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Original Research

Safety of Once-Daily Oxymetazoline HCl Ophthalmic Solution, 0.1% in Patients with Acquired Blepharoptosis: Results from Four Randomized, Double-Masked Clinical Trials

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Pages 4035-4048 | Published online: 08 Oct 2021

References

  • Alniemi ST, Pang NK, Woog JJ, Bradley EA. Comparison of automated and manual perimetry in patients with blepharoptosis. Ophthal Plast Reconstr Surg. 2013;29:361–363. doi:10.1097/IOP.0b013e31829a7288
  • Cahill KV, Burns JA, Weber PA. The effect of blepharoptosis on the field of vision. Ophthal Plast Reconstr Surg. 1987;3:121–125. doi:10.1097/00002341-198703030-00001
  • McKean-Cowdin R, Varma R, Wu J, Hays RD, Azen SP; Los Angeles Latino Eye Study Group. Severity of visual field loss and health-related quality of life. Am J Ophthalmol. 2007;143:1013–1023. doi:10.1016/j.ajo.2007.02.022
  • Meyer DR, Stern JH, Jarvis JM, Lininger LL. Evaluating the visual field effects of blepharoptosis using automated static perimetry. Ophthalmology. 1993;100:651–658. doi:10.1016/S0161-6420(93)31593-9
  • Finsterer J. Ptosis: causes, presentation, and management. Aesthetic Plast Surg. 2003;27:193–204. doi:10.1007/s00266-003-0127-5
  • Beard C. Muller’s superior tarsal muscle: anatomy, physiology, and clinical significance. Ann Plast Surg. 1985;14:324–333. doi:10.1097/00000637-198504000-00005
  • Freddo TF, Chaum E, eds. Anatomy of the Eye and Orbit: The Clinical Essentials. 1st ed. Philadelphia: Wolters Kluwer Health; 2018.
  • Hamedani AG, Gold DR. Eyelid dysfunction in neurodegenerative, neurogenetic, and neurometabolic disease. Front Neurol. 2017;8:329. doi:10.3389/fneur.2017.00329
  • Latting MW, Huggins AB, Marx DP, Giacometti JN. Clinical evaluation of blepharoptosis: distinguishing age-related ptosis from masquerade conditions. Semin Plast Surg. 2017;31:5–16. doi:10.1055/s-0037-1598188
  • Lim JM, Hou JH, Singa RM, Aakalu VK, Setabutr P. Relative incidence of blepharoptosis subtypes in an oculoplastics practice at a tertiary care center. Orbit. 2013;32:231–234. doi:10.3109/01676830.2013.788673
  • Sudhakar P, Vu Q, Kosoko-Lasaki O, Palmer M. Upper eyelid ptosis revisited. Am J Clin Med. 2009;6:5–14.
  • Bacharach J, Lee WW, Harrison AR, Freddo TF. A review of acquired blepharoptosis: prevalence, diagnosis, and current treatment options. Eye (Lond). 2021;35:2468–2481. doi:10.1038/s41433-021-01547-5
  • Forman WM, Leatherbarrow B, Sridharan GV, Tallis RC. A community survey of ptosis of the eyelid and pupil size of elderly people. Age Ageing. 1995;24:21–24. doi:10.1093/ageing/24.1.21
  • Hashemi H, Khabazkhoob M, Emamian MH, et al. The prevalence of ptosis in an Iranian adult population. J Curr Ophthalmol. 2016;28:142–145. doi:10.1016/j.joco.2016.04.005
  • Kim MH, Cho J, Zhao D, et al. Prevalence and associated factors of blepharoptosis in Korean adult population: the Korea National Health and Nutrition Examination Survey. Eye (Lond). 2017;31:940–946. doi:10.1038/eye.2017.43
  • Cahill KV, Bradley EA, Meyer DR, et al. Functional indications for upper eyelid ptosis and blepharoplasty surgery: a report by the American Academy of Ophthalmology. Ophthalmology. 2011;118(12):2510–2517. doi:10.1016/j.ophtha.2011.09.029
  • Pauly M, Sruthi R. Ptosis: evaluation and management. Kerala J Ophthalmol. 2019;31:11–16. doi:10.4103/kjo.kjo_2_19
  • Battu VK, Meyer DR, Wobig JL. Improvement in subjective visual function and quality of life outcome measures after blepharoptosis surgery. Am J Ophthalmol. 1996;121:677–686. doi:10.1016/S0002-9394(14)70634-8
