Stimulating Tear Production: Spotlight on Neurostimulation

References

• The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5(2):93–107.
   PubMed Web of Science ®Google Scholar
• Yu JH, Asche CV, Fairchild CJ. The economic burden of dry eye disease in the United States: a decision tree analysis. Cornea. 2007;30:379–387. doi:10.1097/ICO.0b013e3181f7f363
   Web of Science ®Google Scholar
• Sall K, Stevenson OD, Mundorf TK, et al. Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. Ophthalmol. 2000;107:631–639. doi:10.1016/S0161-6420(99)00176-1
   PubMed Web of Science ®Google Scholar
• Clayton JA. Dry eye. N Engl J Med. 2018;378:2212–2223. doi:10.1056/NEJMra1407936
   PubMed Web of Science ®Google Scholar
• Kossler AL, Wang JH, Feuer W, et al. Lacrimal nerve stimulation by a neurostimulator for tear production. Invest Ophthalmol Vis Sci. 2009;50:4244.
   Google Scholar
• Rokyta R, Fricova J. Neurostimulation methods in the treatment of chronic pain. Physiol Res. 2012;61:S23–S31. doi:10.33549/physiolres.932392
   Web of Science ®Google Scholar
• Ben-Menachem E. Nerve stimulation for the treatment of epilepsy. Lancet Neurol. 2002;1:477–482. doi:10.1016/S1474-4422(02)00220-X
   PubMed Web of Science ®Google Scholar
• Shealy CN, Mortimer JT, Reswick JB. Electrical inhibition of pain by stimulation of the dorsal columns: preliminary clinical report. Anesth Analg. 1967;46:489–491.
   PubMed Web of Science ®Google Scholar
• Allergan TrueTear. Available from: https://www.truetear.com. Accessed April 1, 2021.
   Google Scholar
• Stern ME, Beuerman RW, Fox RI, et al. The pathology of dry eye; the interaction between the ocular surface and lacrimal glands. Cornea. 1998;17:584–589. doi:10.1097/00003226-199811000-00002
   PubMed Web of Science ®Google Scholar
• Dartt D. Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Prog Retin Eye Res. 2009;28:155–177. doi:10.1016/j.preteyeres.2009.04.003
   PubMed Web of Science ®Google Scholar
• LeDoux MS, Zhou QH, Murphy RB, et al. Parasympathetic innervation of the meibomian glands in rats. Invest Ophthalmol Vis Sci. 2001;42:2434–2441.
   PubMed Web of Science ®Google Scholar
• Li DQ, Zhuo C, Xiu JS, et al. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004;45:4302–4311. doi:10.1167/iovs.04-0299
   PubMed Web of Science ®Google Scholar
• Luo LH, Li DQ, Corrlaes RM, et al. Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens. 2005;31:186–193. doi:10.1097/01.ICL.0000162759.79740.46
   PubMedGoogle Scholar
• De Paiva CS, Corrales RM, Villarreal AL, et al. Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res. 2006;83:526–535. doi:10.1016/j.exer.2006.02.004
   PubMed Web of Science ®Google Scholar
• Luo L, Li DQ, Doshi A, et al. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci. 2004;2:124–130.
   Google Scholar
• Baudouin C, Messmer EM, Aragona P, et al. Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction. Br J Ophthalmol. 2016;100(3):300–306. doi:10.1136/bjophthalmol-2015-307415
   PubMed Web of Science ®Google Scholar
• Wernoe TB. [The vasodilatory naso-ocular reflex and its diagnostic value]. Acta Psychiatr Scand. 1927;2:385–398. doi:10.1111/j.1600-0447.1927.tb07448.x
   Google Scholar
• Kossler AL Chronic electrical stimulation for tear & secretion: lacrimal vs. anterior ethmoid nerve. American Academy of Ophthalmology (AAO) Annual Meeting; 2017.
