Clinical Characteristics, Histopathology, and Treatment Outcomes of Pythium Keratitis: A Retrospective Cohort Study

References

• Hasika R, Lalitha P, Radhakrishnan N, Rameshkumar G, Prajna NV, Srinivasan M. Pythium keratitis in South India: incidence, clinical profile, management, and treatment recommendation. Indian J Ophthalmol. 2019;67(1):42–47. doi:10.4103/ijo.IJO_445_18
   PubMed Web of Science ®Google Scholar
• Thanathanee O, Enkvetchakul O, Rangsin R, Waraasawapati S, Samerpitak K, Suwan-apichon O. Outbreak of Pythium keratitis during rainy season: a case series. Cornea. 2013;32(2):199–204. doi:10.1097/ICO.0b013e3182535841
   PubMed Web of Science ®Google Scholar
• Permpalung N, Worasilchai N, Plongla R, et al. Treatment outcomes of surgery, antifungal therapy and immunotherapy in ocular and vascular human pythiosis: a retrospective study of 18 patients. J Antimicrob Chemother. 2015;70(6):1885–1892. doi:10.1093/jac/dkv008
   PubMed Web of Science ®Google Scholar
• Krajaejun T, Sathapatayavongs B, Pracharktam R, et al. Clinical and epidemiological analyses of human pythiosis in Thailand. Clin Infect Dis. 2006;43(5):569–576. doi:10.1086/506353
   PubMed Web of Science ®Google Scholar
• Mendoza L, Hernandez F, Ajello L. Life cycle of the human and animal oomycete pathogen Pythium insidiosum. J Clin Microbiol. 1993;31(11):2967–2973. doi:10.1128/JCM.31.11.2967-2973.1993
   PubMed Web of Science ®Google Scholar
• Lekhanont K, Chuckpaiwong V, Chongtrakool P, Aroonroch R, Vongthongsri A. Pythium insidiosum keratitis in contact lens wear: a case report. Cornea. 2009;28(10):1173–1177. doi:10.1097/ICO.0b013e318199fa41
   PubMed Web of Science ®Google Scholar
• Lelievre L, Borderie V, Garcia-Hermoso D, et al. Imported Pythium insidiosum keratitis after a swim in Thailand by a contact lens-wearing traveler. Am J Trop Med Hyg. 2015;92(2):270–273. doi:10.4269/ajtmh.14-0380
   PubMed Web of Science ®Google Scholar
• Permpalung N, Worasilchai N, Manothummetha K, et al. Clinical outcomes in ocular pythiosis patients treated with a combination therapy protocol in Thailand: a prospective study. Med Mycol. 2019;57(8):923–928. doi:10.1093/mmy/myz013
   Web of Science ®Google Scholar
• Sharma S, Balne PK, Motukupally SR, et al. Pythium insidiosum keratitis: clinical profile and role of DNA sequencing and zoospore formation in diagnosis. Cornea. 2015;34(4):438–442. doi:10.1097/ICO.0000000000000349
   PubMed Web of Science ®Google Scholar
• He H, Liu H, Chen X, Wu J, He M, Zhong X. Diagnosis and treatment of Pythium insidiosum corneal ulcer in a chinese child: a case Report and literature Review. Am J Case Rep. 2016;17:982–988. doi:10.12659/AJCR.901158
   Google Scholar
• Agarwal S, Iyer G, Srinivasan B, Agarwal M. Panchalam Sampath Kumar S, Therese LK. Clinical profile of Pythium keratitis: perioperative measures to reduce risk of recurrence. Br J Ophthalmol. 2018;102(2):153–157. doi:10.1136/bjophthalmol-2017-310604
   PubMed Web of Science ®Google Scholar
• Bagga B, Sharma S, Madhuri Guda SJ, et al. Leap forward in the treatment of Pythium insidiosum keratitis. Br J Ophthalmol. 2018;102(12):1629–1633. doi:10.1136/bjophthalmol-2017-311360
   PubMed Web of Science ®Google Scholar
• Chitasombat MN, Jongkhajornpong P, Lekhanont K, Krajaejun T. Recent update in diagnosis and treatment of human pythiosis. PeerJ. 2020;8:e8555. doi:10.7717/peerj.8555
   PubMed Web of Science ®Google Scholar
• Mendoza L, Vilela R. The mammalian pathogenic oomycetes. Curr Fungal Infect Rep. 2013;7.