  • Federici TJ, Meyer DR, Lininger LL. Correlation of the vision-related functional impairment associated with blepharoptosis and the impact of blepharoptosis surgery. Ophthalmology. 1999;106:1705–1712. doi:10.1016/S0161-6420(99)90354-8
  • Ho SF, Morawski A, Sampath R, Burns J. Modified visual field test for ptosis surgery (Leicester Peripheral Field Test). Eye (Lond). 2011;25:365–369. doi:10.1038/eye.2010.210
  • Chou E, Liu J, Seaworth C, et al. Comparison of revision rates on anterior- and posterior-approach ptosis surgery: a retrospective review of 1519 cases. Ophthal Plast Reconstr Surg. 2018;34:246–253. doi:10.1097/IOP.0000000000000938
  • Esmaeli-Gutstein B, Hewlett BR, Pashby RC, Oestreicher J, Harvey JT. Distribution of adrenergic receptor subtypes in the retractor muscles of the upper eyelid. Ophthal Plast Reconstr Surg. 1999;15:92–99. doi:10.1097/00002341-199903000-00005
  • Park SJ, Jang SY, Baek JS, Chin S, Jang JW. Distribution of adrenergic receptor subtypes and responses to topical 0.5% apraclonidine in patients with blepharoptosis. Ophthalmic Plast Reconstr Surg. 2018;34:547–551. doi:10.1097/IOP.0000000000001095
  • Skibell BC, Harvey JH, Oestreicher JH, et al. Adrenergic receptors in the ptotic human eyelid: correlation with phenylephrine testing and surgical success in ptosis repair. Ophthalmic Plast Reconstr Surg. 2007;23:367–371. doi:10.1097/IOP.0b013e3181462a2e
  • Hauck MJ, Steele EA, Perry CB. Predictability of the phenylephrine test with regard to eyelid skin appearanc ein patients who undergo Muller muscle-conjunctival resection without blepharoplasty. Ophthal Plast Reconstr Surg. 2019;36:191–193. doi:10.1097/IOP.0000000000001510
  • Garibaldi DC, Hindman HB, Grant MP, Iliff NT, Merbs SL. Effect of 0.5% apraclonidine on ptosis in Horner syndrome. Ophthal Plast Reconstr Surg. 2006;22:53–55. doi:10.1097/01.iop.0000196322.05586.6a
  • Kirkpatrick CA, Shriver EM, Clark TE, Kardon RH. Upper eyelid response to topical 0.5% apraclonidine. Ophthal Plast Reconstr Surg. 2018;34:13–19. doi:10.1097/IOP.0000000000000843
  • Lee GN, Lin LW, Mehta S, Freitag SK. Response to phenylephrine testing in upper eyelids with ptosis. Digit J Ophthalmol. 2015;21:1–12.
  • Mendonça TB, Lummertz AP, Bocaccio FJ, Procianoy F. Effect of low-concentration, nonmydriatic selective alpha-adrenergic agonist eyedrops on upper eyelid position. Dermatol Surg. 2017;43:270–274. doi:10.1097/DSS.0000000000000967
  • Nagane Y, Utsugisawa K, Suzuki S, et al. Topical naphazoline in the treatment of myasthenic blepharoptosis. Muscle Nerve. 2011;44:41–44. doi:10.1002/mus.22002
  • Rehmani A, Mehta I, Smith E. Treatment of ptosis using brimonidine tartrate for anterior laminectomy-induced Horner syndrome. J Neuroophthalmol. 2020;40:95–96. doi:10.1097/WNO.0000000000000826
  • Uncini A, De Nicola G, Di Muzio A, et al. Topical naphazoline in treatment of myopathic ptosis. Acta Neurol Scand. 1993;87:322–324. doi:10.1111/j.1600-0404.1993.tb05516.x
  • Wijemanne S, Vijayakumar D, Jankovic J. Apraclonidine in the treatment of ptosis. J Neurol Sci. 2017;376:129–132. doi:10.1016/j.jns.2017.03.025
  • Araujo SV, Bond JB, Wilson RP, Moster MR, Schmidt CM Jr., Spaeth GL. Long term effect of apraclonidine. Br J Ophthalmol. 1995;79:1098–1101. doi:10.1136/bjo.79.12.1098
  • Robin AL, Ritch R, Shin D, Smythe B, Mundorf T, Lehmann RP. Topical apraclonidine hydrochloride in eyes with poorly controlled glaucoma. The Apraclonidine Maximum Tolerated Medical Therapy Study Group. Trans Am Ophthalmol Soc. 1995;93:421–438.