   Google Scholar
• Brinton M, Kossler AL, Patel ZM, et al. Enhanced tearing by electrical & stimulation of the anterior ethmoid nerve. Invest Ophthalmol Vis Sci. 2017;58:2341–2348. doi:10.1167/iovs.16-21362
   PubMed Web of Science ®Google Scholar
• Gumus K, Pflugfelder SC. Intranasal tear neurostimulation: an emerging concept in the treatment of dry eye. Int Ophthalmol Clin. 2016;57:101–108. doi:10.1097/IIO.0000000000000163
   Google Scholar
• Baudouin C, Aragona P, Messmer EM, et al. Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting. Ocul Surf. 2013;11:246–258. doi:10.1016/j.jtos.2013.07.003
   PubMed Web of Science ®Google Scholar
• Baudouin C, Messmer EM, Aragona P, et al. [A new approach for better comprehension of diseases of the ocular surface]. J Fr Ophthalmol. 2007;30:239–246. French. doi:10.1016/S0181-5512(07)89584-2
   PubMed Web of Science ®Google Scholar
• Brinton M, Chung JL, Kossler A, et al. Electronic enhancement of tear secretion. J Neural Eng. 2016;13(1):016006. doi:10.1088/1741-2560/13/1/016006
   PubMed Web of Science ®Google Scholar
• Friedman NJ, Butron K, Robledo N, et al. A nonrandominized, open-label study to evaluate the effect of nasal stimulation on tear production in subjects with dry eye disease. Clin Ophthalmol. 2016;10:795–804.
   PubMed Web of Science ®Google Scholar
• Orrick B, Watson M, Angjeli E, et al. Quantitation of tear production by tear meniscus height following acute use of the intranasal tear neurostimulator. Invest Ophthalmol Vis Sci. 2016;58:2692.
   Web of Science ®Google Scholar
• Woodward A, Senchyna M, Franke M, et al. Effect of intranasal neurostimulation on tear protein content in patients with dry eye. Invest Ophthalmol Vis Sci. 2017;58(8):2673.
   Web of Science ®Google Scholar
• Dieckmann G, Kataguiri P, Pondelis N, et al. In vivo confocal microscopy demonstrates intranasal neurostimulation-induced goblet cell alterations. Invest Ophthalmol Vis Sci. 2017;58:2694.
   Web of Science ®Google Scholar
• Green KB, Kamat M, Franke M, et al. Tear total lipid concentration in patients with dry eye following intranasal neurostimulation. Invest Ophthalmol Vis Sci. 2017;58(8):2693.
   Web of Science ®Google Scholar
• Cohn GS, Corbett D, Tenen A, et al. Randomized, controlled, double-masked, multicenter, pilot study evaluating safety and efficacy of intranasal neurostimulation for dry eye disease. Invest Ophthalmol Vis Sci. 2019;60(1):147–153. doi:10.1167/iovs.18-23984
   PubMed Web of Science ®Google Scholar
• Abbvie News Center. AbbVie to Acquire Allergan in transformative move for both companies. Available from: https://news.abbvie.com/news/press-releases/abbvie-to-acquire-allergan-in-transformative-move-for-both-companies.htm. Accessed August 30, 2021.
   Google Scholar
• Ji MH, Moshfeghi MD, Periman L, et al. Novel extranasal tear stimulation: pivotal study results. Transl Vis Sci Technol. 2020;9(12):23. doi:10.1167/tvst.9.12.23
   PubMed Web of Science ®Google Scholar
• PR Newswire. Olympic ophthalmics presents clinical evidence for iTEAR100. Accessed March 15, 2021.
   Google Scholar
• Pedrotti E, Bosello F, Fasolo A, et al. Transcutaneous periorbital electrical stimulation in the treatment of dry eye. Br J Ophthalmol. 2016;101(6):814–819.
   Web of Science ®Google Scholar
• Cai MM, Zhang J. Effectiveness of transcutaneous electrical stimulation combined with artificial tears for the treatment of dry eye: a randomized controlled trial. Exp Ther Med. 2020;20(6):175. doi:10.3892/etm.2020.9305
   Web of Science ®Google Scholar
• Zilstorff-Pedersen K. Quantitative measurements of the nasolacrimal reflex. Acta Otolaryngol. 1959;50:501–506. doi:10.3109/00016485909129225
   PubMedGoogle Scholar
• EyeWire News. Oyster point announces results of Phase 3 Trial of OC-01 nasal spray for treatment of signs and symptoms of dry eye disease. Accessed March 15, 2021.
