A Decade of Effective Dry Eye Disease Management with Systane Ultra (Polyethylene Glycol/Propylene Glycol with Hydroxypropyl Guar) Lubricant Eye Drops

References

• Moon JH, Kim KW, Moon NJ. Smartphone use is a risk factor for pediatric dry eye disease according to region and age: a case control study. BMC Ophthalmol. 2016;16(1):188. doi:10.1186/s12886-016-0364-4
   PubMed Web of Science ®Google Scholar
• International Dry Eye WorkShop Study Group. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5(2):93–107. doi:10.1016/S1542-0124(12)70082-4
   Web of Science ®Google Scholar
• Craig JP, Nelson JD, Azar DT, et al. TFOS DEWS II report executive summary. Ocul Surf. 2017;15(4):802–812. doi:10.1016/j.jtos.2017.08.003
   PubMed Web of Science ®Google Scholar
• Jones L, Downie LE, Korb D, Benitez-Del-Castillo JM, Dana R. TFOS DEWS II management and therapy report. Ocul Surf. 2017;15(3):575–628.
   PubMed Web of Science ®Google Scholar
• Patel VD, Watanabe JH, Strauss JA, Dubey AT. Work productivity loss in patients with dry eye disease: an online survey. Curr Med Res Opin. 2011;27(5):1041–1048. doi:10.1185/03007995.2011.566264
   PubMed Web of Science ®Google Scholar
• O’Brien PD, Collum LM. Dry eye: diagnosis and current treatment strategies. Curr Allergy Asthma Rep. 2004;4(4):314–319. doi:10.1007/s11882-004-0077-2
   PubMed Web of Science ®Google Scholar
• Messmer EM. The pathophysiology, diagnosis, and treatment of dry eye disease. Dtsch Arztebl Int. 2015;112(5):71–81. doi:10.3238/arztebl.2015.0071
   PubMed Web of Science ®Google Scholar
• Nassiri N, Rodriguez Torres Y, Meyer Z, Beyer MA, Vellaichamy G, Dhaliwal AS. Current and emerging therapy of dry eye disease. Part A: pharmacological modalities. Exp Rev Ophthalmol. 2017;12(4):269–297. doi:10.1080/17469899.2017.1327350
   Web of Science ®Google Scholar
• Sutu C, Fukuoka H, Afshari NA. Mechanisms and management of dry eye in cataract surgery patients. Curr Opin Ophthalmol. 2016;27(1):24–30. doi:10.1097/ICU.0000000000000227
   PubMed Web of Science ®Google Scholar
• Gayton JL. Etiology, prevalence, and treatment of dry eye disease. Clin Ophthalmol. 2009;3:405–412. doi:10.2147/OPTH.S5555
   PubMedGoogle Scholar
• Che Arif FA, Hilmi MR, Kamal KM, Ithnin MH. Evaluation of 18 artificial tears based on viscosity and pH. Malaysian J Ophthalmol. 2020;2(2):96–111. doi:10.35119/myjo.v2i2.109
   Google Scholar
• Springs C. Novel ocular lubricant containing an intelligent delivery system: details of its mechanism of action. Dev Ophthalmol. 2010;45:139–147.
   PubMedGoogle Scholar
• Pucker AD, Ng SM, Nichols JJ. Over the counter (OTC) artificial tear drops for dry eye syndrome. Cochrane Database Syst Rev. 2016;2:CD009729. doi:10.1002/14651858.CD009729.pub2
   PubMed Web of Science ®Google Scholar
• Benelli U. Systane lubricant eye drops in the management of ocular dryness. Clin Ophthalmol. 2011;5:783–790. doi:10.2147/OPTH.S13773
   PubMedGoogle Scholar
• Christensen MT, Cohen S, Rinehart J, et al. Clinical evaluation of an HP guar gellable lubricant eye drop for the relief of dryness of the eye. Curr Eye Res. 2004;28(1):55–62. doi:10.1076/ceyr.28.1.55.23495
   Web of Science ®Google Scholar
• Ubels JL, Clousing DP, Van Haitsma TA, et al. Pre-clinical investigation of the efficacy of an artificial tear solution containing hydroxypropyl-guar as a gelling agent. Curr Eye Res. 2004;28(6):437–444. doi:10.1080/02713680490503787
   Web of Science ®Google Scholar
• Moon SW, Hwang JH, Chung SH, Nam KH. The impact of artificial tears containing hydroxypropyl guar on mucous layer. Cornea. 2010;29(12):1430–1435. doi:10.1097/ICO.0b013e3181ca636b
   PubMed Web of Science ®Google Scholar
• Ng A, Keech A, Jones L. Tear osmolarity changes after use of hydroxypropyl-guar-based lubricating eye drops. Clin Ophthalmol. 2018;12:695–700. doi:10.2147/OPTH.S150587
   PubMed Web of Science ®Google Scholar
• Aragona P, Papa V, Micali A, Santocono M, Milazzo G. Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eye. Br J Ophthalmol. 2002;86(2):181–184. doi:10.1136/bjo.86.2.181
   PubMed Web of Science ®Google Scholar
• Rangarajan R, Kraybill B, Ogundele A, Ketelson HA. Effects of a hyaluronic acid/hydroxypropyl guar artificial tear solution on protection, recovery, and lubricity in models of corneal epithelium. J Ocul Pharmacol Ther. 2015;31(8):491–497. doi:10.1089/jop.2014.0164
