/S0140-6736(00)02165-6
  • Prummel M, Terwee C, Gerding M, et al. A randomized controlled trial of orbital radiotherapy versus sham irradiation in patients with mild Graves’ ophthalmopathy. J Clin Endocrinol Metab. 2004;89:15–20. doi:10.1210/jc.2003-030809
  • Gorman C, Garrity J, Fatourechi V, et al. A prospective, randomized, double-blind, placebo-controlled study of orbital radiotherapy for Graves’. Ophthal Ophthalmol. 2001;108:1523–1534. doi:10.1016/S0161-6420(01)00632-7
  • Rajendram R, Taylor P, Wilson V, et al. Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 x 2 factorial, double-blind, randomised controlled trial. Lancet Diabetes Endocrinol. 2018;6:299–309.
  • Prummel M, Mourits M, Blank L, et al. Randomized double-blind trial of prednisone versus radiotherapy in Graves’ ophthalmopathy. Lancet. 1993;342:949–954. doi:10.1016/0140-6736(93)92001-A
  • Marcocci C, Bartalena L, Bogazzi F, et al. Orbital radiotherapy combined with high dose systemic glucocorticoids for Graves’ ophthalmopathy is more effective than radiotherapy alone: results of a prospective randomized study. J Endocrinol Invest. 1991;14:853–860. doi:10.1007/BF03347943
  • Bartalena L, Marcocci C, Chiovato L, et al. Orbital cobalt irradiation combined with systemic corticosteroids for Graves’ ophthalmopathy: comparison with systemic corticosteroids alone. J Clin Endocrinol Metab. 1983;56:1139–1144.
  • McCord CD. Orbital decompression for Graves’ disease. Exposure through lateral canthal and inferior fornix incision. Ophthalmology. 1981;88(6):533–541. doi:10.1016/S0161-6420(81)34995-1
  • Leone CR, Bajandas FJ. Inferior orbital decompression for dysthyroid optic neuropathy. Ophthalmology. 1981;88(6):525–532.
  • Shorr N, Baylis HI, Goldberg RA, Perry JD. Transcaruncular approach to the medial orbit and orbital apex. Ophthalmology. 2000;107(8):1459–1463. doi:10.1016/S0161-6420(00)00241-4
  • Kazim M, Trokel SL, Acaroglu G, Elliott A. Reversal of dysthyroid optic neuropathy following orbital fat decompression. Br J Ophthalmol. 2000;84(6):600–605. doi:10.1136/bjo.84.6.600
  • Jacobs SM, McInnis CP, Kapeles M, Chang S-H. Incidence, risk factors, and management of blindness after orbital surgery. Ophthalmology. 2018;125(7):1100–1108. doi:10.1016/j.ophtha.2018.01.030
  • Kennedy DW, Goodstein ML, Miller NR, Zinreich SJ. Endoscopic transnasal orbital decompression. Arch Otolaryngol Head Neck Surg. 1990;116(3):275–282. doi:10.1001/archotol.1990.01870030039006
  • Chu EA, Miller NR, Lane AP. Selective endoscopic decompression of the orbital apex for dysthyroid optic neuropathy. Laryngoscope. 2009;119(6):1236–1240. doi:10.1002/lary.20240
  • Farling PA. Thyroid disease. Br J Anaesth. 2000;85(1):15–28. doi:10.1093/bja/85.1.15
  • O’Shea JJ, Kontzias A, Yamaoka K, et al. Janus kinase inhibitors in autoimmune diseases. Ann Rheum Dis. 2013;72(suppl2):ii111–ii5. doi:10.1136/annrheumdis-2012-202576
  • Xie W, Huang Y, Xiao S, et al. Impact of Janus kinase inhibitors on risk of cardiovascular events in patients with rheumatoid arthritis: systematic review and meta-analysis of randomised controlled trials. Ann Rheum Dis. 2019;78(8):1048–1054. doi:10.1136/annrheumdis-2018-214846
  • Seavey MM, Dobrzanski P. The many faces of Janus kinase. Biochem Pharmacol. 2012;83(9):1136–1145. doi:10.1016/j.bcp.2011.12.024
  • Stebbing J, Phelan A, Griffin I, et al. COVID-19: combining antiviral and anti-inflammatory treatments. Lancet Infect Dis. 2020;20(4):400–402. doi:10.1016/S1473-3099(20)30132-8
  • Kaur K, Kalra S, Kaushal S. Systematic review of tofacitinib: a new drug for the management of rheumatoid arthritis. Clin Ther. 2014;36(7):1074–1086. doi:10.1016/j.clinthera.2014.06.018
  • Markham A. Baricitinib: first global approval. Drugs. 2017;77(6):697–704. doi:10.1007/s40265-017-0723-3