  • Stewart WC, Ritch R, Shin DH, Lehmann RP, Shrader CE, van Buskirk EM. The efficacy of apraclonidine as an adjunct to timolol therapy. Apraclonidine Adjunctive Therapy Study Group. Arch Ophthalmol. 1995;113:287–292. doi:10.1001/archopht.1995.01100030041019
  • Afrin® Original oxymetazoline decongestant nasal spray [package insert]. Whippany, NJ: Bayer Healthcare LLC; Revised February 2017.
  • Druce HM, Ramsey DL, Karnati S, Carr AN. Topical nasal decongestant oxymetazoline (0.05%) provides relief of nasal symptoms for 12 hours. Rhinology. 2018;56:343–350.
  • Duzman E, Anderson J, Vita JB, Lue JC, Chen CC, Leopold IH. Topically applied oxymetazoline. Ocular vasoconstrictive activity, pharmacokinetics, and metabolism. Arch Ophthalmol. 1983;101:1122–1126. doi:10.1001/archopht.1983.01040020124022
  • Visine L.R. (oxymetazoline hydrochloride 0.025%) [package insert]. New Brunswick, NJ: Johnson & Johnson Healthcare Products, Inc.; 2016.
  • Slonim CB, Foster S, Jaros M, et al. Association of oxymetazoline hydrochloride, 0.1%, solution administration with visual field in acquired ptosis: a pooled analysis of 2 randomized clinical trials. JAMA Ophthalmol. 2020;138:1168–1175. doi:10.1001/jamaophthalmol.2020.3812
  • Putterman AM, Fett DR. Müller’s muscle in the treatment of upper eyelid ptosis: a ten-year study. Ophthalmic Surg. 1986;17:354–360.
  • Putterman AM, Urist MJ. Muller muscle-conjunctiva resection. Technique for treatment of blepharoptosis. Arch Ophthalmol. 1975;93:619–623. doi:10.1001/archopht.1975.01010020595007
  • Haenisch B, Walstab J, Herberhold S, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010;24:729–739. doi:10.1111/j.1472-8206.2009.00805.x
  • Hosten LO, Snyder C. Over-the-counter ocular decongestants in the United States - mechanisms of action and clinical utility for management of ocular redness. Clin Optom. 2020;12:95–105. doi:10.2147/OPTO.S259398
  • Sugden D, Anwar N, Klein D. Rat pineal α1-adrenoceptor subtypes: studies using radioligand binding and reverse transcription-polymerase chain reaction analysis. Br J Pharmacol. 1996;118:1246–1252. doi:10.1111/j.1476-5381.1996.tb15530.x
  • Barsegian A, Botwinick A, Reddy HS. The phenylephrine test revisited. Ophthalmic Plast Reconstr Surg. 2018;34:151–154. doi:10.1097/IOP.0000000000000903
  • Ramey JT, Bailen E, Lockey RF. Rhinitis medicamentosa. J Investig Allergol Clin Immunol. 2006;16:148–155.
  • Vaidyanathan S, Williamson P, Clearie K, Khan F, Lipworth B. Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion. Am J Respir Crit Care Med. 2010;182:19–24. doi:10.1164/rccm.200911-1701OC
  • McAuliffe-Curtin D, Buckley C. Review of alpha adrenoceptor function in the eye. Eye (Lond). 1989;3:472–476. doi:10.1038/eye.1989.71
  • Gobbels MJ, Achten C, Spitznas M. Effect of topically applied oxymetazoline on tear volume and tear flow in humans. Graefes Arch Clin Exp Ophthalmol. 1991;229:147–149. doi:10.1007/BF00170547