   Google Scholar
• Ramappa M, Nagpal R, Sharma S, Chaurasia S. successful medical management of presumptive Pythium insidiosum keratitis. Cornea. 2017;36(4):511–514. doi:10.1097/ICO.0000000000001162
   PubMedGoogle Scholar
• Maeno S, Oie Y, Sunada A, et al. Successful medical management of Pythium insidiosum keratitis using a combination of minocycline, linezolid, and chloramphenicol. Am J Ophthalmol Case Rep. 2019;15:100498. doi:10.1016/j.ajoc.2019.100498
   PubMedGoogle Scholar
• Krajaejun T, Pracharktam R, Wongwaisayawan S, Rochanawutinon M, Kunakorn M, Kunavisarut S. Ocular pythiosis: is it under-diagnosed? Am J Ophthalmol. 2004;137(2):370–372. doi:10.1016/S0002-9394(03)00908-5
   Web of Science ®Google Scholar
• Mendoza L, Mandy W, Glass R. An improved Pythium insidiosum-vaccine formulation with enhanced immunotherapeutic properties in horses and dogs with pythiosis. Vaccine. 2003;21(21–22):2797–2804. doi:10.1016/S0264-410X(03)00225-1
   Web of Science ®Google Scholar
• Jones DB. Decision-making in the management of microbial keratitis. Ophthalmology. 1981;88(8):814–820. doi:10.1016/S0161-6420(81)34943-4
   PubMed Web of Science ®Google Scholar
• Chindamporn A, Vilela R, Hoag KA, Mendoza L. Antibodies in the sera of host species with pythiosis recognize a variety of unique immunogens in geographically divergent Pythium insidiosum strains. Clin Vaccine Immunol. 2009;16(3):330–336. doi:10.1128/CVI.00429-08
   Google Scholar
• Kammarnjesadakul P, Palaga T, Sritunyalucksana K, et al. Phylogenetic analysis of Pythium insidiosum Thai strains using cytochrome oxidase II (COX II) DNA coding sequences and internal transcribed spacer regions (ITS). Med Mycol. 2011;49(3):289–295. doi:10.3109/13693786.2010.511282
   PubMed Web of Science ®Google Scholar
• Worasilchai N, Chindamporn A, Plongla R, et al. In vitro susceptibility of Thai Pythium insidiosum isolates to antibacterial agents. Antimicrob Agents Chemother. 2020;64(4):e02099–02019. doi:10.1128/AAC.02099-19
   Web of Science ®Google Scholar
• Vanittanakom N, Supabandhu J, Khamwan C, et al. Identification of emerging human-pathogenic Pythium insidiosum by serological and molecular assay-based methods. J Clin Microbiol. 2004;42(9):3970–3974. doi:10.1128/JCM.42.9.3970-3974.2004
   PubMed Web of Science ®Google Scholar
• Vemuganti GK, Garg P, Gopinathan U, et al. Evaluation of agent and host factors in progression of mycotic keratitis: a histologic and microbiologic study of 167 corneal buttons. Ophthalmology. 2002;109(8):1538–1546. doi:10.1016/S0161-6420(02)01088-6
   PubMed Web of Science ®Google Scholar
• Agarwal S, Iyer G, Srinivasan B, et al. Clinical profile, risk factors and outcome of medical, surgical and adjunct interventions in patients with Pythium insidiosum keratitis. Br J Ophthalmol. 2019;103(3):296–300. doi:10.1136/bjophthalmol-2017-311804
   PubMed Web of Science ®Google Scholar