   PubMed Web of Science ®Google Scholar
• Walsh K, Jones L. The use of preservatives in dry eye drops. Clin Ophthalmol. 2019;13:1409–1425. doi:10.2147/OPTH.S211611
   PubMed Web of Science ®Google Scholar
• Moshirfar M, Pierson K, Hanamaikai K, Santiago-Caban L, Muthappan V, Passi SF. Artificial tears potpourri: a literature review. Clin Ophthalmol. 2014;8:1419–1433. doi:10.2147/OPTH.S65263
   PubMedGoogle Scholar
• Charnock C. Are multidose over-the-counter artificial tears adequately preserved? Cornea. 2006;25(4):432–437. doi:10.1097/01.ico.0000183538.53017.69
   PubMed Web of Science ®Google Scholar
• Ammar DA, Noecker RJ, Kahook MY. Effects of benzalkonium chloride-preserved, polyquad-preserved, and sofZia-preserved topical glaucoma medications on human ocular epithelial cells. Adv Ther. 2010;27(11):837–845. doi:10.1007/s12325-010-0070-1
   PubMed Web of Science ®Google Scholar
• Codling CE, Maillard JY, Russell AD. Aspects of the antimicrobial mechanisms of action of a polyquaternium and an amidoamine. J Antimicrob Chemother. 2003;51(5):1153–1158. doi:10.1093/jac/dkg228
   Web of Science ®Google Scholar
• Ribeiro M, Barbosa FT, Ribeiro LEF, Sousa-Rodrigues CF, Ribeiro EAN. Effectiveness of using preservative-free artificial tears versus preserved lubricants for the treatment of dry eyes: a systematic review. Arq Bras Oftalmol. 2019;82(5):436–445. doi:10.5935/0004-2749.20190097
   PubMed Web of Science ®Google Scholar
• Meadows DL, Ketelson HA, Davis J. Extensional rheological properties of an artificial tear delivery system. Invest Ophthalmol Vis Sci. 2008;49(13):1545.
   Google Scholar
• Davitt WF, Bloomenstein M, Christensen M, Martin AE. Efficacy in patients with dry eye after treatment with a new lubricant eye drop formulation. J Ocul Pharmacol Ther. 2010;26(4):347–353. doi:10.1089/jop.2010.0025
   PubMed Web of Science ®Google Scholar
• Bhatnagar KR, Pote S, Pujari S, Deka D. Validity of subjective assessment as screening tool for dry eye disease and its association with clinical tests. Int J Ophthalmol. 2015;8(1):174–181. doi:10.3980/j.issn.2222-3959.2015.01.31
   Web of Science ®Google Scholar
• Tsubota K, Fujihara T, Saito K, Takeuchi T. Conjunctival epithelium expression of HLA-DR in dry eye patients. Ophthalmologica. 1999;213(1):16–19. doi:10.1159/000027387
   PubMed Web of Science ®Google Scholar
• Versura P, Profazio V, Schiavi C, Campos EC. Hyperosmolar stress upregulates HLA-DR expression in human conjunctival epithelium in dry eye patients and in vitro models. Invest Ophthalmol Vis Sci. 2011;52(8):5488–5496. doi:10.1167/iovs.11-7215
   Web of Science ®Google Scholar
• Fernandez KB, Epstein SP, Raynor GS, et al. Modulation of HLA-DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution. Clin Ophthalmol. 2015;9:1137–1145. doi:10.2147/OPTH.S81355
   PubMed Web of Science ®Google Scholar
• Labetoulle M, Messmer EM, Pisella PJ, Ogundele A, Baudouin C. Safety and efficacy of a hydroxypropyl guar/polyethylene glycol/propylene glycol-based lubricant eye-drop in patients with dry eye. Br J Ophthalmol. 2017;101(4):487–492. doi:10.1136/bjophthalmol-2016-308608
   PubMed Web of Science ®Google Scholar
• Asbell P, Vingrys AJ, Tan J, Ogundele A, Downie LE. Clinical outcomes of fixed versus as-needed use of artificial tears in dry eye disease: a 6-week, observer-masked Phase 4 clinical trial. Invest Ophthalmol Vis Sci. 2018;59(6):2275–2280. doi:10.1167/iovs.17-23733
   PubMed Web of Science ®Google Scholar
• Aguilar A, Berra M, Tredicce J, Berra A. Efficacy of polyethylene glycol-propylene glycol-based lubricant eye drops in reducing squamous metaplasia in patients with dry eye disease. Clin Ophthalmol. 2018;12:1237–1243. doi:10.2147/OPTH.S164888
   PubMed Web of Science ®Google Scholar
• Torkildsen G. The effects of lubricant eye drops on visual function as measured by the Inter-blink interval Visual Acuity Decay test. Clin Ophthalmol. 2009;3:501–506. doi:10.2147/OPTH.S6225
   PubMedGoogle Scholar
• Guillon M, Maissa CA, Wong S, Griffin JM, Christensen MT. Functional visual performance of systane ultra after 4 weeks of use. Invest Ophthalmol Vis Sci. 2011;52(14):3834.