   Google Scholar
• Keiger CJH, Case LD, Kendal-Reed M, et al. Nicotinic cholinergic receptor expression in the human nasal mucosa. Ann Otol Rhinol Laryngol. 2003;112(1):7–84. doi:10.1177/000348940311200115
   Web of Science ®Google Scholar
• Alimohammadi H, Silver WL. Evidence for nicotinic acetylcholine receptors on nasal trigeminal nerve endings of the rat. Chem Senses. 2000;25(1):61–66. doi:10.1093/chemse/25.1.61
   PubMed Web of Science ®Google Scholar
• Galor A, Moein H-R, Lee C, et al. Review: neuropathic pain and dry eye. Ocul Surf. 2018;16(1):31–44. doi:10.1016/j.jtos.2017.10.001
   PubMed Web of Science ®Google Scholar
• Dieckmann G, Goyal S, Hamrah P. Neuropathic corneal pain: approaches for management. Ophthalmol. 2017;124(11):S34–S47. doi:10.1016/j.ophtha.2017.08.004
   PubMed Web of Science ®Google Scholar
• Rosenthal P, Borsook D. The corneal pain system. Part I: the Missing Piece of the Dry Eye Puzzle. Ocul Surf. 2012;10:2–14. doi:10.1016/j.jtos.2012.01.002
   PubMed Web of Science ®Google Scholar
• Vance CG, Dailey DL, Rakel BA, Sluka KA. Using TENS for pain control: the state of the evidence. Pain Manag. 2014;4(3):197–209. doi:10.2217/pmt.14.13
   PubMedGoogle Scholar
• Hayek SM, Sweet JA, Miller JP, Sayegh RR. Successful management of corneal neuropathic pain with intrathecal targeted drug delivery. Pain Med. 2016;17(7):1302–1307. doi:10.1093/pm/pnv058
   Web of Science ®Google Scholar
• Zayan K, Aggarwal S, Felix E, et al. Transcutaneous electrical nerve stimulation for the long-term treatment of ocular pain. Neuromodulation. 2020;23(6):781–787. doi:10.1111/ner.13146
   Web of Science ®Google Scholar
• Melzack R, Wall PD. Pain Mechanisms: a New Theory. Science. 1965;150:3699. doi:10.1126/science.150.3699.971
   Web of Science ®Google Scholar
• Radhakrishnan R, Sluka K. Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-induced antihyperalgesia. J Pain. 2016;6:673–680. doi:10.1016/j.jpain.2005.06.001
   Web of Science ®Google Scholar
• Jiang L, Yuan DL, Li ML, et al. Combination of flunarizine and transcutaneous supraorbital neurostimulation improves migraine prophylaxis. Acta Neurol Scand. 2019;139:276–283.
   Web of Science ®Google Scholar
• Han SB, Liu YC, Mohamed-Noriega K, et al. Objective imaging diagnostics for dry eye disease. J Ophthalmol. 2020;2020:1–11. doi:10.1155/2020/3509064
   Web of Science ®Google Scholar
• Ibrahim OMA, Dogru M, Takano Y, et al. Application of visante optical coherence tomography tear meniscus height measurement in the diagnosis of dry eye disease. Ophthalmol. 2010;117(10):1923–1929. doi:10.1016/j.ophtha.2010.01.057
   Web of Science ®Google Scholar
• Ban Y, Shimazaki-den S, Tsubota K, Shimazaki J. Morphological evaluation of meibomian glands using noncontact infrared meibography. Ocul Surf. 2013;11(1):47–53. doi:10.1016/j.jtos.2012.09.005
   PubMed Web of Science ®Google Scholar
• Arita R, Morishige N, Fujii T, et al. Tear interferometric patterns reflect clinical tear dynamics in dry eye patients. Invest Ophthalmol Vis Sci. 2016;57(8):3928–3934. doi:10.1167/iovs.16-19788
   PubMed Web of Science ®Google Scholar
• Cohen Y, Epshtein S, Harris A, et al. Tear film imager for dynamic mapping of the human tear film. Appl Opt. 2019;58(29):7987–7995. doi:10.1364/AO.58.007987
   Web of Science ®Google Scholar
• Jung JH, Ji YW, Hwang HS, et al. Proteomic analysis of human lacrimal and tear fluid in dry eye disease. Nature. 2017;7:1.
   Google Scholar
• US Food & Drug Administration. De Novo Classification Request for Intranasal Tear Neurostimulator. Available from: https://www.accessdata.fda.gov/cdrh_docs/reviews/DEN160030.pdf. Accessed October 13, 2021.
   Google Scholar