   Google Scholar
• Torkildsen G, Brujic M, Cooper MS, Karpecki P, Majmudar P. Evaluation of a new artificial tear formulation for the management of tear film stability and visual function in patients with dry eye. Clin Ophthalmol. 2017;11:1883–1889. doi:10.2147/OPTH.S144369
   PubMed Web of Science ®Google Scholar
• Corcoran P, Hollander DA, Ousler GW, et al. Dynamic sensitivity of corneal TRPM8 receptors to menthol instillation in dry eye versus normal subjects. J Ocul Pharmacol Ther. 2017;33(9):686–692. doi:10.1089/jop.2017.0050
   Web of Science ®Google Scholar
• Kislan T. Cross-over evaluation of blink tears versus systane ultra in mild dry eye patients. Optometry. 2010;81(6):287. doi:10.1016/j.optm.2010.04.041
   Google Scholar
• Waduthantri S, Yong SS, Tan CH, Htoon HM, Tong L. Lubricant with gelling agent in treating dry eye in adult Chinese patients. Optom Vis Sci. 2012;89(11):1647–1653. doi:10.1097/OPX.0b013e31826cfc41
   PubMed Web of Science ®Google Scholar
• Zheng LL, Myung D, Yu CQ, Ta CN. Comparative In vitro cytotoxicity of artificial tears. JSM Ophthalmol. 2015;3(1):1026.
   Google Scholar
• Wong D, Albietz JM, Tran H, Du Toit C, Li AH. Treatment of contact lens related dry eye with antibacterial honey. Cont Lens Anterior Eye. 2017;40(6):389–393. doi:10.1016/j.clae.2017.10.001
   PubMed Web of Science ®Google Scholar
• Maharana PK, Raghuwanshi S, Chauhan AK, Rai VG, Pattebahadur R. Comparison of the efficacy of carboxymethylcellulose 0.5%, hydroxypropyl-guar containing polyethylene glycol 400/propylene glycol, and hydroxypropyl methyl cellulose 0.3% tear substitutes in improving ocular surface disease index in cases of dry eye. Middle East Afr J Ophthalmol. 2017;24(4):202–206. doi:10.4103/meajo.MEAJO_165_15
   PubMed Web of Science ®Google Scholar
• McDonald M, Schachet JL, Lievens CW, Kern JR. Systane(R) ultra lubricant eye drops for treatment of contact lens-related dryness. Eye Contact Lens. 2014;40(2):106–110. doi:10.1097/ICL.0000000000000018
   PubMed Web of Science ®Google Scholar
• Kading D. A two-week clinical evaluation of the safety of systane ultra in contact lens-wearing patients. Clin Ophthalmol. 2010;4:27–32. doi:10.2147/OPTH.S8079
   Google Scholar
• Gokul A, Wang MTM, Craig JP. Tear lipid supplement prophylaxis against dry eye in adverse environments. Cont Lens Anterior Eye. 2018;41(1):97–100. doi:10.1016/j.clae.2017.09.013
   Web of Science ®Google Scholar
• Bitton E, Crncich V, Brunet N. Does the temperature of an artificial tear affect its comfort? Clin Exp Optom. 2019;101(5):641–647. doi:10.1111/cxo.12664
   Web of Science ®Google Scholar
• Davidson R, Schultz-Scott B. Efficacy evaluation of systane® ultra in patients with dry eye undergoing cataract surgery. In: 30th Congress of the European Society of Cataract and Refractive Surgery. 2012.
   Google Scholar
• Labiris G, Ntonti P, Sideroudi H, Kozobolis V. Impact of polyethylene glycol 400/propylene glycol/hydroxypropyl-guar and 0.1% sodium hyaluronate on postoperative discomfort following cataract extraction surgery: a comparative study. Eye Vis. 2017;4:13. doi:10.1186/s40662-017-0079-5
   Google Scholar